學歷

國防醫學大學 醫學士 1989

美國 耶魯大學 細胞生物學系 哲學博士 1997

經歷

1997-2007   國防醫學院  生物及解剖學科 助理教授

2007-2013   國防醫學院  生物及解剖學科 副教授

2013-至今   國防醫學院  生物及解剖學科 教授

2017-2023   國防醫學院  生物及解剖學科暨研究所 主任及所長

2005-至今   三軍總醫院  精神醫學部 主治醫師

2019-2021 國防醫學院  第55屆教育委員會常務委員會主任委員

2019-2021 國防醫學院  教師發展中心主任

2023-2024 國防醫學院   學術研究倫理審議委員會  主任委員

2024-至今 國防醫學院  軍事教育基金經費稽核委員會  委員

2025-至今 國防醫學大學 研究發展處  處長

研究領域

1.骨生長、再塑造、及礦物化細胞分子機轉

2.抗骨吸收及促骨生成藥物應用於骨質疏鬆症治療之研究

3.骨髓間葉幹細胞及再生醫學應用於骨組織工程及骨折癒合之研究

4.3D列印人類含血管骨類器官及動態培養

5.生物機械力學及流體力學應用於骨生長及再塑造

獲獎情形

2014   國防醫學院  盧致德優良醫學論文獎

2015   國防醫學院  優良導師

2016   國防醫學院  梁序穆暨許織雲教授傑出研究獎

2020   國防部優良教師

專業學會成員

The Association of Anatomy

Taiwanese Society of Psychiatry

The American Society for Bone Mineral Research

專科醫師

精神科

研究成果

1.     Wang JW, Yeh CB, Chou S-J, Lu KC, Chu TH, Chen WY, Chien JL, Yen MH, Chen TH, Shyu JF*. YC-1 alleviates bone loss in ovariectomized rats by inhibiting bone resorption and inducing extrinsic apoptosis in osteoclasts. Journal of Bone and Mineral Metabolism. 2018. Sep. 36:508-518. (IF=2.472, 72/133, 54.1% in Medicine, Research & Experimental)

2.     Lu, CL, Shyu JF, Wu CC, Hung CF, Liao MT, Liu WC, Zheng CM, Hou YC, Lin YF, Lu KC. Association of anabolic effect of calcitriol with osteoclast-derived Wnt 10b secretion. Nutrients. 2018 Aug. 25, 1890. (IF=4.171, 16/87, 18.4% in Nutrition and Diabetics)

3.     Lu CL, Yeih DF, Hou YC, Jow GM, Li ZY, Liu WC, Cai-Mei Zheng , Yuh-Feng Lin, Shyu JF, Chen R, Huang CY, Lu KC. The emerging role of nutritional vitamin D in secondary hyperparathyroidism in CKD. Nutrients. 2018 Dec. 10, 1890. (IF=4.171, 16/87, 18.4% in Nutrition and Diabetics)

4.     Changa HA, Fang WH,Wan FJ, Tzenga NS, Liu YP, Shyu JF, Huanga SY, Chang TC, Chang CC. Age-specific associations among functional COMT Val¹⁵⁸Met polymorphism, resting parasympathetic nervous control and generalized anxiety disorder. Psychoneuroendocrinology. 2019 March 21. 106:57-64. (IF=4.013, 36/146, 24.7% in Psychiatry)

5.     Zheng CM, Hus YH, Wu CC, Lu CL, Liu WC, Zheng JQ, Lin YF, Chiu HW, Chang TJ, Shyu, JF*, Lu KC. Osteoclast-released Wnt-10b underlies cinacalcet related bone improvement in chronic kidney disease. International Journal of Molecular Sciences. 2019 June 8, 20:2800. (IF=4.183, 78/298, 26.2% in Biochemistry & Molecular Biology)

6.     Zheng CM, Wu CC, Lu CL, Hou YC, Wu MS, Hsu YH, Chen R, Chang TJ, Shyu JF, Lin YF, Lu KC. Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients. International Journal of Medical Sciences. 2019 Oct. 21, 16(12):1587-96. (IF=2.333, 53/160, 33.1% in Medicine, General & Internal)

7.     Guo GH, Tseng FJ, Wang SH, Chen PJ, Shyu JF, Pan RY. Nutritional factors associated with femoral neck bone mineral density in children and adolescents. BMC Musculoskeletal Disorders. 2019 Dec., 20:520. (IF=2.002, 34/76, 44.7% in Orthopedics)

8.     Guo GH, M.S., Tseng FJ, Wang SH, Chen PJ, Shyu JF, Weng CF, Pan RY. Autologous Chondrocyte Implantation Versus Microfracture in the Knee: A Meta-analysis and Systematic Review. The Journal of Arthroscopic and Related Surgery. 2020 Jan., 36(1):289-303. (IF=4.433, 5/76, 6.6% in Orthopedics)

9.     Chang HA, Fang WH, Liu YP, Tzeng NS, Shyu JF, Wan FJ, Huang SY, Chang TC, and Chang CC. BDNF Val⁶⁶Met polymorphism to generalized anxiety disorder pathways: Indirect effects via attenuated parasympathetic stress-relaxation reactivity. J Abnormal Psychology. 2020 Jan. (IF=5.519, 7/129, 5.4% in Clinical Psychology)

10.     Hsiao CY, Chen TH, Huang BS, Chen PH, Su CH, Shyu JF*, Tsai PJ. Comparison between the Therapeutic Effects of Differentiated and Undifferentiated Wharton's Jelly Mesenchymal Stem Cells in Rats with Streptozotocin-induced Diabetes. World Journal of Stem Cell. 2020 Jan. Accepted (IF=3.534, 94/193, 48.7% in Cell Biology)

11.  Chang HA, Fang WH, Tzeng NS, Liu YP, Shyu JF, Wan FJ. Age-dependent association of polymorphisms in the promoter and 5'-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder. J Affective Disorders. 2020 April, 124-130.

12. Hsiao CY, Chen TH, Chu TH, Ting YN, Tsai PJ, Shyu JF*. Calcitonin induces bone formation by increasing expression of Wnt10b from osteoclasts in ovariectomy-induced osteoporotic rats. Frontiers in Endocrinology. 2020. Sep. 11: 613 (IF=5.555, 32/145 (22.1%) in Endocrinology and Metabolism)

13. Liu, WC, Shyu JF, Lim PS, Fang TC, Liu CL, Zheng CM. Concentration and Duration of Indoxyl Sulfate Exposure Affects Osteoclastogenesis by Regulating NFATc1 via Aryl Hydrocarbon Receptor. International Journal of Molecular Sciences, 2020 Oct., 11265. (IF=, 5.923, 67/297=22.6% in Biochemistry and Molecular Biology)

14. Shyu, JF, Liu WC, Zheng CM, Fang TC, Hou YC, Chang CT, Liao TY, Chen YC, Lu KC. Toxic effects of indoxyl sulfate on osteoclastogenesis and osteoblastogenesis. International Journal of Molecular Sciences, 2021 Oct. 22, 11265. (IF=, 5.923, 67/297=22.6% in Biochemistry and Molecular Biology)

15. Chiu HW, Hou YC, Lu CL, Lu KC, Liu WC, Shyu JF, Chang JF, Zheng CM*. Cinacalcet improves bone parameters through regulation of osteoclast endoplasmic reticulum stress, autophagy, and apoptotic pathways in chronic kidney disease-mineral and bone disorder. Journal of Bone and Mineral Research, 2022 Feb. 37:215-225. (IF= 6.741, 19/145=13.1% in Endocrinology & Metabolism)

16. Tseng FJ, Gou GH, Wang SH, Shyu, JF, Pan RY. Chronic liver disease and cirrhosis increase morbidity in geriatric patients treated surgically for hip fractures: analysis of the US Nationwide Inpatient Sample. BMC Geriatrics, 2022 Feb. 22:150. (IF= 4.076, 10/37=27.0% in Gerontology)

  *Corresponding author

參與研究計畫

專利

(A)發明專利(B)新型專利(C)新式樣專利。