E-MAIL

ycchen4315@mail.ndmctsgh.edu.tw

經歷

國防醫學院生物醫學工程學科講師
助理教授
副教授

專長學科

1.心臟電生理
2.細胞箝定與離子電流
3.電子電路設計

期刊發表

1. Chen YC, Kao YH, Huang CF, Cheng CC, Chen YJ, Chen SA. Heat stress responses modulate calcium regulations and electrophysiological  characteristics in atrial myocytes. J Mol Cell Cardiol. 2010 Apr;48(4):781-8.
2. Tsai CF, Chen YC, Lin YK, Chen SA, Chen YJ*. Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium. Basic Res Cardiol. 2011 Nov;106(6):979-93.
3. Lin YK, Chen YC, Chen JH, Chen SA, Chen YJ*. Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation. Basic Res Cardiol. 2012 Sep;107(5):293.
4. Lu YY, Chen YC, Kao YH, Chen SA, Chen YJ*. Extracellular matrix of collagen modulates arrhythmogenic activity of pulmonary veins through p38 MAPK activation. J Mol Cell Cardiol. 2013 Jun;59:159-66.
5. Chang CJ, Chen YC, Kao YH, Lin YK, Chen SA, Chen YJ*. Dabigatran and thrombin modulate electrophysiological characteristics of pulmonary vein and left atrium. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1176-83.
6. Lin YK, Chen YC, Huang JH, Lin YJ, Huang SS, Chen SA, Chen YJ. Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. J Biomed Sci. 2013 Dec 20;20:94.
7. Chen YC, Lu YY, Cheng CC, Lin YK, Chen SA, Chen YJ. Sinoatrial node electrical activity modulates pulmonary vein arrhythmogenesis. Int J Cardiol. 2014 May 15;173(3):447-52.
8. Kao YH, Chen YC, Lin YK, Shiu RJ, Chao TF, Chen SA, Chen YJ. FGF-23 dysregulates calcium homeostasis and electrophysiological properties in HL-1 atrial cells. Eur J Clin Invest. 2014 Aug;44(8):795-801.
9. Chen YC, Wen ZH, Lee YH, Chen CL, Hung HC, Chen CH, Chen WF, Tsai MC. Dihydroaustrasulfone alcohol inhibits PDGF-induced proliferation and migration of human aortic smooth muscle cells through inhibition of the cell cycle. Mar Drugs. 2015 Apr 17;13(4):2390-406.
10. Huang SY, Chen YC, Kao YH, Hsieh MH, Chen YA, Chen WP, Lin YK, Chen SA, Chen YJ. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria. Int J Cardiol. 2016 Jan 1;202:846-857.
11. Lu YY, Lin YK, Wen ZH, Chen YC*, Chen SA, Chen YJ. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. (SCI) *Corresponding Author
12. Lu YY, Chen YC, Kao YH, Lin YK, Yeh YH, Chen SA, Chen YJ*. Colchicine modulates calcium homeostasis and electrical property of HL-1 cells. J Cell Mol Med. 2016 Jun;20(6):1182-90.
13. Lin YK, Cheng CC, Tsai MC, Wu PY, Chen YA, Chen YC*, Chen SA, Chen YJ*. Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities. Exp Ther Med. 2017 May;13(5):2486-2492. (SCI) *equal to corresponding Author
14. Chang JH, Chang SL, Hong PD, Chen PN, Hsu CH*, Lu YY*, Chen YC*. Epigallocatechin-3-gallate modulates arrhythmogenic activity and calcium homeostasis of left atrium. Int J Cardiol. 2017 Jun 1;236:174-180.
15. Huang SY, Chen YC, Kao YH, Hsieh MH, Lin YK, Chen SA, Chen YJ*. Redox and Activation of Protein Kinase A Dysregulates Calcium Homeostasis in Pulmonary Vein Cardiomyocytes of Chronic Kidney Disease. J Am Heart Assoc. 2017 Jul 12;6(7). pii: e005701. doi: 10.1161/JAHA.117.005701. (SCI)
16. Lu YY, Wu WS, Lin YK, Cheng CC, Chen YC*, Chen SA, Chen YJ*. Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway. Eur J Clin Invest. 2018 Jan;48(1).
17. Chan CS, Chen YC, Chang SL, Lin YK, Kao YH, Chen SA, Chen YJ*. Heart Failure Differentially Modulates the Effects of Ivabradine on the Electrical Activity of the Sinoatrial Node and Pulmonary Veins. J Card Fail. 2018 Oct 5. pii: S1071-9164(18)31061-3. (SCI)
18. Lee TI, Chen YC, Lin YK, Chung CC, Lu YY, Kao YH, Chen YJ. Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2019 Apr 4;20(7).
19. Huang JH, Chen YC, Lu YY, Lin YK, Chen SA, Chen YJ. Arginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes. J Biomed Sci. 2019 Sep 17;26(1):71. doi:10.1186/s12929-019-0564-3.
20. Cheng WL, Kao YH, Chen YC, Lin YK, Chen SA, Chen YJ. Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling. Transl Res. 2020 Feb;216:43-56.
21. Lin YK, Cheng CC, Huang JH, Chen YA, Lu YY*, Chen YC*, Chen SA, Chen YJ. Various subtypes of phosphodiesterase inhibitors differentially regulate pulmonary vein and sinoatrial node electrical activities. Exp Ther Med. 2020 Apr;19(4):2773-2782. *equal to corresponding Author
22. Lu YY, Cheng CC, Wu HJ, Lin YK*, Chen YC*, Chen SA, Chen YJ. Effects of ANP on pulmonary vein electrophysiology, Ca2+ homeostasis and adrenergic arrhythmogenesis via PKA. Clin Exp Pharmacol Physiol. 2020 Feb;47(2):247-254.
23. Ke HY, Chin LH, Tsai CS, Lin FZ, Chen YH, Chang YL, Huang SM, Chen YC*, Lin CY*. Cardiac calcium dysregulation in mice with chronic kidney disease. J Cell Mol Med. 2020 Mar;24(6):3669-3677. *equal to corresponding Author
24. Hung Y, Chen YC, Huang SY, Lu YY, Lin YK, Kao YH, Lin WS, Chen SA, Chen YJ. Klotho modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes via PI3K/Akt signalling. Europace. 2020 Jul 1;22(7):1132-1141.
25. Yang HY, Lin FZ, Yang HW, Yu PL, Huang SM, Chen YC*, Tsai CS*, Lin CY*. The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes. J Cell Mol Med. 2020 Jun;24(12):6762-6772. *equal to corresponding Author
26. Yugo D, Chen YC, Lin YK, Liu CM, Huang JH, Chen SA, Chen YJ. Effects of phosphodiesterase-1 inhibitor on pulmonary vein electrophysiology and arrhythmogenesis. Eur J Clin Invest. 2021 Sep;51(9):e13585.
27. Huang SY, Chen YC, Kao YH, Lu YY, Lin YK, Higa S, Chen SA, Chen YJ. Calcium dysregulation increases right ventricular outflow tract arrhythmogenesis in rabbit model of chronic kidney disease. J Cell Mol Med. 2021 Dec;25(24):11264-11277.
28. Lin FJ, Li SJ, Lu YY*, Wu WS*, Chen YC*, Chen SA, Chen YJ. Toll-like receptor 4 activation modulates pericardium-myocardium interactions in lipopolysaccharide-induced atrial arrhythmogenesis. Europace. 2021 Apr 9:euab073.
29. Cheng WL, Chen YC, Li SJ, Lee TI, Lee TW, Higa S, Chung CC, Kao YH, Chen SA, Chen YJ. Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling. Acta Physiol (Oxf). 2022 Mar;234(3):e13784.
30. Chin CG, Chen YC, Lin YK, Lu YY, Cheng WL, Chung CC, Chen SA, Chen YJ. Effect of macrophage migration inhibitory factor on pulmonary vein arrhythmogenesis through late sodium current. Europace. 2022 Sep 3:euac152.
31. Chen YC, Lu YY, Wu WS, Lin YK, Chen YA, Chen SA, Chen YJ. Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes-related ventricular arrhythmogenesis. Physiol Rep. 2022 Nov;10(21):e15499.
32. Liu CH, Chen YC, Lu YY, Lin YK, Higa S, Chen SA, Chen YJ. Gender Difference in Lithium-Induced Sodium Current Dysregulation and Ventricular Arrhythmogenesis in Right Ventricular Outflow Tract Cardiomyocytes. Biomedicines. 2022 Oct 28;10(11):2727.
33. Chung CC, Lin YK, Chen YC, Kao YH, Yeh YH, Trang NN, Chen YJ. Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis. Cardiovasc Diabetol. 2023 Feb 6;22(1):27.
34. Liu CM, Lin FJ, Chen YC, Lin YK, Lu YY, Chan CS, Higa S, Chen SA, Chen YJ. Modulation of post-pacing action potential duration and contractile responses on ventricular arrhythmogenesis in chloroquine-induced long QT syndrome. Eur J Pharmacol. 2023 Feb 15;941:175493.
35.  Chan CS, Lin FJ, Chen YC, Lin YK, Higa S, Chen SA, Chen YJ. Glucagon-like Peptide-1 Receptor ActivationReduces Pulmonary Vein Arrhythmogenesis and Regulates Calcium Homeostasis. Int J Mol Sci. 2023 Aug 23;24(17):13100.
36. Lee TI, Trang NN, Lee TW, Higa S, Kao YH, Chen YC*, Chen YJ*. Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy. Int J Mol Sci. 2023 Nov 9;24(22):16142. *equal to corresponding Author
37. Chin CG, Chen YC, Lin YK, Lu YY, Cheng WL, Chung CC, Chen SA, Chen YJ. Effect of macrophage migration inhibitory factor on pulmonary vein arrhythmogenesis through late sodium current. Europace. 2023 Feb 16;25(2):698-706.
38. Lu YY, Cheng CC, Chen YC, Lin YK, Higa S, Kao YH, Chen YJ. Adenosine monophosphate-regulated protein kinase inhibition modulates electrophysiological characteristics and calcium homeostasis of rabbit right ventricular outflow tract. Fundam Clin Pharmacol. 2024 Apr;38(2):262-275.
39. Chin CG, Chen YC, Lin FJ, Lin YK, Lu YY, Cheng TY, Chen SA, Chen YJ. Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling. J Biomed Sci. 2024 Apr 22;31(1):42.
40. Cheng TY, Chen YC, Li SJ, Lin FJ, Lu YY, Lee TI, Lee TW, Higa S, Kao YH, Chen YJ. Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis. Transl Res. 2024 Jun;268:1-12.
41. Liu CM, Lin FJ, Chhay C, Chen YC, Lin YK, Lu YY, Chan CS, Higa S, Chen SA, Chen YJ. Ibrutinib, a Bruton'styrosine kinase inhibitor, regulates ventricular electromechanical activities and enhances arrhythmogenesis. Eur J Pharmacol. 2024 Aug 15;977:176675.
42. Cheng TY, Lee TW, Li SJ, Lee TI, Chen YC, Kao YH, Higa S, Chen PH, Chen YJ. Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia. J Adv Res. 2024 Aug 5:S2090-1232(24)00332-1.
43. Mushtaq I, Hsieh TH, Chen YC, Kao YH, Chen YJ. MicroRNA-452-5p regulates fibrogenesis via targeting TGF-β/SMAD4 axis in SCN5A-knockdown human cardiac fibroblasts. iScience. 2024 May 23;27(6):110084.
44. Chung CC, Kao YH, Chen YC, Lin YK, Higa S, Hsu KC, Chen YJ. PCSK9 Enhances Cardiac Fibrogenesis via the Activation of Toll-like Receptor and NLRP3 Inflammasome Signaling. Int J Mol Sci. 2025 Feb 23;26(5):1921.
45. Hung Y, Cheng CC, Lu YY, Huang SY, Chen YC*, Lin FJ, Lin WS, Kao YH, Lin YK, Chen SA, Chen YJ*. Indoxyl Sulfate Induces Ventricular Arrhythmias Attenuated by Secretoneurin in Right Ventricular Outflow Tract Cardiomyocytes. Cardiovasc Toxicol. 2025 Mar;25(3):471-485. *equal to corresponding Author
46. Lin FZ, Chen YC, Yang HY, Lin WS, Lu YY. Phosphodiesterase 10A Inhibitor Modulates Right Ventricular Outflow Tract Electrophysiological Activities and Calcium Homeostasis via the cGMP/PKG Pathway. J Cell Mol Med. 2025 Mar;29(5):e70480.