學位

2011-2014 美國哥倫比亞大學生命科學系 博士後研究員

2005-2011 美國奧克拉荷馬大學細胞與行為神經生物學 博士

2002-2004 美國德州大學達拉斯分校應用認知與神經科學 碩士

1995-1999 國立台灣大學昆蟲學系 學士

經歷

2015-迄今 國防醫學院生命科學研究所 助理教授

專長學科

本實驗室的研究哺乳類嗅覺系統，目前研究主軸為大腦嗅覺皮質，以齧齒類(大、小鼠)和靈長類，作為模式物種來研究以下題目:

1. 大腦嗅覺皮質與中樞嗅覺路徑之架構。

2. 嗅覺與氣味引起的情緒反應。

3. 嗅覺失調與神經退化性疾病。

近年學術論文著作

[01] Chen, C.F.F.* and Wilson, D.A. Spatial segregation of piriform output neurons toward cognitive and emotional networks. PNAS Nexus. 2026. February 12; 5(2): pgag026. *Corresponding author. https://doi.org/10.1093/pnasnexus/pgag026

[02] Huang, C.Y., Chiu, S.F., Chu, L.J., Yeh, Y.M., Huang, P.J., Lan, K.L., Tai, Y.L., Liu, C.C., Chen, C.F.F., Lin, W.N., Huang, K.Y.* Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells. PLOS Pathogens. 2025. June 2;21(6): e1013216.

[03] Chen, Y.F., Tsao, C.Y., Chen, Y.T., Chang, H.C., Li, W.Y., Chiang, J.L., Chen, C.F.F., Chen, C.H., Gau, S.S.F., Lee. K.Y., Lee, L.J., and Wang, Y.C.* Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder. Behavioural Brain Research. 2025. March 5;480:115365.

[04] Chen, H.L., Chen, C.F.F.*, Huang, H.B. Distinct age-specific effects on olfactory associative learning in C57BL/6 substrains. Frontiers in Behavioral Neuroscience. 2022. February 2. *Corresponding author. https://doi.org/10.3389/fnbeh.2022.808978

[05] Shabangu, T., Chen, H.L., Zhuang, Z.H., Pierani, A., Chen, C.F.F.*, Chou, S.J*. Specific contribution of neurons from the Dbx1 lineage to the piriform cortex. Scientific Reports. 2021. April 16;11(1):8349. *Co-corresponding author.

[06] Weng, S.J.*, Chen, C.F.F.*, Huang, Y.S., Chiu, C.H., Wu, S.C., Lin, C.Y., Chueh, S.H., Cheng, C.Y., Ma, K.H. Olfactory ensheathing cells improve the survival of porcine neural xenografts in a Parkinsonian rat model. Xenotransplantation. 2020 March;27(2): e12569. *Equal first author.

[07] Jhao, Y.T., Chiu, C.H., Chen, C.F.F., Chou, T.K., Lin, Y.W., Ju, Y.T., Wu, S.C., Yan, R.F., Shiue, C.Y., Chueh, S.H., Halldin, C., Cheng, C.Y., Ma, K.H.. The effect of Sertoli cells on xenotransplantation and allotransplantation of ventral mesencephalic tissue in a rat model of Parkinson’s disease. Cells. 2019. Nov 11;8(11) 1420

[08] Li, I.H., Shih, J.H., Jhao, Y.T., Chen, H.C., Chiu, C.H., Chen, C.F.F., Huang, Y.S., Shiue, C.Y., Ma, K.H. Regulation of Noise-Induced loss of serotonin transporters with resveratrol in a rat model using 4-[₁₈F]-ADAM/small-animal positron emission tomography. Molecules. 2019. Apr 5;24(7)

[09] Ma, K.H., Liu, T.T., Weng, S.J., Chen, C.F.F., Liao, M.H., Chang, K.W., Sung, C.C., Hsu, T.H., Huang, W.S., Cheng, C.Y. Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT. Scientific Reports. 2016 Dec 12;6 38695.

[10] Shih, J.H., Ma, K.H., Chen, C.F.F., Cheng, C.Y., Pao, L.H., Weng, S.J., Huang, Y.S., Shiue, C.Y., Yeh, M.K., Li, I.H. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study. European Neuropsychopharmacology. 2016. Jan; 26(1): 92-104.

[11] Chen, C.F.F., Zou, D.J., Altomare, C.G., Xu, L., Greer, C.A., and Firestein, S.J. Non-sensory target-dependent organization of piriform cortex. Proceedings of the National Academy of Sciences. 2014. 111(47) 16931-6. https://www.pnas.org/doi/10.1073/pnas.1411266111

     [12] Chen, C.F.F., Barnes, D.C. and Wilson, D.A. Generalized versus stimulus-
      specialized fear differentially modifies stimulus encoding in primary sensory
      cortex of awake rats. Journal of Neurophysiology. 2011. 106(6) 3136-   
      44. https://pubmed.ncbi.nlm.nih.gov/21918001/

     [13] Rennaker, R.L., Chen, C.F.F., Ruyle, A.M., Sloan, A.M. and Wilson, D.A.
      Spatial and temporal distribution of odorant-evoked activity in the piriform
      cortex. Journal of Neuroscience. 2007. 27(7) 1534 -42. 
      https://www.jneurosci.org/content/27/7/1534.long