經歷
國家衛生研究院特聘研究員且兼任副院長
國防醫學院院長
軍醫局醫務計畫處處長
國防醫學院上校教育長
國防醫學院生命科學研究所常務執行委員
國防醫學院醫學科學研究所所長
國防醫學院研究發展室主任
國防醫學院微生物及免疫學科副教授、教授、主任
國防醫學院生物醫學工程學科主任
專長學科
1. 自體免疫及免疫調控
2. 基因轉殖與剔除
3. 細胞免疫
4. 基因操控
5. 轉譯醫學
Publications (*correspondence)
(*correspondence)
Wang, L.-T., Wang, H.-H., Doan, D.-T.-T., Lin, Y.-F., Liao, C.-Y., Hsu, P.-J., Chang, C.-C., Yen, M.-L., Liu, K.-J., Sytwu, H.-K., Yen, B.-L. (2026) 3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation. Biomaterials 330:123998
Tsai, Y.-W., Liu, Y.-W, Hsu, C.-Y., Fu, S.-H. Chien, M.-W., Dong, J.-L. Sun, C.-C., Chen, C.-T., *Sytwu, H.-K. (2025) Blimp-1 benefits gut-homing regulatory T cells by maintaining migration/suppressive function in autoimmune diabetes-prone mice. The Lancet EBioMedicine 121:106002
Wang, K.-C., Wang, L.-W., Chen, C.-M., Chen, J.-W., Lin, G.-J., Chin, L.-T., Hu, C.-F., Sytwu, H.-K., Chen, S.-J. (2025) An innovative AQP4 loop C-targeted monoclonal antibody reduces complement-dependent cytotoxicity and lessens experimental neuromyelitis optica. Multiple Sclerosus Related Disorders 104:106803
Chen, Y.-Z., Tseng, K.-Y., Tseng, M.-N., Tsai, J.-N., Hsu, C.-C., Liao, Y.-C., Lin, C.-C., Tsai, D.-J., Chen, F.-J., Hsieh, L.-Y., Lin, C.-M., Wu, C.-J., Sytwu, H.-K., Lo, H.-J. (2025) Expansion of a predominant azole-resistant Candida tropicalis genotype from 2012 to 2018: evidence from orchard environments in Taiwan. Medical Mycology, myaf098. doi: 10.1093/mmy/myaf098
Cheng, H.-R., Kuo, S.-C., Lai, J.-F., Wu, H.-C., Chen, F.-J., Sytwu, H.-K., Lo, S.-W., Bentley, S.-D., Huang, Y.-C. (2025) Genomic analysis of the Streptococcus pneumoniae in Taiwan: a nationwide study from 2006 to 2022. Microbial Genomics 11:001498
Hsu, P.-W., Yeh, C.-H., Lo, C.-J., Tsai, T.-H., Chan, Y.-H., Chou, Y.-J., Yang, N.-I., Cheng, M.-L., Sheu, W.-H., *Lai, C.-C., *Sytwu, H.-K., *Tsai, T.-F. (2025) Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease. Biomarker Research 13:107
Yang, Y.-H., Lee, Y.-H., Lee, H.-A., Chang, L.-H., Chen, C.-Y., Chen, S.-C., Huang, S.-F., *Sytwu, H.-K. (2025) Data Resource Profile: Harmonized Electronic Health Records from the National Biobank Consortium of Taiwan (NBCT). International Journal of Epidemiology, 54(4), dyaf130
Wang, L.-T., Wang, H.-H., Jiang, S.-S., Chang, C.-C., Hsu, P.-J., Liu, K.-J., Sytwu, H.-K., Yen, B.-L., Yen, M.-L. (2025) Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: implications for anti-TNFα-refractory patients. Pharmacological Research 215:107716
Lin, Y.-H., Wang, Y.-H., Peng, Y.-J., Liu, F.-C., Sytwu, H.-K., Cheng, C.-P. (2025) Interleukin 26 attenuates osteoblast differentiation in osteoarthritis patients by activating COX2 and NF-κB pathways. International Journal of Medical Sciences 22:1504-1515
Wu, I.-W., Liao, Y.-C., Tsai, T.-H., Lin, C.-H., Shen, Z.-Q., Chan, Y.-H., Tu, C.-W., Chou, Y.-J., Lo, C.-J., Yeh, C.-H., Chen, C.-Y., Pan, H.-C., Hsu, H.-J., Lee, C.-C., Cheng, M.-L., Sheu, W.-H., *Lai, C.-C., *Sytwu, H.K., *Tsai, T.-F. (2025) Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease. Gut Microbes 17(1):2473506
Yang, C.-W., Hsu, H.-Y., Lee, Y.-Z., Jan, J.-T., Chang, S.-Y., Lin, Y.-L., Yang, R.-B., Chao, T.-L., Liang, J.-J., Lin, S.-J., Liao, C.-C., Chang, C.-S., Sytwu, H.-K., Hung, M.-S., Chen, C.-T., Lee, S.-J. (2025) Corrigendum to "Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin" [Biochem. Pharmacol. 215 (2023) 115688]. Biochemical Pharmacology 232:116753
Yeh, C.-H., Tsai, T.-H., Chen, C.-H., Chou, Y.-J., Mao, C.-T., Su, T.-P., Yang, N.-I., Lai, C.-C., *Chen, C.-T., *Sytwu, H.-K., *Tsai, T.-F. (2024) Artificial intelligence-enhanced electrocardiography improves the detection of coronary artery disease. Computational and Structural Biotechnology Journal 27:278-286
Huang, Y.-S., Lu, K.-C., Chang, Y.-T., Ka, S.-M., Guo, C.-Y., Hsieh, H.-Y., Shih, H.-M., Sytwu, H.-K., Wu, C.-C. (2024) Melatonin Alleviates Albumin-Induced Tubular Cell Injury by Activating Clock-Controlled Nuclear Enriched Abundant Transcript 1-Mediated Proliferation. ACS Pharmacology & Translational Science 2024, 7:3607-3617
Tseng, K.-Y., Chen, Y.-Z., Zhou, Z.-L., Tsai, J.-N., Tseng, M.-N., Liu, H.-L., Wu, C.-J., Liao, Y-C., Lin, C.-C., Tsai, D.-J., Chen, F.-J., Hsieh, L.-Y., Huang, K.-C., Huang, C.-H., Chen, K.-T., Chu, W.-L., Lin, C.-M., Shih, S.-M., Hsiung, C.-A., Chen, Y.-C., Sytwu, H.-K., Yang, Y.-L., Lo, H.-J. (2024) Detection in Orchards of Predominant Azole-Resistant Candida tropicalis Genotype Causing Human Candidemia, Taiwan. Emerging Infectious Diseases 30(11):2323-2332
Tseng, K.-Y., Liao, Y.-C., Chen, Y.-Z., Chen, F.-C., Chen, F.-J., Sytwu, H.-K., Hsieh, L.-Y., Lan, C.-Y., Lo, H.-J. (2024) Rapid identification of the predominant azole-resistant genotype in Candida tropicalis. FEMS Yeast Research 24:foae025
Wang, L.-T., Lee, W., Liu, K.-J., Sytwu, H.-K., Yen, M.-L., Yen, B.-L. (2024) Mesenchymal stromal/stem cells know best: the remarkable complexities of its interactions with polymorphonuclear neutrophils. Stem Cells. 42:403-415
Yen, B.-L., Wang, L.-T., Wang, H.-H., Hung, C.-P., Hsu, P.-J., Chang, C.-C., Liao, C.-Y., Sytwu, H.-K., Yen, M.-L. (2024) Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/SIRT1 axis. [J Biomed Sci 31:49 (2024)]. Journal of Biomedical Science 31:61
Yen, B.-L., Wang, L.-T., Wang, H.-H., Hung, C.-P., Hsu, P.-J., Chang, C.-C., Liao, C.-Y., Sytwu, H.-K., Yen, M.-L. (2024) Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/SIRT1 axis. Journal of Biomedical Science 31:49
Ciou, J.-J., Chien, M.-W., Hsu, C.-Y., Liu, Y.-W., Dong, J.-L., Tsai, S.-Y., Yang, S.-S, Lin, S.-H., Yen, B. L.-J., * Fu, S.-H., *Sytwu, H.-K. (2024) Excess Salt Intake Activates IL-21-dominant Autoimmune Diabetogenesis via A Saltregulated Ste20-related Proline/alanine-rich Kinase in CD4 T Cells. Diabetes 73:592-603
Tsou, H.-H., Lee, F.-J., Wu, S.-I., Fan, B., Wu, H.-Y., Lin, Y.-H., Hsu, Y.-T., Cheng, C., Cheng, Y.-C., Jiang, W.-M., Chiou, H.-Y., Chen, W.-J., Hsiung, C.-A., Chen, P.-C., Sytwu, H.-K. (2024) Suppression of the alpha, delta, and omicron variants of SARS-Cov-2 in Taiwan. PLoS One. 2024 Mar 18;19(3):e0300303
Huang, S.-H., Hong, Z.-J., Chen, M.-F., Tsai, M.-W., Chen, S.-J., Cheng, C.-P., Sytwu, H.-K., Lin, G.-J. (2024) Corrigendum to "Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells" [Int. Immunopharmacol. 126 (2024) 111300]. Interational Immunopharmacology 131:111683
Huang, S.-H., Hong, Z.-J., Chen, M.-F., Tsai, M.-W., Chen, S.-J., Cheng, C.-P., Sytwu, H.-K., Lin, G.-J. (2024) Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells. Interational Immunopharmacology 126:111300
Jang, Y.-A., Wu, H.-Y., Hsu, Y.-T., Chen, Y.-K., Chiou, H.-Y., Sytwu, H.-K., Chen, W.-J., Tsou, H.-H. (2024) Beyond the waves: Unraveling pandemic outcomes with genomic insights and immunity analysis - Evidence from 14 countries. Preventive Medicine 178:107820
Chen, Y.-Z., Tseng, K.-Y., Wang, S.-C., Huang, C.-L., Lin, C.-C., Zhou, Z.-L., Tsai, D.-J., Lin, C.-M., Chen, Y.-L., Chen, K.-T., Liao, Y.-C., Chen, F.-J., Sytwu, H.-K., Lan, C.-Y., Lo, H.-J. (2023) Fruits are vehicles of drug-resistant pathogenic Candida tropicalis. Microbiology Spectrum. 11(6):e0147123
Hsieh, C.-C, Yang, C.-Y., Peng, B., Ho, S.-L., Tsao, C.-H., Lin, C.-K., Lin, C.-S., Lin, G.-J., Lin, H.-Y., Huang, H.-C., Chang, S.-C., Sytwu, H.-K., Chia, W.-T., Chen, Y.-W. (2023) Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis. Biomedicines. 11:2669
Jiang, W.-M., Wen, T.-H., Huang, Y.-C., Chiou, H.-Y., Chen, W.-J., Hsiung, C.-A., Sytwu, H.-K., Tsou, H.-H. (2023) Interregional mobility in different age groups is associated with COVID-19 transmission in the Taipei metropolitan area, Taiwan. Scientific Reports 13:17285
Yang, C.-W., Hsu, H.-Y., Lee, Y.-Z., Jan, J.-T., Chang, S.-Y., Lin, Y.-L., Yang, R.-B., Chao, T.-L., Liang, J.-J., Lin, S.-J., Liao, C.-C., Chang, C.-S., Sytwu, H.-K., Hung, M.-S., Chen, C.-T., Lee, S.-J. (2023) Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin. Biochemical Pharmacology 215:115688
Yen, B.-L., Liu, K.-J., Sytwu, H.-K., Yen, M.-L. (2023) Clinical implications of differential functional capacity between tissue-specific human mesenchymal stromal/stem cells. The FEBS Journal 2023 290(11):2833-2844
Wang, Y.-H., Peng, Y.-J., Liu, F.-C., Lin, G.-J., Huang, S.-H., Sytwu, H.-K., Cheng, C.-P. (2023) Interleukin 26 Induces Macrophage IL-9 Expression in Rheumatoid Arthritis. International Journal of Molecular Sciences 24(8):7526
Wang, L.-T., Yen, B.-L., Wang, H.-H., Chao, Y.-Y., Lee, W., Huang, L.-Y., Chiu, S.-K., Siu, L.-K., Liu, K.-J., Sytwu, H.-K., Yen, M.-L. (2023) Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome. Thorax 78:504-514
Kuo, S.-C., Fan, B., Zhu, H., Wu, M.-H., Lee, F.-J., Cheng, Y.-C., Wu, H.-Y., Hsu, Y.-T., Hsiung, C.-A., Wu, S.-I., Chen, W.-J., Chiou, H.-Y., Sytwu, H.-K., Tsou, H.-H. (2022) Contribution of Testing Strategies and Contact Tracing towards COVID-19 Outbreaks Control: A Mathematical Modeling Study. Tropical Medicine and Infectious Disease 7:376
Wu, I.-W., Tsai, T.-H., Lo, C.-J., Chou, Y.-J., Yeh, C.-H., Chan, Y.-H., Chen, J.-H., Hsu, P.-W., Pan, H.-C., Hsu, H.-J., Chen, C.-Y., Lee, C.-C., Shyu, Y.-C., Lin, C.-L., Cheng, M.-L., *Lai, C.-C., *Sytwu, H.-K., *Tsai, T.-F. (2022) Discovering a trans-omics biomarker signature that predisposes high risk diabetic patients to diabetic kidney disease. NPJ Digital Medicine 5(1):166
Yang, Y.-S., Huang, T.-W., Huang, Y.-C., Huang, W.-C., Hsu, S.-Y., Wu, H.-C., Chen, F.-J., Shang, H.-S., Sytwu, H.-K., Kuo, S.-C. (2022) In-vitro and in-vivo efficacy of minocycline-based therapy for Elizabethkingia anophelis and the impact of reduced minocycline susceptibility. International Journal of Antimicrobial Agents 60:106678
Lee, Y.-Z., Hsu, H.-Y., Yang, C.-W., Lin, Y.-L., Chang, S.-Y., Yang, R.-B., Liang, J.-J., Chao, T.-L., Liao, C.-C., Kao, H.-C., Chang, J.-Y., Sytwu, H.-K., Chen, C.-T., Lee, S.-J. (2022) The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 14:1511
Liu, Y.-W., Fu, S.-H., Chien, M.-W., Hsu, C.-Y., Lin, M.-H., Dong, J.-L., Lu, Rita J.-H., Lee, Y.-J., Chen, P.-Y., Wang, C.-H., *Sytwu, H.-K. (2022) Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit. JCI Insight 7(11):e151614
Wu, I.-W., Tsai, T.-H., Lo, C.-J., Chou, Y.-J., Yeh, C.-H., Cheng, M.-L., *Lai, C.-C., *Sytwu, H.-K., *Tsai, T.-F. (2022) Discovery of a Biomarker Signature That Reveals a Molecular Mechanism Underlying Diabetic Kidney Disease via Organ Cross Talk. Diabetes Care 45(6):e102-e104
Tsai, M.-K., Sytwu, H.-K., Hsieh, T.-Y., Chien, W.-C., Lai, C.-H., Chen, H.-C. (2022) Association Between Depression or Anxiety and the Risk of Hepatitis B Flares: A Nationwide Population-Based Cohort Study. Journal of Inflammation Research 15:2983-2993
Tsou, H.-H., Kuo, S.-C., Lin, Y.-H., Hsiung, C.-A., Chiou, H.-Y., Chen, W.-J., Wu, S.-I., Sytwu, H.-K., Chen, P.-C., Wu, M.-H., Hsu, Y.-T., Wu, H.-Y., Lee, F.-J., Shih, S.-M., Liu, D.-P., Chang, S.-C. (2022) A comprehensive evaluation of COVID-19 policies and outcomes in 50 countries and territories. Scientific Reports 12:8802
Huang, S.-H., Kuo, S.-L., Chen, S.-J., Lin, J.-R., Chen, Y.-W., Hong, Z.-J., Sytwu, H.-K., Lin, G.-J. (2022) Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes. International Journal of Molecular Sciences 23(3):1169
Yeh, C.-H., Chou, Y.-J., Tsai, T.-H., Hsu, P.-W., Li, C.-H., Chan, Y.-H., Tsai, S.-F., Ng, S.-C., Chou, K.-M., Lin, Y.-C., Juan, Y.-H., Fu, T.-C., *Lai, C.-C., *Sytwu, H.-K., *Tsai, T.-F. (2022) Artificial-Intelligence-Assisted Discovery of Genetic Factors for Precision Medicine of Antiplatelet Therapy in Diabetic Peripheral Artery Disease. Biomedicines 10(1):116.
Yang, N.-I., Yeh, C.-H., Tsai, T.-H., Chou, Y.-J., Hsu, P.-W., Li, C.-H., Chan, Y.-H., Kuo, L.-T., Mao, C.-T., Shyu, Y.-C., Hung, M.-J., *Lai, C.-C., *Sytwu, H.-K., *Tsai, T.-F. (2021) Artificial Intelligence-Assisted Identification of Genetic Factors Predisposing High-Risk Individuals to Asymptomatic Heart Failure. Cells 10(9):2430
Tsai, Y.-W., Dong, J.-L., Jian, Y.-J., Fu, S.-H., Chien, M.-W., Liu, Y.-W., *Hsu, C.-Y., *Sytwu, H.-K. (2021) Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases. Microorganisms 9 (9):1930
Wang, L.-T., Liu, K.-J., Sytwu, H.-K., Yen, M.-L., Yen, B.-L. (2021) Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells. Stem Cells Translational Medicine 10:1288-1303
Hsu, H.-Y., Yang, C.-W., Lee, Y.-Z., Lin, Y.-L., Chang, S.-Y., Yang, R.-B., Liang, J.-J., Chao, T.-L., Liao, C.-C., Kao, H.-C., Wu, S.-H., Chang, J.-Y., Sytwu, H.-K., Chen, C.-T., Lee, S.-J. (2021) Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2. Frontiers in Pharmacology 12:706901
Lin, J.-R., Huang, S.-H., Wu, C.-H., Chen, Y.-W., Hong, Z.-J., Cheng, C.-P., Sytwu, H.-K., Lin, G.-J. (2021) Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes. Pharmaceuticals (Basel) 14(5):475
Hsu, P.-C., Chen, Y.-H., Cheng, C.-F., *Kuo, C.-Y., *Sytwu, H.-K. (2021) Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines. Life (Basel) 11(5):423
Lee, W., Wang, L.-T., Yen, M.-L., Hsu, P.-J., Lee, Y.-W., Liu, K.-J., Lin, K.-I., Su, Y.-W., Sytwu, H.-K., Yen, B.-L. (2021) Resident vs nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes. Stem Cells Translational Medicine 2021 10:711–724
Su, F.-Y., Huang, S.-C., Wei, P.-C., Hsu, P.-H., Li, J.-P., Su, L.-W., Hsieh, Y.-L., Hu, C.-M., Hsu, J.-L., Yang, C.-Y., Chung, C.-Y., Shew, J.-Y., Lan, J.-L., Sytwu, H.-K., Lee, E. Y-H. P., Lee, W.-H. (2021) Redox sensor NPGPx restrains ZAP70 activity and modulates T cell homeostasis. Free Radical Biology and Medicine 165:368-384
Kuo, C.-S., Yang, C.-Y., Lin, C.-K., Lin, G.-J., Sytwu, H.-K., Chen, Y.-W. (2021) Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients. Biomedicine & Pharmacotherapy 133:111057
Yang, C.-W., Lee, Y.-Z., Hsu, H.-Y., Jan, J.-T., Lin, Y.-L., Chang, S.-Y., Peng, T.-T., Yang, R.-B., Liang, J.-J., Liao, C.-C., Chao, T.-L., Pang, Y.-H., Kao, H.-C., Huang, W.-Z., Lin, J.-H., Chang, C.-P., Niu, G.-H., Wu, S.-H., Sytwu, H.-K., Chen, C.-T., Lee, S.-J. (2020) Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives. Frontiers in Pharmacology 2020 Dec 14;11:606097
Tsai, Y.-W., Fu, S.-H., Dong, J.-L., Chien, M.-W., Liu, Y.-W., Hsu, C.-Y., *Sytwu, H.-K. (2020) Adipokine-Modulated Immunological Homeostasis Shapes the Pathophysiology of Inflammatory Bowel Disease. International Journal of Molecular Sciences 21(24), 9564
*Sytwu H.-K. (2020) Expeditious responses to COVID-19 crisis: From governmental management to laboratory approach. Biomedical Journal 43:311-313
Huang, S.-F., Huang, Y.-C., Chang, F.-Y., Lin, J.-C., Chiu, C.-H., Chen, C.-W., Wang, F.-D., Chiu, Y.-L., Cheng, S.-H., Cheng, C.-Y., Lin, Y.-C., Chen, C.-P., Huang, C.-H., Liu, P.-Y., Lee, Y.-T., Lee, C.-H., Chen, Y.-S., Sy, C.-L., Tseng, Y.-T., Hsu, C.-T., Tseng, C.-C., Lee, Y.-L., Liu, C.-E., Sytwu, H.-K. (2020) Rapid establishment of a COVID-19 biobank in NHRI by National Biobank Consortium of Taiwan. Biomedical Journal 43:314-317
Yang, C.-W., Peng, T.-T., Hsu, H.-Y., Lee, Y.-Z., Wu, S.-H., Lin, W.-H., Ke, Y.-Y., Hsu, T.-A., Yeh, T.-K., Huang, W.-Z., Lin, J.-H., Sytwu, H.-K., Chen, C.-T., Lee, S.-J. (2020) Repurposing old drugs as antiviral agents for coronaviruses. Biomedical Journal 43:368-374
Ke, Y.-Y., Peng, T.-T., Yeh, T.-K., Huang, W.-Z., Chang, S.-E., Wu, S.-H., Hung, H.-C., Hsu, T.-A., Lee, S.-J., Song, J.-S., Lin, W.-H., Chiang, T.-J., Lin, J.-H., Sytwu, H.-K., Chen, C.-T. (2020) Artificial intelligence approach fighting COVID-19 with repurposing drugs. Biomedical Journal 43:355-362
Yen, B.L., Yen, M.-L., Wang, L.-T., Liu, K.-J., Sytwu, H.-K. (2020) Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID-19. Stem Cells Translational Medicine 2020;9:1163-1173
Tsou, H.-H., Cheng, Y.-C., Yuan, H.-Y., Hsu, Y.-T., Wu, H.-Y., Lee, F.-J., Hsiung, C.-A., Chen, W.-J., Sytwu, H.-K., Wu, S.-I., Shih, S.-M., Wen, T.-H., Kuo, S.-C. (2020) The effect of preventing subclinical transmission on the containment of COVID-19: Mathematical modeling and experience in Taiwan. Contemporary Clinical Trials 96:106101
Huang, Y.-S., Lu, K.-C., Chao, H.-W., Chen, A., Chao, T.-K., Guo, C.-Y., Hsieh, H.-Y., Shih, H.-M., Sytwu, H.-K., Wu, C.-C. (2020) The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. Journal of Cellular Physiology 2020;1-13
Yen, B.-L., Hwa, H.-L., Hsu, P.-J., Chen, P.-M., Wang, L.-T., Jiang, S.-S., Liu, K.-J., Sytwu, H.-K., Yen, M.-L. (2020) HLA-G Expression in Human Mesenchymal Stem Cells (MSCs) Is Related to Unique Methylation Pattern in the Proximal Promoter as well as Gene Body DNA. International Journal of Molecular Sciences 21(14), 5075
Yang, C.-Y., Tsao, C.-H., Hsieh, C.-C., Lin, C.-K., Lin, C.-S., Li, Y.-H., Chang, W.-C., Cheng, J.-C., Lin, G.-J., Sytwu, H.-K., Wang, Y.-L., Chen, Y.-W. (2020) Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model. PLoS One 15(7):e0236101
Wu, Y.-F., *Sytwu, H.-K., *Lung, F.-W. (2020) Polymorphisms in the Human Aquaporin 4 Gene Are Associated With Schizophrenia in the Southern Chinese Han Population: A Case-Control Study. Frontiers in Psychiatry 11:596
Peng, Y.-J., Peng, C.-T., Lin, Y.-H., Lin, G.-J., Huang, S.-H., Chen, S.-J., Sytwu, H.-K., Cheng, C.-P. (2020) Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway. Mediators of Inflammation 1237281
Chang, F.-Y., Chen, H.-C., Chen, P.-J., Ho, M.-S., Hsieh, S.-L., Lin, J.-C., Liu F,-T., Sytwu, H.-K. (2020) Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19). Journal of Biomedical Science 27:72
Hsu, P.-C., Cheng, C.-F., Hsieh, P.-C., Chen, Y.-H., *Kuo, C.-Y., *Sytwu, H.-K. (2020) Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine 5867064
Fu, S.-H., Chien, M.-W., Hsu, C.-Y., Liu, Y.-W., *Sytwu, H.-K. (2020) Interplay between Cytokine Circuitry and Transcriptional Regulation Shaping Helper T Cell Pathogenicity and Plasticity in Inflammatory Bowel Disease. International Journal of Molecular Sciences 21(9), 3379
Hsu, C.-Y., Fu, S.-H., Chien, M.-W., Liu, Y.-W., Chen, S.-J., *Sytwu, H.-K. (2020) Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases. International Journal of Molecular Sciences 21(9), 3207
Huang, S.-H., Wu, C.-H., Chen, S.-J., Sytwu, H.-K., Lin, G.-J. (2020) Immunomodulatory effects and potential clinical applications of dimethyl sulfoxide. Immunobiology 225(3):151906
Lin, Y.-H., Wang, Y.-H., Peng, Y.-J., Liu, F.-C., Lin, G.-J., Huang, S.-H., Sytwu, H.-K., Cheng, C.-P. (2020) Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway. Cells 2020, 9(4), 938
Chen, H.-Y., Wu, Y.-F., Chou, F.-C., Wu, Y.-H., Yeh, L.-T., Lin, K.-I., Liu, F.-T., *Sytwu, H.-K. (2020) Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases. Journal of Immunology 204(5):1158-1172
Lin, Y.-C., Liao, Y.-J., Lee, Y.-H., Tseng, S.-F., Liu, J.-Y., Chen, Y.-S., Shui, H.-A., Lin, F.-Z., Lin, K.-H., Chen, Y.-C., Tsai, M.-C., Sytwu, H.-K., Wang, C.-C., Chuang, Y.-P. (2019) Staphylococcal Phosphatidylinositol-Specific Phospholipase C potentiates lung injury via complement sensitization. Cellular Microbiology 21(10), e13085
Lin, G.-J., Wu, C.-H., Yu, C.-C., Lin, J.-R., Liu, X.-D., Chen, Y.-W., Chang, H.-M., Hong, Z.-J., Cheng, C.-P., Sytwu, H.-K., Huang, S.-H. (2019) Adoptive transfer of D">Toxicology and Applied Pharmacology 378:114641
Yang, C.-Y., Lin, C.-K., Hsieh, C.-C., Tsao, C.-H., Lin, C.-S., Peng, B., Chen, Y.-T., Ting, C.-C., Chang, W.-C., Lin, G.-J., Sytwu, H.-K., Chen, Y.-W. (2019) Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model. Head & Neck 2019 41(5):1260-1269
Chen, S.-J., Lin, G.-J., Chen, J.-W., Wang, K.-C., Tien, C.-H., Hu, C.-F., Chang, C.-N., Hsu, W.-F., Fan, H.-C., *Sytwu, H.-K. (2019) Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis. International Journal of Molecular Sciences 20(6), 1332
Chen, F.-J., Huang, W.-C., Liao, Y.-C., Wang, H.-Y., Lai, J.-F., Kuo, S.-C., Lauderdale, T.-L., Sytwu, H.-K. (2019) Molecular Epidemiology of Emerging Carbapenem Resistance in Acinetobacter nosocomialis and Acinetobacter pittii in Taiwan, 2010-2014. Antimicrob Agents Chemother 63(4) e02007-18
Wu, Y.-F., *Sytwu, H.-K., *Lung, F.-W. (2018) Human Aquaporin 4 Gene Polymorphisms and Haplotypes Are Associated With Serum S100B Level and Negative Symptoms of Schizophrenia in a Southern Chinese Han Population. Frontiers in Psychiatry 11:657
Hsu, C.-F., Hsiao, C.-H., Tseng, S.-F., Chen, J.-R., Liao, Y.-J., Chen, S.-J., Lin, C.-S., Sytwu, H.-K., Chuang, Y.-P. (2018) PrtA immunization fails to protect against pulmonary and invasive infection by Streptococcus pneumoniae. Respiratory Research 19:187
Chen, H.-K., Zhang, S.-M., Chang, J.-L., Chen, H.-C., Lin, Y.-C., Shih, C.-P., Sytwu, H.-K., Fang, M.-C., Lin, Y.-Y., Kuo, C.-Y., Liao, A.-H., Chu, Y.-H., Wang, C.-H. (2018) Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer. Cancers 10(9) 311
Hsu, C.-Y., Yeh, L.-T., Fu, S.-H., Chien, M.-W., Liu, Y.-W., Miaw, S.-C., Chang, D.-M., *Sytwu, H.-K. (2018) SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes. The Journal of Clinical Investigation 128(9):3779-3793
Huang, Y.-S., Lu, K.-C., Chao, T.-K., Chen, J.-S., Chen, A., Guo, C.-Y., Hsieh, H.-Y., Shih, H.-M., Sytwu, H.-K., Wu, C.-C. (2018) Role of MTNR1A and PITX1 coexpression in protecting tubular epithelial cells in membranous nephropathy. Journal of Pineal Research 65(1):e12482
Wang, A. Y.-L., Loh, C. Y.-Y., Chen, S.-J., Kao, H.-K., Lin, C.-H., Chuang, S.-H., Lee, C.-M., Sytwu, H.-K., Wei, F.-C. (2018) Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1. Molecular Immunology 99:53-65
Wang, A. Y.-L., Loh, C. Y.-Y., Chen, S.-J., Kao, H.-K., Lin, C.-H., Chuang, S.-H., Lee, C.-M., Sytwu, H.-K., Wei, F.-C. (2018) Characterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice. Data in Brief 119:117-127
Wang, L.-T., Jiang, S.-S., Ting, C.-H., Hsu, P.-J., Chang, C.-C., Sytwu, H.-K., Liu, K.-J., Yen, B.-L. (2018) Differentiation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Results in Downregulation of c-Myc and DNA Replication Pathways with Immunomodulation Toward CD4 and CD8 Cells. Stem Cells 36:903-914
Chien, M.-W., Fu, S.-H., Hsu, C.-Y., Liu, Y.-W., *Sytwu, H.-K. (2018) The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases. International Journal of Molecular Sciences 19(3), 780
Chou, F.-C., Chen, H.-Y., Kuo, C.-C., *Sytwu, H.-K. (2018) Roles of Galectins in Tumors and in Clinical Immunotherapy. International Journal of Molecular Sciences 19(2), 430
Huang, Y.-S., Fu, S.-H., Lu, K.-C., Chen, J.-S., Hsieh, H.-Y., Sytwu, H.-K., Wu, C.-C. (2017) Inhibition of tumor necrosis factor signaling attenuates renal immune cell infiltration in experimental membranous nephropathy. Oncotarget 8:111631-111641
Yang, C.-Y., Hsieh, C.-C., Lin, C.-K., Lin, C.-S., Peng, B., Lin, G.-J., Sytwu, H.-K., Chang, W.-L., Chen, Y.-W. (2017) Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells. BMC Complementary and Alternative Medicine 17:555
Chou, F.-C., Chen, H.-Y., Chen, H.-H., Lin, G.-J., Lin, S.-H., *Sytwu, H.-K. (2017) Differential Modulation of IL-12 Family Cytokines in Autoimmune Islet Graft Rejection. Diabetologia 60:2409-2417
Divakar Kulshrestha, Yeh, L.-T., Chien, M.-W., Chou, F.-C., *Sytwu, H.-K. (2017) Peripheral autoimmune regulator induces exhaustion of CD4+ and CD8+ effector T cells to attenuate autoimmune diabetes in NOD mice. Frontiers in Immunology 8:1128
Fu, S.-H., Yeh, L.-T., Chu, C.-C., Yen, B.-L., *Sytwu, H.-K. (2017) New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function. Journal of Biomedical Science 24:49
Yang, C.-Y., Lin, C.-K., Tsao, C.-H., Hsieh, C.-C., Lin, G.-J., Ma, K.-H., Shieh, Y.-S., Sytwu, H.-K., Chen, Y.-W. (2017) Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget 8:33756-33769
Lee, H.-T., Liu, S.-P., Lin, C.-H., Lee, S.-W., Hsu, C.-Y., Sytwu, H.-K., Hsieh, C.-H., Shyu, W.-C. (2017) A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 7:855-875
Yang, C.-Y., Lin, C.-K., Lin, G.-J., Hsieh, C.-C., Huang, S.-H., Ma, K.-H., Shieh, Y.-S., Sytwu, H.-K., Chen, Y.-W. (2017) Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells. Clinical Oral Investigations 21:419-427
Peng, Y.-J., Wang, C.-Y., Lin, Y.-H., Lin, G.-J., Huang, S.-H., Shyu, J.-F., Sytwu, H.-K., Cheng, C.-P. (2016) Interleukin 26 suppresses receptor activator of nuclear factor κB ligand induced osteoclastogenesis via down-regulation of nuclear factor of activated T-cells, cytoplasmic 1 and nuclear factor κB activity. Rheumatology 55:2074-2083
Liu, Y.-L., Yang, S.-S., Chen, S.-J., Lin, Y.-C., Chu, C.-C., Huang, H.-H., Chang, F.-W., Yu, M.-H., Lin, S.-H., Wu, G.-J., *Sytwu, H.-K. (2016) OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis. Scientific Reports 6：37205
Wang, L.-T., Ting, C.-H., Yen, M.-L., Liu, K.-J., Sytwu, H.-K., Wu, K.-K., Yen, B. L. (2016) Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials. Journal of Biomedical Science 23:76
Liao, A.-H., Lu, Y.-J., Lin, Y.-C., Chen, H.-K., Sytwu, H.-K., Wang, C.-H. (2016) Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth. Theranostics 6:817-827
Chou, F.-C., Kuo, C.-C., Chen, H.-Y., Chen, H.-H., *Sytwu, H.-K. (2016) DNA demethylation of the Tim-3 promoter is critical for its stable expression on T cells. Genes and Immunity 17, 179-186
Lin, G.-J., Huang, Y.-S., Lin, C.-K., Huang, S.-H., Shih, H.-M., Sytwu, H.-K., Chen, Y.-W. (2016) Daxx and TCF4 interaction links to oral squamous cell carcinoma growth by promoting cell cycle progression via induction of cyclin D1 expression. Clinical Oral Investigations 20:533-540
Wu, C.-C., Liu, F.-L., Sytwu, H.-K., Tsai, C.-Y., Chang, D.-M. (2016) CD146+ mesenchymal stem cells display greater therapeutic potential than CD146- cells for treating collagen-induced arthritis in mice. Stem Cell Research Therapy 7:23
Chen, S.-J., Huang, S.-H., Chen, J.-W., Wang, K.-C., Yang, Y.-R., Liu, P.-F., Lin, G.-J., Sytwu, H.-K. (2016) Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis. International Immunopharmacology 31:169-177
Hsu, P.-J., Liu, K.-J., Chao, Y.-Y., Sytwu, H.-K., Yen, B.L. (2015) Assessment of the immunomodulatory properties of human mesenchymal stem cells (MSCs). Journal of Visualized Experiments 106:53265
Ka, S.-M., Lin, J.-C., Lin, T.-J., Liu, F.-C., Chao, L.-K., Ho, C.-L., Yeh, L.-T., Sytwu, H.-K., Hua, K.-F., Chen, A. (2015) Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Research & Therapy 17:331
Chien, M.-W., Lin, M.-H., Huang, S.-H., Fu, S.-H., Hsu, C.-Y., Yen, B.-L., Chen, J.-T., Chang, D.-M., *Sytwu, H.-K. (2015) Glucosamine modulates T cell differentiation through downregulating N-linked glycosylation of CD25. The Journal of Biological Chemistry 290:29329-29344
Chen, H.-C., Lee, J.-T., Shih, C.-P., Chao, T.-T., Sytwu, H.-K., Li, S.-L., Fang, M.-C., Chen, H.-K., Lin, Y.-C., Kuo, C.-Y., Wang, C.-H. (2015) Hypoxia Induces a Metabolic Shift and Enhances the Stemness and Expansion of Cochlear Spiral Ganglion Stem/Progenitor Cells. BioMed Research International 2015;359537.
Wang, W.-B., Yen, M.-L., Liu, K.-J., Hsu, P.-J., Lin, M.-H., Chen, P.-M., Sudhir, P.-R., Chen, C.-H., Chen, C.-H., Sytwu, H.-K., Yen, B.-L. (2015) Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports 5:392-404
Tsai, P.-J., Wang, H.-S., Lin, G.-J., Chou, S.-C., Chu, T.-H., Chuan, W.-T., Lu, Y.-J., Weng, Z.-C., Su, C.-H., Hsieh, P.-S., Sytwu, H.-K., Lin, C.-H., Chen, T.-H., Shyu, J.-F. (2015) Undifferentiated Wharton’s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T Cell-Mediated Autoimmunity in Non-Obese Diabetic Mice. Cell Transplant 24:1555-1570
Tseng, F.-J., Chia, W.-T., Wang, C.-H., Shyu, J.-F., Gou, G.-H., Shui, H.-A., Sytwu, H.-K., Pan, R.-Y., Weng, C.-F. (2015) Carbon Monoxide Inhibits Receptor Activator of NF-κB (RANKL)-Induced Osteoclastogenesis. Cellular Physiology and Biochemistry 36:1250-1258
Wu, C.-C., Huang, Y.-S., Chen, J.-S., Huang, C.-F., Su, S.-L., Lu, K.-C., Lin, Y.-F., Chu, P., Lin, S.-H., Sytwu, H.-K. (2015) Resveratrol Ameliorates Renal Damage, Increases Expression of Heme Oxygenase-1, and Has Anti-Complement, Anti-Oxidative, and Anti-Apoptotic Effects in a Murine Model of Membranous Nephropathy. PLoS One 2015 May 8;10(5):e0125726
Fu, S.-H., Lin, M.-H., Yeh, L.-T., Wang, Y.-L., Chien, M.-W., Lin, S.-H., Chang, D.-M., *Sytwu, H.-K. (2015) Targeting tumor necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response. Gut 64:765-775.
Hueng, D.-Y., Sytwu, H.-K. (2015) Letter to the Editor: Fusion antibody Fc-endostatin. Journal of Neurosurgery 122:1249
Chuang, Y.-P., Peng, Z.-R., Tseng, S.-F., Lin, Y.-C., Sytwu, H.-K., Hsieh, Y.-C. (2015) The impact of glpQ2 gene on virulence in a Streptococcus pneumoniae serotype 19AST320 strain. Infection and Immunity 83:682-692
Cheng, C.-J., Sung, C.-C., Wu, S.-T., Lin, Y.-C., Sytwu, H.-K., Huang, C.-L., Lin, S.-H. (2015) Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance. The Journal of Clinical Endocrinology & Metabolism 100:E155-163
Li, C.-H., Lin, M.-H., Chu, S.-H., Tu, P.-H., Fang, C.-C., Yen, C.-H., Liang, P.-I., Huang, J.-C., Su, Y.-C., Sytwu, H.-K., Chen, Y.-M. (2014) Role of glycine N-methyltransferase in the regulation of T cell responses in experimental autoimmune encephalomyelitis. Molecular Medicine 20:684-696
Yeh, L.-T., Chuang, Y.-P., Chen, S.-J., Chu, C.-C., *Sytwu, H.-K. (2014) Diabetic animal models with infectious diseases: focus on the dysfunction of immune system. Journal of Diabetes & Metabolism 2014. 5:8
Lin, G.-J., Sytwu, H.-K., Yu, J.-C., Chen, Y.-W., Kuo, Y.-L., Yu, C.-C., Chang, H.-M., Chan, D.-C., Huang, S.-H. (2014) Dimethyl sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells. Toxicology and applied pharmacology 282:207-214
Chen, C.-L., Liu, F.-L., Lee, C.-C., Chen, T.-C., Ahmed Ali AA, Sytwu, H.-K., Chang, D.-M., Huang, H.-S. (2014) Modified Salicylanilide and 3-Phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione Derivatives as novel inhibitors of osteoclast differentiation and bone resorption. Journal of Medicinal Chemistry 57:8072-8085
Huang, Y.-S., Hsieh, H.-Y. , Shih, H.-M., Sytwu, H.-K., Wu, C.-C. (2014) Urinary Xist is a potential biomarker for membranous nephropathy. Biochemical and Biophysical Research Communications 452:415-421
Chen, Y.-W., Huang, H.-S., Shieh, Y.-S., Ma, K.-H., Huang, S.-H., Hueng, D.-Y., Sytwu, H.-K., Lin, G.-J. (2014) A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo. PLoS One 2014;9(8):e104703
Chen, P.-I., Liu, K.-J., Hsu, P.-J., Wei, C.-F., Bai, C.-H., Ho, L.-J., Sytwu, H.-K., Yen, B.L. (2014) Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2. Journal of Leukocyte Biology 96:295-303
Tseng, F.-J., Chia, W.-T., Shyu, J.-F., Gou, G.-H., Sytwu, H.-K., Hsia, C.-W., Tseng, M.-J., Pan, R.-Y. (2014) Interactomics profiling of the negative regulatory function of carbon monoxide on RANKL-treated RAW 264.7 cells during osteoclastogenesis. BMC Systems Biology 8:57
Hueng, D.-Y., Lin, G.-J., Sytwu, H.-K. (2014) Letter to the Editor: Glioma immunoenvironment. Journal of Neurosurgery 120:1012-1013
Chen, Y.-W., Lin, G.-J., Hueng, D.-Y., Huang, S.-H., Chia, W.-T., Shieh, Y.-S., Ma, K.-H., Sytwu, H.-K. (2014) Enhanced Anti-Tumor Activity of Triptolide in Combination with Irradiation for the Treatment of Oral Cancer. Planta Medica 80:255-261
Lin, M.-H., Yeh, L.-T., Chen, S.-J., Chiou, H.-Y., *Chu, C.-C., Yen, B.L., Lin, K.-I., Chang, D.-M., *Sytwu, H.-K. (2014) T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells. Clinical Immunology 151:101–113
Hueng, D.-Y., Sytwu, H.-K. (2014) Letter to the editor: Vestibular schwannoma growth and hearing loss. Journal of Neurosurgery 120:786
Hueng, D.-Y., Li, Y.-F., Sytwu, H.-K. (2014) Letter to the editor: Atypical meningiomas. Journal of Neurosurgery 120:781
Feng, S.-W., Sytwu, H.-K., Hueng, D.-Y. (2014) Letter to the editor: Cell transplantation. Journal of Neurosurgery 120:574
Hueng, D.-Y., Sytwu, H.-K. (2014) Letter to the editor: Blood-brain barrier. Journal of Neurosurgery 120:290-291
Cheng, C.-H., Hong, C.-W., Yang, C.-H., Wu, Y.-J., Lee, C.-H., Sytwu, H.-K., Hueng, D.-Y. (2013) Letter to the editor: Glioblastoma. Journal of Neurosurgery 119:1641
Chou, F.-C., Kuo, C.-C., Wang, Y.-L., Lin, M.-H., Yen, B.L., *Sytwu, H.-K. (2013) Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses. Cell Transplantation 22:2135-2145
Yang, S.-S., Fang, Y.-W., Tseng, M.-H., Chu, P.-Y., Yu, I.-S., Wu, H.-C., Lin, S.-W., Chau, T., Uchida S, Sasaki S, Lin, Y.-F., Sytwu, H.-K., Lin, S.-H. (2013) Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo. J Am Soc Nephrol 24:1587-1597
Tsai, W.-C., Chen, Y., Huang, L.-C., Lee, H.-S., Ma, H.-I., Huang, S.-M., Sytwu, H.-K., Hueng, D.-Y. (2013) EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas. Journal of Neuro-oncology 114:281-290
Yen, B.L., Yen, M.-L., Hsu, P.-J., Liu, K.-J., Wang, C.-J., Bai, C.-H., Sytwu, H.-K. (2013) Multipotent Human Mesenchymal Stromal Cells Mediate Expansion of Myeloid-Derived Suppressor Cells via Hepatocyte Growth Factor/c-Met and STAT3. Stem Cell Reports 1:139-151
Yeh, L.-T., Maiw, S.-C., Lin, M.-H., Chou, F.-C., Shieh, S.-J., Chuang, Y.-P., Lin, S.-H., Chang, D.-M., *Sytwu, H.-K. (2013) Different modulation of Ptpn22 on effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic non-obese diabetic mice. Journal of Immunology 191:594-607
Wang, K.-C., Tsai, C.-P., Lee, C.-L., Chen, S.-Y., Lin, G.-J., Yen, M.-H., Sytwu, H.-K., Chen, S.-J. (2013) Alpha lipoic acid enhances endogenous peroxisome proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis. Clinical Science 125:329-340
Lin, G.-J., Huang, S.-H., Chen, S.-J., Wang, C.-H., Chang, D.-M., *Sytwu, H.-K. (2013) Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases. International Journal of Molecular Sciences 14:11742-11766.
Hueng, D.-Y., Ma, H.-I., Sytwu, H.-K. (2013) Letter to the Editor: Chordoma. Journal of Neurosurgery: Spine 18:533-534
Chao, T.-T., Wang, C.-H., Chen, H.-C., Shih, C.-P., Sytwu, H.-K., Huang, K.-L., Chen, S.-Y. (2013) Adherent culture conditions enrich the side population obtained from the cochlear modiolus-derived stem/progenitor cells. International Journal of Pediatric Otorhinolaryngology 77:779-784
Lee, C.-H., Chang, W.-C., Yeh, C.-C., Jiang, P.-J., Sytwu, H.-K., Hueng, D.-Y. (2013) Letter to the Editor: Chordoma stem cells. Journal of Neurosurgery 118:913-914.
Chiu, S.-H., Wang, I.-D., Sytwu, H.-K., Hueng, D.-Y. (2013) Letter to the Editor: Atypical meningioma. Journal of Neurosurgery 118:912-913
Cheng, C.-P., Sheu, M.-J., Sytwu, H.-K., Chang, D.-M. (2013) Decoy receptor 3 suppresses RANKL-induced osteoclastogenesis via down-regulating NFATc1 and enhancing cell apoptosis. Rheumatology 52:609-622
Huang, S.-H., Lin, G.-J., Chu, C.-H., Yu, J.-C., Chen, T.-W., Chen, Y.-W., Chien, M.-W., Chu, C.-C., *Sytwu, H.-K. (2013) Triptolide ameliorates autoimmune diabetes and prolongs islet graft survival in nonobese diabetic mice. Pancreas 42:442-451
Huang, S.-H., Lin, G.-J., Chien, M.-W., Chu, C.-H., Yu, J.-C., Chen, T.-W., Hueng, D.-Y., Liu, Y.-L., *Sytwu, H.-K. (2013) Adverse Effect on Syngeneic Islet Transplantation by Transgenic Co-expression of Decoy Receptor 3 and Heme Oxygenase-1 in the Islet of NOD Mice. Transplantation Proceedings 45:580-584
Chou, F.-C., Chen, H.-Y., Chen, S.-J., Fang, M.-C., *Sytwu, H.-K. (2013) Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes. Journal of Diabetes Research 2013:138412
Shih, C.-P., Chen, H.-C., Chen, H.-K., Chiang, M.-C., Sytwu, H.-K., Lin, Y.-C., Li, S.-L., Shih, Y.-F., Liao, A.-H., Wang, C.-H. (2013) Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane. Journal of Controlled Release 167:167-174
Huang, Y.-S., Li, I.-H., Chueh, S.-H., Hueng, D.-Y., Tai, M.-C., Liang, C.-M., Lien, S.-B., Sytwu, H.-K., Ma, K.-H. (2013) Mesenchymal stem cells from rat olfactory bulbs can differentiate into cells with cardiomyocyte characteristics. Journal of Tissue Engineering and Regenerative Medicine 9:E191-201
Lin, M.-H., Chou, F.-C., Yeh, L.-T., Fu, S.-H., Chiou, H.-Y., Lin, K.-I., Chang, D.-M., *Sytwu, H.-K. (2013) B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia 56:136-146
Ou, C.-C., Chen, Y.-W., Hus, S.-C., Sytwu, H.-K., Loh, S.-H., Li, J.-W. Liu, J.- Y. (2013) Triptolide transcriptionally represses HER2 in ovarian cancer cells by targeting NF-kB. Evidence-Based Complementary and Alternative Medicine 2012:350239.
Hueng, D.-Y., Sytwu, H.-K. (2012) Letter to the Editor: Syringomyelia. Journal of Neurosurgery: Spine 18:202
Dai, M.-S., Vassaux, G., Xu, M., You, R.-I., Hsieh, Y.-F., Ouisse, L.-H., Lo, K.-Y., Sytwu, H.-K., Chao, T.-Y. (2012) Early Treg suppression by a listeriolysin-O-expressing E. coli vaccine in heterologous prime-boost vaccination against cancer. Vaccine 30:6903-6911
Hou, H.-S., Liao, C.-L., Sytwu, H.-K., Liao, N.-S., Huang, T.-Y., Hsieh, T.-Y., Chu, H.-C. (2012) Deficiency of Interleukin-15 Enhances Susceptibility to Acetaminophen-Induced Liver Injury in Mice. PLoS One 2012;7(9):e44880
Hueng, D.-Y., Tsao, C.-H., Sytwu, H.-K., Chen, Y.-W. (2012) Letter to the editor: Brain Biopsy. Journal of Neurosurger. 117:384
Hueng, D.-Y., Liang, C.-M., Sytwu, H.-K., Ma, S.-I. (2012) Letter to the editor: Tumor model. Journal of Neurosurgery 117:383
Yo, Y.-T., Lin, Y.-W., Wang, Y.-C., Balch C, Huang, R.-L., Chan, M.-W., Sytwu, H.-K., Chen, C.-K., Chang, C.-C., Nephew KP, Huang, T., Yu, M.-H., Lai, H.-C. (2012) Growth inhibition of ovarian tumor-initiating cells by niclosamide. Molecular Cancer Therapeutics 11:1703-1712
Lai, C.-Y., Lin, S.-Y., Wu, C.-K., Yeh, L.-T., Sytwu, H.-K., Miaw, S.-C. (2012) Tyrosine Phosphorylation of c-Maf Enhances the Expression of IL-4 Gene. Journal of Immunology 189:1545-1550
Chuang, Y.-P., Wang, C.-H., Wang, N.-C., Chang, D.-M., *Sytwu, H.-K. (2012) Modulatory function of invariant natural killer T cells in systemic lupus erythematosus. Clinical and Developmental Immunology 2012:478429
Chou, F.-C., Huang, S.-H., *Sytwu, H.-K. (2012) Genetically Engineered Islets and Alternative Sources of Insulin-producing Cells for Treating Autoimmune Diabetes: Quo Vadis? International Journal of Endocrinology 2012:296485
Chen, S.-J., Wang, Y.-L., Fan, H.-C., Lo, W.-T., Wang, C.-C., *Sytwu, H.-K. (2012) Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis. Clinical and Developmental Immunology 2012:970789
Chen, S.-J., Liu, Y.-L., *Sytwu, H.-K. (2012) Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation. Clinical and Developmental Immunology 2012:258391
Hueng, D.-Y., Sytwu, H.-K. (2012) Letter to the editor: Brain edema. Journal of Neurosurgery 116:688-689
Yang, C.-T., Fu, B.-S., Wang, H.-Y., Sytwu, H.-K., Hueng, D.-Y. (2012) Letter to the editor: Glioma spheroids. Journal of Neurosurgery 116:691-693
Wu, C.-C., Lu, K.-C., Lin, G.-J., Hsieh, H.-Y., Chu, P., Lin, S.-H., Sytwu. H.-K. (2012) Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy. Journal of Pineal Research 52:460-469
Wu, C.-C., Sytwu, H.-K., Lin, Y.-F. (2012) Cytokines in Diabetic Nephropathy. Advances in Clinical Chemistry 56:55-74
Wu, C.-C., Lu, K.-C., Lin, Y.-F., Chen, J.-S., Huang, C.-F., Chen, C.-C., Lin, S.-H., Chu, P., Sytwu, H.-K. (2012) Pathogenic Role of Effector Cells and Immunoglobulins in Cationic Bovine Serum Albumin-Induced Membranous Nephropathy. Journal of Clinical Immunology 32:138-149
Wu, C.-C., Wu, T.-C., Liu, F.-L., Sytwu, H.-K., Chang, D.-M. (2012) TNF-α inhibitor reverse the effects of human umbilical cord-derived stem cells on experimental arthritis by increasing immunosuppression. Cellular Immunology 273:30-40
Lin, S.-H., Yu, I.-S., Jiang, S.-T., Lin, S.-W., Chu, P., Chen, A., Sytwu, H.-K., Sohara E, Uchida S, Sasaki S, Yang, S.-S. (2011) Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 108:17538-17543
Ka, S.-M., Hsieh, T.-T., Lin, S.-H., Yang, S.-S., Wu, C.-C., Sytwu, H.-K., Chen, A. (2011) Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. American Journal of Physiology - Renal Physiology 301:1218-1230
Cheng, C.-P., Sytwu, H.-K., Chang, D.-M. (2011) Decoy Receptor 3 Attenuates Collagen-induced Arthritis by Modulating T Cell Activation and B Cell Expansion. Journal of Rheumatology 38:2522-2535
Wu, C.-C., Sytwu, H.-K., Lu, K.-C., Lin, Y.-F. (2011) Role of T Cells in Type 2 Diabetic Nephropathy. Experimental Diabetes Research 2011:514738
Chen, P.-M., Yen, M.-L., Liu, K.-J., Sytwu, H.-K., Yen, B.L. (2011) Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. Journal of Biomedical Science 18:49
Wang, Y.-L., Chou, F.-C., Chen, S.-J., Lin, S.-H., Chang, D.-M., *Sytwu, H.-K. (2011) Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases – an unrevealed role in downregulation of Th17 cells. Journal of Autoimmunity 37:160-170
Liu, K.-J., Wang, C.-J., Chang, C.-J., Hu, H.-I., Hsu, P.-J., Wu, Y.-C., Bai, C.-H., Sytwu, H.-K., Yen, B.L. (2011) Surface expression of HLA-G is involved in mediating immunomodulatory effects of placenta-derived multipotent cells (PDMCs) towards natural killer lymphocytes. Cell Transplantation 20:1721-1730
Hueng, D.-Y., Sytwu, H.-K., Huang, S.-M., Chang, C., Ma, H.-I. (2011) Isolation and characterization of tumor stem-like cells from human meningiomas. Journal of Neuro-oncology 104:45-53
Hueng, D.-Y., Lin, G.-J., Huang, S.-H., Liu, L.-W., Ju, D.-T., Chen, Y.-W., Sytwu, H.-K., Chang, C., Huang, S.-M., Yeh, Y.-S., Lee, H.-M., Ma, H.-I. (2011) Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. Journal of Neuro-oncology 104:21-31
Lin, G.-J., Huang, S.-W., Chen, Y.-W., Hueng, D.-Y., Chia, W.-T., Chien, M.-W., Yen, B.L., *Sytwu, H.-K. (2011) Transgenic expression of murine chemokine decoy receptor D6 by islets reveals the role of inflammatory CC chemokines in the development of autoimmune diabetes in NOD mice. Diabetologia 54:1777-1787
Hueng, D.-Y., Ma, H.-I., Sytwu, H.-K., Liu, M.-Y. (2011) Letters to the editor: Temozolomide and pituitary adenoma. Journal of Neurosurgery 114:1820-1821
Chuang, Y.-P. Lin, Y.-C., *Sytwu, H.-K. (2011) α-Galactosylceramide ameliorates autoimmune diabetes in non-obese diabetic mice through a suppressive effect mediated by CD8+ T cells. Immunology Letters 138:54-62
Lo, Y.-F., Nozu K, Iijima K, Morishita T, Huang, C.-C., Yang, S.-S., Sytwu, H.-K., Fang, Y.-W., Tseng, M.-H., Lin, S.-H. (2011) Recurrent Deep Intronic Mutations in the SLC12A3 Gene Responsible for Gitelman's Syndrome. Clin J Am Soc Nephrol 6:630-639
Ma, H.-I., Chiou, S.-H., Hueng, D.-Y., Tai, L.-K., Huang, P.-I., Kao, C.-L., Chen, Y.-W., Sytwu H.-K. (2011) Celecoxib and Radioresistant Glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Journal of Neurosurgery 114:651-662
Wu, C.-C., Chen, J.-S., Huang, C.-F., Chen, C.-C., Lu, K.-C., Chu, P., Sytwu, H.-K., Lin, Y.-F. (2011) Approaching biomarkers of membranous nephropathy from murine model to human disease. Journal of Biomedicine and Biotechnology 2011:581928
Shyu, J.-F., Wang, H.-S., Shyr, Y.-M., Wang, S.-E., Chen, C.-H., Tan, J.-S., Lin, M.-F., Hsieh, P.-S., Sytwu, H.-K., Chen, T.-H. (2010) Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue. The Journal of Endocrinology 208:233-244
Chen, H.-C., Sytwu, H.-K., Chang, J.-L., Wang, H.-W., Chen, H.-K., Kang, B.-H., Liu, D.-W., Chen, C.-H., Chao, T.-T., Wang, C.-H. (2010) Hypoxia enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of hypoxia-inducible factor-1alpha. Hearing Research 275:43-52.
Yang, S.-S., Lo, Y.-F., Yu, I.-S., Lin, S.-W., Chang, T.-H., Hsu, Y.-J., Chao, T.-K., Sytwu, H.-K., Shinichi Uchida, Sei Sasaki, Lin, S.-H. (2010) Generation and analysis of the thiazide-sensitive Na+-Cl- cotransporter S707X knockin mice as a model of Gitelman’s syndrome. Human Mutation 31:1304-1315
Yang, S.-S., Lo, Y.-F., Wu, C.-C., Lin, S.-W., Yeh, C.-J., Chu, P., Sytwu, H.-K., Shinichi Uchida, Sei Sasaki, Lin, S.-H. (2010) SPAK knockout mice manifest Gitelman’s syndrome and impaired vasoconstriction. Journal of the Amercian Society of Nephrology 21:1868-1877
Chia, W.-T., Pan, R.-Y., Tseng, F.-J., Chen, Y.-W., Feng, C.-K., Lin, G.-J., Liu, H.-H., Lee, H.-S., Chang, D.-M., *Sytwu, H.-K. (2010) Experimental osteoarthritis induced by surgical realignment of the patella in BALB/c mice. The Journal of Bone & Joint Surgery-BritishVolume 92-B(12):1710-1716
Chen, S.-J. , Wang, Y.-L., Lo, W.-T., Wu, C.-C., Hsieh, C.-W. , Huang, C.-F., Lan, Y.-H., Wang, C.-C. , Chang, D.-M., Sytwu, H.-K. (2010) Erythropoietin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis. Clinical and Experimental Immunology 162:210-223
Chen, H.-C., Ma, H.-I., Sytwu, H.-K., Wang, H.-W., Chen, C.-C., Liu, S.-C., Chen, C.-H., Chen, H.-K., Wang, C.-H. (2010) Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. Journal of Neuroscience Research 88:3308-3318
Wang, Y.-L., Chou, F.-C., Sung, H.-H., Fan, P.-L., Hsueh, C.-W., Lin, W.-C., Chen, S.-J., Lin, W.-W., *Sytwu, H.-K. (2010) Decoy receptor 3 protects non-obese diabetic mice from autoimmune diabetes by regulating dendritic cell maturation and function. Molecular Immunology 47:2552-2562
Huang, S.-H., Chu, C.-H., Yu, J.-C., Chuang, W.-C., Lin, G.-J., Chen, P.-L., Chou, F.-C., Chau, L.-Y., *Sytwu, H.-K. (2010) Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation. Diabetologia 53:2389–2400
Tseng, K.-Y., Chung, M.-H., Sytwu H.-K., Lee, H.-M., Chen, K.-Y., Chang, C., Lin, C.-K., Yen, C.-H., Chen, J.-H., Lin, G.-J., Ma, H.-I., Yeh, Y.-S., Ju, D.-T., Liu, M.-Y., Hueng, D.-Y. (2010) Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. Journal of Neuro-oncology 100: 217-223
Chen, Y.-W., Lin, G.-J., Chuang, Y.-P., Chia, W.-T., Hueng, D.-Y., Lin, C.-K., Nieh, S., *Sytwu, H.-K. (2010) Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anti-Cancer Drugs 21:502-513
Wu, C.-C., Chen, J.-S., Lu, K.-C., Chen, C.-C., Lin, S.-H., Chu, P., Sytwu, H.-K., Lin, Y.-F.(2010) Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy. Clinica Chimica Acta 411:700-704
Chia, W.-T., Lin, C.-F., Yeh, L.-T., Chang, D.-M., *Sytwu, H.-K. (2010) A noncontact footpad thickness assay to evaluate rheumatoid disease. Rheumatology International 30:547-550
Liu, F.-L., Lin, L.-H., Sytwu, H.-K., Chang, D.-M. (2010) GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. Experimental and molecular pathology 88:163-170
Chen, S.-J., Wang, Y.-L., Wu, S.-F., Wang, C.-C., Kao, J.-H., Tao, P.-L., Wu, C.-C., Chang, D.-M., *Sytwu, H.-K. (2009) Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells. Molecular Immunology 47:567-574
Lin, G.-J., Huang, S.-H., Chen, Y.-W., Hueng, D.-Y., Chien, M.-W., Chia, W.-T., Chang, D.-M., *Sytwu, H.-K. (2009) Melatonin prolongs islet graft survival in diabetic NOD mice. Journal of Pineal Research 47:284-292
Shieh, S.-J., Chou, F.-C., Yu, P.-N., Lin, W.-C., Chang, D.-M., Roffler, S., *Sytwu, H.-K. (2009) Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects NOD mice from autoimmune diabetes. Journal of Immunology 183:2277-2285
Chou, F.-C., *Sytwu, H.-K. (2009) Overexpression of thioredoxin in islets by lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice. Journal of Biomedical Science 16:71
Chou, F.-C., Shieh, S.-J., *Sytwu, H.-K. (2009) Attenuation of Th1 cell immune response through galectin-9-TIM-3 interactions inhibits autoimmune diabetes in NOD mice. European Journal of Immunology 39:2403-2411
Chen, Y.-W., Lin, G.-J., Chia, W.-T., Lin, C.-K., Chuang, Y.-P., *Sytwu, H.-K. (2009) Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncology 45:562-568
Chia, W.-T., Yeh, L.-T., Lee, H.-S. Chang, D.-M. , *Sytwu, H.-K. (2009) IL-1b in irrigation fluid and mRNA expression in synovial tissue of the knee joint as therapeutic markers of inflammation in collagen antibody-induced arthritis. Disease Markers 26:1-7
Dai, N.-T., Yeh, M.-K., Chiang, C.-H., Chen, K.-C., Liu, T.-H., Feng, A.-C., Chao, L.-L., Shih, C.-M., Sytwu, H.-K., Chen, S.-L., Chen, T.-M., Adams EF. (2009) Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer. Biochemical and Biophysical Research Communications 386:21-25
Chung, M.-T., Lai, H.-C., Sytwu, H.-K., Yan, M.-D., Shih, Y.-L., Chang, C.-C., Yu, M.-H, Liu, H.-S., Chu, D.-W., Lin, Y.-W. (2009) SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecologic Oncology 112:646-653
Chung, M.-T., Sytwu, H.-K., Yan, M.-D., Shih, Y.-L., Chang, C.-C., Yu, M.-H., Chu, T.-Y., Lai, H.-C., Lin, Y.-W. (2009) Promoter methylation of SFRPs gene family in cervical cancer. Gynecologic Oncology 112:301-306
Hsu, Y.-J., Yang, S.-S., Chu, N.-F., Sytwu, H.-K., Cheng, C.-J., Lin, S.-H. (2009) Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure. Nephrol Dial Transplant 24:1170-1175
Wang, C.-J., Chou, F.-C., Chu, C,-H., Wu, J.-C., Lin, S.-H., Chang, D.-M., *Sytwu, H.-K. (2008) Protective role of programmed death 1 ligand 1 in nonobese diabetic mice: The paradox in transgenic models. Diabetes 57:1861-1869
Chuang, Y.-P., Chu, C.-H., *Sytwu, H.-K. (2008) Genetic manipulation of islet cells in autoimmune diabetes: from bench to bedside. Frontiers in Bioscience-Landmark 13:6155-6169
Chia, W.-T., Chen, Y.-W., Cheng, L.-Y., Lee, H.-S., Chang, D.-M., *Sytwu, H.-K. (2008) MMP-9 mRNA as a therapeutic marker in acute and chronic stages of arthritis induced by type II collagen antibody. Journal of the Formosan Medical Association 107:245-252
Ho, T.-C., Yang, Y.-C., Chen, S.-L., Kuo, P.-C., Sytwu, H.-K., Cheng, H.-C., Tsao, Y.-P. (2008) Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma. Molecular Immunology 45:898-909
Wu, C.-C., Lu, K.-C., Chen, J.-S., Hsieh, H.-Y., Lin, S.-H., Chu, P., Wang, J.-Y., *Sytwu, H.-K. *Lin, Y.-F. (2008) HO-1 induction ameliorates experimental murine membranous nephropathy: anti-oxidative, anti-apoptotic, and immunomodulatory effects. Nephrol Dial Transplant 23:3082-3090
Wu, C.-C., Chen, J.-S., Lin, S.-H., Chen, A., *Sytwu, H.-K. *Lin, Y.-F. (2008) Experimental model of membranous nephropathy in mice: Sequence of histologic and biochemical events. Laboratory Animals 42:350-359
Wu, C.-C., Chen, J.-S., Chen, S.-J., Lin, S.-H., Chen, A., Chang, L.-C., *Sytwu, H.-K. *Lin, Y.-F. (2007) Kinetics of adaptive immunity to cationic bovine serum albumin induced membranous nephropathy: Evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines. Kidney International 72:831-840
Ka, S.-M., Sytwu, H.-K., Chang, D.-M., Hsieh, S.-L., Tsai, P.-Y., Chen, A. (2007) Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice. Journal of the American Society of Nephrology 18:2473-2485
Liu, F.-L., Chen, C.-H., Chu, S.-J., Chen, J.-H., Lai, J.-H., Sytwu, H.-K., Chang, D.-M. (2007) Interleukin (IL)-23 p19 expression induced by IL-1b in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kB and AP-1 dependent pathway. Rheumatology 46:1266-1273
Chen, Y.-C., Chen, S.-Y., Ho, P.-S., Lin, C.-H., Cheng, Y.-Y., Wang, J.-K., *Sytwu, H.-K. (2007) Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. Leukemia Research 31:805-815
Chao, T.-K., Rifai, A., Ka, S.-M., Yang, S.-M., Shui, H.-A., Lin, Y.-F., Sytwu, H.-K., Lee, W.-H., Kung, J.T., Chen, A. (2006) The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney International 70:283-297
Chen, S.-J., Liao, C.-L., Hsieh, S.-L., Chu, M.-L., Wang, C.-J., Hung, J.-T., *Sytwu, H.-K., *Wang, C.-C. (2006) Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae. Clinical Science 111:253-263
Chen, S.-J., Liao, C.-L., Hsieh, S.-L., Chu, M.-L., Fang, M.-C., *Sytwu, H.-K., *Wang, C.-C. (2006) Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: Evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines. Immunology Letters 105:6-15
Hung, J.-T., Liao, J.-H., Lin, Y.-C., Chang, H.-Y., Wu, S.-F., Chang, T.-H., Kung, J., Hsieh, S.-L., McDevitt, H., *Sytwu, H.-K. (2005) Immunopathogenic role of Th1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic (NOD) model. Journal of Autoimmunity 25:181-192
Cheng, C.-P., Loh, Y.-X., Lin, C.-I., Lai, Y.-J., Chen, Y.-C., Sytwu, H.-K., Gustafson-Wagner, E.A., and Lin, J.J.-C. (2005) Electrophysiological characteristics of ventricular myocytes of Xina-deficient mice. Advances in Heart Disease 25-29
Dai, N.-T., Yeh, M.-K., Liu, D., Adams, E.F., Chiang C.-H, Yen, C.-Y., Shih, C.-M., Sytwu, H.-K., Chen, T.-M., Wang, H.-J., Williamson, M.R., Coombes, A.G.A. (2005) A co-cultured skin model based on cell support membranes. Biochemical and Biophysical Research Communications 329:905-908
Chu, H.-C., Lin, Y.-L., Sytwu, H.-K., Lin, S.-H., Liao, C.-L., and Chao, Y.-C. (2005) Effects of minocycline on Fas-mediated fulminant hepatitis in mice. British Journal of Pharmacology 144:275-282
Sung, H.-H., Juang, J.-H., Lin, Y.-C., Kuo, C.-H., Hung, J.-T., Chen, A., Chang, D.-M., Chang, S.-Y., Hsieh, S.-L., *Sytwu, H.-K. (2004) Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in non-obese diabetic mice. Journal of Experimental Medicine 199:1143-1151
Wang, C.-J., *Sytwu, H.-K. (2004) Application of transgenic and gene knockout mice for the study on immunological diseases. Formosan Journal of Medicine 8:207-213
Sung, H.-H., Shen, K.-L., and *Sytwu, H.-K. (2004) Immunomodulation by decoy receptor 3: lessons from tumors to therapeutic approaches. Journal of Medical Sciences 24:301-306
Chang, S.-L., Chang , L.-T., Chiang, Y.-M., Hsieh, R.-H., Tzeng, C.-R., Wu, T.-K., Sytwu, H.-K., Shyur, L.-F., Yang, W.-C. (2004) Polyacetylenic compound and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. Planta Medica 70:1045-1051
Wu, S.-F., Liu, T.-M., Lin, Y.-C., *Sytwu, H.-K., Juan, H.-F., Chen, S.-T., Shen, K.-L., Hsi, S.-C., and Hsieh, S.-L. (2004) Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic mice: from regulatory mechanism to clinical implication. Journal of Leukocyte Biology 75:293-306
*Sytwu, H.-K., Lin, W.-D., Roffler, S. R., Hung, J.-T., Sung, H.-H., Wang, C.-H., Cheng, T.-L., Tsou, S.-C., Hsi, S.-C., Shen, K.-L. (2003) Anti-4-1BB-based immunotherapy for autoimmune diabetes: Lessons from a transgenic non-obese diabetic (NOD) model. Journal of Autoimmunity 21:247-254
Chen, S.-Y., Chen, Y.-C., Wang, J.-K., Hsu, H.-P., Ho, P.-S., Chen, Y.-C., and *Sytwu, H.-K. (2003) Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZBXNZW) F1 mice. Clinical Immunology 108:103-110
Wu, S.-F., Liao, C.-L., Lin, Y.-L., Yeh, C.-T., Chen, L.-K., Huang, Y.-F., Chou, H.-Y., Huang, J.-L., Shaio, M.-F., and *Sytwu, H.-K. (2003) Evaluation of protective efficacy and immune mechanisms of using a nonstructural protein NS1 in DNA vaccine against dengue 2 virus in mice. Vaccine 21:3919-3929
Lai, H.-J., Sytwu, H.-K., Sun, C.-A., Yu, M.-H., Yu, C.-P., Liu, H.-S., Chang, C.-C., and Chu, T.-Y. (2003) Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis. International Journal of Cancer 103, 221-225
Tang, I.-K., Ji, D.-D., Chou, C.-F., Lin, H.-C., Liao, C.-L., Sytwu, H.-K. , Wang, J.-J. Liu, Y.-T. (2002). Characterization of a highly attenuated Salmonella enterica serovar Typhimurium mutant strain. J Microbiol Immunol Infect 35: 229-235
Hsieh, S.-L., Chen, N.-J., Tarbell, K., Liao, N.-S, Lai, Y.-G., Lee, K.-M., Lee, K.-H., Wu, S.-C., Sytwu, H.-K., Han, S.-H., McDevitt, H. (2000). Transgenic mice expressing surface markers for INF-g and IL-4 producing cells. Molecular Immunology 37:281-293
Liu, D.-W., Tsao, Y.-P., Kung, J.T., Ding, Y.-A., Sytwu, H.-K., Xiao, X., and Chen, S.-L. (2000) Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. Journal of Virology 74:2888-2894
Liu, Y.-T., Chen, C.-G., Chao, D.-C., Lee, F., Liao, C.-L., Sytwu, H.-K. , Chou, C.-F., and Ji, D.-D. (1999) Sequence analysis of the Gluconobacter oxydans RecA protein and construction of a recA-deficient mutant. Can J of Microbiol 45: 347-351
Chao, C.-C., Sytwu, H.-K., Chen, E. L., Toma, J., and McDevitt, H. O. (1999) The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci USA 96: 9299-9304
Singer, S., Tisch, R., Yang, X.-D., Sytwu, H.-K., Liblau, R., and McDevitt, H. O. (1998) Prevention of diabetes in NOD mice by a mutated I-Ab transgene. Diabetes 47:1570-1577
Michie, A. S., Sytwu, H.-K., McDevitt, H. O., and Yang, X.-D. (1998) The roles of a-4 integrins in the development of insulin-dependent diabetes mellitus. Current topics in microbiology and immunology 231, 65-83
Yang, X.-D., Sytwu, H.-K., McDevitt, H. O., and Michie, A. S. (1997) Involvement of b7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in nonobese diabetic mice. Diabetes 46, 1542-1547
Sytwu, H.-K., Liblau, R., and McDevitt, H. O. (1996) The roles of Fas/APO-1 (CD95) and tumor necrosis factor (TNF) in antigen induced programmed cell death in T cell receptor transgenic mice. Immunity, Cell Press, 5, 17-30
Sytwu, H.-K., Sheu, W.-J., Shih, J.-M., and Chen, S.-L. (1992) Detection and analysis of human papilloma virus type 1 infection of skin warts from a dermatology clinic in Taiwan by Southern hybridization. Chinese J Microbiol Immunol 24:200-214
Lee, S.-H., Sytwu, H.-K., Liao, C.-L., Lee, J.-H., and Liu, Y.-T. (1989) The β-lactam antibiotic resistance of E. coli isolated from clinic. J. Med. Sci. 10:17-24
Chapter Book
Yen, B.-L., Liu, K.-J., Yen, M.-L., Sytwu, H.-K. (2016) The modulatory effects of MSCs on the adaptive immune system. The Biology & Therapeutic Applications of Mesenchymal Cells, 490-495, editor Atkinson K, Wiley & Sons, Inc., Hoboken, NJ, USA (http://as.wiley.com/WileyCDA/WileyTitle/productCd-1118907515.html)
21 Nov. 2016
Shyi-Jou, Chen, Hueng-Chuen, Fan, *Huey-Kang, Sytwu. (2012) Immunomodulation of Potent Antioxidant Agents: Preclinical Study to Clinical Application in Multiple Sclerosis. p139-162, Experimental Autoimmune Encephalomyelitis. Edited by Robert Weissert, INTECH BOOK (www.intechopen.com)
Chia-Chao Wu, Kuo-Cheng Lu, Jin-Shuen Chen, Yuh-Feng Lin and *Huey-Kang Sytwu. (2011) Immunopathogenic Mechanism and Therapeutic Intervention in an Experimental Murine Model of Membranous Nephropathy. p87-104, AN UPDATE ON GLOMERULOPATHIES – ETIOLOGY AND PATHOGENESIS. Edited by Sharma S. Prabhakar, INTECH BOOK (www.intechopen.com)
Patent
Yen, B.L., Liu, K.-J., Sytwu, H.-K. (2012) Method for Generating Immunomodulatory Cells, The Cells Prepared Therefrom, and Use Thereof, US 13/607,976 (NHRI TTO case # 1010005)