🔬 研究主題
探討氧氣濃度、高壓氧、微重力或超重力對於成體幹細胞及胚胎發育的影響。
🎓 學歷
• 2001.08-2006.08 Ph.D. Biochemistry and Molecular Biology, University of Southern California, U.S.A.
• 1997.08-2000.12 M.S. Molecular Physiology and Biophysics, Vanderbilt University, U.S.A.
• 1993.09-1997.06 B.S. 生命科學系，國立清華大學
🧳 經歷
• 2007.05-2011.01 Postdoctoral Research Fellow, Dr. John Yu’s lab, 中央研究院基因體研究中心 幹細胞實驗室
• 2006.10-2007.03 Postdoctoral Research Associate, Dr. Robert Maxson’s lab, University of Southern California
• 2001.08-2006.08 Graduate Research Assistant, Dr. Robert Maxson’s lab, University of Southern California
• 2000.11-2001.07 Research Assistant, Dr. Robert Maxson’s lab, University of Southern California
• 1998.05-2000.10 Graduate Research Assistant, Dr. James Sutcliffe’s lab, Vanderbilt University
📚 研究著作
一、SCI 論文
1. Chen ST, Jheng CY, Lee YC, Huang WC, Lee SY, and Chen YH*. Intermittent hypoxia-reoxygenation-induced miRNAs inhibit expression of IRF and interferon genes but activate NF-kB and expression of pulmonary fibrosis markers in human small airway epithelial cells. (2025) Life Sciences 370: 123569 (Impact Factor = 5.2, R/C = 40/354 = 11.3% in Pharmacology and Pharmacy by 2023 JCR)
2. Li YM, Chung YL, Wu YF, Wang CK, Chen CM, and Chen YH*. Maternal exposure to hyperbaric oxygen at the preimplantation stages increases apoptosis and ectopic Cdx2 expression and decreases Oct4 expression in mouse blastocysts via Nrf2-Notch1 upregulation and Nf2 downregulation. (2024) Developmental Dynamics 253(5): 467-489 (Impact Factor = 2.0, R/C = 6/22 = 27.3% in Anatomy and Morphology by 2023 JCR)
3. Yang YY, Lin CJ, Wang CC, Chen CM, Kao WJ, and Chen YH*. Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10 and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4 and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells. (2020) Frontiers in Cell and Developmental Biology 8: 572276 (Impact Factor = 4.6, R/C = 5/39 = 12.8% in Developmental Biology by 2023 JCR)
4. Chen CC, Hsia CW, Ho CW, Liang CM, Chen CM, Huang KL, Kang BH, and Chen YH*. Hypoxia and Hyperoxia Differentially Control Proliferation of Rat Neural Crest Stem Cells via Distinct Regulatory Pathways of the HIF1α–CXCR4 and TP53–TPM1 Proteins. (2017) Developmental Dynamics 246(3): 162-185 (Impact Factor = 2.0, R/C = 6/22 = 27.3% in Anatomy and Morphology by 2023 JCR)
5. Lin SC, Gou GH, Hsia CW, Ho CW, Huang KL, Wu YF, Lee SY, and Chen YH*. Simulated microgravity disrupts cytoskeleton organization and increases apoptosis of rat neural crest stem cells via upregulating CXCR4 expression and RhoA-ROCK1-p38 MAPK-p53 signaling. (2016) Stem Cells and Development 25(15): 1172-1193 (Impact Factor = 2.5, R/C = 41/97 = 42.3% in Hematology by 2023 JCR)
6. Chen YH, Yu J. Epigenetic disruptions of histone signatures for the trophectoderm and inner cell mass in mouse parthenogenetic embryos. (2015) Stem Cells and Development 24(5): 550-564 (Impact Factor = 2.5, R/C = 41/97 = 42.3% in Hematology by 2023 JCR)
7. Chen YH, Yu J. Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos. (2012) Developmental Dynamics 241(11): 1651-1664 (Impact Factor = 2.0, R/C = 6/22 = 27.3% in Anatomy and Morphology by 2023 JCR)
8. Chen YH, Ishii M, Sucov HM, and Maxson RE. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. (2008) BMC Developmental Biology 8: 75 (Impact Factor = 1.978, R/C = 33/41 = 80.5% in Developmental Biology by 2023 JCR)
9. Chen YH, Ishii M, Sun J, Sucov HM, and Maxson RE. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. (2007) Developmental Biology 308: 421-437 (Impact Factor = 2.5, R/C = 16/39 = 41% in Developmental Biology by 2023 JCR)
10. Nurmi EL, Bradford Y, Chen YH, Hall J, Arnone B, Gardiner MB, Hutcheson HB, Gilbert JR, Pericak-Vance MA, Copeland-Yates SA, Michaelis RC, Wassink TH, Santangelo SL, Sheffield VC, Piven J, Folstein SE, Haines JL, and Sutcliffe JS. Linkage disequilibrium at the Angelman syndrome gene UBE3A in autism families. (2001) Genomics 77: 105-113 (Impact Factor = 3.4, R/C = 63/191 = 33% in Genetics and Heredity by 2023 JCR)
二、研討會論文
1. Lee YC, Chen ST, and Chen YH*. (2024) Hypoxia-Reoxygenation Induced Dysregulated miRNA Expression Associated with Lung Injury and Immune Dysfunction in Human Small Airway Epithelial Cells. The 94th Aerospace Medical Association Annual Scientific Meeting, Chicago, IL, U.S.A. Aerospace Medicine and Human Performance, 95(8): 495–496.
2. Li YM, Chang Y, Chen CM, Chen YH*. (2022) Hyperbaric oxygen induced overexpression of coronaviral and influenza viral entry genes and toll-like receptor pathway genes and may exacerbate virus-associated cytokine storm in COPD airway epithelial cells. The 2022 Undersea & Hyperbaric Medical Society Annual Scientific Meeting, New Orleans, LA, U.S.A. Undersea and Hyperbaric Medicine, 49(1): A3.
3. Tsao YC, Chen JJ, Hsu YT, Chang Y, Chen YH*. (2022) High oxygen tension takes its toll: Disparate effects of hyperbaric oxygen and hyperoxia on viral entry gene and toll-like receptor pathway gene expression in normal and COPD-diseased human airway epithelial cells. The 2022 Undersea & Hyperbaric Medical Society Annual Scientific Meeting, New Orleans, LA, U.S.A. Undersea and Hyperbaric Medicine, 49(1): E79.
4. Lin FC, Wang CC, Chang Y, Chen CM, Chen YH*. (2022) Hyperbaric oxygen exposure disparately affects lineage-specific and apoptosis-associated marker expression in differentiated normal and COPD-diseased human bronchial epithelial cells. The 2022 Undersea & Hyperbaric Medical Society Annual Scientific Meeting, New Orleans, LA, U.S.A. Undersea and Hyperbaric Medicine, 49(1): E80.
5. Chang SY, Chen ST, Chen YH*. (2021) Intermittent Hypoxia-Reoxygenation and Consecutive Hypoxia Decreased Expression of the SARS-CoV-2 Receptor Gene ACE2, the Interferon-Stimulated Genes CTSL and TNFSF10, the Hypoxia Inducible Factor Gene HIF2A and the Stem Cell Marker Gene TP63 in COPD-Diseased Human Small Airway Epithelial Cells. The 2021 American Thoracic Society International Conference, San Diego, CA, U.S.A. American Journal of Respiratory and Critical Care Medicine, 203: A4167.
6. Yang YY, Wang CC, Chang Y, Chen CM, Chen YH*. (2021) Hyperbaric Oxygen Exposure Increases Spheroid Formation and Decreases SARS-CoV-2 Viral Receptor Expression Via NRF2 Upregulation as Well as Inhibits Mucociliary Differentiation and Increases Expression of Stem/Progenitor Cell Markers Via HIF2A Upregulation in the Air-Liquid Interface-Cultured Normal Human Bronchial Epithelial Cells. The 2021 American Thoracic Society International Conference, San Diego, CA, U.S.A. American Journal of Respiratory and Critical Care Medicine, 203: A4168.
7. Yu-Chia T, Chen JJ, Chang Y, Hsu YT, Chen YH*. (2021) Consecutive Hyperoxia Exposure Increased Expression of Interferon α and γ Receptor Genes IFNAR2 and IFNGR2, the SARS-CoV-2, MERS and Influenza Viral Entry Genes TMPRSS2, DPP4 and ST3GAL4, as Well as the Interferon-Stimulated and Fibrosis-Associated Genes DUOX2, MDK, PI3, S100P, ASS1, OAS1 and MX1 in COPD-Diseased Human Small Airway Epithelial Cells. The 2021 American Thoracic Society International Conference, San Diego, CA, U.S.A. American Journal of Respiratory and Critical Care Medicine, 203: A4191.
🏆 獎項
2024
• The Annual Distinguished Mentor Award provided by National Defense Medical Center in Taipei, Taiwan, R.O.C.
• The Honorable Mention Award at the 51st Poster Competition in the Aerospace and Undersea Medicine at the National Military Medicine Annual Symposium in Taiwan, 2024.
2021
• The Excellence in Research Award at the 48th National Military Medicine Annual Symposium in Taiwan.
2020
• The Second Place Award at the 47th Poster Competition in the Aerospace and Undersea Medicine at the National Military Medicine Annual Symposium in Taiwan.
2019
• The Outstanding Achievement Award for the annual research grant provided by the Medical Affairs Bureau–Ministry of National Defense, Taiwan, R.O.C.