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師資介紹

陳思妤 助理教授

陳思妤 助理教授      
Ssu-Yu Chen

現職

助理教授

地址及聯絡電話

11490 台北市內湖區民權東路六段161號7樓7302-1室
(02)8792-3100 ext 18460

E-mail

windblowvoice@gmail.com

最高學歷

美國杜克大學醫學院藥理學和癌症生物學系博士 (2022/08-2026/07)
國防醫學大學生物化學所碩士 (2018/08-2020/07)
國防醫學大學藥學系學士 (2012/09-2016/07)

研究興趣

探討人類母乳誘導細胞死亡機制
鐵死亡 (ferroptosis) 相關機制及其癌症應用

研究論文

Lin C-C., Rose J., Zhang A., Mirando A. J., Mestre A. A., Ding C-K., Liao Y., Chen S-Y., Setayeshpour Y., Wu J., Li Z., Yan D., Hilton M. J., Pei Zhou P., and Chi J-T., MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation, Nature Chemical Biology, 2026, 1-9.

Lin C-C., Lin Y-T., Chen S-Y., Setayeshpour Y., Chen Y., Dunn D. E., Nguyen T., Mestre A. A., Banerjee A., Guruprasad L., Soderblom E. J., Zhang G-F., Lin C-Y., Filonenko V., Jeong S. Y., Floyd S. R., Hayflick S. J., Gout I., and Chi J-T*., Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase, J Clin Invest. 2025;135(19):e190215.

Chen S-Y., Shyu I-L.*, Chi J-T.*, NINJ1 in Cell Death and Ferroptosis: Implications for Tumor Invasion and Metastasis, MDPI. Cancers, 2025 Feb 26;17(5):800.

Chen S-Y., Wu J., Chen Y., Wang Y-E., Setayeshpour Y., Federico C., Mestre A. A., Lin C-C.*, Chi J-T.*, NINJ1 Regulates Ferroptosis via xCT Antiporter Interaction and CoA Modulation, Cell Death & Disease, (2024) 15:755.

Huang W-Z., Liu T-M., Liu S-T., Chen S-Y., Huang S-M., Chen G-S.*, Oxidative Status Determines the Cytotoxicity of Ascorbic Acid in Human Oral Normal and Cancer Cells, International Journal of Molecular Sciences, 2023 Mar 2;24(5):4851.

Chen S-Y., Chang Y-L., Liu S-T., Chen G-S.*, Lee S-P.*, Huang S-M.*, Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells, International Journal of Molecular Sciences, 2021 Apr 2; 22(7): 3711.

Wu T-M., Liu S-T., Chen S-Y., Chen G-S.*, Wu C-C.*, Huang S-M.*, Mechanisms and Applications of the Anti-cancer Effect of Pharmacological Ascorbic Acid in Cervical Cancer Cells, Frontiers in Oncology, 2020 Sep 2;10:1483.

Chen S-Y., Liu S-T., Lin W-R., Lin C-K.*, Huang S-M.*, The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1, International Journal of Molecular Sciences, 2019 Oct 22;20 (20):5225.

其他資訊

RESEARCH · PUBLICATIONS · PROJECTS

研究・學術成果

研究主軸

鐵死亡、氧化還原與腫瘤微環境
解析NINJ1、xCT及輔酶A代謝如何調節鐵死亡,並探索腫瘤微環境的存活機制。
官網研究方向:人類母乳誘導細胞死亡、鐵死亡機轉及癌症研究
01NINJ1/xCT/CoA02CoAlation與粒線體抗氧化03腹水/卵巢癌鐵死亡抵抗三項主軸依近年代表論文歸納,詳細研究方向請洽本人。

研究領域關鍵字雲

整理自 11 篇論文

字體大小代表該主題在論文與計畫中出現的頻率;顏色對應研究主軸。將滑鼠移到關鍵字上可看到英文名稱與統計。

鐵死亡粒線體抗氧化卵巢癌口腔癌與子宮頸癌模式輔酶 A 代謝氧化還原恆定腹水微環境癌細胞死亡xCT / SLC7A11脂質過氧化腫瘤侵襲與轉移銅與雙硫崙NINJ1CoAlationc-Myc 穩定性DEC1藥理性抗壞血酸肌肉病理MESH1
NINJ1/xCT/CoACoAlation與粒線體抗氧化腹水/卵巢癌鐵死亡抵抗研究方法與技術

研究論文

11 篇論文
20263 篇11.Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancerNature Communications 17(1):4190・IF 15.710.MESH1 functions as a metazoan PAPS phosphatase to regulate sulfationNature Chemical Biology 22(9):1391-1399・IF 13.79.MESH1-mediated coenzyme A degradation drives ferroptosis sensitivity and muscle pathologyJournal of Clinical Investigation 136(11):e202212・IF 13.620252 篇8.Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductaseJournal of Clinical Investigation 135(19):e190215・IF 13.67.NINJ1 in Cell Death and Ferroptosis: Implications for Tumor Invasion and Metastasis第一作者Cancers 17(5):800・IF 4.420241 篇6.NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation第一作者Cell Death and Disease 15(10):755・IF 12.220231 篇5.Oxidative Status Determines the Cytotoxicity of Ascorbic Acid in Human Oral Normal and Cancer CellsInternational Journal of Molecular Sciences 24(5):4851・IF 4.920221 篇4.Stabilization of the c-Myc Protein via the Modulation of Threonine 58 and Serine 62 Phosphorylation by the Disulfiram/Copper Complex in Oral Cancer CellsInternational Journal of Molecular Sciences 23(16):9137・IF 4.920211 篇3.Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer CellsInternational Journal of Molecular Sciences 22(7):3711・IF 4.920201 篇2.Mechanisms and Applications of the Anti-cancer Effect of Pharmacological Ascorbic Acid in Cervical Cancer CellsFrontiers in Oncology 10:1483・IF 3.320191 篇1.The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1International Journal of Molecular Sciences 20(20):5225・IF 4.9書目依 2026-09-23 彙整表,IF 為 2025 JCR;點論文題名可開啟原文(DOI)。

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  • 更新日期:2026-05-20