研究著作

Selected Publications * corresponding Author


1. Wang YL, Chou FC, Chen SJ, Lin SH, Chang DM, Sytwu HK. Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases - An unrevealed role in downregulation of Th17 cells. Journal of Autoimmunity 2011;37:160-170.

2. Chen SJ*, Wang YL, Lo WT, Wu CC, Hsieh CW, Huang CF, Lan YH, Wang CC, Chang DM, Sytwu HK Erythropoietin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis Clin Exp Immunol 2010;162:210-223 (SCI)

3. Wang K.C., Tsai C.P., Lee C.L., Chen S.Y., Chen S.J.* The Prevalence of Long Spinal Cord Lesions and Anti-Aquaporin 4 Antibodies in Neuromyelitis Optica Patients in Taiwan, European Neurology 2011;65:99–104 (SCI)

4. Fan HC, Hu CF, Jung CJ, Chen SJ*. Current Proceedings of Childhood Stroke. Stroke Research and Treatment 2011 Feb 7;2011:432839.

5. Hu CF, Fan HC, Chang CF, Lai CC, Lee YJ, Chen SJ*. Chorea: a Rare Presentation of Moyamoya Disease: A Case Report and Literature Review. Fu-Jen Journal of Medicine 2011; 9(2):107-112.

6. Fan HC, Giiang LH, Huang TY, Juan CJ, Chen JY, Wang AC, Chen SJ*. Cerebrospinal Fluid Flow Quantification of the Cerebral Aqueduct in Children and Adults with Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging. Fu-Jen Journal of Medicine 2011; 9(2):59-72.

7. Book Chapter Immunomodulation of Potent Antioxidant Agents: Preclinical Study to Clinical Application in Multiple Sclerosis by Shyi-Jou Chen Hueng-Chuen Fan and Huey-Kang Sytwu in the book "Experimental Autoimmune Encephalomyelitis - Models, Disease Biology and Experimental Therapy" edited by Robert Weissert, ISBN 978-953-51-0038-6, InTech, February 2, 2012

8. C-F Hu, H-C Fan , C-F Chang , S-J Chen*. Current Approaches to the Treatment of Head Injury in Children. Pediatr Neonatol. 2013 Apr;54(2):73-81.

9. Lin MH, Yeh LT, Chen SJ, Chiou HY, Chu CC, Yen LB, Lin KI, Chang DM, Sytwu HK.T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells. Clin Immunol. 2014 Apr;151(2):101-13.

10. K-C Wang, Lee C-L, Chen SY, Chen J-C, Yang C-W, Chen S-J, * and Ching-Piao, Tsai C-P* Distinct Serum Cytokine Profiles in Neuromyelitis Optica and Multiple Sclerosis Journal of Interferon & Cytokine Research February 2013, 33(2): 58-64. (SCI )

11. Chen SJ, Wang YL, Fan HC, Lo WT, Wang CC, Sytwu HK * Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis. Clinical and Developmental Immunology ,Volume 2012 (2012), Article ID 970789, 16 pages (SCI)

12. Chen SJ, Liu YL, Huey-Kang Sytwu HK*. Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation. Clinical and Developmental Immunology 2012: Article ID 258391, 10 pages

13. Lin MH, Yeh LT, Chen SJ, Chiou HY, Chu CC, Yen LB, Lin KI, Chang DM, Sytwu HK.T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells. Clin Immunol. 2014 Apr;151(2):101-13.

14. Wang KC, Lin KH, Lee TC, Lee CL, Chen SY, Chen SJ, Chin LT, Tsai CP. Poor responses to interferon-beta treatment in patients with neuromyelitis optica and multiple sclerosis with long spinal cord lesions. PLoS One. 2014 Jun 2;9(6):e98192.

15. Wang, Chien-Ying; Chiou, Guang-Yuh; Chien, Yueh; Wu, Chia-Chao3; Wu, Tzee-Chung; Lo, Wen-Tsung; Chen, Shyi-Jou; Chiou, Shih-Hwa; Peng, Ho-Jen; Huang, Ching-Fen. Induced Pluripotent Stem Cells Without c-Myc Reduce Airway Responsiveness and Allergic Reaction in Sensitized Mice. Transplantation 2013; 96(11): 958–965

16. Chen, Shyi-Jou *Immune-Mediated Limbic EncephalitisdTip of the Iceberg in Childhood Autoimmune Epilepsy. Pediatrics and Neonatology (2013) 54, 217e218

17. Kai-Chen Wang, Ching-Piao Tsai, Chao-Lin Lee, Shao-Yuan Chen, Gu-Jiun Lin , Mao-Hsiung Yen, Huey-Kang Sytwu, and Shyi-Jou Chen ∗ Alpha lipoic acid enhances endogenous peroxisome proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis . Clin Sci (Lond). 2013 Oct;125(7):329-40

18. W-D Lin, K-P Chang, C-H Wang, S-J Chen, P-C Fan, W-C Weng, W-C Lin, Y Tsai, C-H Tsai, I-C Chou*, F-J Tsai. Molecular Aspects of Dravet Syndrome Patients in Taiwan. Clinica Chimica Acta 2013 Jun 5;421:34-40.

19. Wang LW, Chang YC, Chen SJ, Tseng CH, Tu YF, Liao NS, Huang CC, Ho CJ.TNFR1-JNK signaling is the shared pathway of neuroinflammation and neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain. J Neuroinflammation. 2014 Dec 24;11:215.

20. Kai-Chen Wang, Kuan-Hsiang Lin, Tzu-Chi Lee, Chao-Lin Lee, Shao-Yuan Chen, Shyi-Jou Chen, Li-Te Chin*, Ching-Piao Tsai. Poor Responses to Interferon-Beta Treatment in Patients with Neuromyelitis Optica and Multiple Sclerosis with Long Spinal Cord Lesions. PLOS ONE 2014 9( 6):e98192

21. Shyi-Jou Chen; Shing-Hwa Huang; Jing-Wun Chen; Kai-Chen Wang; Yung-Rong Yang; Pi-Fang Liu; Gu-Jiun Lin; Huey-Kang SytwuMelatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis Int Immunopharmacology. 2016 31:169-177.



Oral Presentation:

1. 2009 10th Asian & Oceanian Congress of Child Neurology. Inviting Speaker: Shyi-Jou Chen. Topic: Multiple Sclerosis and ADEM in Children

2. 2010 10th ISS (International Infantile Seizure Symposium) and ISENMD Inviting Speaker: Shyi-Jou Chen. Topic: Infantile Epilepsy in Lysomosomal storage diseases.



Poster:

1. 2006 International Child Neurology Congress Congress; ICNA Montréal, Québec

Shyi-Jou Chen; Wen-Chin Huang; Cheng-Yu Chen; Kai-Ping Chang; Chih-Chien Wang THE CLINICAL CHARACTERISTICS OF MALFORMATIONS OF CORTICAL DEVELOPMENT IN THIRTEEN PEDIATRIC CASES INCLUDING FAMILIAL AND SPORADIC CASES IN TAIWAN.

2. 2008 The 50th Meeting of the Japanese Society of Child Neurology Decoy Receptor 3 ameliorates experimental autoimmune encephalitis through down regulation of innate and adaptive immunity concomitant with suppression of TH17 cells. Shyi-Jou Chen, 1 Yen-Lin Wang,2 Su-Feng Wu3, Chich-Chien Wang, 1 Jen-Hsin Kao,2,4 Pao-Luh Tao4, Chia-Cho Wu5, Chien-Len Liao, 6 Huey-Kang Sytwu2, 6,7 1Department of Pediatrics, 2Graduate Institute of Life Sciences, 4Department of Pharmacology, 5Department of Nephrology, 6Department of Microbiology and Immunology, 7Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan 3Department of Microbiology and Immunology, National Chung Cheng University, Cha-Yi 621, Taiwan

3. 2010 Aug 23, 14th International Congress of Immunology PP-012-12 Page 581(Int. Immunology) Erythropoietin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis Shyi-Jou Chen *†, Yen-Lin Wang †‡**, Wen-Tsung Lo*, Chia-Cho Wu §, Chia-Wen Hsieh †, Ching-Feng Huang*,Yu-Hsin Lan †, Chih-Chien Wang *, Deh-Ming Chang § and Huey-Kang Sytwu† ‡‖** Department of Pediatrics, † Department of Microbiology and Immunology, ‡ Graduate Institute of Life Sciences, § Department of Nephrology, ‖ Graduate Institute of Medical Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

聯絡分機

13353
實驗室分機: 18934

E-mail

chensjou@yahoo.com.tw