最高學歷
國防醫學院
生命科學研究所博士
研究興趣
探討Hippo訊息傳導路徑在發育過程中是如何調控細胞增生與分化，以及當此訊息傳導失調所引發的致病機轉。
研究組蛋白修飾酶(histone modifying enzymes)是如何參與模式生物的發育過程，以及當此些修飾酶突變時所引發的發育缺失與人類相關疾病之致病機轉。
Image Credit: 楊承展 同學
研究論文
Wang, L.H., Aberin, M.A.E., Wu, S., and Wang,S.P. (2021). The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape. Biochemical Society Transactions 49(3): 1041-1054.
Ho,C.W., Chung,Y.C., Chiu,Y.L., and Wang,L.H* (2021). The bHLH transcription factor E protein negatively regulates endoreplication in the salivary gland cells. J Med Sci 41(1):29-37. (*corresponding author)
Chang,L.W., Tseng,I-C., Wang,L.H*., and Y. Henry Sun,Y.H*. (2020). Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene. Scientific Reports 10: 12783. (*co-corresponding author).
Wang,L.H*., and Baker,N.E*. (2019). Salvador-Warts-Hippo pathway regulates Sensory Organ Development via Caspase-dependent Non-apoptotic signaling. Cell Death and Disease 10(9): 669. (*co-corresponding author).
Wang,L.H*., and Baker,N.E*. (2018). Spatial regulation of expanded transcription in the Drosophila wing imaginal disc. PLoS ONE 13(7): e0201317. (*co-corresponding author).
Wang,S.P., Tang,Z#., Chen,C.W#., Shimada,M#., Koche,R.P#., Wang,L.H., Nakadai,T., Chramiec,A., Krivtsov,A.V., Armstrong,S.A., and Roeder,R.G. (2017). A UTX–MLL4– p300 transcriptional regulatory network coordinately shapes active enhancer landscapes for eliciting transcription. Molecular Cell 67(2):308-321. (#co-second authors).
Wang,S.P. and Wang,L.H* (2016). Disease implication of Hyper-Hippo signaling. Open Biology 6: 160119. (*corresponding author).
Wang,L.H., and Baker,N.E. (2015). E proteins and ID proteins: Helix-Loop-Helix Partners in Development and Disease. Developmental Cell 35(3), 269-280.
Wang,L.H., and Baker,N.E. (2015). Salvador-warts-hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Developmental Cell 32(2), 191-202. Previewed by T.A. Cook in Developmental Cell (Jan 26, 2015).