最高學歷
國立中興大學 生命科學系博士
教授課程
有機化學、分子生物學、生物化學研究技術、生命科學文獻閱讀及口頭報告(全英文課程)
獲獎情形
113年 國防部優良教師
106年 國防部優良教師
106年 國防醫學院「延攬及留住大專校院特殊優秀人才獎」教學組
105年 國防醫學院優良教師
研究領域
探究皮膚微環境與脂質代謝體學變化與皮膚致病機制之關連透過次世代定序與HPLC代謝體分析對罕見皮膚紫質症EPP診斷與功能性突變研究
研究論文
Lu GY, Liu ST, Huang SM, Chang YL and Lin WS (2014) Multiple effects of digoxin on subsets of cancer-associated genes through the alternative splicing pathway, Biochimie, 106, 131-139 (co-corresponding author) (IF = 2.963; Biochemistry and Molecular Biology, 128/290 =44.1%)
Chang, Y. L., Gao, H. W., Chiang, C. P., Wang, W. M., Huang, S. M., Ku, C. F., Liu, G. Y., & Hung, H. C. (2015). Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion. J Invest Dermatol, 135(3), 807-815. (IF = 6.287; Dermatology, 2/63 =3.2%)
Chu, Y. W., Liu, S. T., Cheng, H. C., Huang, S. M., Chang, Y. L., Chiang, C. P., Liu, Y. C., & Wang, W. M. (2015). Opposing Effects of Zac1 and Curcumin on AP-1-Regulated Expressions of S100A7. PLoS One, 10(12), e0144175. (IF = 2.806; Multidisciplinary Sciences, 15/64 =23.4%)
Hung, C. T., Huang, S. M., Cheng, H. C., Liu, S. T., Chang, Y. L., Liu, Y. C., & Wang, W. M. (2015). The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes. J Dermatol Sci, 79(3), 262-267. (IF = 3.733; Dermatology, 7/63 =11.1%)
Cheng, C. P., Huang, L. C., Chang, Y. L., Hsieh, C. H., Huang, S. M., & Hueng, D. Y. (2016). The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas. Oncotarget, 7(27), 41460-41472. (IF = 5.168; Oncology, 44/217 =20.3%)
Shih, C. C., Liao, M. H., Hsiao, T. S., Hii, H. P., Shen, C. H., Chen, S. J., Ka, S. M., Chang, Y. L., & Wu, C. C. (2016). Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One, 11(9), e0163690. (IF = 2.806; Multidisciplinary Sciences, 15/64 =23.4%)
Chang, Y. L., Huang, L. C., Chen, Y. C., Wang, Y. W., Hueng, D. Y., & Huang, S. M. (2017). The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines. Int J Biochem Cell Biol, 92, 155-163. (IF = 3.505; Biochemistry & Molecular Biology, 95/290 =32.8%)
Chen, W. L., Huang, A. F., Huang, S. M., Ho, C. L., Chang, Y. L., & Chan, J. Y. (2017). CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling. Oncotarget, 8(33), 54115-54135. (IF = 5.168; Oncology, 44/217 =20.3%)
Chung, M. H., Wang, Y. W., Chang, Y. L., Huang, S. M., & Lin, W. S. (2017). Risk of cancer in patients with heart failure who use digoxin: a 10-year follow-up study and cell-based verification. Oncotarget, 8(27), 44203-44216. (IF = 5.168; Oncology, 44/217 =20.3%)
Hsu, Y. J., Hsu, S. C., Hsu, C. P., Chen, Y. H., Chang, Y. L., Sadoshima, J., Huang, S. M., Tsai, C. S., & Lin, C. Y. (2017). Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. Int J Cardiol, 228, 543-552. (IF = 6.189; Oncology, 16/126 =12.7%)
Hsu, Y. J., Hsu S. C., Chang Y. L., Huang S. M., Shih C. C., Tsai C. S., & Lin C. Y. (2018). Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy. Int J Cardiol, 252, 128-135. (IF = 6.189; Oncology, 16/126 =12.7%)
Chang, Y. L., Liu S. T., Wang Y. W., Lin W. S., & Huang S. M. (2018). Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224. Oncotarget, 9(17), 13390-13406. (IF = 5.168; Oncology, 44/217 =20.3%)
Chang, Y. L., Jian K. R., Lin C. S., Wang H. W., & Liu S. C. (2018). Dexamethasone attenuates methacholine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-kappaB activation. Int Forum Allergy Rhinol, 8(1), 64-71. (IF = 2.135; Otorhinolaryngology, 11/42 =26.2%)
Kuo, Chun Lin; Liu, Shu Ting; Chang, Yung Lung; Wu, Chia Chun; Huang, Shih Ming. (2018). Zac1 regulates IL-11 expression in osteoarthritis. Oncotarget, 9, 32478-32495. (IF = 5.168; Oncology, 44/217 =20.3%)
Hsieh Li, Shu Man; Liu, Shu Ting; Chang, Yung Lung; Ho, Ching Liang; Huang, Shih Ming. (2018). Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1. Journal of Biomedical Science. 25:81 (IF = 3.466; Medicine, Research & Experimental, 46/133 =26.2%)