經歷
1. 國立台灣大學解剖學暨細胞生物學研究所助教(2005-2009)
2. 國立台灣大學解剖學暨細胞生物學研究所博士後研究員 (2009~2011)
3. 國防醫學院生物及解剖學科助理教授 (2011~2014)
4. 國防醫學院生物及解剖學科副教授 (2014~2018)
5. 國防醫學院生物及解剖學科教授 (2018至今)
研究領域
探討藥物或特定蛋白質對於膠質母細胞瘤以及膀胱癌細胞轉移、血管新生與死亡之相關訊息傳遞。
獲獎情形
1. 110年國防部優良教師
2. 110年高影響係數研究優良論文獎
3. 111年高影響係數研究優良論文獎、優良導師
4. 112年高影響係數研究優良論文獎
5. 113年醫學系優良總區段長、區段優良教師、優良導師
著作
著作:
1. Tzu-Min Chen, Jen-Fu Yang, Yi-Hsuan Lin, Yu-Ling Tsai, Chien-Rui Lai, Wen-Chiuan Tsai, Ying Chen* Farnesoid X receptor induction decreases invasion and tumor progression by JAK2/occludin signaling in human glioblastoma cells. Exp Cell Res. 2025 April 1:447:114500.
2. Yi-Hsuan Lin, Tzu-Min Chen, Chien-Rui Lai, Yu-Ling Tsai, Wen-Chiuan Tsai, Ying Chen* GW4064 inhibits migration and invasion in human glioblastoma multiforme through the downregulation of PKCα. Eur J Pharmacol. 2025 Mar 15:991:177329
3. Hui-Kung Ting, Yi-Chien Dou, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Sheng-Tang Wu*, Ying Chen* Pyr3 inhibits cell viability and PKCa activity to suppress migration in human bladder cancer cells. Eur J Pharmacol. 2025 Feb 5:988:177235.
4. Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Hisao-Hsien Wang*, Ying Chen*, Sheng-Tang Wu*, The reduction of PSMB4 in T24 and J82 bladder cancer cells inhibits angiogenesis and migration of endothelial cells. Int. J. Mol. Sci. 2024, May 25, 5999.
5. Jong-Shiaw Jin, Yu-Ling Tsai, Ying-Chuan Chen, Ying Chen, Jiann-Ruey Ong, Jung-Mao Chou, Wen-Chiuan Tsai. Effectively α-Terpineol Suppresses Glioblastoma Aggressive Behavior and Downregulates KDELC2 Expression. Phytomedicine 2024 May 127, 155471.
6. Hsiao-Chun Chen, Yu-Ling Pan, Ying Chen, Tsung-Hsuan Yang, Erh-Tung Hsu, Yu-Ting Huang, Ming-Hsien Chiang*. Monoclonal Antibodies as a Therapeutic Strategy against Multidrug-Resistant Bacterial Infections in a Post-COVID-19 Era. Life (Basel). 2024 Feb 9;14(2):246.
7. Chien-Chang Kao, Chien-Rui Lai, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Tze-Yun Ong, Hisao-Hsien Wang, Sheng-Tang Wu*, Ying Chen*. GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer. Chem Biol Interact. 2024 Jan 10:389:110869.
8. Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po-Chien Shen, and Ying Chen*. Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells. European Journal of Pharmacology. 2023, 938, 175411.
9. Hsin-Han Chang, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Chien-Rui Lai, Wen-Chiuan Tsai, Yu‐Chen Cheng*, Ying Chen*. ONX-0914 Induces Apoptosis and Autophagy with p53 Regulation in Human Glioblastoma Cells. Cancers 2022, 14(22), 5712.
10. Chien-Rui Lai, Yu-Ling Tsai, Wen-Chiuan Tsai, Tzu-Min Chen, Hsin-Han Chang, Chih-Ying Changchien, Sheng-Tang Wu, Hisao-Hsien Wang, Ying Chen* and Yu-Huei Lin*. Farnesoid X Receptor Overexpression Decreases the Migration, Invasion and Angiogenesis of Human Bladder Cancers via AMPK Activation and Cholesterol Biosynthesis Inhibition. Cancers 2022, 14(18), 4398.
11. Chen-Liang Tsai, Chih-Ying Changchien, Ying Chen, Chine-Rui Lai, Tzu-Min Chen, Hsin-Han Chang, Wen-Chiuan Tsai, Yu-Ling Tsai, Hao-Chung Tsai, Hung-Yi Lin, Ming-Sheng Shen, Chieh-Yung Wang, Yu-Huei Lin* Survival benefit of statin with anti-angiogenesis efficacy in lung cancer-associated pleural fluid through FXR modulation. Cancers 2022, 14, 2765.
12. Chine-Rui Lai, Hisao-Hsien Wang, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Chen-Ray Lee, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu*, Ying Chen*. Enhancement of Farnesoid X receptor inhibits migration, adhesion and angiogenesis through proteasome degradation and VEGF reduction in bladder cancers. Int. J. Mol. Sci. 2022, 23(9), 5259.
13. Chieh-Hsin Lin, Hsin-Han Chang, Chien-Rui Lai, Hisao-Hsien Wang, Wen-Chiuan Tsai, Yu-Ling Tsai, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu*, and Ying Chen*. Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers. Int. J. Mol. Sci. 2022, 23, 2154.
14. Feng-Cheng Pai, Hsiang-Wei Huang, Yu-Ling Tsai, Wen-Chiuan Tsai, Yu-Chen Cheng, Hsin-Han Chang* and Ying Chen* Inhibition of FABP6 reduces tumor cell invasion and angio-genesis through the decrease in MMP-2 and VEGF in human glioblastoma cells. Cells 2021,10(10), 2782.
15. Wei-Teing Chen, Yu-Huei Lin, Chih-Ying Changchien, Ying Chen, Hsin-Han Chang, Wen-Chiuan Tsai, Hao-Chung Tsai, Chieh-Yung Wang, Ming-Sheng Shen, Li-Ting Cheng and Chen-Liang Tsai*. Concurrent Blockade of Endothelial EGFR and VEGF Signaling on Malignant Associated Pleural Fluid Induced Angiogenesis: From Clinic to Bench. Biomedicines 2021, 9, 1327.
16. Ying Chen, Hisao-Hsien Wang, Hsin-Han Chang, Yun-Hsuan Huang, Jeffrey R. Wang, Chih-Ying Changchien, Sheng-Tang Wu*. Guggulsterone induces apoptosis and inhibits lysosomal-dependent migration in human bladder cancer cells. Phytomedicine 2021 Jul;87:153587. Co-first author.
17. Siou-Min Luo, Wen-Chiuan Tsai, Chia-Kuang Tsai, Ying Chen, Dueng-Yuan Hueng. ARID4B Knockdown Suppresses PI3K/AKT Signaling and Induces Apoptosis in Human Glioma Cells. Onco Targets Ther. 2021 Mar 10;14:1843-1855.(Co-corresponding author)
18. Chih‐Ying Changchien, Hsin‐Han Chang, Ming‐Shen Dai, Wen‐Chiuan Tsai, Hao‐Chung Tsai, Chieh‐Yung Wang, Ming‐Sheng Shen, Li‐Ting Cheng, Herng‐Sheng Lee, Ying Chen*, Chen‐Liang Tsai*. Distinct JNK/VEGFR signaling on angiogenesis of breast cancer‐associated pleural fluid based on hormone receptor status. Cancer Sci. 2021 Feb;112(2):781-791. (Co-corresponding author)
◎學術會議論文:
1. YiHsuan Lin, TzuMin Chen, YuLing Tsai, ChienRui Lai, WenChiuan Tsai, Ying Chen. Effects of FXR Agonist GW4064 on the Migration and Invasion in human glioblastoma multiforme. 2024 The 47th Annual Meeting of the Molecular Biology Society of Japan
2. Tzu-Min Chen, Yi-Hsuan Lin, Yu-Ling Tsai, Chien-Rui Lai, Hsin-Han Chang, Wen-Chiuan Tsai, Ying Chen. Farnesoid X receptor induction decreases migration, invasion, and tumor progression through JAK2 inactivation and tight junction enhancement in human glioblastoma cells. 2023 The 46th Annual Meeting of the Molecular Biology Society of Japan
3. Feng-Cheng Pai, Hsiang-Wei Huang, Hsin-Han Chang, Wen-Chiuan Tsai, Ying Chen. Blockade of FABP6 reduces tumor cell invasion and angiogenesis in human glioblastoma cells. 2021 The 44th annual meeting of the Molecular Biology Society of Japan
實驗室簡介
本實驗室主要研究神經膠質瘤與膀胱癌細胞移行、侵襲與血管新生的相關機制。探討膽酸結合蛋白質在神經膠癌細胞與膀胱癌中扮演的角色，以及中草藥對腦癌與膀胱癌的影響，歡迎對於研究癌細胞有興趣的研究夥伴加入我們。
