學位

國防醫學院 醫學科學研究所 博士
國立陽明大學 醫學生物技術研究所 碩士
國立陽明大學 醫事技術學系 學士

經歷

三軍總醫院 病理部血庫中心 檢驗技術官
三軍總醫院 病理部臨床病理科分生組 檢驗技術官
國防醫學院 病理及寄生蟲研究所 兼任講師
國防醫學院 病理及寄生蟲研究所 兼任助理教授

研究領域與專長

臨床微生物與分子診斷
新興傳染病檢測技術開發
細菌抗藥性機制分析
PCR、qPCR、基因定序與多重檢測技術
人工智慧於感染症診斷之應用

獲獎情形

111年度台灣醫事檢驗學會 學術論文獎（臨床應用組）
111年三軍總醫院 杏林獎 醫事人員優良著作獎第二名
111年度三軍總醫院 優良醫事人員
112年三軍總醫院 杏林獎 優良研究論著績效獎第四名
113年三軍總醫院 杏林獎 醫事人員優良著作獎第一名
113年三軍總醫院 杏林獎 論文引用次數評比第四名

相關著作

1. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Perng, Cherng-Lih, Hung, Kuo-Sheng, Chiu, Chun-Hsiang, Shang, Hung-Sheng. Enhancing public health outcomes with AI-powered clinical surveillance: Precise detection of COVID-19 variants using qPCR and nanopore sequencing. *Journal of Infection and Public Health*. 2025;18:102663.
2. Lin, Tai-Han, Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Hung-Hsin, Yen, Chiung-Tzu, Tang, Sheng-Hui, Pan, Pin-Ching, Perng, Cherng-Lih, Chang, Feng-Yee. AI-Driven Innovations for Early Sepsis Detection by Combining Predictive Accuracy With Blood Count Analysis in an Emergency Setting: Retrospective Study. *Journal of Medical Internet Research*. 2025;27:e56155.
3. Lin, Tai-Han, Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Perng, Cherng-Lih, Chang, Feng-Yee, Chen, Chien-Wen, Shang, Hung-Sheng. Accelerating antimicrobial stewardship: An AI-CDSS approach to combating multidrug-resistant pathogens in the era of increasing resistance. *Clinica Chimica Acta*. 2025:120336.
4. Lin, Hung-Hsin, Chung, Hsing-Yi, Lin, Tai-Han, Chang, Chih-Kai, Perng, Cherng-Lih, Hung, Kuo-Sheng, Yanagihara, Katsunori, Shang, Hung-Sheng, Jian, Ming-Jr. BioInnovate AI: A Machine Learning Platform for Rapid PCR Assay Design in Emerging Infectious Disease Diagnostics. *Diagnostics*. 2025;15:1445.
5. Chen, Chi-Sheng, Hung, Kuo-Sheng, Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Chen, Hsiang-Cheng, Chang, Feng-Yee, Wang, Chih-Hung, Hung, Yi-Jen. Host-Pathogen Interactions in K. pneumoniae Urinary Tract Infections: Investigating Genetic Risk Factors in the Taiwanese Population. *Diagnostics*. 2024;14:415.
6. Chang, Chih-Kai, Chen, Chi-Sheng, Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Feng-Yee, Lin, Jung-Chung, Hsieh, Shan-Shan, Tang, Sheng‐Hui, Perng, Cherng-Lih, Chen, Chien-Wen. Monitoring coronavirus disease progression and clinical impact through quantitative viral load testing. *Clinica Chimica Acta*. 2024;560:119731.
7. Lin, Tai-Han, Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Hung-Hsin, Yu, Ching-Mei, Perng, Cherng-Lih, Chang, Feng-Yee, Chen, Chien-Wen, Shang, Hung-Sheng. Innovative strategies against superbugs: Developing an AI-CDSS for precise Stenotrophomonas maltophilia treatment. *Journal of Global Antimicrobial Resistance*. 2024;38:173-180.
8. Jian, Ming-Jr, Lin, Tai-Han, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Chang, Feng-Yee, Shang, Hung-Sheng. Artificial intelligence-clinical decision support system in infectious disease control: combatting multidrug-resistant Klebsiella pneumoniae with machine learning. *Infection and Drug Resistance*. 2024:2899-2912.
9. Lin, Tai-Han, Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Perng, Cherng-Lih, Liao, Guo-Shiou, Yu, Jyh-Cherng, Dai, Ming-Shen, Yu, Cheng-Ping, Shang, Hung-Sheng. An advanced machine learning model for a web-based artificial intelligence–based clinical decision support system application: Model development and validation study. *Journal of Medical Internet Research*. 2024;26:e56022.
10. Lin, Tai-Han, Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Hung-Hsin, Yu, Ching-Mei, Perng, Cherng-Lih, Chang, Feng-Yee, Chen, Chien-Wen, Chiu, Chun-Hsiang. Artificial intelligence-clinical decision support system for enhanced infectious disease management: Accelerating ceftazidime-avibactam resistance detection in Klebsiella pneumoniae. *Journal of Infection and Public Health*. 2024;17:102541.
11. Tai, Chi-Sheng, Jian, Ming-Jr, Lin, Tai-Han, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Hsieh, Po-Shiuan, Shang, Hung-Sheng. Diagnostic Accuracy of the LabTurbo QuadAIO Common Flu Assay for Detecting Influenza A Virus, Influenza B Virus, RSV, and SARS-CoV-2. *Diagnostics*. 2024;14:2200.
12. Jian, Ming-Jr, Lin, Tai-Han, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Chang, Feng-Yee, Shang, Hung-Sheng. Pioneering Klebsiella Pneumoniae Antibiotic Resistance Prediction With Artificial Intelligence-Clinical Decision Support System–Enhanced Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: Retrospective Study. *Journal of Medical Internet Research*. 2024;26:e58039.
13. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Chen, Chi-Sheng, Li, Shih-Yi, Lin, Jung-Chung, Yeh, Kuo-Ming, Yang, Ya-Sung, Chen, Chien-Wen, Hsieh, Shan-Shan. The application of a novel 5-in-1 multiplex reverse transcriptase–polymerase chain reaction assay for rapid detection of SARS-CoV-2 and differentiation between variants of concern. *International Journal of Infectious Diseases*. 2023;127:56-62.
14. Chen, Chi-Sheng, Jian, Ming-Jr, Chang, Chih-Kai, Chung, Hsing-Yi, Li, Shih-Yi, Lin, Jung-Chung, Yeh, Kuo-Ming, Yang, Ya-Sung, Chen, Chien-Wen, Hsieh, Shan-Shan. Monitoring algorithm of hospitalized patients in a medical center with SARS-CoV-2 (Omicron variant) infection: clinical epidemiological surveillance and immunological assessment. *PeerJ*. 2023;11:e14666.
15. Chung, Hsing‐Yi, Jian, Ming-Jr, Chang, Chih‐Kai, Lin, Jung‐Chung, Yeh, Kuo‐Ming, Chen, Chien‐Wen, Hsieh, Shan‐Shan, Hung, Kuo‐Sheng, Chen, Chi‐Sheng, Tang, Sheng‐Hui. Accelerating pandemic response with the emergency Omicron RT‐PCR test: A comprehensive solution for COVID‐19 diagnosis and tracking. *Journal of Medical Virology*. 2023;95:e28914.
16. Jian, Ming-Jr, Chen, Chi-Sheng, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Shang, Hung-Sheng. Clinical evaluation of direct reverse transcription PCR for detection of SARS-CoV-2 compared to conventional RT-PCR in patients with positive rapid antigen test results during circulation of emerging viral variants. *Diagnostics*. 2023;13:3668.
17. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Yang, Ya-Sung, Hsieh, Shan-Shan, Chen, En-Sung, Yang, Mei-Hsiu. Multicenter study evaluating novel multi-specimen pooling assay for the detection of SARS-CoV-2: High sensitivity and high throughput testing. *Journal of Microbiology, Immunology and Infection*. 2022;55:1069-1075.
18. Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Lin, De-Yu, Chang, Feng-Yee, Hung, Kuo-Sheng, Perng, Cherng-Lih. SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performance. *International Journal of Infectious Diseases*. 2022;114:112-114.
19. Jian, Ming-Jr, Perng, Cherng-Lih, Chung, Hsing-Yi, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Hsieh, Shan-Shan, Pan, Pin-Ching, Chang, Hao-Ting. Clinical assessment of SARS-CoV-2 antigen rapid detection compared with RT-PCR assay for emerging variants at a high-throughput community testing site in Taiwan. *International Journal of Infectious Diseases*. 2022;115:30-34.
20. Chang, Chih-Kai, Jian, Ming-Jr, Chung, Hsing-Yi, Lin, Jung-Chung, Hsieh, Shan-Shan, Tang, Sheng‐Hui, Perng, Cherng-Lih, Chen, Chien-Wen, Hung, Kuo-Sheng, Chang, Feng-Yee. Clinical comparative evaluation of the LabTurboTM AIO® reverse transcription-polymerase chain reaction and World Health Organization-recommended assays for the detection of emerging SARS-CoV-2 variants of concern. *Infection and Drug Resistance*. 2022:595-603.
21. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Hsieh, Shan-Shan, Hung, Kuo-Sheng, Tang, Sheng-Hui, Perng, Cherng-Lih. Emergency SARS-CoV-2 variants of concern: novel multiplex real-time RT-PCR assay for rapid detection and surveillance. *Microbiology spectrum*. 2022;10:e02513-21.
22. Yang, Bing-Heng, Chung, Hsing-Yi, Kao, Li-Ting, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Yang, Ya-Sung, Hsieh, Shan-Shan. Emergency SARS-CoV-2 variants of concern: rapidly direct RT-qPCR detection without RNA extraction, clinical comparison, cost-effective, and high-throughput. *Aging*. 2022;14.
23. Chen, Chi-Sheng, Chang, Chia-Ning, Hu, Chih-Fen, Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Perng, Cherng-Lih, Hung, Kuo-Sheng, Chang, Feng-Yee, Wang, Chih-Hung. Critical pediatric neurological illness associated with COVID-19 (Omicron BA. 2.3. 7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical center. *International Journal of Infectious Diseases*. 2022;124:45-48.
24. Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chiu, Sheng-Kang, Wang, Yi-Hui, Liao, Shu-Jung, Li, Shih-Yi, Hsieh, Shan-Shan. Novel automated sample-to-result SARS-CoV-2 laboratory-developed RT-PCR assay for high-throughput testing using LabTurbo AIO 48 system. *Clinica Chimica Acta*. 2021;514:54-58.
25. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Chiu, Sheng-Kang, Wang, Yi-Hui, Liao, Shu-Jung, Li, Shih-Yi. Novel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open system. *Emerging microbes & infections*. 2021;10:161-166.
26. Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Hsieh, Shan-Shan, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Chang, Feng-Yee, Chiu, Sheng-Kang, Hung, Kuo-Sheng. Investigation of one familial cluster of COVID-19 in Taiwan: differentiation of genetic variation among isolates and implications for epidemiological investigation and surveillance by genomic assay. *Infection and Drug Resistance*. 2021:971-977.
27. Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Li, Shih-Yi, Hsieh, Shan-Shan, Liu, Ming-Tsan, Yang, Ji-Rong. Clinical comparison of three sample-to-answer systems for detecting SARS-CoV-2 in B. 1.1. 7 lineage emergence. *Infection and Drug Resistance*. 2021:3255-3261.
28. Jian, Ming-Jr, Chung, Hsing-Yi, Chang, Chih-Kai, Hsieh, Shan-Shan, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Chang, Feng-Yee, Hung, Kuo-Sheng, Liu, Ming-Tsan. Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of America. *PeerJ*. 2021;9:e11991.
29. Chung, Hsing-Yi, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Yang, Ya-Sung, Chen, Chien-Wen, Hsieh, Shan-Shan, Tang, Sheng-Hui, Perng, Cherng-Lih. Multicenter study evaluating one multiplex RT-PCR assay to detect SARS-CoV-2, influenza A/B, and respiratory syncytia virus using the LabTurbo AIO open platform: epidemiological features, automated sample-to-result, and high-throughput testing. *Aging (Albany NY)*. 2021;13:24931.
30. Perng, Cherng-Lih, Jian, Ming-Jr, Chang, Chih-Kai, Lin, Jung-Chung, Yeh, Kuo-Ming, Chen, Chien-Wen, Chiu, Sheng-Kang, Chung, Hsing-Yi, Wang, Yi-Hui, Liao, Shu-Jung. Novel rapid identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time RT-PCR using BD Max Open System in Taiwan. *PeerJ*. 2020;8:e9318.
31. Jian, Ming-Jr, Perng, Cherng-Lih, Sun, Jun-Ren, Cheng, Yun-Hsiang, Chung, Hsing-Yi, Cheng, Yu-Hsuan, Lee, Shih-Yi, Kuo, Shu-Chen, Shang, Hung-Sheng. Multicentre MDR Elizabethkingia anophelis isolates: Novel random amplified polymorphic DNA with capillary electrophoresis systems to rapid molecular typing compared to genomic epidemiology analysis. *Scientific reports*. 2019;9:1806.
32. Cheng, Y-H, Perng, C-L, Jian, M-J, Lee, S-Y, Sun, J-R, Shang, H-S. Multicentre study evaluating matrix-assisted laser desorption ionization–time of flight mass spectrometry for identification of clinically isolated Elizabethkingia species and analysis of antimicrobial susceptibility. *Clinical Microbiology and Infection*. 2019;25:340-345.
33. Jian, Ming-Jr, Cheng, Yun-Hsiang, Chung, Hsing-Yi, Cheng, Yu-Hsuan, Yang, Hung-Yi, Hsu, Chih-Sin, Perng, Cherng-Lih, Shang, Hung-Sheng. Fluoroquinolone resistance in carbapenem-resistant Elizabethkingia anophelis: phenotypic and genotypic characteristics of clinical isolates with topoisomerase mutations and comparative genomic analysis. *Journal of Antimicrobial Chemotherapy*. 2019;74:1503-1510.
34. Jian, Ming-Jr, Cheng, Yun-Hsiang, Perng, Cherng-Lih, Shang, Hung-Sheng. Molecular typing and profiling of topoisomerase mutations causing resistance to ciprofloxacin and levofloxacin in Elizabethkingia species. *PeerJ*. 2018;6:e5608.