聯絡分機
02-8792-3100 #18814
E-mail
jyang62@asu.edu
yjh1130823@mail.ndmutsgh.edu.tw
經歷
2025-國防醫學大學 生物化學研究所
2015-2025 亞利桑那州立大學 副研究學者
2012-2013 亞利桑那州立大學 助教
2011-2011 亞利桑那州立大學 研究助理
2009-2010 亞利桑那州立大學 助教
2004-2008 中央研究院生物多樣性研究中心 研究助理
2000-2002 中央研究院植物研究所 研究助理
研究著作
1. Structure and function of F-type ATP synthase
Po-Lin Chiu, Jay-How Yang, Dewight Williams, Eaazhisai Kandiah, Petra Fromme (2021) " Redox modulation on chloroplast ATP synthase" Acta Crystallographic a-Foundation and Advances, 77: A167.
Jay-How Yang, Dewight Williams, Petra Fromme, Po-Lin Chiu (2020) " Structure basis of redox modulation on chloroplast ATP synthase" Communication Biology, (doi: 10.1038/s42003-020-01221-8) (Impact factor: 12.5; Citation: 27).
Jay-How Yang, Dewight Williams, Eaazhisai Kandiah, Petra Fromme, Po-Lin Chiu (2020) " Redox modulation on chloroplast ATP synthase " Microscopy and Microanalysis, 26:120-121.
Jay-How Yang, Petra Fromme, Po-Lin Chiu (2018) " Mechanism of Light Regulation on Chloroplast ATP Synthase Revealed by Single-Particle cryo-EM " Biochimica et Biophysica Acta-Bioenergetics, 1859: e84-e85.
Jay-How Yang, Iosifina Sarrou, Jose M. Martin-Garcia, Shangji Zhang, Kevin E. Redding, Petra Fromme (2015) " Purification and biochemical characterization of the ATP-synthase from Heliobacterium modesticaldum" Protein Expression and Purification 114:1-8 (Impaction factor:1.70; Citation:4)
Jay-How Yang, Raimund Fromme, Petra Fromme, Kevin Redding, Iosifina Sarrous, James E Evans (2014) " Isolation and characterization of the F1F0 ATP synthase from Heliobacterium modesticaldum" Biochimica et Biophysica Acta-Bioenergetics, 1837: e22.
2. Serial Femtosecond Nano-crystallography
Pandey S, Calvey G, Katz AM, Malla TN, Koua FHM, Martin-Garcia JM, Poudyal I, Yang Jay-How, Vakili M, Yefanov O, Zielinski KA, Bajt S, Awel S, Doerner K, Frank M, Gelisio L, Jernigan R, Kirkwood H, Kloos M, Koliyadu J, Mariani V, Miller MD, Mills G, Nelson G, Olmos JL Jr, Sadri A, Sato T, Tolstikova A, Xu W, Ourmazd A, Spence JCH, Schwander P, Barty A, Chapman HN, Fromme P, Mancuso AP, Phillips GN Jr, Bean R, Pollack L, Schmidt M. (2021) “ Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography.” International Union of Crystallography Journal 8: 878-895. (Impact factor: 5.4; Citation: 42).
Gisriel, C.; Coe, J.; Letrun, R.; Yefanov, O. M.; Luna-Chavez, C.; Stander, N. E.; Lisova, S.; Mariani, V.; Kuhn, M.; Aplin, S.; Grant, T. D.; Dörner, K.; Sato, T.; Echelmeier, A.; Cruz Villarreal, J.; Hunter, M. S.; Wiedorn, M. O.; Knoska, J.; Mazalova, V.; Roy-Chowdhury, S.; Yang, Jay-How.; Jones, A.; Bean, R.; Bielecki, J.; Kim, Y.; Mills, G.; Weinhausen, B.; Meza, J. D.; Al-Qudami, N.; Bajt, S.; Brehm, G.; Botha, S.; Boukhelef, D.; Brockhauser, S.; Bruce, B. D.; Coleman, M. A.; Danilevski, C.; Discianno, E.; Dobson, Z.; Fangohr, H.; Martin-Garcia, J. M.; Gevorkov, Y.; Hauf, S.; Hosseinizadeh, A.; Januschek, F.; Ketawala, G. K.; Kupitz, C.; Maia, L.; Manetti, M.; Messerschmidt, M.; Michelat, T.; Mondal, J.; Ourmazd, A.; Previtali, G.; Sarrou, I.; Schön, S.; Schwander, P.; Shelby, M. L.; Silenzi, A.; Sztuk-Dambietz, J.; Szuba, J.; Turcato, M.; White, T. A.; Wrona, K.; Xu, C.; Abdellatif, M. H.; Zook, J. D.; Spence, J. C. H.; Chapman, H. N.; Barty, A.; Kirian, R. A.; Frank, M.; Ros, A.; Schmidt, M.; Fromme, R.; Mancuso, A. P.; Fromme, P.; Zatsepin, N. A., (2019) “Membrane protein megahertz crystallography at the European XFEL.” Nature Communications 10(1), 5021. (Impact factor: 12.12; Citation: 59).
Scott C Jensen, Brendan Sullivan, Daniel Hartzler, Jose Meza Aguilar, Salah Awel, Saša Bajt, Shibom Basu, Richard Bean, Henry Chapman, Chelsie Conrad, Matthias Frank, Raimund Fromme, Jose M Martin-Garcia, Thomas D Grant, Michael Heymann, Mark S. Hunter, Gihan Ketawala, Richard A Kirian, Juraj Knoska, Christopher Kupitz, Xuanxuan Li, Mengning Liang, Stella Lisova, Valerio Mariani, Victoria Mazalova, Marc Messerschmidt, Michael Moran, Garrett Nelson, Dominik Oberthür, Alex Schaffer, Raymond G Sierra, Natalie Vaughn, Uwe Weierstall, Max O. Wiedorn, Lourdu Xavier, Jay-How Yang, Oleksandr Yefanov, Nadia A Zatsepin, Andrew Aquila, Petra Fromme, Sébastien Boutet, Gerald T Seidler, Yulia Pushkar (2019) " X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis" The Journal of Physical Chemistry Letters 10(3): 441–446. (Impact factor: 6.71; Citation: 7).
Woitowich NC, Halavaty AS, Waltz P, Kupitz C, Valera J, Tracy G, Gallagher KD, Claesson E, Nakane T, Pandey S, Nelson G, Tanaka R, Nango E, Mizohata E, Owada S, Tono K, Joti Y, Nugent AC, Patel H, Mapara A, Hopkins J, Duong P, Bizhga D1 Kovaleva SE, St Peter R, Hernandez CN1, Ozarowski WB, Roy-Chowdhuri S, Jay-How Yang, Edlund P, Takala H, Ihalainen J, Brayshaw J, Norwood T, Poudyal I, Fromme P, Spence JCH, Moffat K, Westenhoff S, Schmidt M, Stojković EA (2018) " Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome " International Union of Crystallography Journal 5:619-634. (Impact factor: 5.4; Citation: 21)
Kartik Ayyer, Oleksandr M. Yefanov, Dominik Oberthür, Shatabdi Roy-Chowdhury, Lorenzo Galli, Valerio Mariani, Shibom Basu, Jesse Coe, Chelsie E. Conrad, Raimund Fromme, Alexander Schaffer, Katerina Dörner, Daniel James, Christopher Kupitz, Markus Metz, Garrett Nelson, Paulraj Lourdu Xavier, Kenneth R. Beyerlein, Marius Schmidt, Iosifina Sarrou, John C. H. Spence, Uwe Weierstall, Thomas A. White, Jay-How Yang, Yun Zhao, Mengning Liang, Andrew Aquila, Mark S. Hunter, Joseph S. Robinson, Jason E. Koglin, Sébastien Boutet, Petra Fromme, Anton Barty, Henry N. Chapman (2016) " Macromolecular diffractive imaging using imperfect crystals" Nature 530: 203-206. (Impact factor: 24.36; Citation: 125).
3. Time-resolved SFX with X-ray Free Electron Lasers (XFEL)
Kupitz, C., S. Basu, I. Grotjohann, R. Fromme, N. A. Zatsepin, K. N. Rendek, M. S. Hunter, R. L. Shoeman, T. A. White, D. Wang, D. James, Jay-How Yang, D. E. Cobb, B. Reeder, R. G. Sierra, H. Liu, A. Barty, A. L. Aquila, D. Deponte, R. A. Kirian, S. Bari, J. J. Bergkamp, K. R. Beyerlein, M. J. Bogan, C. Caleman, T. C. Chao, C. E. Conrad, K. M. Davis, H. Fleckenstein, L. Galli, S. P. Hau-Riege, S. Kassemeyer, H. Laksmono, M. Liang, L. Lomb, S. Marchesini, A. V. Martin, M. Messerschmidt, D. Milathianaki, K. Nass, A. Ros, S. Roy-Chowdhury, K. Schmidt, M. Seibert, J. Steinbrener, F. Stellato, L. Yan, C. Yoon, T. A. Moore, A. L. Moore, Y. Pushkar, G. J. Williams, S. Boutet, R. B. Doak, U. Weierstall, M. Frank, H. N. Chapman, J. C. Spence and P. Fromme (2014). "Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser." Nature 513: 261-265. (Impact factor: 24.36; Citation: 448).
Diandra Doppler, Mohammad T Rabbani, Romain Letrun, Jorvani Cruz Villarreal, Dai Hyun Kim, Sahir Gandhi, Ana Egatz-Gomez, Mukul Sonker, Joe Chen, Faisal HM Koua, Jay-How Yang, Mohamed Youssef, Victoria Mazalova, Saša Bajt, Megan L Shelby, Matt A Coleman, Max O Wiedorn, Juraj Knoska, Silvan Schön, Tokushi Sato, Mark S Hunter, Ahmad Hosseinizadeh, Christopher Kuptiz, Reza Nazari, Roberto C Alvarez, Konstantinos Karpos, Sahba Zaare, Zachary Dobson, Erin Discianno, Shangji Zhang, James D Zook, Johan Bielecki, Raphael de Wijn, Adam R Round, Patrik Vagovic, Marco Kloos, Mohammad Vakili, Gihan K Ketawala, Natasha E Stander, Tien L Olson, Katherine Morin, Jyotirmory Mondal, Jonathan Nguyen, José Domingo Meza-Aguilar, Gerdenis Kodis, Sara Vaiana, Jose M Martin-Garcia, Valerio Mariani, Peter Schwander, Marius Schmidt, Marc Messerschmidt, Abbas Ourmazd, Nadia Zatsepin, Uwe Weierstall, Barry D Bruce, Adrian P Mancuso, Thomas Grant, Anton Barty, Henry N Chapman, Matthias Frank, Raimund Fromme, John CH Spence, Sabine Botha, Petra Fromme, Richard A Kirian, Alexandra Ros (2022). " Co-flow injection for serial crystallography at X-ray free-electron lasers." Journal of applied crystallography 55 (1): 1-13. (https://doi.org/10.1107/S1600576721011079/te5082sup1.pdf)(Impact factor: 6.1; Citation: 12).
4. Structure and function studies of proteins involved in human diseases
Rebecca J Jernigan, Dhenugen Logeswaran, Diandra Doppler, Nirupa Nagaratnam, Mukul Sonker, Jay-How Yang, Gihan Ketawala, Jose M Martin-Garcia, Megan L Shelby, Thomas D Grant, Valerio Mariani, Alexandra Tolstikova, Michelle Z Sheikh, Mimi Cho Yung, Matthew A Coleman, Sahba Zaare, Emily K Kaschner, Mohammad Towshif Rabbani, Reza Nazari, Michele A Zacks, Brandon Hayes, Raymond G Sierra, Mark S Hunter, Stella Lisova, Alexander Batyuk, Christopher Kupitz, Sebastien Boutet, Debra T Hansen, Richard A Kirian, Marius Schmidt, Raimund Fromme, Matthias Frank, Alexandra Ros, Julian J-L Chen, Sabine Botha, Petra Fromme (2023) " Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser" Structure, 31(2):138-151.e5. (doi: https://doi.org/10.1016/j.str.2022.12.009) (Impact factor: 5.871; Citation: 8).
Nirupa Nagaratnam, Jose M Martin-Garcia, Jay-How Yang, Matthew R Goode, Gihan Ketawala, Felicia M Craciunescu, James D Zook, Manashi Sonowal, Dewight Williams, Thomas D Grant, Raimund Fromme, Debra T Hansen, Petra Fromme (2022) " Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis" PloS one,17(8): e0267370. (doi: https://doi.org/10.1371/journal.pone.0267370) (Impact factor: 3.7; Citation: 2).
Lin CM, Yang Jay-How, Lee HJ, Lin YP, Tsai LP, Hsu CS, Luxton GWG, Hu CF. (2021) " Whole Exome Sequencing Identifies a Novel Homozygous Missense Mutation in the CSB Protein-Encoding ERCC6 Gene in a Taiwanese Boy with Cockayne Syndrome" Life,11(11):1230. (doi: 10.3390/life11111230) (Impact factor: 3.817; Citation: 2).
Karie E. Robertson, Chloe D. Truong, Felicia M. Craciunescu, Jay-How Yang, Po-Lin Chiu, Petra Fromme, Debra T. Hansen (2020) "Membrane directed expression in Escherichia coli of BBA57 and other virulence factors from the Lyme disease agent Borrelia burgdorferi" Scientific Reports, 10 (1). (Impact factor: 3.99; Citation: 4).
Zhen Gong, Jose M. Martin-Garcia, Sasha M. Daskalova, Felicia M. Craciunescu, Lusheng Song, Katerina Dörner, Debra T. Hansen, Jay-How Yang, Joshua LaBaer, Brenda G. Hogue, Tsafrir S. Mor , Petra Fromme (2015) "Biophysical Characterization of a Vaccine Candidate against HIV-1: The Transmembrane and Membrane Proximal Domains of HIV-1 gp41 as a Maltose Binding Protein Fusion" ; PLoS ONE 10 (8). (Impact factor: 2.87; Citation: 7).
Jose Martin-Garcia, Nirupa Nagaratnam, Rebecca Jernigan, Jay-How Yang, Michele Zacks, April Spinale, Marc Giulianotti, Barbara Mroczkowski, Andrew Flint, Petra Fromme (2019) " Using Microgravity at the Inernational Space Station to Lead to New Therapeutics for Taspase1: A Novel Cancer Target"; Acta Crystallorgaphica 75: a110.
5. Biochemical characterization of chlorophyll from green and non-green tissue
Chen, C. M., Jay-How Yang, Liu, c. H., Lin, K. H., & Yang, C. M., (2014) “Molecular, structural, and phylogenetic characterization of two chlorophyllase isoforms in Pachira macrocarpa” Plant Systematics and Evolution 300: 633-643. (Impact factor: 1.154; Citation: 13).
Chen, C. M., Chao, P. Y., Huang, M. Y., Jay-How Yang, Yang, Z. W., Lin, K. h., & Yang, C. M., (2012) “Chlorophyllase activity in green and non-green tissues of variegated plants”, South African Journal of Botany, 81: 44–49. (Impact factor:1.504; Citation: 12).).
Hsu, M. H., Huang, W. D., Yang, Z. W., Chen, J. C., Jay-How Yang, Huang, M. Y., Luhr, H. S., & Yang, C. M., (2006) “Grey relational analysis of the effects of climate factors and air qualities on the rice growth monitored by SPOT satellite remote sensing normalized difference vegetation index (NDVI) after operation of Beitou garbage incinerator” Journal of the Agricultural Association of China 7(3):245-261.
Hsu, M. H., Huang, W. D., Yang, Z. W., Jay-How Yang, Wu, C. W., Luhr, H. S., & Yang, C. M., (2005) “Surveys on the 2004 large-scale burst of rice diseases and blacken panicle in guandu plain” Sci. Agri. 53(5/6):123-137.
Huang, W. D., Hsu, M. H., Chen, J. C., Yang, Z. W., Jay-How Yang, Peng, Y. M., Luhr, H. S., & Yang, C. M., (2005) “Using satellite telemetry data to compare the growth of rice in the guandu plain before and after the operation of the beitou garbage incinerator” Sci. Agri. 53(7/8):202-221.
Huang, W. D., Hsu, M. H., Yang, Z. W., Jay-How Yang, Chen, J. C., Luhr, H. S., & Yang, C. M., (2005) “Analysis of the change in rice yield in the guandu plain area before and after the operation of the Beitou garbage incinerator” Sci. Agri. 53(1/2):22-30.
Yang, C. M., Tsai, H. M., & Jay-How Yang, (2003) “Glucose and δ-aminolevulinic acid stimulate the dark chlorophyll synthesis of rice seedlings” Acta Botanica Sinica 45(4):422-426. (Impact factor:1.414)
Jay-How Yang, Yang, J. S., & Yang, C. M., (2000) “ Grey prediction model of the chlorophyll dark synthesis in cotyledons of Honey dew melon” Chinese Bioscience 42(1):79-88.
Jay-How Yang, Tsai, H. M., & Yang, C. M., (1997) “ Study on the chlorophyll dark synthesis in the primary leaf of chinese Lotus” Chinese Bioscience 40(1):1-6.
得獎事蹟
2021 Extinguished alumni award
2015 Outstanding graduate student award (Arizona State University)
2014 Alternate Sponsored Fellowship (Pacific Northwest National Laboratory)