E-MAIL

ccshih@mail.ndmutsgh.edu.tw

經歷

澳洲雪梨大學藥學院訪問學者 (2024-2025)

國防醫學院生科所執行秘書

英國帝國大學醫學院國家心肺研究所訪問學者 (2017-2018)

英國倫敦大學巴茲與倫敦醫學暨牙醫學院威廉哈維研究所訪問學者 (2013-2014)

國防醫學院藥理學科教師

研究興趣

學術著作

1. W Tai, D Khanal, PTH Kwong, GTY Yau, P Tang, CC Shih*, HK Chan* (2026, Feb). Xinafoic acid as a novel excipient to enhance dispersion and stability of spray dried highly hygroscopic inhalable beta-hydroxybutyrate powders. Journal of Drug Delivery Science and Technology, 116:107946. 本人為通訊作者.

2. LT Wang, CC Shih, YH Chen, CF Chang, HL Fan, TW Chen, YW Chen, S Krupalakshmi, YF Lin, YL Shih, TY Hsieh, WY Huang, WC Huang (2026, Jan). Interferon-α enhances NK cell function to counteract autologous platelet-mediated tumor immune evasion. Cancer Cell International, 26:92.

3. HY Hung, CC Shih, MH Liao, SJ Chen, HC Huang, CC Wu (2025, Dec). NKCC1 inhibition as a breakthrough in combating coagulopathy and boosting survival in LPS-induced DIC rat model. European Journal of Pharmacology, 1008:178348.

4. KN Chou, XJ Lu, HF Lai, YL Chiu, CC Shih (2025, Sep). Neuroinflammation and immune microenvironment alterations following heat stroke: A transcriptomic perspective. Computers in Biology and Medicine, 196(PtB):110773.

5. HY Ke, MH Chen, CM Tsao, HP Hii, CW Kuo, SM Ka, CC Wu, CC Shih* (2025, Jul). Therapeutic potential of butyrate against heat Stress-Induced intestinal damage, systemic inflammation, and multiple organ Dysfunction: Insights from in vitro and in vivo experiments. European Journal of Pharmacology, 999:177710. 本人為通訊作者.

6. W Tai, HJ Wang, D Khanal, PTH Kwong, P Tang, CC Shih*, HK Chan* (2025, Jul). Development of inhalable spray dried nalbuphine hydrochloride powders. International Journal of Pharmaceutics, 682:125952.  本人為通訊作者.

7. JS Wu, H Lohelaid, CC Shih, HK Liew, V Wang, WF Hu, YH Chen, M Saarma, M Airavaara, KY Tseng (2024, Nov). Targeting Rap1b signaling cascades with CDNF: Mitigating platelet activation, plasma oxylipins and reperfusion injury in stroke. Molecular Therapy, 32(11):4021-4044.

8. HY Ke, JH Chen, SY Kao, CM Tsao, CW Kuo, CC Wu, CC Shih* (2024, Sep). Heat stress–induced platelet dysfunction is associated with loss of fibrinogen and is improved by fibrinogen supplementation. Thrombosis Research, 241:109091. 本人為通訊作者.

9. SY Kao, CM Tsao, HY Ke, MF Chou, CC Wu, CC Shih* (2024, Sep). Loss of plasma fibrinogen contributes to platelet hyporeactivity in rats with septic shock. Thrombosis Research, 241:109072.  本人為通訊作者.

10. CC Shih*, WC Liao, HY Ke, CW Kuo, CM Tsao, WC Tsai, YL Chiu, HC Huang, CC Wu (2023, May). Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke. Biomedicine & Pharmacotherapy, 161:114565. 本人為第一作者、通訊作者.

11. CC Shih, SJ Chen, WK Chang, HJ Tsai, HC Huang, CC Wu, CM Tsao (2023, Mar). Stimulation of Angiotensin II Type 2 Receptor Attenuates Organ Injury in Rats With Polymicrobial Sepsis. Journal of the Chinese Medical Association, 86(7):688-695. 本人為第一作者.

12. HP Hii, WZ Lo, YH Fu, MH Chen, CC Shih, CM Tsao, SM Ka, YL Chiu, CC Wu, CC Shih* (2022, Dec). Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol. Life Sciences, 310:121039. 本人為通訊作者.

13. HJ Tsai, CF Chian, CC Shih, SJ Chen, WJ Liaw, HC Huang, CM Tsao, CC Wu (2022, Nov). Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis. Journal of Surgical Research, 279:526-532.

14. CC Shih, MV Chan, NS Kirkby, I Vojnovic, JA Mitchell, PC Armstrong, TD Warner (2021, Dec). Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators. British Journal of Pharmacology, 178:4758-4771. 本人為第一作者.

15. HJ Tsai, CC Shih, KY Chang, MH Liao, WJ Liaw, CC Wu, CM Tsao (2021, Jan). Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Scientific Reports, 11:610.

16. HC Huang, TS Hsiao, MH Liao, CM Tsao, CC Shih*, CC Wu* (2020, Sep). Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties. European Journal of Pharmacology, 882:173279. 本人為通訊作者.

17. PC Armstrong, PM Ferreira, MV Chan, MH Lundberg Slingsby, M Crescente, CC Shih, NS Kirkby, AJ Hobbs, TD Warner (2020, Jul). Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti‐platelet therapy. Journal of thrombosis and haemostasis, 18:1705-1713.

18. FK Chuang, CL Liao, MK Hu, YL Chiu, AR Lee, SM Huang, YL Chiu, PL Tsai, BC Su, TH Chang, CC Lin, CC Shih, LC Yen (2020, Jun). Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. International Journal of Molecular Sciences, 21(11), 4050.

19. CC Shih, JH Chen, MH Liao, CM Tsao, HC Huang, CC Wu (2020, Mar). The effect of adenosine A2A receptor antagonist istradefylline on multiple organ dysfunction in heatstroke rats. Journal of Medical Sciences, 40(2):76-82. 本人為第一作者.

20. B Ahmetaj‐Shala, R Kawai, I Marei, Z Nikolakopoulou, CC Shih, B Konain, DM Reed, R Mongey, NS Kirkby, JA Mitchell (2020, Jan). A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering. FASEB Journal, 34:1745-1754.

21. FK Chuang, SM Huang, CL Liao, AR Lee, SP Lien, YL Chiu, TH Chang, PL Tsai, RJ Lin, CC Shih, YJ Tsai, GJ Lin, LC Yen (2019, Dec). Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. Antimicrobial Agents and Chemotherapy, 64(1), e00941-19.

22. CC Shih, PY Liu, JH Chen, MH Liao, CM Hsieh, SM Ka, CC Wu, HT Lin, TH Wu, YC Chen (2018, Dec). Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLOS ONE, 13 (12): e0208279. 本人為第一作者.

23. HJ Tsai, MH Liao, CC Shih, SM Ka, CM Tsao, CC Wu (2018, Oct). Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Critical Care, 22:269.

24. B Ahmetaj-Shala, M Olanipekun, A Tesfai, N MacCallum, NS Kirkby, GJ Quinlan, CC Shih, R Kawai, S Mumby, M Paul-Clark, EJ Want, JA Mitchell (2018, Sep). Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping. Scientific Reports, 8:13987.

25. CC Shih, LP Hsu, MH Liao, SS Yang, ST Ho, CC Wu (2017, Nov). Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice. European Journal of Pharmacology, 814, 248-254. 本人為第一作者.

其他資訊

◎Research Interests

☆Biomarkers and treatments of septic shock                  

☆The mechanisms of platelet hyporeactivity in heat stroke and sepsis

◎Lab Alumni