專長學科

病毒學, 生物化學, 細胞分子生物學

研究主題

1. 探討黃質病毒(日本腦炎病毒, 登革病毒及茲卡病毒)之致病機轉及相關疫苗之研發。
2. 篩選可抑制黃質病毒的小分子藥物及探討機轉。
3. 開發有效及安全的 COVID-19 疫苗、藥物及探討致病機轉。

聯絡方式

電話：02-87923100 分機18548
地址：(11490) 台北市內湖區民權東路六段161號8樓8324-2室

E-mail

yenlichen@mail.ndmutsgh.edu.tw

研究著作

1.Fu-Kai Chuang, Shih-Ming Huang, Ching-Len Liao, An-Rong Lee, Shu-Pei Lien, Yu-Lung Chiu, Tsung-Hsien Chang, Pei-Ling Tsai, Ren-Jye Lin, Chih-Chin Shih, Yi-Jing Tsai, Gu-Jiun Lin, Li-Chen Yen*: Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. Antimicrobial Agents and Chemotherapy. 2020 Jan; 64(1): e00941-19. (*Corresponding author) (SCI: IF=4.904, 2019)
2.Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu, An-Rong Lee, Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien Chang, Chang-Chi Lin, Chih-Chin Shih, Li-Chen Yen*: Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. International Journal of Molecular Sciences. 2020 Jun; 21(11): 4050 (*Corresponding author) (SCI: IF=4.556, 2019)
3.Ren-Jye Lin, Chih-Heng Huang, Ping-Cheng Liu, I-Chieh Lin, Yu-Ling Huang, An-Yu Chen, Hsin-Ping Chiu, Shin-Ru Shih, Li-Hsiung Lin, Shu-Pei Lien, Li-Chen Yen, Ching-Len Liao: Zinc finger protein ZFP36L1 inhibits influenza A virus through translational repression by targeting HA, M and NS RNA transcripts. Nucleic Acids Research. 2020 Jul; 48(13):7371-7384. (SCI: IF=11.501, 2019)
4.Kai-Che Wei, Wan-Ju Wei, Yi-Shan Liu, Li-Chen Yen, Tsung-Hsien Chang: Assessment of Prolonged Dengue Virus Infection in Dermal Fibroblasts and Hair-Follicle Dermal Papilla Cells. Viruses. 2020 Feb, 12(3): 267. (SCI: IF=3.816, 2019)
5.Sheng-Cheng Wu, Hui-Chen Su, Li-Chen Yen, Li-Kang Chiao, Jehng-Kang Wang, Yi-Lin Chiu, Ching-Liang Ho, Shih-Ming Huang: Gene Expression Profiling Identifies the Role of Zac1 in Cervical Cancer Metastasis. Scientific Reports. 2020 Jul; 10(1):11837. (SCI: IF=3.998, 2019)
6.Ruey-Wen Lin, Guang-Wu Chen, Hsiang-Hsuan Sung, Ren-Jye Lin, Li-Chen Yen, Yu-Ling Tseng, Yung-Kun Chang, Shu-Pei Lien, Shin-Ru Shih, Ching-Len Liao: Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability. Journal of Biomedical Science. 2019 Jul; 26(1):55. (SCI: IF=5.762, 2019)
7.Li-Chen Yen, Jia-Teh Liao, Hwei-Jen Lee, Wei-Yuan Chou, Chun-Wei Chen, Yi-Ling Lin, Ching-Len Liao: The C-Terminus of the Core β-Ladder domain in Japanese Encephalitis Virus Nonstructural Protein 1 Is Flexible for Accommodation of Heterologous Epitope Fusion. Journal of Virology. 2016 Feb; 90(3): 1178-89. (First author) (SCI: IF=4.501, 2019)
8.Yi-Ting Huang, Jia-Teh Liao, Li-Chen Yen, Yung-Kun Chang, Yi-Ling Lin, Ching-Len Liao: Japanese encephalitis virus replicon-based vaccine expressing enterovirus-71 epitope confers dual protection from lethal challenges. Journal of Biomedical Science. 2015 Sep; 22(1):74. (SCI: IF=5.762, 2019)
9.Li-Chen Yen, Yi-Ling Lin, Hsiang-Hsuan Sung, Jia-Teh Liao, Chang-Huei Tsao, Chih-Mao Su, Chih-Kung Lin, Ching-Len Liao. Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron specific microRNA recognition elements into viral genome. Vaccine. 2013, Vol. 31, 5915-5922