學位

國防醫學院醫學科學研究所博士

經歷

1.         國防醫學院生物及解剖學科副教授 (2021.8 迄今)

2.         國防醫學院生物及解剖學科助理教授 (2015.6-2021.7)

3.         國防醫學院生物及解剖學科兼任講師 (2013.2-2015.6)

4.         三軍總醫院外科加護病房副護理長 (2015.3~2015.6)

5.         三軍總醫院燒傷中心護理師 (2007.7~2015.2)

專長學科

人體結構學、實地解剖學

獲獎情形

1.  111年度國防醫學研究發展計畫成果發表績優(2023.11)

2.  參與2023中華民國解剖學學會解剖教學影片競賽獲得佳作(2023.03)

3.  111學年度整合課程優良區段長(2023.09)

4.  111學年度整合課程優良區段教師(2023.09)

5.  110學年度整合課程優良區段長(2022.09)

6.  109年度國防醫學研究發展計畫成果發表績優(2021.11)

7.  國防部優良教師(2021.09)

8.  109學年度整合課程優良區段長(2021.09)

9.  108學年度整合課程優良教師及優良區段長(2020.09)

10.108學年度優良導師(2020.09)

11.線上教學意見回饋醫學系統計表現優異教師(2020.06)

12.一種用以減少疤痕形成的醫藥組合物獲頒『第十六屆國家新創獎』(2019.12)

13.107學年度整合課程優良教師(2019.10)

14.106學年度整合課程優良教師第一名(2018.09)

15.105年度國防醫學研究發展計畫成果發表績優獎(2017.11)

16.105學年度整合課程優良教師第一名(2017.09)

17.指導研究生康明璇參加國軍軍醫學術研討會海報競賽醫學應用之相關研究組 榮獲第三名(2016.11)

18.皮膚替代物製備方法與用途獲頒第九屆國家新創獎(2012.10)

研究論文

著作:

1.         Chou K.C., Cherng J.H., Ou K.L., & Wang Y.W. (2024). Gold nanoclusters on a silk fibroin scaffold accelerate fibroblast proliferation and improve burn recovery in a mouse burn model. Materials and Design, 244, 113221. (SCI 58/334, MATERIALS SCIENCE, MULTIDISCIPLINARY)本人為通訊作者.

2.         Wen, C. C., Huang, S. M., & Wang, Y. W. (2024). Anatomical Anal Stenosis after PPH: Insights from a Retrospective Study and Rat Model. International journal of molecular sciences, 25(6), 3543. (SCI, 74/297, BIOCHEMISTRY & MOLECULAR BIOLOGY)本人為通訊作者.

3.         Huang, T. Y., Wang, Y. W., Liao, H. X., & Su, W. T. (2024). Sprayable hydroxypropyl chitin/collagen extract of Ampelopsis brevipedunculata hydrogel accelerates wound healing. Journal of wound care, 33(Sup2), S10–S23.(SCI 59/94, DERMATOLOGY)

4.         Tsai C.L., Changchien C.Y., Chen Y., Chang H.H., Tsai W.C., Wang Y.W., Chou K.C., Chiang M.H., Tsai Y.L., Tsai H.C., Wang C.Y., Shen M.S., Cheng L.T., Lin H.Y., Yang T.B., Chian C.F. (2022, Mar) Accelerated Wound Healing and Keratinocyte Proliferation through PI3K/Akt/pS6 and VEGFR2 Signaling by Topical Use of Pleural Fluid. Cells, 11(5):817. (SCIE, 53/195, Cell biology).

5.         Chou K.C., Chen C.T., Cherng J.H., Li M.C., Wen C.C., Hu S.I., Wang Y.W. (2021, Oct). Cutaneous regeneration mechanism of β-sheet silk fibroin in a rat burn wound healing model. Polymers, 13(20):3537. (SCI, 16/89, POLYMER SCIENCE). 本人為通訊作者.

6.         Cherng J.H., Chou S.C., Chen C.L., Wang Y.W., Chang S.J., Fan G.Y., Leung F.S., Meng E. (2021, Oct). Bacterial cellulose as a potential bio-scaffold for effective re-epithelialization therapy. Pharmaceutics, 13(10):1592. (SCI, 44/271, PHARMACOLOGY & PHARMACY).

7.         Ou K.L., Wen C.C., Lan C.Y., Chen Y.A., Wang C.H., Wang Y.W. (2021, Apr). The optimal application of medium potency topical corticosteroids in preventing laser-induced inflammatory responses—an animal study. Life, 11(4):350. (SCI, 27/93, Biology). 本人為通訊作者.

8.         Chia-Yu Wang, Po-Da Hong, Ding-Han Wang, Juin-Hong Cherng, Shu-Jen Chang, Cheng-Che Liu, Tong-Jing Fang, Yi-Wen Wang (2020, Nov). Polymeric Gelatin Scaffolds Affect Mesenchymal Stem Cell Differentiation and Its Diverse Applications in Tissue Engineering. International Journal of Molecular Sciences, 21(22):8632. (SCI, 74/297, BIOCHEMISTRY & MOLECULAR BIOLOGY). 本人為通訊作者.

9.         Wang Y.W., Liu C.C., Cherng J.H., Lin C.S., Chang S.J., Hong Z.J., Liu C.C., Chiu Y.K., Hsu S.D., Chang H.. Biological effects of chitosan-based dressing on hemostasis mechanism. Polymers, 2019,11(11):1906.

10.     Wang C.Y., Sartika D., Wang D.H., Hong P.D., Cherng J.H., Chang S.J., Liu C.C., Wang Y.W.*, Wu S.T.*. Wet-spinning-based Molding Process of Gelatin or Tissue Regeneration. Journal of Visualized Experiments, 2019, 2019(145):e58932.

11.     Huang W.S., Wang Y.W., Hung K.C., Hsieh P.S., Fu K.Y., Dai L.G., Liou N.H., Ma K.H., Liu J.C., Dai N.T.. High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content. PeerJ, 2018, 2018(5):e4815.

12.     Wang Y.H., Liu C.C., Cherng J.H., Fan G.Y., Wang Y.W., Chang S.J., Hong Z.J., Lin Y.C., Hsu S.D.. Evaluation of Chitosan-based Dressings in a Swine Model of Artery-Injury-Related Shock. Scientific Reports, 2019, 9(1):14608.

13.     Dai N.T., Huang W.S., Chang F.W., Wei L.G., Huang T.C., Li J.K., Fu K.Y., Dai L.G., Hsieh P.S., Huang N.C., Wang Y.W., Chang H.I., Parungao R., Wang Y.. Development of a Novel Pre-Vascularized Three-Dimensional Skin Substitute Using Blood Plasma Gel. Cell Transplantation, 2018, 27(10):1535-1547.

14.     Meng E., Fan G.Y., Cherng J.H., Chang S.J., Poongodi R., Wang C.H., Wang Y.W., Wang Y.H., Liu C.C.. Severe burn injury in a swine model for clinical dressing assessment. Journal of Visualized Experiments, 2018, 2018(141):e57942.

15.     Wang C.C., Wang C.H., Chen H.C., Cherng J.H., Chang S.J., Wang Y.W., Chang A., Yeh J.Z., Huang Y.H., Liu C.C.. Combination of resveratrol-containing collagen with adipose stem cells for craniofacial tissue-engineering applications. International Wound Journal, 2018, 15(4):660-672.

16.     Dai N.T., Chang H.I., Wang Y.W., Fu K.Y., Huang T.C., Huang N.C., Li J.K., Hsieh P.S., Dai L.G., Hsu C.K., Maitz P.K.. Restoration of skin pigmentation after deep partial or full-thickness burn injury. Advanced Drug Delivery Reviews, 2018, 123:155-164.

17.     Chang Y.L., Huang L.C., Chen Y.C., Wang Y.W., Hueng D.Y., Huang S.M..The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines. International Journal of Biochemistry and Cell Biology, 2017, 92:155-163.

18.     Lin C.H., Ho C.W., Chen L.C., Chang C.C., Wang Y.W., Chiou C.P., Chiang S.L.. Effects of a 12-Week exercise training on insulin sensitivity, quality of life, and depression status in patients with type 2 diabetes. Journal of Medical Sciences(Taiwan), 2017,37(6):227-236.

19.     Chang Y.L., Liu S.T., Wang Y.W., Lin W.S., Huang S.M.. Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224. Oncotarget, 2018, 9(17):13390-13406.

20.     Chang Y.L., Hsu Y.J., Chen Y., Wang Y.W., Huang S.M.. Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines. Oncotarget,2017, 8(60): 101461-101474.

21.     Chung M.H., Wang Y.W., Chang Y.L., Huang S.M., Lin W.S.. Risk of cancer in patients with heart failure who use digoxin: A 10-year follow-up study and cell-based verification. Oncotarget, 2017, 8(27):44203-44216.

22.     Wang YW, Liou NH, Cherng JH, Chang SJ, Ma KH, Fu E, Liu JC, Dai NT. siRNA-targeting transforming growth factor-β type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. J Invest Dermato. 2014; 134:2016–25. (IF: 7.216, Ranking: 1/62 in Dermatology)

專書論文

1.     Shu-Jen Chang, Dewi Sartika, Gang-Yi Fan, Juin-Hong Cherng and Yi-Wen Wang. Animal Models of Burn Wound Management. Animal Models in Medicine and Biology (ISBN: 978-1-83880-012-3). London, UK: IntechOpen. Apr, 2020:1-14. 本人為通訊作者.

專利:

1.         一種用以減少疤痕形成的醫藥組合物，I542352 (2016.07)

2.   Pharmaceutical composition and method for reducing scar formation，US 20170016005A1 (2017.01)

3. 減輕瘢痕形成之醫藥組成物及方法，日本專利特許第6363737號 (2018.07)

實驗室簡介

臨床常可見各種傷口衍伸之困境有待解決，包含傷口感染、傷口清創手術後的出血、傷口癒合困難、癒合後的疤痕增生等問題，本實驗室長期以來致力於相關議題的研究。目前實驗室的研究重點包含1. 調控表皮細胞、血管內皮細胞或纖維母細胞之TGF-β訊息傳遞路徑對傷口癒合、血管新生與疤痕增生的影響；2. 以天然高分子聚合物如絲素蛋白(silk fibroin)、膠原纖維(collagen)、明膠(gelatin)、與殼聚醣(chitosan)，運用3D列印、凍乾或濕紡技術製成傷口敷料或組織工程皮膚，達到保護傷口、止血、預防感染及促進傷口癒合之目的。運用細胞實驗及動物實驗探討治療效果及作用機轉，期望能改善傷口癒合相關問題。