專長學科

研究專長：病毒學，先天性免疫學，幹細胞類器官技術

研究介紹

研究介紹：
1. 先天性免疫系統與病毒感染間的交互作用
2. 以類器官作為病毒致病機制與抗病毒藥物篩選之研究平台

研究主題：
1. 新興微小 RNA 病毒之分子病理學研究
2. 病毒感染類器官模型
3. 干擾素轉錄因子的訊息傳遞
4. 病毒蛋白調節先天性免疫反應的機制
5. 人體抗反轉錄病毒蛋白在免疫學上的角色

聯絡分機

聯絡分機：02-8792-3100 ext.18140 or 18486
實驗室分機: 02-8792-3100 ext.18551

E-mail

E-mail : changth@mail.ndmutsgh.edu.tw

得獎事蹟

榮譽：
高影響係數研究優良獎 (2025)
國防醫學大學優良導師 (2025)
國防醫學研究計畫成果發表績優 (2024)
國防醫學院優良教師 (2024)
巴德基金會研究優良獎 (2024)
第二十屆國家新創獎 (2023)
巴德基金會研究優良獎 (2021)
韓紹華先生獎助金 (2021)
第48屆國軍軍醫學術研討會論文壁報競賽基礎醫學研究組-研究優良獎(2021)
許雨階先生獎助金 (2020)
台灣病毒學會聯合學術研討會-優秀論文獎 （2016）
台北國際發明暨技術交易展-銀牌獎 （2015）
高雄國際發明展-金牌獎（2014）
馬來西亞研究與發明協會-國家特別獎 （2014）
高雄榮民總醫院-優秀論文獎 （2012, 2013, 2014, 2015）
高雄榮民總醫院-研究成果優等獎 (2012)
美國國家衛生研究院-傑出研究獎 (FARE 2010)
國防醫學院-優秀博士論文獎 (2004)
財團法人陳宗仁先生免疫學研究發展基金會-成績優異獎 (1998)

研究著作

Publication： Tsung-Hsien Chang- Google Scholar學術搜尋

(A) Articles:

Lin SL, Lee ST, Huang SE, Chang TH, Geng YJ, Sulistyowati E, Yeh JL. Delivery of Superoxide Dismutase 3 Gene with Baculoviruses Inhibits TNF-α Triggers Vascular Smooth Muscle Cell Proliferation and Inflammation. Curr Gene Ther. 2025;25(4):546-558.

Liao YC, Yeh CC, Chueh YF, Huang MS, Wu JS, Wen YX, Chang YT, Lai YR, Chen JJ, Chang TH*. Effects of the oxoaporphine alkaloid hernandonine on dengue virus. Evidence for its mechanisms of action. Phytomedicine. 2024 Nov;134:155986.

Cheng CY, Huang CM, Lin CL, Chang TH, Sung PJ, Cheng MJ, Chen JJ. A NEW HOMOISOFLAVONOID AND ANTI-INFLAMMATORY CONSTITUENTS FROM Polygonatum alte-lobatum Chemistry of Natural Compounds. 2024 May. 60, 428–431.

Jungbauer-Groznica M, Wiese K, Fischer I, Markus J, Chang TH, Gösler I, Kowalski H, Blaas D, Real-Hohn A. Aichivirus A1 replicates in human intestinal epithelium and bronchial tissue: lung-gut axis? Virus Research. 2024 Feb 17:199338. doi: 10.1016/j.virusres.2024.199338. Epub ahead of print. PMID: 38373599.

Chin, CH, Liaw, CC, Chang TH, Shu CW, Sung PJ, Cheng MJ, Wang IC, Jih-Jung Chen JJ. Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata. Chemistry of Natural Compounds. 2024 Jan, 60, 50–54.

Cheng CY, Huang CM, Lin CL, Chang TH, Sung PJ, Cheng MJ & Chen JJ. A New Coumarin and Anti-Inflammatory Constituents from Polygonatum chingshuishanianum. Chemistry of Natural Compounds. 2023 Sep. 59, 835–838. https://doi.org/10.1007/s10600-023-04129-x

Chen HM, Huang CM, Huang HY, Chang TH, Liaw CC, Sung PJ, Chu YC, Cheng MJ*, Kuo CW*, Chen JJ*. A New 2H-pyran-2-one derivative and anti-inflammatory constituents from Alpinia pricei var. pricei. Chemistry of Natural Compounds 2023 Jul. 59, 662–665. https://doi.org/10.1007/s10600-023-04081-w.

Wu FS, Huang CM, Chen LC*, Chang TH, Shu CW, Sung PJ, Chu YC, Cheng MJ*, Hsiao JW*, Chen JJ*. New Cinnamic acid derivative and anti-inflammatory constituents from Capparis lanceolaris. Chemistry of Natural Compounds 2023 Jun, 59 (3), 493-496.

Chen HT, Chuang CW, Cheng JC, Yeh YJ, Chang TH, Shi YT, Chao CH. Terpenoids with anti-influenza activity from the leaves of Euphorbia leucocephala. Natural Product Research 2023 Mar; 37 (6):936-943.

Wei KC, Wei WJ, Liao CL, Chang TH*. Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1. Microbiology Spectrum. 2023 Feb 14;11(1):e0358622. doi: 10.1128/spectrum.03586-22.

Tsai WL, Cheng JS, Liu PF, Chang TH, Sun WC, Chen WC, Shu CW. Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells. Aging (Albany NY). 2022 Jul 12;14. doi: 10.18632/aging.204170.

Jan MW, Chiu CY, Chen JJ, Chang TH *, Tsai KJ* Human platelet lysate induces antiviral responses against Parechovirus A3. Viruses. 2022, 14(7), 1499.

Chen HM, Huang CM, Chen LC, Yang CS, Chang TH, Chen CL, Sung PJ, Kuo WL, Cheng MJ, Hsiao JW, Chen JJ. NEW TRITERPENOID AND ANTI-INFLAMMATORY CONSTITUENTS OF Eriobotrya deflexa f. deflexa. Chemistry of Natural Compounds. 2022, 58(3), 1-4.

Wei KC, Lai SF, Huang WL, Yang KC, Lai PC, Wei WJ, Chang TH, Huang YC, Tsai YC, Lin SC, Lin SJ, Lin SC. An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis. J Mol Med (Berl). 2022 Jan;100(1):135-146. doi: 10.1007/s00109-021-02146-3. Epub 2021 Oct 23. PMID: 34689211; PMCID: PMC8724166.

Jan MW, Su HL, Chang TH*, Tsai KJ*. Characterization of Pathogenesis and Inflammatory Responses to Experimental Parechovirus Encephalitis. Front Immunol. 2021 Nov 25;12:753683. doi: 10.3389/fimmu.2021.753683. PMID: 34899705; PMCID: PMC8654935.

Wang IC, Chen LC., Chang TH, Chen CL, Sung PJ, Lin RA, Cheng MJ, Hsiao JW, Chen JJ. New Coumarin and Bioactive Constituents of Chionanthus retusus. Chemistry of Natural Compounds 2021, 57, 835–839. /doi.org/10.1007/s10600-021-03492-x

Chen BC, Huang TS, Huang NY, Chen CS, Chen YS*, Chang TH*. Low Seroprevalence of Aichi Virus Infection in Taiwan. Pathogens 2021, 10 (5), 553. doi.org/10.3390/pathogens10050553

Huang CM, Chang CH, Yang CS, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Cheng CY, Chen JJ. A NEW
ACENAPHTHYLENE AND BIOACTIVE CONSTITUENTS OF Salvia arisanensis. Chemistry of Natural Compounds. 2021, 57(6), 991-995. https://doi.org/10.1007/s10600-021-03535-3

Wu FS, Hung CJ, Lin CL, Huang HY, Kuo YH, Chang TH, Chen CL, Sung PJ, Cheng MJ, Kuo CW, Chen JJ. New benzophenone and bioactive constituents of Hypericum nokoense. Chemistry of Natural Compounds 2021, 57 (4), 645-649.

Chiang AJ, Li CJ, Tsui KH, Chang C, Chang YI, Chen LW, Chang TH*, Sheu JJ*. UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR. Biomolecules. 2021, 11(1), 37. doi.org/10.3390/biom11010037.
Kung MH, Jan MW, Chen JJ, Shieh YC, Chang TH*. Detection of Parechovirus A1 with Monoclonal Antibody against
Capsid Protein VP0. Microorganisms. 2020 Nov 16;8(11):1794. doi: 10.3390/microorganisms8111794.

Kung MH, Lin YS, Chang TH*. Aichi virus 3C protease modulates LC3- and SQSTM1/p62-involved antiviral response. Theranostics. 2020 Jul 14;10(20):9200-9213. doi: 10.7150/thno.47077.

Chuang FK, Liao CL, Hu MK, Chiu YL, Lee AR, Huang SM, Chiu YL, Tsai PL, Su BC, Chang TH, Lin CC, Shih CC, Yen LC. Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. Int J Mol Sci. 2020 Jun 5;21(11):4050. doi: 10.3390/ijms21114050.

Hsiao JW, Li-Chai Chen LC, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Hung CJ*, Chen JJ*. A New sesquiterpenoid and bioactive constituents of Curcuma zedoaria. Chem Nat Compd 2020, 56:1-5DOI 10.1007/s10600-020-03230-9.
Wu FS, Hung CJ, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Huang HT, Che JJ. New Norneolignan and Bioactive Constituents of Clitoria ternatea. Chem Nat Compd 2020. 56:1000-1004. DOI 10.1007/s10600-020-03213-w.

Wei KC, Wei WJ, Liu YS, Yen LC, Chang TH*. Assessment of Prolonged Dengue Virus Infection in Dermal Fibroblasts and Hair-Follicle Dermal Papilla Cells. Viruses (Viruses-Basel). 2020 Feb 28;12(3). pii: E267. doi: 10.3390/v12030267.

Chuang FK, Huang SM, Liao CL, Lee AR, Lien SP, Chiu YL, Chang TH, Tsai PL, Lin RJ, Shih CC, Tsai YJ, Lin GJ, Yen LC. Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. Antimicrob Agents chemother. 2019 Dec 20;64(1). pii: e00941-19.

Hung WT, Cheng MF, Tseng FC, Chen YS, Lee SJ, Chang TH, Lin HH, Hung CH, Wang JL. Bloodstream Infection with Extended-spectrum Beta-lactamase–producing Escherichia coli: the role of virulence genes. Journal of Microbiology, Immunology and Infection. 2019 Dec, 52(6):947-955.

Huang HC, Chen LC, Chang TH, Zhu TF, Chen CL, Cheng MJ, Chen JJ. A New Lignanamide Derivative and Bioactive Constituents of Lycium chinense. Chemistry of Natural Compounds. 2019 Nov 1, 55 (6): 1002-1006.
Fang CW, Chen LC, Huang HC, Chang TH, Chen CL, Cheng MJ and Chen JJ. A NEW ISOCHROMENO[4,3-b]CHROMEN-7(5H)-ONE DERIVATIVE AND BIOACTIVE CONSTITUENTS OF Filipendula kiraishiensis. Chemistry of Natural Compounds. 2019 Sep, 55(5): 821-824.

Chang YT, Kung MH, Hsu TH, Hung WT, Chen YS, Yen LC, Chang TH*. Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells. Viruses. 2019 Aug, 11(8):763 DOI: 10.3390/v11080763.

Lin SL, Yeh JL, Tsai PC, Chang TH, Huang WC, Lee ST, Wassler M, Geng YJ, Sulistyowati E. Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene. Transl Stroke Res. 2019 Aug 15, 10(4):413-427.

Chen BC, Chang JT, Huang TS, Chen JJ, Chen YS, Jan MW, Chang TH*. Parechovirus A Detection by a Comprehensive Approach in a Clinical Laboratory. Viruses (Viruses-Basel). 2018 Dec 12;10(12). pii: E711. doi: 10.3390/v10120711.

Wei CY, Wang SW, Ye JW, Hwang TL, Cheng MJ, Sung PJ, Chang TH, Chen JJ. New Aporphine and Lignan Derivatives from the Root Wood of Hernandia nymphaeifolia with Anti-inflammatory Effect in fMLP/CB-induced Human Neutrophils. Molecules 2018, 23(9), 2286; doi: 10.3390/molecules23092286.

Wei KC, Huang MS and Chang TH* Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells. Frontiers in Cellular and Infection Microbiology 2018 Aug, 8:268, 1-10 ; doi.org/10.3389/fcimb.2018.00268.

Chang JT, Chen YS, Chen BC, Huang TS, Chang TH*. Human Parechovirus Infection in Children in Taiwan: a Retrospective, Single-Hospital Study. Jpn J Infect Dis. 2018 Jul 24;71(4):291-297. doi: 10.7883/yoken.

Cheng LY, Chen CL, Kuo YH, Chang TH, Lin IW, Wang SW, Chung MI, Chen JJ.Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1860-1863. doi:10.1016/j.bmcl. 2018.04.006.

Lin TH, Su HH, Kang HT, Chang TH*. The Interactive Roles of Lipopolysaccharides and dsRNA/Viruses on Respiratory Epithelial Cells and Dendritic Cells in Allergic Respiratory Disorders: The Hygiene Hypothesis (review). Int. J. Mol. Sci. 2017, 18(10), 2219; doi:10.3390/ijms18102219.

Chang JT, Yang CS, Chen BC, Chen YS, Chang TH*. Complete Genome Sequence of the First Human Parechovirus type 3 Isolated in Taiwan. Journal of the Chinese Medical Association. 2017. 80(11):737-739.

Chen JJ, Wang SW, Chen CL, Kuo YH, Cheng MJ, Chang TH, Sung PJ, Kuo WL, Lim YP. A NEW AMIDE AND ANTIOXIDANT CONSTITUENTS OF Piper taiwanense. Chemistry of Natural Compounds 2017, 53 (6), 1117-1121.

Tsai WL, Chang TH*, Sun WC, Chan HH, Wu CC, Hsu PI, Cheng JS and Yu ML. Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase. Oncotarget, 2017. 8(54):91928-91937. //doi.org/10.18632/oncotarget.20248.

Chen CH, Hwang TL, Chen LC, Chang TH, Wei CS, Chen JJ. Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia. Phytochemistry. 2017. 143:186-193. doi: 10.1016/j.phytochem.2017.08.004.

Hsu HC, Tsai SY, Wu SL, Jeang SR, Ho MY, Liou WS, Chiang AJ, Chang TH. Longitudinal perceptions of the side effects of chemotherapy in patients with gynecological cancer. Support Care Cancer. 2017. 25(11):3457-3464. doi:10.1007/s00520-017-3768-7.

Huang NC, Hung WT, Tsai WL, Lai FY, Lin YS, Huang MS, Chen JJ, Lin WY, Weng JR, Chang TH*. Ficus septica plant extracts for treating Dengue virus in vitro. PeerJ. 2017, 5:e3448. doi: 10.7717/peerj.3448.

Tsai WL*, Cheng JS, Shu CW, Lai KH, Chan HH, Wu CC, Wu JM, Hsu PI, Chung RT, Chang TH*. Asunaprevir evokes hepatocytes innate immunity to restrict the replication of hepatitis C and dengue virus. Frontiers in Microbiology, 2017 Apr 20; 8:668 doi.org/10.3389/fmicb.2017.00668.

Lin TH, Cheng CC, Su HH, Huang NC, Chen JJ, Kang HY, Chang TH*. Lipopolysaccharide attenuates induction of pro-allergic cytokines, thymic stromal lymphopoietin and interleukin 33, in respiratory epithelial cells stimulated with polyI:C and Human Parechovirus. Frontiers in Immunology, 2016, 7:440. 1-17.

Chang TH, Yoshimi R, Ozato K. Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6. Journal of Immunology. 2015,195(11):5367-79.

Chen LC, Liao HR, Chen PY, Kuo WL, Chang TH, Sung PJ, Wen ZH, Chen JJ. Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities. Molecules. 2015, 20(10):18551-18564.

Chou CP, Peng NJ, Chang TH, Yang TL, Hu C, Lin HS, Huang JS, Pan HB. Clinical roles of breast 3T MRI, FDG PET/CT, and breast ultrasound for asymptomatic women with an abnormal screening mammogram. Journal of the Chinese Medical Association. 2015, 78(12):719-25.

Chiang AJ, hen DR, Cheng JT, Chang TH*. Detection of human papillomavirus in squamous cell carcinoma arising from dermoid cysts. Taiwan Association of Obstetrics and Gynecology. 2015, 54(5):559-66.

Chen JJ, Yang CK, Kuo YH, Hwang TL, Kuo WL, Lim YP, Sung PJ, Chang TH, Cheng MJ. New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses. International Journal of Molecular Science. 2015, 16:9719-9731.

Peng NJ*, Chou CP, Pan HB, Chang TH*, Hu C, Chiu YL, FU TY, Chang HT. FDG-PET/CT detection of very early breast cancer in women with breast microcalcification lesions found on screening mammography. Journal of Medical Imaging and Radiation Oncology. 2015, 59(4):445-452.

Wang LF, Lin YS, Huang NC, Yu CY, Tsai WL, Chen JJ, Kubota T, Matsuoka M, Chen SR, Yang CS, Lu RW, Lin YL, Chang
TH*. Hydroxychloroquine- Inhibited Dengue Virus Is Associated with Host Defense Machinery. Journal of Interferon and Cytokine Research. 2015, 35(3): 143-156. (Featured on the cover)

Chen JJ, Sung PJ, Chen IS, Cheng MJ, Lim YP, Liao HR, Chang TH, Wei DC and Chen JY. Beilschmide, a new amide and cytotoxic constituents from Beilschmiedia erythrophloia. Chemistry of Natural Compounds. 2015, 51(2): 302-305.

Chang JT, Yang CS, Chen YS, Chen BC, Chiang AJ, Chang YH, Tsai WL, Lin YS, David Chao D, Chang TH*. Genome and Infection Characteristics of Human Parechovirus Type 1: the interplay between viral infection and type I interferon antiviral system. PLOS ONE. 2015,10(2):e0116158.

Cho FN#, Chang TH#, Shu CW, Ko MC, Liao SK, Wu KH, Yu MS, Lin SJ, Hong YC, Chen CH, Hung CH, Chang YH. Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptor through trogocytosis. PLOS ONE. 2014, 9(10):e109352. (# equal contribution).

Nakatsu Y, Matsuoka M, Chang TH, Otsuki N, Noda M, Kimura H, Sakai K, Kato H, Takeda M and Toru Kubota. Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production. PLOS ONE. 2014, 9(4):e94999.

Chou CP, Huang NC, Jhuang SJ, Pan HB, Peng NJ, Cheng JT, Chen CF, Chen JJ and Chang TH*. Ubiquitin-conjugating Enzyme UBE2C is Highly Expressed in Breast Microcalcification Lesions. PLOS ONE. 2014, 9(4):e93934.

Chen JJ, Cheng MJ, Liao CH, Sung PJ, Wang TC, Chang TH and Yun-Ping Lim. Gmelinoiridoside, a new iridoid glycoside from Gmelina philippensis. Chemistry of Natural Compounds. 2014, 50(6):1005-08.

Chen YS, Chen BC, Lin YS, Chang JT, Huang TS and Chang TH* Detection of Aichi virus with antibody targeting of conserved viral protein 1 epitope. Applied Microbiology and Biotechnology. 2013, 97(19):8529-8536.

Chang JT, Chen YS, Chen BC, David Chao D, Chang TH* Complete Genome Sequence of the First Aichi Virus Isolated in Taiwan. Genome Announcements. 2013, 1(1). doi:pii: e00107-12.

Chang TH, Xu S, Tailor P, Kanno T, Ozato K. The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation. Journal of Immunology. 2012, 189(7):3548-56.

Chang TH*, Chen SR, Yu CY, Lin YS, Chen YS, Kubota T, Matsuoka M, Lin YL. Dengue virus blocks extracellular signal-regulated kinase and nuclear factor-B activation to downregulate cytokine production. PLOS ONE. 2012, 7(8):e41635.

Yu CY, Chang TH, Liang JJ, Chiang RL, Lee YL, Liao CL, Lin YL. Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity. PLOS Pathogens. 2012, 8(6):e1002780.

Cho JY, Hwang YL , Chang TH , Lim YP , Sung PJ , Lee TH , Chen JJ. New coumarins and anti-inflammatory constituents from Zanthoxylum avicennae. Food Chemistry. 2012, 135:17-23.

Liang Q, Deng H, Li X, Wu X, Tang Q, Chang TH, Peng H, Rauscher III FJ, Ozato K, Zhu F. Tripartite Motif-Containing Protein 28 is a small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7. Journal of Immunology. 2011, 187:4754-4763.

Ng S-SM, Chang TH, Tailor P, Ozato K, Kino T. Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication in interferon production. FEBS Letter. 2011, 585, 1331.

Yu CY, Chiang RL, Chang TH, Liao CL, Lin YL. The Interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. Journal of Virology. 2010, 84:2424-31.

Ozato K, Yoshimi R, Chang TH, Atsumi T, Wang H, Morse HC 3rd. Comment on “Gene Disruption study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-B-Dependent Cytokine Expression in Fibroblasts”. Journal of Immunology. 2009, 183:7619.

Chang TH, Kubota T, Matsuoka M, Jones S, Bray M, Ozato K. Ebola virus VP35 blocks type I interferon transcription in dendritic cells by interacting with the cellular SUMOylation machinery. PLOS Pathogens. 2009, Jun;5(6):e1000493.

Kubota T, Matsuoka M, Chang TH, Bray M, Jones S, Tashiro M, Kato A, Ozato K. Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. Journal of Virology. 2009 83:6952-6.

Yoshimi R, Chang TH, Atsumi T, Wang H, Morse HC 3rd, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. Journal of Immunology. 2009, 182(12): 7527-38.

Chan YL, Chang TH, Liao CL, Lin YL. The Cellular Antiviral protein Viperin is attenuated by proteasome-mediated protein degradation in Japanese Encephalitis Virus-Infected Cells. Journal of Virology. 2008, 82(21): 10455-64.

Ozato K, Shin DM, Chang TH, Morse HC 3rd. TRIM family proteins and their emerging roles in innate immunity. Nature Immunology Review 2008, 8(11): 849-60.

Kubota T, Matsuoka M, Chang, TH, Tailor P, Sasaki T, Tashiro M, Kato A, Ozato K. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. Journal of Biological Chemistry. 2008, 81(17): 8967-76.

Chang TH, Liao CL, Lin YL. Flavivirus induced interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-B activation. Microbes and Infection. 2006, 8(1): 157-71.

Hung JT, Liao JH, Lin YC, Chang HY, Wu SF., Chang TH, Kung JT, Hsieh SL, McDevitt H, Sytwu HK. Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. Journal of Autoimmunity. 2005, 25(3): 181-92.
(* corresponding author)

(B) 專利 Patent

『檢測愛知病毒之單株抗體』中華民國專利 發明第 I 627408號. 2018/6-2036/5

『抗小鼠 TRIM12c/TRIM5a之單株抗體』中華民國專利 發明第 I 597291號. 2017/9-2037/2

『一種檢測愛知病毒之抗體及其檢測方法』 中華民國專利 發明第 I 451087號。 高雄國際發明展 金牌獎，馬來西亞研究與發明協會特別獎 （2014），台北國際發明暨技術交易展 銀牌獎 （2015）。"Detection antobody and method for Aichi virus" No. I 451087 ROC invention patent (Issued by 09/01/2014). Gold medal, 2014 Kaohsiung International Exhibition; Special Award, The Malaysian Institute of Invention and Research。

『一種類器官模型用於篩選抗人類副腸孤病毒藥物的方法』中華民國專利 發明第 I 861777號. 2024/11--2043/5

(C) Conference Abstracts

Liao YC, Yeh CC, Chueh YF, Huang MS, Wu JS, Wen YX, Chang YT, Lai YR, ChenJJ, Chang TH * Develop broad-spectrum anti-emerging virus drugs based on the mechanism of virus entry and release. The 51th Military Medical Conference 11/22, 2024. Taipei, Taiwan

Wu JS, Liao YC, Yeh CC, Chueh YF, Huang MS, Wen YX, Chang YT, Lai YR, Chen JJ, Chang TH* Modulating Lipid Raft-mediated Endocytosis to Reduce Dengue Virus Infection. The 51th Military Medical Conference 11/22, 2024. Taipei, Taiwan

Wen YX, Liao YC, Chueh YF, Chang YT, Chang TH* Evaluation of Hernandonine's Antiviral Efficacy Using 2D Human Cell Lines and 3D Human Brain Organoids as Infection Models for Dengue Virus The 51th Military Medical Conference 11/22, 2024. Taipei, Taiwan

Ho JJ, Hsien YS, Chang TH Using virus-like particles to simulate SARS-CoV-2 release, entry and triggered-inflammation in cells. The 48th Military Medical Conference 11/24, 2021. Taipei, Taiwan

Chang TH*, Kung MH, Lin YS. LC3- and SQSTM1/p62-involved antiviral innate immune response is modulated by Aichi virus 3C protease. The 48th Military Medical Conference 11/24, 2021. Taipei, Taiwan

Chang TH*. Detection of Emerging Infectious Viruses, Aichi Virus and Human Parechovirus, by A Comprehensive Approach. BIO Asia-Taiwan. 7/25-7/28, 2019, International Conference & Exhibition, Taipei, Taiwan

洪宛廷, 龔明祥, 張聰賢Mechanism study of Aichi virus-infection triggers antiviral and inflammatory responses in primary mouse intestinal epithelial cells. 2018/10/28台灣病毒學會年會, Taipei, Taiwan

Jenn-Tzong Chang*, Yao-Shen Chen, Bao-Chen Chen, Tsi-Shu Huang, Tsung-Hsien Chang* . The human parechovirus infection in children in southern Taiwan: a retrospective, single-hospital study. 2018/10/28台灣病毒學會年會, Taipei, Taiwan

Chang TH, Ming-Hsiang Kung MH, Yao-Shen Chen YS. The role of autophagy markers LC3 and p62/SQSTM1 in RIG-I-like receptor-mediated antiviral signaling pathway. July 14-18/2018, American Society for Virology, University of Maryland, College Park, MD

Chang TH, Chang JT, Jan MW, Kung MH, Chen BC, Chen YS. The pathogenic effect of Human parechovirus in human glioblastoma cells. 2018/4/14-15 The 10th Asia-Pacific International Symposium on Medical Laboratory Science. Kaohsiung Taiwan.

Ming-Wei Jan, Yuan-Ting Hong, Bao-Chen Chen, Tsi-Shu Huang, Jenn-Tzing Chang, Yao-Shen Chen, Tsung-Hsien Chang, The neurovirulence of human parechovirus in neonatal mice 2017/11/16~17 Chinese-Taipei Society of Laboratory Animal Sciences annual meeting. Taipei, Taiwan.

徐宗賢, 張運德, 龔明祥, 張聰賢　Knockdown of autophagy molecules LC3 and p62 enhance Aichi virus replication by downregulating host antiviral innate immunity 20170623，台北第12屆急診年會與會員大會暨學術研討會Taoyuan, Taiwan. 2017 Jun-23

張芳誠，張運德，張聰賢Verification of the anti-dengue virus effect of Trim12c/Trim5 with CRISPR/Cas9-mediated gene knockout approach 20170623，台北第12屆急診年會與會員大會具學術研討會 （學會優等獎）Taoyuan, Taiwan. 2017 Jun-23

Chang TH, Chang JT, Chen BC, Chen YS. HUMAN PARECHOVIRUSE TYPE 3 MODULATES HOST ANTIVIRAL INNATE IMMUNITY. INTERNATIONAL UNION OF MICROBIOLOGICAL SOCITIES, (2017, Jul 17-21) Singapore.

Chang TH and Hung WT. Detection of Aichi virus with monoclonal antibody targeting of viral protein 1, 2017 The 9th Asia-Pacific From of Medical Laboratory Sciences.2017. Taoyuan, Taiwan. 2017 Apr-15-16

Chang JT, Chang TH, Chen BC, Chen YS. Human parechovirus causes diseases highly correlated with healthcare-associated infections in infants younger than 3 months old. The 1st Annual meeting of Taiwan Society of Virology, Taipei, Taiwan, 2016 Nov-5.

Chang RI, Kung MH, Chen YS, Chen BC, Chang YD, Chang TH*. Aichi virus downregulates autophagic flux-associated antiviral innate immunity. The 1st Annual meeting of Taiwan Society of Virology, Taipei, Taiwan, 2016 Nov-5.
Chang TH* and Hung WT, Human parechovirus type 1 induces proallergic cytokines expression The 1st Annual meeting of Taiwan Society of Virology, Taipei, Taiwan, 2016 Nov-5.

Chang TH*, Wang LF, Lin YS, Yang CS, Yu CY, Lin YL. Hydroxychloroquine Activates Host Antiviral Innate Immunity. The 2nd annual meeting of Intonation Interferon and Cytokine Society. October 26-29, Melbourne, Australia, 2014. Cytokine, 70 (1), 33–34 Nov. 2014, SI: 2014 ICIS Abstract Issue.

Chang JT, Chen YS, Chen BC, Chao D, Chang TH*. Genome and Growth Characteristics of a Newly Isolated Human Parechovirus Type 1. The 29th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 2014.

Hsu LH, Yang CS, Chang TH*. Isolation and culture of mouse intestinal epithelial cells and analysis of their innate immune response. The 29th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 2014.

Chang TH*, Chen YS, Chen BC, Chang JT. In vitro infection and detection of the first Aichi Virus isolated in Taiwan. 32nd Annual meeting, American Society of Virology, Pennsylvania Stat college park, July 20-24, 2013.

Lin SL, Yeh JL, Tsai PC, Huang WC, Chang TH, Lee ST, Wassler M, Geng YJ. Enhanced Expression Of Superoxide Dismutase Attenuates Smooth Muscle Cell proliferation And Intima Hyperplasia In Rat Carotid Artery Injured By Balloon Denudation. American Heart Association Scientific Sessions, Los Angeles, November 3 - 7, 2012.

Chuang SJ. Pan HB, Chou CP, Peng N, Cheng JT, Chang TH*. Analysis of UBE2C tumor biomarker in breast microcalcifications tissue. Taiwan Society of Laboratory Medicine, Tenth members Conference Taipei, Taiwan, November 3-4, 2012.

Lin YS, Chen YS, Huang TS, Chen BJ, Chan H-JY, Chang TH*. A pioneer study of Innate Immune Response of Two Emerging Picornaviruses Infection: Aichi virus and Human parechovirus. 27th Annual joint meeting of Biomedical Sciences. Taipei, Taiwan. May 17-18, 2012

Chang TH, Yoshmi R, Kim D, Ozato K. Murine TRIM5a integrates to type I and NFkB activation pathway. Ubiquitin-Like Molecules in Disease meeting, Cambridge, UK. June 27, 2011.

Ozato K, Chang TH, Kubota T, Matsuoka M. SUMO Modification of IRF Family Proteins and Regulation of Anti-Viral Innate Immunity. Tri-Society Annual Conference of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research, Cellular and Cytokine Interactions in Health and Disease. Cytokine, 2011, vol. 56, no. 1, pp. 99-99. (IF: 2.57) Florence, Italy. October 9-12, 2011.

Yoshimi R, Chang TH, Wang H, Atsumi T, MorseIII HC, Ozato K; Autoantigen TRIM21/Ro52 Contributes to Suppression of NF-kB-Dependent Cytokine Expression in Fibroblasts [abstract]. Arthritis Rheum 2009;60 Suppl 10:1330. DOI: 10.1002/art.26404 (IF: 7.87) The 2009 ACR/ARHP Annual Scientific Meeting Philadelphia October 16-21, 2009.

Ozato K, Chang TH, Kubota T, Matsuoka M, Bray M, Jones S. Inhibition of type I interferon transcription by IRF3/7 SUMOylation the process hijacked by the Ebola virus VP35. Tri-Society Annual Conference of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research, Cellular and Cytokine Interactions in Health and Disease. Cytokine 2009 (48) 15. (IF: 2.57) Lisbon, Portugal,October 18-21, 2009.

Ng S, Chang TH, Tailor P, Ozato K, Kino T. Viral infection alters mRNA expression of nuclear hormone receptors and their coregulators in mouse dendritic cells. The 96th annul meeting of American Association of Immunologists, Seattle, Washington. USA. May 8-12, 2009.

Ozato K, Tailor P, Ramakrishna L, Chang TH, Kubota T, Matsuoka M, Morse HC 3rd. The mechanism of interferon gene transcription in dendritic cells. 7thJoint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research. Montreal, Quebec, Canada, Cytokine 2008, 43(3) 277.

Kubota T, Matsuoka M, Chang TH, Tashiro M, Kato A, Ozato K. Ebola virus VP35 interacts with host microtubule associated transporter dynein LC8. IUMS Joint Meetings of the Three Divisions of the International Union of Microbiological Societies, Istanbul, Turkey. August 10-15, 2008.

Yu CY, Chang TH, Chiang RL, Lin YL. Crosstalk of interferon pathway and unfolded protein response in flavivirus infection. International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting, 50th Anniversary of the Discovery of Interferon, September 16–19, 2007, Oxford, England, Journal Interferon and Cytokine Research 2007 27(8) 726.

(D) Genome sequences in GenBank
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/95111003/2006) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185829. VRL 16-APR-2018
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/96060801C/2007) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185830. VRL 16-APR-2018
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/97042912C/2008) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185831. VRL 16-APR-2018
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/106051925/2014) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185832. VRL 16-APR-2018
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/105032177/2016) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185833. VRL 16-APR-2018
Chen BC, Lee CC, Huang NY, Lin CC, Chang TH, Wu KS and Lee HS. Influenza C virus (C/Kaohsiung/107020729/2018) segment 4 hemagglutinin-esterase (HE) gene, partial cds. GenBank# MH185834. VRL 16-APR-2018
Chen BC, Huang NY, Lin CC, Lee CC, Huang TS and Chang TH. Human parechovirus 3 strain VGHKS 080217-2013, complete genome. GenBank #KX068679, 2016.
Chang JT, Yang CS., Chen YS, Chen BC, Lin YS, Chao D and Chang TH*. Human parechovirus 3 strain VGHKS-2007, complete genome. GenBank# KM986843, 2015.
Chang JT, Yang CS, Chen BC, Lee SJ, Chen YS, Lin YS and Chang TH*. Enterovirus D68 strain VGHKS 990702-18 VP1 gene, partial cds. GenBank #KP317495, 2015.
Chang JT, Yang CS, Chen BC, Lee SJ, Chen YS, Lin YS and Chang TH*. Enterovirus D68 strain VGHKS 990622-1 VP1 gene, partial cds. GenBank # KP317494, 2015.
Chang JT., Chen YS, Chen BC, Chao D, and Chang TH*. Human parechovirus 1 strain KVP6 polyprotein gene, complete cds, GenBank# KC 769584, 2013.
Chang JT, Chao D, and Chang TH*. Aichi virus strain kvgh99012632/2010 polyprotein gene, complete cds, GenBank# JX564249.1, 2012.