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師資介紹

黃世明 教授

黃世明 教授      
Shih-Ming Huang

現職

教授

地址及連絡電話

11490 台北市內湖區民權東路六段161號7樓7102室
(02)8792-3100 ext 18790

E-MAIL

shihming@mail.ndmutsgh.edu.tw

最高學歷

美國南加州大學
生化及分子生物博士

個人榮譽

國防醫學院109年度優良老師
國防醫學院106年度優良導師
國防部104年度優良老師
國軍102年優良軍醫代表
國防醫學院98年度優良導師
國防醫學院96年度優良老師
國軍95年優良軍醫代表

研究領域

基因調控
小分子抗癌藥物機轉探討
老藥新用開發
概念圖

主持計畫

國防部 MND-MAB-113135
國防部 MND-MAB-D-112069
行政院科技部 MOST 111-2320-B-016-012
國防部 MND-MAB-111-094
國防部 MND-MAB-110-08
國防部 MAB-109-084
行政院科技部 MOST 108-2320-B-016-003

著作

Chen TW, Fan HL, Liu ST, Huang SM (2025) Chemosensitizer effects of cisplatin and 5-fluorouracil-treated hepatocellular carcinomas by lidocaine. International Journal of Molecular Sciences, 26, 7137.

Tsai YC, Chung YC, Yang CC, Lee CH, Liu CW, Huang SM, Wang LH (2025) Spatiotemporal dynamics of histone H3K27 demethylase during development, Insect Biochemistry and Molecular Biology, 183:104360.

Wu ZS, Huang YH, Huang SM (2025) O-Desmethyltramadol Enhanced Anti-Cancer Efficacy over Tramadol through Non-μ-Opioid Receptor and Differential Cellular Contexts of Human Breast Cancer Cells. International Journal of Molecular Sciences, 26, 4139.

Fan HL, Chen JL, Liu ST, Lee JT, Huang SM, Wu ZF, Lai HC (2025) Remimazolam induced cytotoxicity mediated through multiple stress pathways and acted synergistically with tyrosine kinase inhibitors in hepatocellular carcinoma Redox Report, 30(1):2475696

Chen YC, Su HC, Huang SM, Yu CH, Chang JH, Chiu YL (2025) Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms, BioData Mining, 18:13

Lin CJ, Liu ST, Wu ZS, Huang SM, Chen TW (2025) Exploring the protective role of caffeine against Taraxacum-induced ribotoxic stress mediated through autophagy and mitochondrial depolarization, Scientific Reports, 15:2604

Su YC, Shen YP, Chang CY, Pan KT, Huang SM, Chen LC. (2024) The Effect of Intravascular Laser Irradiation of Blood on Serum Biomarkers and Clinical Outcome in Knee Osteoarthritis Patients: A Double-Blind Randomized Control Trial. International Journal of Molecular Sciences, 25, 13608.

Chen JL, Liu ST, Wu CC, Chen YC, Huang SM (2024) The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells. International Journal of Molecular Sciences, 25, 13474.

Sue SH, Tseng WC, Wu ZS, Huang SM, Chen JL, Wu ZF, Lai HC (2024) The synergistic mechanisms of propofol with cisplatin or doxorubicin in human ovarian cancer cells, Journal of Ovarian Research, 17(1):187.

Wang YL, Wu WX, Yang CC, Huang SM, Chang CC, Li CR, Chiang SL, Chen YJ (2024) Heart rate variability biofeedback enhances cognitive, motor, psychological, and autonomic functions in post-stroke rehabilitation, International Journal of Psychophysiology, 203:112411.

Sue SH, Liu ST, Huang SM (2024) Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells, Scientific Reports, 14:14397 Hsu YP, Huang TH, Liu ST, Huang SM, Chen YC, Wu CC (2024) Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells, International Journal of Molecular Sciences, 25:4905

Wen CC, Huang SM, Wang YW (2024) Anatomical Anal Stenosis after PPH: Insights from a Retrospective Study and Rat Model, International Journal of Molecular Sciences, 25:3543

Lin CM, Ding YX, Huang SM, Chen YC, Lee HJ, Sung CC, Lin SH (2024) Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia, Frontiers in Endocrinology (Lausanne), 15:1291160 Chan WH, Huang SM, Chiu YL (2024) Pulmonary effects of traumatic brain injury in Mice: A gene set enrichment analysis, International Journal of Molecular Sciences, 25:3018

Tsai YC, Huang SM, Peng HH, Lin SW, Lin SR, Chin TY, Huang SM (2024) Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice, Neurobiology of Aging, 135:48-59

Lin YC, Chang PC, Hueng DY, Huang SM, Li YF (2023) Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments, Cancer Cell Interactional, 23(1):154 Feng SW, Wu ZS, Chiu YL, Huang SM (2023) Exploring the Functional Roles of Telomere Maintenance 2 in the Tumorigenesis of Glioblastoma Multiforme and Drug Responsiveness to Temozolomide, International Journal of Molecular Sciences, 24:9256

Chang PC, Lin YC, Yen HJ, Hueng DY, Huang SM, Li YF (2023) Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma, Cancer Cell Interactional, 23(1):62

Huang WZ, Liu TM, Liu ST, Chen SY, Huang SM, Chen GS (2023) Oxidative Status Determines the Cytotoxicity of Ascorbic Acid in Human Oral Normal and Cancer Cells, International Journal of Molecular Sciences, 24:4851 Chen JL, Liu ST, Huang SM, Wu ZF (2022) Apoptosis, proliferation, and autophagy are involved in local anesthetic-induced cytotoxicity of human breast cancer cells, International Journal of Molecular Sciences, 23:15455

Hsieh Li SM, Liu ST, Chang YL, Chen GS, Huang SM (2022) Identification of agents that ameliorate hyperphosphatemia-suppressed myogenin expression involved in the NRF2/p62 pathway in C2C12 skeletal muscle cells, International Journal of Molecular Sciences, 23:15324

Chan WH, Hsu YJ, Cheng CP, Chou KN, Chen CL, Huang SM, Kan WC, Chiu YL (2022) Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study, Journal of Inflammation Research, 15, 4833-4851

Lin CJ, Chen JT, Yeh LJ, Yang RC, Huang SM, Chen TW (2022) Characteristics of the Cytotoxicity of Taraxacum mongolicum and Taraxacum formosanum in Human Breast Cancer Cells, International Journal of Molecular Sciences, 23:11918

Chen GS, Chen SY, Liu ST, Hsieh CC, Lee SP, Huang SM (2022) Stabilization of the c-Myc Protein via the Modulation of Threonine 58 and Serine 62 Phosphorylation by the Disulfiram/Copper Complex in Oral Cancer Cells, International Journal of Molecular Sciences, 23:9173

Feng SW, Chang PC, Chen HY, Hueng DY, Li YF, Huang SM (2022) Exploring the mechanism of adjuvant treatment of glioblastoma using temozolomide and metformin, International Journal of Molecular Sciences, 23:8171

Hu JM, Chang YL, Hsieh CC, Huang SM (2022) The synergistic cytotoxic effects of GW5074 and sorafenib by impacting mitochondrial functions in human colorectal cancer cell lines, Frontiers in Oncology, 12:925653

Lin CM, Sung CC, Yang SS, Chen YC, Huang SM, Lin SH (2022) Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain, FASEB J, 36(6):e22363

Fan HL, Liu ST, Chang YL, Chiu YL, Huang SM, Chen TW (2022) In vitro cell density determines the sensitivity of hepatocarcinoma cells to ascorbate, Frontiers in Oncology, 12:843742

Kao Y, Huang LC, Hsu SY, Huang SM, Hueng DY (2022) Repurposing disulfiram and copper for treating meningioma, Biomedicines, 10, 887

Lin CJ, Liu ST, Yang RC, Wang LH, Tsai CC, Chen TW, Huang SM (2022) Anticancer Effects of Taraxacum via Cell Cycle Arrest, Necrosis, Apoptosis, and Endoplasmic Reticulum Stress, American Journal of Chinese Medicine, 50(2), 569-587

Yang HY, Chen JY, Huo YN, Yu PL, Lin PZ, Hsu SC, Huang SM, Tsai CS, Lin CY (2022) The role of sirtuin 1 in palmitic acid-induced endoplasmic reticulum stress in cardiac myoblasts, Life, 12:182

Huang YH, Sue SH, Wu ZS, Huang SM, Lee SY, Wu ZF (2022) Antitumorigenic Effect of Tramadol and Synergistic Effect with Doxorubicin in Human Breast Cancer Cells, Frontiers in Oncology, 12:811716

Wu ZS, Huang SM, Wang YC (2022) Palmitate Enhances the Efficacy of Cisplatin and Doxorubicin against Human Endometrial Carcinoma Cells, International Journal of Molecular Sciences, 23:80

Huang N, Barndt RB, Lu DD, Wang QC, Huang SM, Wang JK, Chang PY, Chen CY, Hu JM, Su HC, Johnson MD, Lin CY (2022) The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2, Human Cell, 35, 163-172

其他資訊

RESEARCH · PUBLICATIONS · PROJECTS

研究・學術成果

研究主軸

基因調控、細胞死亡與抗癌藥物機轉
從RNA剪接及蛋白穩定性出發，探討小分子藥物再利用與合併治療的細胞機轉。
官網研究方向：基因調控、小分子抗癌藥物作用機轉、老藥新用01SRSF3／RNA剪接02藥物增敏03金屬複合物與癌細胞死亡三項主軸依近年代表論文歸納，詳細研究方向請洽本人。

研究領域關鍵字雲

整理自 175 篇論文・33 項國科會計畫

字體大小代表該主題在論文與計畫中出現的頻率；顏色對應研究主軸。將滑鼠移到關鍵字上可看到英文名稱與統計。

基因調控老藥新用細胞死亡機制高血磷與肌肉萎縮蛋白質穩定性婦癌與口腔癌模式粒線體功能金屬複合物RNA 剪接化療增敏與協同腎小管發育不全心肌與 SIRT1SRSF3中草藥與天然物內質網壓力腦膠質瘤標記乳癌遺傳診斷麻醉藥物抗癌缺氧訊息氧化壓力與促氧化軟骨與骨關節轉錄體與免疫分析抗病毒雷射與物理治療
SRSF3／RNA剪接藥物增敏金屬複合物與癌細胞死亡研究方法與技術

研究計畫

33 項計畫
國科會專題研究計畫32 項115從病理到治療:血管收縮素與腎小管發育不全之關聯一般研究計畫・腎臟115Tramadol與其代謝物O-desmethyltramadol之抗腫瘤分子機制、化療協同效果與選擇性毒殺機制於乳癌模式中的整合性探討一般研究計畫・麻醉114探討心室輔助器植入後對於人類衰竭心肌細胞的Myogenin表現、粒線體功能及免疫細胞浸潤的影響一般研究計畫・心臟血管外科113血管收縮素及皮質類固醇在腎小管發育不全的治療角色一般研究計畫・腎臟113探討心室輔助器植入後對於人類衰竭心肌細胞的Myogenin表現及粒線體代謝的影響一般研究計畫・心臟血管外科112探討麻醉藥物運用在女性癌症治療之潛力及性別差異之癌症治療鼓勵女性從事科學及技術研究專案計畫・麻醉112探討內質網壓力對Tramadol誘導乳癌細胞凋亡之分子機轉一般研究計畫・麻醉112血管收縮素原及皮質類固醇在腎臟近曲小管發育的角色一般研究計畫・腎臟111梗塞性腦中風患者接受靜脈雷射照射治療粒線體功能變化之探討一般研究計畫・復健111探討Tramadol在常氧的乳癌細胞如何誘導缺氧誘導因子1α表現及參與其抗癌功能新進人員研究計畫・麻醉111探討轉錄因子NKX6.1參與惡性平滑肌肉瘤調控機制及抗壞血酸療效之分析一般研究計畫・醫工、骨科、幹細胞111以老藥新用策略篩選治療癌症之潛力促氧化藥物一般研究計畫・醫學生化及分子生物110探討SIRT1在性別差異下造成主動脈壁內血腫的調控機轉一般研究計畫・心臟血管外科109血管收縮素原缺陷導致腎臟近曲小管發育不良之機轉與治療:以動物模式驗證一般研究計畫・腎臟109一種可提升皮膚或皮瓣移植術後微血管新生的新療法之作用機轉探討與動物實驗評估新進人員研究計畫・細胞生物及解剖108探討巨噬細胞極化、醣化終產物、單核苷酸多態性、DNA甲基化與肌少症之相關性一般研究計畫・精神醫學、老人醫學及家庭醫學108探討調控剪接蛋白SRSF3 表現的機轉及其抑癌路徑一般研究計畫・醫學生化及分子生物107藉由調控表皮細胞的TGF-β訊息傳遞路徑在傷口癒合過程中探討細胞間之相互作用-2新進人員研究計畫・細胞生物及解剖106腎素-血管收縮素系統在腎臟近曲小管發育所扮演的角色一般研究計畫・腎臟106篩選血癌藥物調控USP2a 表現之機轉及潛在作用之標記蛋白一般研究計畫・腫瘤106探討發炎體與鈣離子調控在尿毒性心肌病變之作用機轉一般研究計畫・心臟血管外科106藉由調控表皮細胞的TGF-β訊息傳遞路徑在傷口癒合過程中探討細胞間之相互作用新進人員研究計畫・細胞生物及解剖102探討轉錄因子Zac1調控白介素11表現之機轉及其在癌化過程可能扮演之角色一般研究計畫・醫學之生化及分子生物100外源性交聯及生長激素在動態承載力刺激下對損傷椎間盤治療效果於活體鼠尾部與活體豬腰椎模型之探討一般研究計畫・醫學工程98探討在子宮頸癌細胞株中人類乳突病毒蛋白E2與轉錄因子Zac1兩蛋白質基因調控功能的交互作用一般研究計畫・醫學之生化及分子生物97人類乳突病毒蛋白E2與轉錄因子Zac1兩者蛋白質在子宮頸癌中功能間互相作用之研究一般研究計畫・婦產科96調控核內接受器輔因子功能之因子研究(3/3)新進人員研究計畫・醫學之生化及分子生物95調控核內接受器輔因子功能之因子研究(2/3)新進人員研究計畫・醫學之生化及分子生物94調控核內接受器輔因子功能之因子研究(1/3)新進人員研究計畫・醫學之生化及分子生物92探討Zac1在AP-1活化過程中的調控機轉 (2/2)新進人員研究計畫・醫學之生化及分子生物91探討Zac1在AP-1活化過程中的調控機轉 (1/2)新進人員研究計畫・醫學之生化及分子生物90探討Zac1在AP-1活化過程中的調控機轉新進人員研究計畫・醫學之生化及分子生物財團法人國家衛生研究院1 項92–94Career Development Grant（CDG）三年期研究計畫研究人員發展獎助資料來源：國科會學術研發服務網（年度為計畫核定年度）；其他補助機關計畫由本人提供。

研究論文

175 篇論文
20265 篇175.Chronic Hypoxia-Induced Reprogramming of Smooth Muscle Cells: Insights into Transcription Factors, Cellular Stresses, and Therapeutic Implications通訊作者Biomedicines 14(8):1843・IF 4.5174.Differential cytotoxicity mechanisms of copper complexed with disulfiram for combination chemotherapy in human endometrial cancer cells通訊作者Frontiers in Oncology 16・IF 3.3173.Immune Microenvironment and Genetic Signatures of End-Stage Renal Disease and Their Association with Sepsis: Insights from Public Transcriptomic Data and a Multicenter Clinical Cohort通訊作者Biomedicines 14(4)・IF 4.5172.Lidocaine enhances antitumor effects of sorafenib and GW5074 in colorectal cancer cellsJournal of Enzyme Inhibition and Medicinal Chemistry 41(1)・IF 5.4171.Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathwaysRedox Report 31(1)・IF 7.420257 篇170.Chemosensitizer Effects of Cisplatin- and 5-Fluorouracil-Treated Hepatocellular Carcinomas by LidocaineInternational Journal of Molecular Sciences 26(15)・IF 4.9169.Exploring the protective role of caffeine against Taraxacum-Induced ribotoxic stress mediated through autophagy and mitochondrial depolarizationScientific Reports 15(1)・IF 3.9168.Glucosamine mitigates hyperglycemic-induced oxidative stress via the SIRT1 pathway in human corneal epithelial cellsScientific Reports 2025;15(1):35806・IF 3.9167.Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithmsBiodata Mining 18(1)・IF 6.1166.O-Desmethyltramadol Enhanced Anti-Cancer Efficacy over Tramadol Through Non-μ-Opioid Receptor and Differential Cellular Contexts of Human Breast Cancer Cells通訊作者International Journal of Molecular Sciences 26(9)・IF 4.9165.Remimazolam induced cytotoxicity mediated through multiple stress pathways and acted synergistically with tyrosine kinase inhibitors in hepatocellular carcinomaRedox Report 30(1)・IF 7.4164.Spatiotemporal dynamics of histone H3K27 demethylase during developmentInsect Biochemistry and Molecular Biology 183・IF 3.7202411 篇163.Anatomical Anal Stenosis after PPH: Insights from a Retrospective Study and Rat ModelInternational Journal of Molecular Sciences 25(6)・IF 4.9162.Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells通訊作者Scientific Reports 14(1)・IF 3.9161.Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte CellsInternational Journal of Molecular Sciences 25(9)・IF 4.9160.Heart rate variability biofeedback enhances cognitive, motor, psychological, and autonomic functions in post-stroke rehabilitationInternational Journal of Psychophysiology 203・IF 2.6159.Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemiaFrontiers in Endocrinology 15・IF 4.6158.Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in miceNeurobiology of Aging 135:48-59・IF 3.5157.Low-dose estrogen release from silastic capsule enhanced flap wound healing in an animal modelInternational Wound Journal 21(10)・IF 2.5156.Pulmonary Effects of Traumatic Brain Injury in Mice: A Gene Set Enrichment AnalysisInternational Journal of Molecular Sciences 25(5)・IF 4.9155.The Effect of Intravascular Laser Irradiation of Blood on Serum Biomarkers and Clinical Outcome in Knee Osteoarthritis Patients: A Double-Blind Randomized Control TrialInternational Journal of Molecular Sciences 25(24)・IF 4.9154.The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells通訊作者International Journal of Molecular Sciences 25(24)・IF 4.9153.The synergistic mechanisms of propofol with cisplatin or doxorubicin in human ovarian cancer cellsJournal of Ovarian Research 17(1)・IF 4.220234 篇152.Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in gliomaCancer Cell International 23(1)・IF 6151.Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironmentsCancer Cell International 23(1)・IF 6150.Exploring the Functional Roles of Telomere Maintenance 2 in the Tumorigenesis of Glioblastoma Multiforme and Drug Responsiveness to TemozolomideInternational Journal of Molecular Sciences 24(11)・IF 4.9149.Oxidative Status Determines the Cytotoxicity of Ascorbic Acid in Human Oral Normal and Cancer CellsInternational Journal of Molecular Sciences 24(5)・IF 4.9202215 篇148.Anticancer Effects of Taraxacum via Cell Cycle Arrest, Necrosis, Apoptosis, and Endoplasmic Reticulum StressAmerican Journal of Chinese Medicine 50(2):569-587・IF 5.5147.Antitumorigenic Effect of Tramadol and Synergistic Effect With Doxorubicin in Human Breast Cancer CellsFrontiers in Oncology 12・IF 3.3146.Apoptosis, Proliferation, and Autophagy Are Involved in Local Anesthetic-Induced Cytotoxicity of Human Breast Cancer CellsInternational Journal of Molecular Sciences 23(24)・IF 4.9145.Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic StudyJournal of Inflammation Research 15:4833-4851・IF 4.1144.Characteristics of the Cytotoxicity of Taraxacum mongolicum and Taraxacum formosanum in Human Breast Cancer CellsInternational Journal of Molecular Sciences 23(19)・IF 4.9143.Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and MetforminInternational Journal of Molecular Sciences 23(15)・IF 4.9142.Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domainFASEB Journal 36(6)・IF 4.2141.Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle CellsInternational Journal of Molecular Sciences 23(23)・IF 4.9140.In Vitro Cell Density Determines the Sensitivity of Hepatocarcinoma Cells to AscorbateFrontiers in Oncology 12・IF 3.3139.Palmitate enhances the efficacy of cisplatin and doxorubicin against human endometrial carcinoma cellsInternational Journal of Molecular Sciences 23(1)・IF 4.9138.Stabilization of the c-Myc Protein via the Modulation of Threonine 58 and Serine 62 Phosphorylation by the Disulfiram/Copper Complex in Oral Cancer CellsInternational Journal of Molecular Sciences 23(16)・IF 4.9137.The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2Human Cell 35(1):163-178・IF 3.1136.The Effect of Disulfiram and Copper on Cellular Viability, ER Stress and ALDH Expression of Human Meningioma CellsBiomedicines 10(4)・IF 4.5135.The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac MyoblastsLife 12(2)・IF 3.4134.The Synergistic Cytotoxic Effects of GW5074 and Sorafenib by Impacting Mitochondrial Functions in Human Colorectal Cancer Cell LinesFrontiers in Oncology 12・IF 3.3202113 篇133.Ckap2l knockdown exerts antitumor effects by increasing mir-4496 in glioblastoma cell linesInternational Journal of Molecular Sciences 22(1):46044・IF 4.9132.Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus NephritisFrontiers in Medicine 7・IF 3131.Differential cytotoxicity mechanisms of copper complexed with disulfiram in oral cancer cellsInternational Journal of Molecular Sciences 22(7)・IF 4.9130.Effect of hydrocortisone on angiotensinogen (Agt) mutation–causing autosomal recessive renal tubular dysgenesisCells 10(4)・IF 5.2129.Grpel2 knockdown exerts redox regulation in glioblastomaInternational Journal of Molecular Sciences 22(23)・IF 4.9128.Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancerScientific Reports 11(1)・IF 3.9127.Mechanisms of cisplatin in combination with repurposed drugs against human endometrial carcinoma cellsLife 11(2):46040・IF 3.4126.Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytesEuropean Journal of Pharmacology 910・IF 4.7125.Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomasScientific Reports 11(1)・IF 3.9124.Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytesHuman Cell 34(3):771-784・IF 3.1123.The anti-cancer effect of four curcumin analogues on human glioma cellsOncotargets and Therapy 14:4345-4359・IF 2.8122.The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma CellsFrontiers in Oncology 11・IF 3.3121.The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional ValidationFrontiers in Endocrinology 12・IF 4.6202010 篇120.Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus InfectionAntimicrobial Agents and Chemotherapy 64(1)・IF 4.5119.Antiviral activity of compound l3 against dengue and zika viruses in vitro and in vivoInternational Journal of Molecular Sciences 21(11):46035・IF 4.9118.Autosomal Recessive Renal Tubular Dysgenesis Caused by a Founder Mutation of AngiotensinogenKidney International Reports 5(11):2042-2051・IF 5.7117.Cardiac calcium dysregulation in mice with chronic kidney diseaseJournal of Cellular and Molecular Medicine 24(6):3669-3677・IF 4.2116.Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosisPediatric Research 87(7):1251-1255・IF 3.1115.Gene expression profiling identifies the role of Zac1 in cervical cancer metastasisScientific Reports 10(1)・IF 3.9114.High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signalingAging 12(21):21446-21468113.Mechanisms and Applications of the Anti-cancer Effect of Pharmacological Ascorbic Acid in Cervical Cancer CellsFrontiers in Oncology 10・IF 3.3112.The anti-fibrotic and anti-inflammatory effects of 2,4-diamino-5-(1-hydroxynaphthalen-2-yl)-5H-chromeno[2,3-b] pyriine-3-carbonitrile in corneal fibroblastsPharmacological Reports 72(1):115-125・IF 3.8111.The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytesJournal of Cellular and Molecular Medicine 24(12):6762-6772・IF 4.2201912 篇110.Adipose-Derived Neural Stem Cells Combined with Acellular Dermal Matrix as a Neural Conduit Enhances Peripheral Nerve RepairCell Transplantation 28(46275):1220-1230・IF 3.2109.Carvedilol ameliorates experimental atherosclerosis by regulating cholesterol efflux and exosome functionsInternational Journal of Molecular Sciences 20(20)・IF 4.9108.CD164 regulates proliferation, progression, and invasion of human glioblastoma cellsOncotarget 10(21):2041-2054107.Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4Journal of Biomedical Science 26(1)・IF 12.1106.Hericium erinaceus Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging MiceJournal of Medicinal Food 22(5):469-478105.Macrophage phenotypes and Gas6/Axl signaling in apical lesionsJournal of Dental Sciences 14(3):281-287・IF 3.1104.Platelet-derived growth factor-AA is a substantial factor in the ability of adipose-derived stem cells and endothelial progenitor cells to enhance wound healingFASEB Journal 33(2):2388-2395・IF 4.2103.Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer HeLa cellsPlos One 14(4)・IF 2.6102.The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1Cancer Management and Research 11:6567-6579・IF 2.6101.The mechanisms underlying the cytotoxic effects of copper via differentiated embryonic chondrocyte gene 1International Journal of Molecular Sciences 20(20)・IF 4.9100.The potential of acellular dermal matrix combined with neural stem cells induced from human adipose-derived stem cells in nerve tissue engineeringAnnals of Plastic Surgery 82(1S):S108-S11899.Whole-exome sequencing detects mutations in pediatric patients with atypical hemolytic uremic syndrome in TaiwanClinica Chimica Acta 494:143-150・IF 2.920185 篇98.Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224Oncotarget 9(17):13390-1340697.Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathyInternational Journal of Cardiology 252:128-135・IF 3.296.Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1Journal of Biomedical Science 25(1)・IF 12.195.Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomasOncotarget 9(21):15705-1572094.Zac1 regulates IL-11 expression in osteoarthritisOncotarget 9(65):32478-32495201714 篇93.CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signalingOncotarget 8(33):54115-5413592.Correction: Hepatitis C virus core protein down-regulates p21 Waf1/Cip1 and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells (PLoS ONE (2013) 8:4 (e61089) DOI: 10.1371/journal.pone.0061089)Plos One 12(7)・IF 2.691.Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human MacrophagesJournal of Agricultural and Food Chemistry 65(15):3141-3150・IF 6.290.Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1Oncotarget 8(66):110039-11005189.Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with AlopeciaScientific Reports 7(1)・IF 3.988.HAF mediates the evasive resistance of anti-angiogenesis TKI through disrupting HIF-1α and HIF-2α balance in renal cell carcinomaOncotarget 8(30):49713-4972487.HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expressionJournal of Molecular Medicine 95(6):629-639・IF 4.286.Risk of cancer in patients with heart failure who use digoxin: A 10-year follow-up study and cell-based verificationOncotarget 8(27):44203-4421685.Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse modelInternational Journal of Cardiology 228:543-552・IF 3.284.Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virusBiochemical and Biophysical Research Communications 491(3):595-602・IF 2.283.The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytesJournal of Biomedical Science 24(1)・IF 12.182.The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney diseaseOncotarget 8(69):113303-11331781.The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell linesInternational Journal of Biochemistry and Cell Biology 92:155-163・IF 2.880.Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell linesOncotarget 8(60):101461-10147420165 篇79.Associations among integrated psychoneuroimmunological factors and metabolic syndromePsychoneuroendocrinology 74:342-349・IF 3.678.Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activityOsteoporosis International 27(11):3355-336477.Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled mannerPlos One 11(12)・IF 2.676.The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomasOncotarget 7(27):41460-4147275.γ3-synuclein expression is a malignant index in oral squamous cell CarcinomaJournal of Dental Research 95(4):439-445・IF 5.9201511 篇74.CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremiaJournal of Molecular and Cellular Cardiology 85:249-261・IF 4.773.Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growthMolecular Carcinogenesis 54(3):167-177・IF 3.272.Human mitochondrial NAD(P)+-dependent malic enzyme participates in cutaneous melanoma progression and invasionJournal of Investigative Dermatology 135(3):807-815・IF 5.771.Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signalingJournal of Vascular Surgery 62(1):210-221.e2・IF 3.670.Novel cancer therapeutics with allosteric modulation of the mitochondrial C-Raf-DAPK complex by Raf inhibitor combination therapyCancer Research 75(17):3568-3582・IF 16.669.Opposing effects of Zac1 and curcumin on AP-1-regulated expressions of S100A7Plos One 10(12)・IF 2.668.Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinomaOral Oncology 51(7):683-689・IF 3.967.The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytesJournal of Dermatological Science 79(3):262-267・IF 466.The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytesOncotarget 6(35):37443-3745765.Thiazide-Sensitive Na+-Cl- Cotransporter (NCC) Gene Inactivation Results in Increased Duodenal Ca2+ Absorption, Enhanced Osteoblast Differentiation and Elevated Bone Mineral DensityJournal of Bone and Mineral Research 30(1):116-12764.Valproic acid promotes radiosensitization in meningioma stemlike cellsOncotarget 6(12):9959-996920147 篇63.A functional polymorphism in the promoter region of TLR3 is associated with susceptibility to end-stage renal diseaseAmerican Journal of Nephrology 40(2):131-139・IF 3.262.Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genesInternational Journal of Biochemistry and Cell Biology 47(1):83-92・IF 2.861.Characterization of a new mouse p53 variant: Loss-of-function and gain-of-functionJournal of Biomedical Science 21(1)・IF 12.160.Multiple effects of digoxin on subsets of cancer-associated genes through the alternative splicing pathwayBiochimie 106:131-139・IF 359.Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivoOncotarget 5(21):10342-1035558.Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathwayInternational Journal of Biochemistry and Cell Biology 53:361-371・IF 2.857.Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathwayBiochemical Journal 464(2):221-229・IF 4.3201310 篇56.CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axisMolecular Cancer 12(1)・IF 33.955.Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1Biochimica Et Biophysica Acta Molecular Cell Research 1833(8):1799-1810・IF 3.754.EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomasJournal of Neuro Oncology 114(3):281-290・IF 3.153.Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failureJournal of Vascular Surgery 57(2):475-485・IF 3.652.Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesisCell Death and Differentiation 20(5):732-743・IF 15.451.Hepatitis C Virus Core Protein Down-Regulates p21Waf1/Cip1 and Inhibits Curcumin-Induced Apoptosis through MicroRNA-345 Targeting in Human Hepatoma CellsPlos One 8(4)・IF 2.650.Nuclear factor κB down-regulates human UDP-glucuronosyltransferase 1A1: A novel mechanism involved in inflammation-associated hyperbilirubinaemiaBiochemical Journal 449(3):761-770・IF 4.349.Promotion of wound healing using adipose-derived stem cells in radiation ulcer of a rat modelJournal of Biomedical Science 20(1)・IF 12.148.Role of the Functional Toll-Like Receptor-9 Promoter Polymorphism (-1237T/C) in Increased Risk of End-Stage Renal Disease: A Case-Control StudyPlos One 8(3)・IF 2.647.The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-RegulationPlos One 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characterization of tumor stem-like cells from human meningiomasJournal of Neuro Oncology 104(1):45-53・IF 3.139.Zac1 functional interactions mediate AP-1 transcriptional activityBiochimica Et Biophysica Acta Molecular Cell Research 1813(12):2050-2060・IF 3.738.Zac1, an Sp1-like protein, regulates human p21WAF1/Cip1 gene expression in HeLa cellsExperimental Cell Research 317(20):2925-2937・IF 3.520102 篇37.Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizationsInternational Journal of Biochemistry and Cell Biology 42(6):902-910・IF 2.836.The subcellular localization and protein stability of mouse alpha-actinin 2 is controlled by its nuclear receptor binding motif in C2C12 cellsInternational Journal of Biochemistry and Cell Biology 42(12):2082-2091・IF 2.820094 篇35.Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activityClinical Cancer Research 15(14):4600-4611・IF 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domainInternational Journal of Biochemistry and Cell Biology 40(10):2078-2089・IF 2.820076 篇28.Human papillomavirus E2 protein associates with nuclear receptors to stimulate nuclear receptor- and E2-dependent transcriptional activations in human cervical carcinoma cellsInternational Journal of Biochemistry and Cell Biology 39(2):413-425・IF 2.827.Human spot 14 protein interacts physically and functionally with the thyroid receptorBiochemical and Biophysical Research Communications 357(1):133-138・IF 2.226.Importin α1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1Biochemical Journal 402(2):359-366・IF 4.325.Molecular pathogenesis of Gilbert's syndrome: Decreased TATA-binding protein binding affinity of UGT1A1 gene promoterPharmacogenetics and Genomics 17(4):229-236・IF 1.724.Physical and functional interactions of human papillomavirus E2 protein with nuclear receptor coactivatorsBiochemical and Biophysical Research Communications 356(3):523-528・IF 2.223.Regulation of nuclear receptor and coactivator functions by the carboxyl terminus of ubiquitin-conjugating enzyme 9International Journal of Biochemistry and Cell Biology 39(5):1035-1046・IF 2.820061 篇22.Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domainsFEBS Journal 273(10):2172-2183・IF 4.220042 篇21.Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1Biochemical Journal 382(1):111-119・IF 4.320.The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2Journal of Molecular Endocrinology 32(2):481-49620031 篇19.Regulation of nuclear receptor activities by two human papillomavirus type 18 oncoproteins, E6 and E7Biochemical and Biophysical Research Communications 303(3):932-939・IF 2.220011 篇18.Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1Oncogene 20(17):2134-2143・IF 7.320002 篇17.Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptorsMolecular and Cellular Biology 20(5):1855-1867・IF 2.716.Synergistic, p160 coactivator-dependent enhancement of estrogen receptor function by CARM1 and p300Journal of Biological Chemistry 275(52):40810-40816・IF 4.119993 篇15.Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4α1Molecular and Cellular Biology 19(10):6509-6522・IF 2.714.Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteinsMolecular and Cellular Biology 19(9):6164-6173・IF 2.713.Regulation of transcription by a protein methyltransferaseScience 284(5423):2174-2177・IF 45.819983 篇12.Conformational stability of the N-terminal amino acid residues of mutated recombinant pigeon liver malic enzymesProtein Engineering 11(5):371-37611.Engineering of a stable mutant malic enzyme by introducing an extra ion- pair to the proteinProteins Structure Function and Genetics 31(1):61-73・IF 2.810.Estrogen receptor activation function 1 works by binding p160 coactivator proteinsMolecular Endocrinology 12(10):1605-161819971 篇9.Functional roles of the N-terminal amino acid residues in the Mn(II)-L-malate binding and subunit interactions of pigeon liver malic enzymeProtein Engineering 10(10):1205-121119962 篇8.Involvement of Phe19 in the Mn2+-L-malate binding and the subunit interactions of pigeon liver malic enzymeBiochemistry 35(30):9873-9879・IF 37.Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cellJournal of Protein Chemistry 15(3):273-27919943 篇6.Affinity Cleavage at the Putative Metal-Binding Site of Pigeon Liver Malic Enzyme by the Fe2+-Ascorbate SystemBiochemistry 33(25):7931-7936・IF 35.Cloning and expression of pigeon liver cytosolic NADP+-dependent malic enzyme cDNA and some of its abortive mutantsArchives of Biochemistry and Biophysics 310(1):158-166・IF 34.Dissociation of Pigeon‐Liver Malic Enzyme in Reverse MicellesEuropean Journal of Biochemistry 225(3):1021-102719921 篇3.Human placental alkaline phosphatase: An improved purification procedure and kinetic studiesEuropean Journal of Biochemistry 209(1):241-24719912 篇2.Kinetic comparison of caiman ε-crystallin and authentic lactate dehydrogenases of vertebratesJournal of Protein Chemistry 10(2):161-1661.Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck ϵ-crystallinArchives of Biochemistry and Biophysics 284(2):285-291・IF 3書目依 2026-09-23 彙整表，IF 為 2025 JCR；點論文題名可開啟原文（DOI）。

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