專長學科

l 致癌病毒與腫瘤之相關研究

l 表觀遺傳調控與癌症

l 肝細胞癌的分子致病機轉

l 癌症的早期診斷標記

聯絡分機

18910

E-mail

lyw@mail.ndmutsgh.edu.tw

得獎事蹟

國防醫學院延攬及留住大專校院特殊優秀人才獎(104-106)

國防醫學院110年度梁序穆暨許織雲教授傑出研究獎(110)

肝病防治學術基金會傑出研究獎(105)

國防醫學院高影響係數研究優良獎(102-105,109,110)

國防部優良教師(103)

研究著作

1. Chang SY, Wu TH, Shih YL, Chen YC, Su HY, Chian CF, Lin YW* (2023, Apr).SOX1 Functions as a Tumor Suppressor by Repressing HES1 in Lung Cancer.Cancers (Basel)., 2023;15(8):2207. 本人為通訊作者.
2. Wu TH, Chang SY, Shih YL, Chian CF, Chang H, Lin YW*. (2020, Jul).Epigenetic Silencing of LMX1A Contributes to Cancer Progression in LungCancer Cells. Int J Mol Sci., 21(15):5425.. (SCI, 78/299; BIOCHEMISTRY &MOLECULAR BIOLOGY). MOST 105-2320-B-016-017-MY3. 本人為通訊作者.
3. Chung HH, Lee CT, Hu JM, Chou YC, Lin YW, Shih YL. NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer. Int J Mol Sci. 2020 Jul 19;21(14):E5106. doi: 10.3390/ijms21145106.
4. Wu TH, Chang SY, Shih YL, Huang TW, Chang H, Lin YW* (2019, Nov). Emetine Synergizes with Cisplatin to Enhance Anti-Cancer Efficacy against Lung Cancer Cells.. Int J Mol Sci., 20(23). pii: E5914. . (SCI, 78/298; Biochemistry & Molecular Biology) 本人為通訊作者.
5. Chung HH, Kuo CC, Hsiao CW, Chen CY, Hu JM, Hsu CH, Chou YC, Lin YW, Shih YL*. (2019, Sep). A Novel Prognostic DNA Methylation Panel for Colorectal Cancer.. Int J Mol Sci., 20(19). pii: E4672. doi:10.3390/ijms20194672.. (SCI, 78/298; Biochemistry & Molecular Biology)
6. Wu JY, Shih YL, Lin SP, Hsieh TY, Lin YW*. (2019, May). YC-1 Antagonizes Wnt/β-Catenin Signaling Through the EBP1 p42 Isoform in Hepatocellular Carcinoma. Cancers (Basel). , 11(5), 661. . (SCI, 31/229; Oncology) 本人為通訊作者.
7. Chen JC, Lo YF, Lin YW, Lin SH, Huang CL, Cheng CJ*. (2019, Feb). WNK4 kinase is physiological intracellular chloride sensor.. Proc Natl Acad Sci, doi: 10.1073/pnas.1817220116.. (SCI, 6/79 ; Multidisciplinary sciences)
8. Chen YC, Kuo CC, Chian CF, Tzao C, Chang SY, Shih YL, Lin YW, Yu MH, Su HY (2018, Jul). Knockdown of POLDIP2 suppresses tumor growth and invasion capacity and is linked to unfavorable transformation ability and metastatic feature in non small cell lung cancer.. Exp Cell Res. , 368(1):42-49.. (SCI, 100/230; Oncology)
9. Chang SY, Kuo CC, Wu CC, Hsiao CW, Hu JM Hsu CH Chou YC, Shih YL*, Lin YW*. (2018, Jan). NKX6.1 hypermethylation predicts the outcome of stage II colorectal cancer patients undergoing chemotherapy. . Genes Chromosomes Cancer, 57:268–277.. (SCI). (SCI, 73/174; Genetics and heredity)MOST 105-2320-B-016-017-MY3. 本人為通訊作者.
10.  Li HJ, Yu PN, Huang KY, Su HY, Hsiao TH, Chang CP, Yu MH, Lin YW*. (2016, Apr). NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.. Oncogene., 35(17):2266-78. doi: 10.1038/onc.2015.289.. (SCI, 15/213;oncology). MOST 102-2320-B-016-016-MY3. 本人為通訊作者.
11. Shih YL, Kuo CC, Yan MD, Lin YW, Hsieh CB, Hsieh TY. (2016, Apr). Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma . Clin Epigenetics., ;8:41. .
12. Chang CC, Huang RL, Liao YP, Su PH, Hsu YW, Wang HC, Tien CY, Yu MH, Lin YW, Lai HC.Kenvin Brian (2015, May). Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm.. BMC Cancer., 15(1):418..
13. Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW*. (2015, Apr). Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. . World J Gastroenterol, 21(13):3960-9.. (SCI, 38/78; Gastroenterology & hepatology). MOST 102-2320-B-016-016-MY3. 本人為通訊作者.
14. Kuo CC, Lin CY, Shih YL, Hsieh CB, Lin PY, Guan SB, Hsieh MS, Lai HC, Chen CJ, Lin YW* (2014, Aug). Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas.. Clin Chem Lab Med, 52(8):1235-45.. (SCI, 5/30; Medical Laboratory technology). MOST 100-2622-B-038-003-CC2. 本人為通訊作者.
15. Chen YC, Huang RL, Huang YK, Liao YP, Su PH, Wang HC, Chang CC, Lin YW, Yu MH, Chu TY, Lai HC. (2014, Jul). Methylomics analysis identifies epigenetically silenced genes and implies an activation of -catenin signaling in cervical cancer.. Int J Cancer, 135(1):117-27.. (SCI, 29/213; oncology)
16. Pei-Ning Yu, Ming-De Yan, Hung-Cheng Lai, Rui-Lan Huang, Yu-Ching Chou, Wen-Chi Lin , Li-Tzu Yeh, Lin Ya-Wen* (2014, Feb). Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. . International Journal of Cancer, 134(3):542-51.. (SCI, 29/213; oncology). NSC 101-2320-B-016-011. 本人為通訊作者.
17. Ya-Wen Lin, Yu-Lueng Shih, Gi-Shih Lien, Fat-Moon Suk, Chung-Bao Hsieh, and Ming-De Yan (2014, Jan). Promoter Methylation of SFRP3 Is Frequent in Hepatocellular Carcinoma. Disease Markers, 2014:351863. doi: 10.1155/2014/351863. Epub 2014 Jan 21.. (SCI, 25/78, Pathology). MOST 101-2320-B-016-011. 本人為第一作者.
18. Wu HC, Lin YC, Liu CH, Chung HC, Wang YT, Lin YW, Ma HI, Tu PH, Lawler SE, Chen RH. (2014). USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.. Nature Communications., 02/2014; 5:3214. DOI: 10.1038/ncomms4214.
19. Wen-Chi Lin, Ming-De Yan, Pei-Ning Yu, Hsin-Jung Li, Chih-Chi Kuo, Chia-Lin Hsu, Ya-Wen Lin* (2013, Dec). The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells.. Biochim Biophys Acta- Molecular Cell Research. , 1833(12):3206-3217.. (SCI, 50/289; Biochemistry & Molecular Biology). NSC 102-2320-B-016-016-MY3. 本人為通訊作者.
20. Ya-Wen Lin, Chun-Ming Tsao, Pei-Ning Yu,Yu-Lueng Shih, Chia-Hsin Lin, Ming-De Yan (2013, Oct). SOX1 suppresses cell growth and invasion in cervical cancer.. Gynecologic Oncology. (SCI, 6/80; Obstetrics & gynecology). NSC 102-2320-B-016-016-MY3. 本人為第一作者、通訊作者.
21. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang SS, Lin SH, Chang JM, Chen A. (2013, Aug). Antroquinonol mitigates accelerated and progressive IgA nephropathy model in mice via activating NrF2 pathway, and inhibiting T cells and NLRP3 inflammasome.. Free Radic Biol Med., 61, 285-297..
22. Yu-Lueng Shih, Chung-Bao Hsieh, Ming-De Yan, Chun-Ming Tsao, Tsai-Yuan Hsieh, Chang-Hsin Liu, Ya-Wen Lin* (2013, Mar). Frequent concomitant epigenetic silencing of SOX1 and SFRPs in human hepatocellular carcinoma.. Journal of Gastroenterology and Hepatology, 28(3):551-9. (SCI, 25/78, Gastroenterology and Hepatology). NSC 101-2320-B-016-011. 本人為通訊作者.
23. Tsao CM, Yan MD, Shih YL, Yu PN, Kuo CC, Lin WC, Li HJ, Lin YW* (2012, Dec). SOX1 functions as a tumor suppressor through antagonizing the WNT/beta-catenin signaling pathway in hepatocellular carcinoma.. Hepatology, 56(6):2277-87.. (SCI, 4/78; Gastroenterology and Hepatology). NSC 101-2320-B-016-011. 本人為通訊作者.

‪Lin Ya Wen - ‪Google 學術搜尋