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師資介紹

邱奕霖 教授兼所長

邱奕霖 教授兼所長      
Yi-Lin Chiu

現職

教授兼所長

地址及連絡電話

台北市內湖區民權東路六段161號7樓7323室
(02)8792-3100 ext 18828

E-MAIL

yilin1107@mail.ndmutsgh.edu.tw

其他資訊

RESEARCH · PUBLICATIONS · PROJECTS

研究・學術成果

研究主軸

腫瘤抗藥性與免疫生物資訊
整合蛋白酶與B細胞腫瘤研究、臨床樣本及轉錄體分析，探討免疫變化與治療抗性。
官網研究方向：絲胺酸蛋白酶與惡性淋巴腫瘤抗藥性、CD19 CAR-T抗性機制、臨床疾病生物資訊分析01絲胺酸蛋白酶與惡性淋巴腫瘤抗藥性02CD19 CAR-T 抗性機制與免疫治療03臨床疾病生物資訊分析三項主軸依近年代表論文歸納，詳細研究方向請洽本人。

研究領域關鍵字雲

整理自 49 篇論文・27 項國科會計畫

字體大小代表該主題在論文與計畫中出現的頻率；顏色對應研究主軸。將滑鼠移到關鍵字上可看到英文名稱與統計。

抗藥性機制M2 巨噬細胞臨床大數據發炎與免疫調節絲胺酸蛋白酶腫瘤微環境轉錄體學細胞凋亡淋巴瘤CAR-T 細胞治療預後與生物標記天然化合物與藥物再利用MatriptaseCD19 抗原逃脫機器學習心血管疾病Prostasin (PRSS8)多發性骨髓瘤基因集富集分析神經發炎與腦損傷酶原活化免疫治療協同策略免疫浸潤分析肝臟疾病前列腺癌BCMA嗜中性白血球癌症轉移與遷移HAI-1 / HAI-2CRISPR 篩選單細胞多體學骨質疏鬆與骨代謝B 細胞XGBoost活性氧物種系統性回顧與統合分析空間轉錄體肌少症N-醣基化奈米抗體血管內皮功能慢性骨髓性白血病阿茲海默症Ibrutinib / BTK肺腺癌標靶治療奈米藥物遞送熱中暑與熱傷害肺動脈高壓傷口修復泌尿系統癌症microRNA帕金森氏症
絲胺酸蛋白酶與惡性淋巴腫瘤抗藥性CD19 CAR-T 抗性機制與免疫治療臨床疾病生物資訊分析疾病機制與轉譯醫學

最高學歷

美國喬治城大學腫瘤生物學博士

個人榮譽

112年 國防醫學院潘樹人先生研究論文績優獎111年 國防醫學院潘樹人先生研究論文績優獎111年 國防醫學院優良導師102年 國防醫學院優良導師

教授課程

生物化學 (醫、牙、藥)高等生物化學 (碩) (主帶)分子生物學 (碩、醫科所)生物化學專題討論 (碩)癌症生化學 (碩)生物化學研究技術 (碩)生物醫學論文表述與寫作 (藥理所)

研究計畫與合作

29 項計畫
國科會專題研究計畫（計畫主持人）5 項115整合機器學習預測、時序性單細胞雙體學與CRISPR篩選解析骨髓瘤BCMA CAR-T抗藥機制：從急性毒殺增敏到去分化逆轉之精準協同療法優秀年輕學者研究計畫（三年期）・血液・2026/08–2029/07114以XGBoost機器學習探索FOXP1/ST14軸在DLBCL免疫微環境和標靶治療耐受性中的潛在作用一般研究計畫・血液111開發可局部釋放標靶絲胺酸蛋白酶奈米抗體之嵌合抗原受體T細胞於惡性淋巴癌治療新進人員研究計畫（三年期）・血液109探討絲胺酸蛋白酶於惡性淋巴癌之抗凋亡角色並發展具雙重效果之化療藥物承載單株抗體治療策略 II新進人員研究計畫・醫學生化及分子生物108探討絲胺酸蛋白酶於惡性淋巴癌之抗凋亡角色並發展具雙重效果之化療藥物承載單株抗體治療策略新進人員研究計畫・生物化學及分子生物國科會專題研究計畫（共同主持人）10 項115靶向 TLR7 訊號途徑：結締組織疾病相關肺動脈高壓血管重塑的潛在治療策略共同主持人新進人員研究計畫・風濕免疫・合作：三軍總醫院風濕免疫科 葉富強醫師・2026/08–2027/07115新型癌症標靶治療：葡萄糖轉運子介導胞移之奈米藥物雛形品開發（3/3）共同主持人一般導向專案研究計畫・奈米生技醫療・合作：陽明交通大學生物醫學工程學系 駱俊良教授・2026/08–2027/07114探討 Prostasin (PRSS8) 在前列腺癌轉移與免疫微環境塑造中的表觀調控機制共同主持人新進人員研究計畫・泌尿・合作：三軍總醫院泌尿外科 陳進利醫師114新型癌症標靶治療：葡萄糖轉運子介導胞移之奈米藥物雛形品開發（2/3）共同主持人一般導向專案研究計畫・奈米生技醫療・合作：陽明交通大學生物醫學工程學系 駱俊良教授113新型癌症標靶治療：葡萄糖轉運子介導胞移之奈米藥物雛形品開發（1/3）共同主持人一般導向專案研究計畫・奈米生技醫療・合作：陽明交通大學生物醫學工程學系 駱俊良教授113探討第一型干擾素在結締組織疾病肺動脈高壓的角色共同主持人新進人員研究計畫（兩年期）・風濕免疫・合作：三軍總醫院風濕免疫科 葉富強醫師110以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標 III共同主持人一般研究計畫・腫瘤・合作：三軍總醫院血液腫瘤科 何景良教授109以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標 II共同主持人一般研究計畫・腫瘤・合作：三軍總醫院血液腫瘤科 何景良教授108微核醣核酸-424/322可藉由調節鈣調磷酸酶/活化T細胞核因子與纖維細胞變間質型細胞轉換及增生等路徑改善心肌肥大以及心臟重塑共同主持人一般研究計畫（三年期）・心臟血管內科・合作：國防醫學院生理學研究所 蔡適鴻教授108以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標共同主持人一般研究計畫・腫瘤國科會大專學生研究計畫（指導教授）2 項114Parkinson's disease中嗜中性白血球活化與α-synuclein相關性之細胞模型建立114-2813-C-016-011-B・大專學生研究計畫・執行學生：陳柏廷（國防醫學院醫學系）112以神經細胞與微膠細胞共培養體外模型探討M2巨噬細胞對阿茲海默症患者大腦皮質神經元凋亡的影響112-2813-C-016-022-B・大專學生研究計畫・執行學生：王思博（國防醫學院醫學系）國防計畫（國防部軍醫局 MND-MAB）6 項114基於動物模型資料庫評估噪音對腦神經細胞的潛在影響機制與誘發阿滋海默症的關聯性MND-MAB-D-114166113結合AI機器學習與單一樣本基因集富集分析發展評估肺腺癌樣本對於多種標靶藥物抗藥性之預測評分系統MND-MAB-D-113140112探討司他汀類藥物對於保護熱傷害及中暑引起腦創傷之潛力與作用機制MND-MAB-D-112112111探討純化活化態絲胺酸蛋白酶並應用於加速傷口修復之機制與效果MND-MAB-D-111071110評估絲胺酸蛋白酶之表達量於肺腺細胞癌小分子標靶藥物抗藥性中扮演的角色MND-MAB-110-058109探討氮醣基化抑制劑對於高侵蝕性淋巴癌中過量絲胺酸蛋白酶matriptase造成之抗藥性之影響MND-MAB-109-043院際合作計畫4 項113探討NUF2於骨肉瘤中對於DNA修復及化療抗藥性的潛在影響PTH113071・合作：衛生福利部桃園醫院112臨床大數據庫結合蝕骨細胞誘導分化策略探討原花青Proanthocyanidin緩解骨質疏鬆症之分子機制PTH112056・合作：衛生福利部桃園醫院111臨床大數據結合生物資訊分析發展精準醫療－以機器學習探討胺基酸補充影響骨質疏鬆症之潛在機制CTH111AK-NDMC-2224・合作：耕莘醫院110利用電腦模擬免疫浸潤技術分析多種慢性腎臟病變主要差異免疫細胞之分佈CMNDMC11005・合作：奇美醫院民診國醫教師合作計畫2 項116刺蝟信號通路（Sonic Hedgehog）以克服多發性骨髓瘤對 Bortezomib 之抗藥性研究民診國醫教師合作計畫・合作：吳宜穎・2027/01–2027/12116探討 PRSS8 在前列腺癌侵襲轉移的功能民診國醫教師合作計畫・合作：陳進利・2027/01–2027/12資料來源：國科會學術研發服務網；其他計畫由本人提供（年度為計畫核定年度）。

研究論文

49 篇論文
20266 篇49.Effectiveness of conventional antimicrobial agents against carbapenem resistant non-carbapenem β-lactams susceptible Pseudomonas aeruginosa infection in critically ill patients: a multicentre retrospective studyBMC Infectious Diseases48.Effects of Resveratrol on MCP-1/CCL2-Related Readouts in Preclinical Animal Models: A Systematic Review and Meta-Analysis第一作者Biomedicines 14(6)・IF 4.547.Elucidating the vasoprotective mechanism of Tetrahydrocurcumin: from unbiased transcriptomic discovery to targeted validation of the PI3K/AKT pathway第一作者BMC Complementary Medicine and Therapies 26(1)・IF 3.446.Hepatitis Viruses Infection Up-Regulating Fibrosis Signals in Hepatocellular CarcinomaBiomedicines 14(8):1717・IF 4.545.Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy通訊作者Cell Death Discovery・IF 10.444.Integrated Transcriptomic and Spatial Analyses Associate M2-like Myeloid Signatures with Neuroimmune Remodeling in Alzheimer's Disease通訊作者International Journal of Molecular Sciences 27(10)・IF 4.920255 篇43.Differential Impact of Interferon-Based and Direct-Acting Antiviral Therapies on Bone Metabolism in Chronic Hepatitis C: Insights from Transcriptomic and Clinical Analyses第一作者Calcified Tissue International 116(1):12942.Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms通訊作者Biodata Mining 18(1)・IF 6.141.MYADM Activates RhoA-Mediated Ameboid Migration to Drive MetastasisCancer Research 85(21):4099-4121・IF 16.640.Neuroinflammation and immune microenvironment alterations following heat stroke: A transcriptomic perspective通訊作者Computers in Biology and Medicine 196・IF 6.339.Prostate Tissue-Induced Platelet Activation and Platelet–Neutrophil Aggregation Following Transurethral Resection of the Prostate Surgery: An In Vitro StudyBiomedicines 13(4)・IF 4.520242 篇38.Pulmonary Effects of Traumatic Brain Injury in Mice: A Gene Set Enrichment Analysis通訊作者International Journal of Molecular Sciences 25(5)・IF 4.937.Transcriptomic analysis reveals Cilostazol's role in ameliorating cardiovascular disease: Inhibition of monocyte-to-macrophage differentiation and reduction of endothelial cell reactive oxygen species production通訊作者Heliyon 10(7)・IF 3.620235 篇36.Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat strokeBiomedicine and Pharmacotherapy 161・IF 7.535.Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial CarcinomaInternational Journal of Molecular Sciences 24(18)・IF 4.934.Exploring the Functional Roles of Telomere Maintenance 2 in the Tumorigenesis of Glioblastoma Multiforme and Drug Responsiveness to TemozolomideInternational Journal of Molecular Sciences 24(11)・IF 4.933.Profiling of miRNAs and their interfering targets in peripheral blood mononuclear cells from patients with chronic myeloid leukaemiaFrontiers in Oncology 13・IF 3.332.The Functional Role of Myogenin in Cardiomyoblast H9c2 Cells Treated with High Glucose and Palmitic Acid: Insights into No-Rejection Heart TransplantationInternational Journal of Molecular Sciences 24(17)・IF 4.920228 篇31.Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic StudyJournal of Inflammation Research 15:4833-4851・IF 4.130.Benzo[a]pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species productionEcotoxicology and Environmental Safety 239・IF 6.129.Correction to: Cross-sectional associations among P3NP, HtrA, Hsp70, Apelin and sarcopenia in Taiwanese population (BMC Geriatrics, (2021), 21, 1, (192), 10.1186/s12877-021-02146-5)BMC Geriatrics 22(1)・IF 3.828.Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activityGenes and Diseases 9(4):1049-1061・IF 9.427.Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostolLife Sciences 310・IF 5.126.In Vitro Cell Density Determines the Sensitivity of Hepatocarcinoma Cells to AscorbateFrontiers in Oncology 12・IF 3.325.miR-424/322 protects against abdominal aortic aneurysm formation by modulating the Smad2/3/runt-related transcription factor 2 axisMolecular Therapy Nucleic Acids 27:656-669・IF 6.124.New insights into sex differences in primary biliary cholangitis. Gender difference in primary biliary cholangitisJournal of the Pakistan Medical Association 72(5):896-900・IF 0.8202110 篇23.Aberrantly reduced expression of miR-342-5p contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistanceCell Death and Disease 12(10)・IF 12.222.Association between interleukin-12 and sarcopeniaJournal of Inflammation Research 14:2019-2029・IF 4.121.Cilostazol induces ENOS and tm expression via activation with Sirtuin 1/krüppel-like FACTOR 2 pathway in endothelial cellsInternational Journal of Molecular Sciences 22(19)・IF 4.920.Cross-sectional associations among P3NP, HtrA, Hsp70, Apelin and sarcopenia in Taiwanese populationBMC Geriatrics 21(1)・IF 3.819.Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational studyBMC Geriatrics 21(1)・IF 3.818.Generation of functional cardiomyocytes from human gastric fibroblast-derived induced pluripotent stem cellsBiomedicines 9(11)・IF 4.517.Risk of non-alcoholic fatty liver disease in xanthelasma palpebrarumJournal of Inflammation Research 14:1891-1899・IF 4.116.Targeting s1pr1 may result in enhanced migration of cancer cells in bladder carcinomaCancers 13(17)・IF 4.415.The bhlh transcription factor e protein negatively regulates endoreplication in the salivary gland cellsJournal of Medical Sciences Taiwan 41(1):29-3714.The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma CellsFrontiers in Oncology 11・IF 3.320207 篇13.Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cellsFASEB Journal 34(7):9498-9511・IF 4.212.Antiviral activity of compound l3 against dengue and zika viruses in vitro and in vivoInternational Journal of Molecular Sciences 21(11):46035・IF 4.911.Gene expression profiling identifies the role of Zac1 in cervical cancer metastasisScientific Reports 10(1)・IF 3.910.Ginkgo biloba Induces Thrombomodulin Expression and Tissue-Type Plasminogen Activator Secretion via the Activation of Krüppel-Like Factor 2 within Endothelial CellsAmerican Journal of Chinese Medicine 48(2):357-372・IF 5.59.In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patientsPlos One 15(12 December)・IF 2.68.Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activationHuman Cell 33(4):1068-1080・IF 3.17.Relationships between vitamin d status and cytokine: Results from interferon-based therapy in non-cirrhotic, treatment-naïve patients with chronic hepatitis c infectionJournal of Inflammation Research 13:1207-1218・IF 4.120191 篇6.Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2Journal of Enzyme Inhibition and Medicinal Chemistry 34(1):692-702・IF 5.420182 篇5.Correction: Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin(PLoS ONE (2018) 13:2 (e0192632) DOI: 10.1371/journal.pone.0192632)Plos One 13(5)・IF 2.64.Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skinPlos One 13(2)・IF 2.620161 篇3.Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled mannerPlos One 11(12)・IF 2.620131 篇2.Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesisCell Death and Differentiation 20(5):732-743・IF 15.420101 篇1.GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells.Journal of Agricultural and Food Chemistry 58(22):12014-12021・IF 6.2書目依 2026-09-23 彙整表，IF 為 2025 JCR；點論文題名可開啟原文（DOI）。

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