經歷

國防醫學院預防醫學研究所副研究員
三軍總醫院臨床病理科結核菌實驗室管理人
國防醫學院預防醫學研究所高防護實驗室管理人
三軍總醫院臨床病理科醫檢師

專長學科

高抗藥細菌與宿主交互作用
新興傳染病致病機轉
高防護實驗室設計

實驗室成員

博士班學生：陳正修(醫學科學研究所)、黃慈葳(生命科學研究所)

碩士班學生:鄧芷緹、黃教哲

助理：林孟禾、鄭雁方

實驗室介紹

新興呼吸道感染症研究室
(Emerging Respiratory Infections Lab)

近年爆發肆虐全球的新冠疫情、伊波拉疫情與猴痘疫情，凸顯廿一世紀微生物病原對人類的威脅愈來愈大。新興傳染病相關的病原體中約有75%屬於人畜共通傳染病，且多為呼吸道感染症。本研究室聚焦呼吸道感染症之研究與探討宿主對抗新興傳染病原之生理機轉變化，包括從病原角度看基因調控與宿主微環境的關係、再從宿主角度看體內之細胞內訊息傳遞及生理功能調控、感染症之早期診斷的預測指標(biomarker)與治療模式開發。我們的研究方向如下:
1.探討新興傳染病的致病機轉: 研究室在過去15年持續探討新興超級細菌的基因調控並發展新型態治療模式。我們研究病原包含結核桿菌、綠膿桿菌、鮑氏不動桿菌等各種重要臨床菌種之抗生素抗藥機制探討並開發新型態治療策略，以期共同對抗全球抗藥性問題。
2.開發擬真系統探討病原與宿主交互作用: 實驗室發展精準組織切片技術(precision-cut tissue slices; PCTS)、 類器官(organoids)、器官晶片（organ on chips）等仿生技術開發擬真系統(ex-vivo model)做為新一代替代動物模式。我們藉由擬真系統探討病原與宿主的交互作用，最終期望發展替代動物系統以減少實驗動物的使用量。

歡迎對上述研究有興趣的同學來討論看看

得獎事蹟

研究著作

1. Cheng YH, Chen CH, Liu PC, Chen WT, Hsu CJ, Chen CC, Sun JR* (2025) Reverse transcription-quantitative PCR assays for detecting SARS-CoV-2 using subgenomic RNA load. Heliyon 11 (4):e42503 (SCI, IF=3.4, 責任作者)

2. Yang YP, Wang CH, Sun JR, Chien Y, Chien CS, Chiou GY, Cheng YH, Chen WT, Liu PC, Tsai SK, Chiang IH, Wang JC, OH Huan, Ching LJ, Lo  WL, Wang CY, Leu HB, Lee CY, Chiou SH. Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models. Biomater Res. 2025 Jul 22:29:0229. (SCI, IF=9.6)

3. Sun JR, Tsai PH, Chien Y, Chan MS, Winnie Khor, Yang HC, Huang CH, Hsiung CN, Hwa TY, Lin YY, Yeh CL, Wang ML, Yang YP, Chen YM, Tsai FT, Lee MS, Cheng YH, Tsai SK, Liu PC, Chou SJ, Chiou SH.Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids J Adv Res. 2024 Jun:60:127-140. (SCI: IF= 11.4, 第一作者)

4. Yang YS, Chen HY, Lin IC, Lin MH, Wang WY, Kuo SC, Chen WT, Cheng YH, Sun JR*. Imipenem reduces the efficacy of vancomycin against Elizabethkingia species. J Antimicrob Chemother . 2024 Aug 1;79(8):2048-2052. (SCI: IF= 3.9, 責任作者)

5. Lee CY, Huang CH, Rastegari E, Rengganaten V, Liu PC, Tsai PH, Chin YF, Wu JR, Chiou SH, Teng YC, Lee CW, Liang Y, Chen AY, Hsu SC, Hung YJ, Sun JR *, Chien CS, Chien Y. 2021. Tumor Necrosis Factor-Alpha Exacerbates Viral Entry in SARS-CoV2-Infected iPSC-Derived Cardiomyocytes. Int J Mol Sci 22. (SCI: IF= 6.208, 責任作者)

6. Yang YS, Jeng WY, Lee YT, Hsu CJ, Chou YC, Kuo SC, Chen CC, Hsu WJ, The Action Study G, Chen HY, Sun JR *. 2021. Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis. Emerg Microbes Infect 10:1873-1880. (SCI: IF= 19.568, 責任作者)

7. Hsu CJ, Lin WC, Chou YC, Yang CM, Wu HL, Cheng YH, Liu PC, Chang JY, Chen HY, Sun JR *. 2022. Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19. Microbiol Spectr 10:e0236221. (SCI: IF= 9.043責任作者)

8. Huang RL, Fu YC, Wang YC, Hong C, Yang WC, Wang IJ, Sun JR, Chen Y, Shen CF, Cheng CM. 2022. A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody Detection. Vaccines (Basel) 10. (SCI: IF= 4.961)

9. Wang YC, Lin SW, Wang IJ, Yang CY, Hong C, Sun JR, Feng PH, Lee MH, Shen CF, Lee YT, Cheng CM. 2022. Interleukin-6 Test Strip Combined With a Spectrum-Based Optical Reader for Early Recognition of COVID-19 Patients With Risk of Respiratory Failure. Front Bioeng Biotechnol 10:796996. (SCI: IF= 6.064)

10. Chin YF, Tang WF, Chang YH, Chang TY, Lin WC, Lin CY, Yang CM, Wu HL, Liu PC, Sun JR, Hsu SC, Lee CY, Lu HY, Chang JY, Jheng JR, Chen CC, Kau JH, Huang CH, Chiu CH, Hung YJ, Tsai HP, Horng JT. 2022. Orally delivered perilla (Perilla frutescens) leaf extract effectively inhibits SARS-CoV-2 infection in a Syrian hamster model. Journal of Food and Drug Analysis: Vol. 30 : Iss. 2 , Article 6 (SCI: IF = 6.157)

11. Hsing-Yu Chen, Chuan-Chung Chuang, Yu-Ching Chou, Wei-Jane Hsu, I-Chieh Lin, ACTION study group and Jun-Ren Sun*. Rapid typing of carbapenem-resistant Acinetobacter baumannii and Acinetobacter nosocomialis by multiplex Pan- and OXAPCR assays. J Med Microbiol. 2021 Jun;70(6). (SCI: IF=3.196, 責任作者).

12. Yi-Tzu Lee, Hsing-Yu Chen, Ya-Sung Yang, Yu-Ching Chou, Tein-Yao Chang, Wei-Jane Hsu, I-Chieh Lin, ACTION Study Group; Jun-Ren Sun*. AdeABC Efflux Pump Controlled by AdeRS Two Component System Conferring Resistance to Tigecycline, Omadacycline and Eravacycline in Clinical Carbapenem Resistant Acinetobacter nosocomialis. Front Microbiol. 2020 Nov 2;11:584789. (SCI: IF=6.064, 責任作者).