經歷

國防醫學大學生理學科 兼任助理教授 (2019 – 2026)
國防醫學大學博士後研究員 (2016-2026)
加拿大阿爾伯塔大學醫學院生理學系訪問研究 (2024)

研究方向

My research focuses on adipose tissue physiology and metabolic disease, particularly the molecular mechanisms linking adipose inflammation, immune signaling, and adaptive thermogenesis. Our work investigates three major signaling pathways—COX-2/PGE2, CCL5/CCR5, and SAA3—to understand how adipose tissue contributes to obesity and insulin resistance, as well as how endogenous thermogenic mechanisms can be harnessed to improve metabolic health.

研究論文

1. Chan, P. C., Lin, P. R., Tian, Y. F., & Hsieh, P. S. (2026, May). Cold-Induced Serum Amyloid A3 Amplifies cAMP–PKA Signaling to Drive Adaptive Thermogenesis in Brown Adipocytes. Journal of Physiology and Biochemistry. (Accepted).
2. Chan, P. C., Jhuang, C. H., Chang, H. Y., & Hsieh, P. S. (2026, May). Brown adipocyte-derived SAA3-CPT1A axis regulates diet-induced thermogenesis and protects against obesity. J Nutr Biochem, 151:110263.
3. Chan, P. C., Hung, L. M., Huang, J. P., Day, Y. J., Yu, C. L., Kuo, F. C., Lu, C. H., Tian, Y. F., & Hsieh, P. S. (2022, Jan). Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity. Clin Sci (Lond), 136(1):121–137.
4. Chan, P. C., Liao, M. T., Lu, C. H., Tian, Y. F., & Hsieh, P. S. (2021, Jan). Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models. Eur J Pharmacol, 891:173703.
5. Chan, P. C., Lu, C. H., Chien, H. C., Tian, Y. F., & Hsieh, P. S. (2022, Nov). Adipose Tissue-Derived CCL5 Enhances Local Pro-Inflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice. Int J Mol Sci, 23(22):14226.
6. Chien, H. C., Chan, P. C., Tu, C. C., Day, Y. J., Hung, L. M., Juan, C. C., Tian, Y. F., & Hsieh, P. S. (2018, Oct). Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis. Chin J Physiol, 61(5):266–279.
7. Chan, P. C., & Hsieh, P. S. (2021, Dec). The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity. Int J Mol Sci, 22(24):13528.
8. Chan, P. C., Wu, T. N., Chen, Y. C., Lu, C. H., Wabitsch, M., Tian, Y. F., & Hsieh, P. S. (2018, Jul). Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance. Clin Sci (Lond), 132(14):1581–1596.
9. Chan, P. C., Wang, Y. C., Chen, Y. L., Hsu, W. N., Tian, Y. F., & Hsieh, P. S. (2017, Nov). Importance of NADPH oxidase-mediated redox signaling in the detrimental effect of CRP on pancreatic insulin secretion. Free Radic Biol Med, 112:200–211.
10. Chan, P. C., Hsiao, F. C., Chang, H. M., Wabitsch, M., & Hsieh, P. S. (2016, Jun). Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance. FASEB J, 30(6):2282–2297.
11. Hsieh, P. S., Jin, J. S., Chiang, C. F., Chan, P. C., Chen, C. H., & Shih, K. C. (2009, Jun). COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity (Silver Spring), 17(6):1150–1157.
12. Chan, P. C., Liao, M. T., & Hsieh, P. S. (2019, Jun). The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. Int J Mol Sci, 20(13):3115.
13. Chan, P. C., & Hsieh, P. S. (2022, Aug). The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases. Int J Mol Sci, 23(16):9448.

研討會論文

1. Chan, P. C., Huang, H. Y., Jhuang, C. H., & Hsieh, P. S. (2025, Mar). Brown Adipocyte-Derived SAA3 Facilitates Fatty Acid Oxidation And Diet-Induced Thermogenesis In Mice. 17th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD 2025)
2. Chan, P. C., & Hsieh, P. S. (2020, Sep). Importance of tissue CCL5/CCR5 signaling on monocytic-MDSCs-derived macrophage polarization and inflammation in epididymal fat of high fat diet-induced obese mice. 56th Annual Meeting of the European Association for the Study of Diabetes (EASD), Virtual Meeting.
3. Chan, P. C., & Hsieh, P. S. (2019, Mar). Importance of RANTES/CCR5 signaling in lipid oxidation and adaptive thermogenesis in mice. The 9th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress.
4. Chan, P. C., & Hsieh, P. S. (2017, Jun). C-C chemokine ligand 5 deficiency promotes adaptive thermogenesis through browning of white adipose tissue in mice. American Diabetes Association (ADA) 77th Scientific Sessions, San Diego, CA, USA.