專長學科
基因調控學
免疫治療學
自體免疫學
癌症免疫學
腸道免疫學
研究主題
1.流行病學大數據資料分析
2.轉錄因子後轉譯修飾功能探討
3.腸道菌叢對免疫功能調控剖析
4.基因轉殖與基因剔除實驗小鼠建立
5.新穎蛋白質與小分子臨床前藥物開發
研究介紹
本實驗室主要以流行病學分析資料及實驗動物模式深入探討轉錄因子在自體免疫疾病及發炎性癌腫瘤中之非對稱性調控角色，並建立多重發炎性免疫疾病之追蹤系統以評估免疫疾病對其癌症發展之預防醫療效力，同時運用基因操控技術以小鼠模式剖析T淋巴細胞中轉錄因子之蛋白表現量及其後轉譯修飾對胰腸系統中由腸道菌相所調控免疫耐受性之影響，並剖析發炎性免疫疾病中之關鍵致病機制以及功能性連結蛋白質及小分子藥物於腫瘤動物模式中之運用發展，進而分析其調控機轉以研發新穎免疫調節治療策略。
聯絡方式
地址: 114臺北市內湖區民權東路六段161號8樓微免學科8320室
電話: (02) 87923100 ext. 18536(辦公室)/ 18529(實驗室)
E-mail
hsucy@mail.ndmutsgh.edu.tw
hsu.chaoyuan@gmail.com
研究著作
1. Yi-Wen Tsai, Shin-Huei Fu, Jia-Ling Dong, Ming-Wei Chien, Yu-Wen Liu, Chao-Yuan Hsu* and Huey-Kang Sytwu* (2020). Adipokine-Modulated Immunological Homeostasis Shapes the Pathophysiology of Inflammatory Bowel Disease. International Journal of Molecular Sciences, 21(24): 9564.
2. Chao Yuan Hsu, Shin Huei Fu, Ming Wei Chien, Yu‐Wen Liu, Shyi‐Jou Chen and Huey‐Kang Sytwu* (2020). Post‐Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases. International Journal of Molecular Sciences, 21(9):3207.
3. Shin-Huei Fu, Ming-Wei Chien, Chao-Yuan Hsu, Yu-Wen Liu and Huey-Kang Sytwu* (2020). Interplay between Cytokine Circuitry and Transcriptional Regulation Shaping Helper T Cell Pathogenicity and Plasticity in Inflammatory Bowel Disease. International Journal of Molecular Sciences, 21, 3379.
4. Chao-Yuan Hsu, Li-Tzu Yeh, Shin-Huei Fu, Ming-Wei Chien, Yu-Wen Liu, Shi-Chuen Miaw, Deh-Ming Chang, and Huey-Kang Sytwu* (2018). SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes. The Journal of clinical investigation. 128:3779-3793.
5. Ming-Wei Chien, Shin-Huei Fu, Chao-Yuan Hsu, Yu-Wen Liu and Huey-Kang Sytwu* (2018). The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases. International journal of molecular sciences. 19:780.
6. Ming-Wei Chien, Ming-Hong Lin, Shing-Hwa Huang, Shin-Huei Fu, Chao-Yuan Hsu, B. Lin-Ju Yen, Jiann-Torng Chen, Deh-Ming Chang and Huey-Kang Sytwu* (2015). Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25. The Journal of biological chemistry.290:29329-44