E-MAIL

ph870317@mail.ndmutsgh.edu.tw

實驗室房號-5356

經歷

1.國防醫學院生物及解剖學科助理教授 (2014~2020)

2.國防醫學院生物及解剖學科副教授 (2020~迄今)

研究領域

1.探討類風濕性關節炎自體免疫疾病的致病機轉及自體免疫疾病治療策略。

2.探討影響噬骨細胞分化相關因子分子機轉及關節炎之治療策略。

獲獎情形

1.第 29 屆中華民國風濕病醫學會 (2011)年會優秀青年研究員獎。

2.國防醫學院107年度優良導師。

3.國防醫學院107年度優良軍醫國防部獎狀。

4.國防醫學院109年度優良教師。

5.國防醫學院109年度國防醫學研究發展計畫成果發表績優。

6.國防醫學大學114年度優良教師。

研究成果

著作:

1.Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells. Huang SH, Hong ZJ, Chen MF, Tsai MW, Chen SJ, Cheng CP, Sytwu HK, Lin GJ. Int Immunopharmacol. 2024 Jan 5;126:111300.

2.Enhancing anatomy education through cooperative learning: harnessing virtual reality for effective gross anatomy learning. Wang CY, Yin T, Ma KH, Shyu JF, Cheng CP, Wang YC, Huang YL, Chiang MH. J Microbiol Biol Educ. 2023 Oct 18;24(3):e00100-23.

3.Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP. (2023, Apr). Interleukin 26 Induces Macrophage IL-9 Expression in Rheumatoid Arthritis. International Journal of Molecular Sciences, 24(8), 7526.

4.Tzeng YS, Peng YJ, Tang SE, Huang KL, Chu SJ, Wu SY, Cheng CP. Intermittent Exposure of Hypercapnia Suppresses Allograft Rejection via Induction of Treg Differentiation and Inhibition of Neutrophil Accumulation. Biomedicines. 2022 Apr 1;10(4):836. doi: 10.3390/biomedicines10040836.

5.Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ. Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway. Cells. 2021 Sep 21;10(9):2500. doi: 10.3390/cells10092500.

6.Lin JR, Huang SH, Wu CH, Chen YW, Hong ZJ, Cheng CP, Sytwu HK, Lin GJ. Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes. Pharmaceuticals (Basel). 2021 May 17;14(5):475. doi: 10.3390/ph14050475.

7.Tseng CK, Liu TT, Lin TC, Cheng CP. Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage. Cell Stress Chaperones. 2021 Jan;26(1):67-76. doi: 10.1007/s12192-020-01152-7. Epub 2020 Aug 25.

8.Peng YJ, Peng CT, Lin YH, Lin GJ, Huang SH, Chen SJ, Sytwu HK, Cheng CP. Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway. Mediators Inflamm. 2020 Jun 10;2020:1237281. doi: 10.1155/2020/1237281. eCollection 2020.

9.Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP. Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway. Cells. 2020 Apr 10;9(4):938. doi: 10.3390/cells9040938.

10.Lin GJ, Wu CH, Yu CC, Lin JR, Liu XD, Chen YW, Chang HM, Hong ZJ, Cheng CP, Sytwu HK, Huang SH. Adoptive transfer of D"MsoNormal" style="text-align:justify;text-justify:inter-ideograph; line-height:150%">11.Peng YJ, Wang CY, Lin YH, Lin GJ, Huang SH, Shyu JF, Sytwu HK, Cheng CP. Interleukin 26 suppresses receptor activator of nuclear factor κB ligand induced osteoclastogenesis via down-regulation of nuclear factor of activated T-cells, cytoplasmic 1 and nuclear factor κB activity. Rheumatology (Oxford). 2016 Nov;55(11):2074-2083. doi: 10.1093/rheumatology/kew302. Epub 2016 Aug 21.

12.Cheng CP, Sheu MJ, Sytwu HK, Chang DM. Decoy receptor 3 suppresses RANKL-induced osteoclastogenesis via down-regulating NFATc1 and enhancing cell apoptosis. Rheumatology (Oxford). 2013 Apr;52(4):609-22.

13.Cheng CP, Sytwu HK, Chang DM. Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansion. J Rheumatol. 2011 Dec; 38(12):2522-35.

14.Cheng CP, Huang HS, Hsu YC, Sheu MJ, Chang DM. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis. J Clin Immunol. 2012 Aug;32(4):762-77.

15.Hsu YC, Cheng CP, Chang DM. Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression. J Rheumatol. 2011 Sep;38(9):1844-57.

16.Tzeng YS, Wu SY, Peng YJ, Cheng CP, Tang SE, Huang KL2, Chu SJ, Hypercapnic acidosis prolongs survival of skin allografts. J. Surg. Res. 2015 May 1;195(1):351-9

學術會議論文 :

1.游秉宸、鄭珈毘 探討在類風濕性關節炎中IL-26對NLRP3發炎小體引起之細胞焦亡和運脂蛋白2之影響 2024 年第三十九屆生物醫學聯合學術年會口頭競賽

2.劉郡、林㛄廷、鄭珈毘、林谷峻、藍心婕 Effects of bisphenol A ( BPA ) on immune tolerance of trophoblast using mixed lymphocyte reaction ( MLR ) model 2023第50屆國軍軍醫學術研討會

3.王奕勳、鄭珈毘IL26 induces macrophages expressing IL9 and IL17A through AKT signaling for regulating T cell maturation 第49屆國軍軍醫學術研討會

4.張云柔、王奕勳、鄭珈毘 To investigate the effect of IL-26 on angiogenesis in rheumatoid arthritis 2023 年第三十八屆生物醫學聯合學術年會

5.黃于葳、鄭珈毘To explore the effect of Interleukin 26 on the adipocyte differentiation 2022 年第三十七屆生物醫學聯合學術年會

6.林宜萱、鄭珈毘. The effects of Interleukin 26 on osteoblast cell differentiation 2020第47屆國軍軍醫學術研討會

7.曾元生、吳舒愉、陳天牧、黃坤崙、鄭珈毘. Effect of Hypercapnia Intermittent Exposure on Acute Rejection after Skin Transplantation in Mice 2020第47屆國軍軍醫學術研討會

8.呂瑩純、黃貴帥、王志堅、鄭珈毘、陳錫洲、黃坤崙. Amniotic Fluid Erythropoietin Differentiate Extreme Preterm from Term Birth 2018第45屆國軍軍醫學術研討會

9.Wang YH, Lin YH, Peng YJ, Cheng CP. Interleukin 26 suppressed RANKL induced osteoclastogenesis by downregulating transcription factor NFATc1. 2016 年第三十一屆生物醫學聯合學術年會

10.劉宗達、彭清宗、鄭珈毘. Investigate The Pathological Mechanism Of Heat-stroke In Rats 2018 第45屆國軍軍醫學術研討會

11.林宜萱、鄭珈毘、彭清宗. To Investigate the Relationship of Oxidative Stress and DCR3 on IL-1α Induced Osteoclastogenesis 2017第44屆國軍軍醫學術研討會

12.王奕勳、林宜萱、鄭珈毘. To Study the Effect of Decoy Receptor 3 in Ovariectomized (OVX) Mice Induced Osteoporosis Animal Model 2016第43屆國軍軍醫學術研討會

13.林振宇、林宜萱、林谷峻及鄭珈毘. Investigate the impact of traumatic stress in disease severity and bone remodeling of collagen-induced arthritis 2016第43屆國軍軍醫學術研討會

14.Lin YH, Yang TH, Chang CC, Cheng CP. DCR3 suppressed IL-1α induced osteoclastogenesis by modulating IL-1α and IL-1ra expression. 2015第42屆國軍軍醫學術研討會

15.Chia-Pi Cheng, Deh-Ming Chang. Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansion.第 29 屆中華民國風濕病醫學會 (2011)年會

實驗室簡介

我們實驗室主要針對自體免疫疾病中不正常的免疫系統的發展和骨重塑系統做相關研究。我們試著找出疾病異常表現的人類特有相關基因作為治療標靶。此外，我們也試圖弄清楚候選基因在疾病進展中免疫系統發育中的作用和分子機制。