Experience
Jul. 2020 – Present
Director & Chair, Dept. of Pharmacology
National Defense Medical University
Aug. 2016 – Present
Professor, Dept. of Pharmacology
National Defense Medical University
Aug. 2005 – Jul. 2016
Associate Professor, Dept. of Pharmacology
National Defense Medical Center
Feb. 2001 – Jul. 2005
Assistant Professor, Dept. of Pharmacology
National Defense Medical Center
May 2000 – Jul. 2000
Visiting Research Fellow, Dept. of Biochemistry
University of Southampton, Southampton, U. K. (funded by the Royal Society, U. K.)
Aug. 1999 – Jan. 2001
Assistant Professor, Graduate Institute of Clinical Medical Sciences
Chang Gung University, Tao-Yuan, Taiwan
Nov. 1998 – Jan. 2001
Research Fellow, Dept. of Anesthesiology
Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
Feb.1998 – Oct. 1998
Postdoctoral Research Fellow, Dept. of Pharmacology
Chang Gung University, Tao-Yuan, Taiwan
Nov. 1997 – Jan. 1998
Postdoctoral Research Fellow, Dept. of Pharmacology
National Defense Medical Center
Jun. 1993 – Jul. 1994
Research Assistant, Lab. of Endocrinology,
Institute of Zoology, Academia Sinica, Taipei, Taiwan
Research Interests
◾ Oxytocin-based Drug Design & Synthesis (Peptides)
◾ Small Molecule Drug Discovery (Arecoline & Arecaidine)
◾ Addiction Studies (Nicotine, Alcohol, Betel Nut)
◾ Hippocampal Synaptic Plasticity (LTP & LTD)
◾ Chronic Pain Mechanisms (Hyperalgesia & Allodynia)
◾ Electrophysiology (Brain Slice & Isolated Spinal Cord)
◾ Migraine & Analgesia
◾ Autism Spectrum Disorder (ASD)
◾ Sexual Behavior & Physiology
Lab Research Focus
Professor Huang's research integrates Neuropharmacology with Drug Discovery. By combining peptide synthesis, small molecule screening, and electrophysiology, his lab aims to develop novel treatments for neurological and psychiatric disorders.
Key research areas include:
1. Drug Design & Synthesis:
◾ Peptides: Designing and synthesizing novel analogs of Oxytocin and Endomorphins to improve stability, efficacy, and blood-brain barrier penetration.
◾ Small Molecules: Investigating the therapeutic potential of Arecoline and Arecaidine (betel nut alkaloids) and their derivatives for neuroprotection and cognitive enhancement.
2. Hippocampal Synaptic Plasticity & Memory:
◾ Utilizing brain slice recordings to investigate how these novel compounds regulate Long-Term Potentiation (LTP) and Long-Term Depression (LTD) in the hippocampus, elucidating the mechanisms of learning and memory.
3. Addiction & Reward Systems:
◾ Studying the neural mechanisms of addiction to Nicotine, Alcohol, and Arecoline.
◾ Exploring novel therapeutic targets to attenuate craving and withdrawal symptoms.
4. Migraine & Pain Mechanisms:
◾ Investigating the analgesic effects of oxytocin and novel peptides in attenuating Hyperalgesia (increased sensitivity) and Allodynia (pain from non-painful stimuli).
◾ Using isolated spinal cord preparations to explore the spinal pathways underlying chronic pain and migraine.
5. Behavioral Neuropharmacology:
◾ Autism (ASD): Examining the role of oxytocin in rescuing social deficits and repetitive behaviors.
◾ Sexual Behavior: Exploring the physiological regulation of sexual behavior and its interaction with the oxytocinergic system.
Publications
Przemyslaw Mielczarek, Kinga Hartman, Eagle Yi-Kung Huang, Ewa Gibula-Tarlowska, Pawel Grochecki, Tymoteusz Slowik, Jolanta H Kotlinska, Jerzy Silberring, and Anna Drabik (2025) The Role of LVV-H7 in Alcohol-Induced Reward Mechanisms. Addict Biol. 30(9): e70086.
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, and Eagle Yi-Kung Huang (2025) Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. Iranian Journal of Basic Medical Sciences 28(9): 1212-1219.
Yuan-Hao Chen, Tung-Tai Kuo, Vicki Wang, Pin-Wen Cheng, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2024) Serotonergic regulation of synaptic dopamine levels mitigates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 14(5): 941-964.
Lok-Hi Chow, Pin-Chen Lin, Ying-Jie Chen, Yuan-Hao Chen, and Eagle Yi-Kung Huang (2024) Yangonin, one of the kavalactones isolated from Piper methysticum G. Frost, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia. Journal of Ethnopharmacology 333: 118394.
Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, and Skye Hsin-Hsien Yeh (2024) Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. J Chin Med Assoc. 87(5): 538-549.
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-Ii Choi, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci. 31(1): 38.
Yen-Lun Chen, Yen-Hsun Lai, Eagle Yi-Kung Huang, Hong-Jaan Wang, and Hao-Yuan Hung (2024) Nalbuphine-6-glucuronide is a potent analgesic with superior safety profiles by altering binding affinity and selectivity for mu-/kappa-opioid receptors. Life Science 340: 122441.
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Hao-Yuan Hung, Pin-Chen Lin, and Eagle Yi-Kung Huang (2024) Intrathecal injections of angiotensin IV and oxytocin conjugates induce antihyperalgesia and antiallodynia in both sexes of rats. Peptides 173: 171150.
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-Ii Choi, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2023) PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease. Int J Mol Sci. 24(5): 4687.
Hsu-Kai Huang, Pin-Chen Lin, Tzu-Ting Huang, Hao-Yuan Hung, Tsai-Wang Huang, Eagle Yi-Kung Huang (2023) Nicotine activates HIF-1α and regulates acid extruders through the nicotinic acetylcholine receptor to promote the Warburg effect in non-small cell lung cancer cells. Eur J Pharmacol. 950: 175778.
Eagle Yi-Kung Huang, Hao-Yuan Hung, Yuan-Hao Chen, Jen-Hsin Kao, Ai-Lun Tsai, and Lok-Hi Chow (2023) Effects of dextromethorphan on nicotine-induced reward, behavioral sensitization, withdrawal signs, and drug seeking-related behavior in rats. Nicotine & Tobacco Research 25(7): 1251-1260.
Kwok-On Ng, Lok-Hi Chow, Chun-Chang Yeh, Eagle Yi-Kung Huang, Wei-Cheng Liu, and Ping-Heng Tan (2022) Case report: the management for a gestational hypertensive woman with influenza A virus pneumonia and peripartum cardiomyopathy. BMC Pregnancy Childbirth 22(1): 497.
Kuan-Yin Tseng, Tung-Tai Kuo, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2022) Tetrabenazine mitigates aberrant release and clearance of dopamine in the nigrostriatal system, and alleviates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 12(5): 1545-1565.
Lok-Hi Chow, Hao-Yuan Hung, Wan-Chuan Wu, Yuan-Hao Chen, Weihong Pan, and Eagle Yi-Kung Huang. (2022) Estrogen can abolish oxytocin-induced spinal antihyperalgesia. Psychoneuroendocrinology 136: 105603.
Hao-Yuan Hung, Wu-Chien Chien, Chi-Hsiang Chung, Li-Ting Kao, Lok-Hi Chow, Yuan-Hao Chen, Jolanta H. Kotlińska, Jerzy Silberring, and Eagle Yi-Kung Huang. (2021) Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study. Drug and Alcohol Dependence 229(Pt A): 109102.
Hsiao-Ming Chao, Eagle Yi-Kung Huang, and Chieh-Fu Chen. (2021) The essentials for the study of vision improving drugs. Journal of Chinese Medicine Research Vol.33: 1-18.
Mielczarek P, Hartman K, Drabik A, Hung HY, Huang EY, Gibula-Tarlowska E, Kotlinska JH, and Silberring J. (2021) Hemorphins-From Discovery to Functions and Pharmacology. Molecules 26(13): 3879.
Wang V, Kuo TT, Huang EY, Ma KH, Chou YC, Fu ZY, Lai LW, Jung J, Choi HI, Choi DS, Li Y, Olson L, Greig NH, Hoffer BJ, and Chen YH. (2021) Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease. ACS Pharmacol Transl Sci. 4(2): 858-869.
Hung HY, Chow LH, Kotlinska JH, Drabik A, Silberring J, Chen YH, and Huang EY. (2021) LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides 136: 170455.
Loh SH, Chang CY, Huang SF, Chao SC, Lin WK, Huang EY, Tsai CS, and Tsai YT. (2020) Functional effects of urotensin-II on intracellular pH regulators in human radial artery smooth muscle cells. Peptides 126: 170236.
Chen YH, Wang V, Huang EY, Chou YC, Kuo TT, Olson L, and Hoffer BJ. (2019) Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. Int J Mol Sci. 20(24) pii: E6251
Chen YH, Hsieh TH, Kuo TT, Kao JH, Ma KH, Huang EY, Chou YC, Olson L, and Hoffer BJ. (2019) Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors. J Neurochem. 150(1): 56-73
Wu WL, Cheng SJ, Lin SH, Chuang YC, Huang EY, and Chen CC. (2019) The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Front Cell Neurosci. 13: 86
Chen YH, Lin BJ, Hsieh TH, Kuo TT, Miller J, Chou YC, Huang EY, and Hoffer BJ. (2019) Differences in nicotine encoding dopamine release between the striatum and shell portion of the nucleus accumbens. Cell Transplantation 28(3): 248-261
Yuan-Hao C, Kuo TT, Huang EY, Hoffer BJ, Kao JH, Chou YC, Chiang YH, and Miller J. (2018) Nicotine-induced conditional place preference is affected by head injury: correlation with dopamine release in the nucleus accumbens shell. Int. J. Neuropsychopharmacol. 21(10): 949-961
Chen YH, Kuo TT, Kao JH, Huang EY, Hsieh TH, Chou YC, and Hoffer BJ. (2018) Exercise ameliorates motor deficits and improves dopaminergic functions in the rat hemi-Parkinson's model. Sci Rep. 8(1): 3973
Chow LH, Chen YH, Lai CF, MD, Lin TY, Chen YJ, Kao JH, and Huang EY. (2018) Sex difference of angiotensin IV-, LVV-hemorphin 7-, and oxytocin-induced antiallodynia at the spinal level in mice with neuropathic pain. Anesthesia & Analgesia 126(6): 2093-2101
Chen YH, Kuo TT, Huang EY, Chou YC, Chiang YH, Hoffer BJ, and Miller J (2018) Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell. Oncotarget 9: 10016-10028
Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, and Chiang YH. (2017) Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience 348: 180-190
Chen YH, Huang EY, Kuo TT, Miller J, Chiang YH, and Hoffer BJ. (2017) Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation 26(7): 1156-1168
Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, and Eagle Yi-Kung Huang (2016) Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS ONE 11(9): e0162218
Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, and Lok-Hi Chow (2016) Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. Neuropeptides 59: 63-69
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J. Hoffer, Pei-Jie Wu, Hsin-I Ma, Jing-Jr Tsai, Yu-Ching Chou, and Yung-Hsiao Chiang (2016) Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. Brain Res. 1642: 581-589
Eagle Yi-Kung Huang, Yuh-Chiang Shen, and Chieh-Fu Chen (2016) Mitochondria: Target for the develop of anti-inflammatory drugs. Journal of Chinese Medicine 27(1): 2701004
Lok-Hi Chow, Pao-Luh Tao, Yuan-Hao Chen, Yu-Hui Lin and Eagle Yi-Kung Huang (2015) Angiotensin IV possibly acts through PKMzeta in hippocampus to regulate cognitive memory in rats. Neuropeptides 53: 1-10
Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao (2015) Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. J. Biomed. Sci. 22(1): 81
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Hsin-I Ma, Barry J. Hoffer, Pi-Fen Tsui, Jing-Jr Tsai, Yu-Ching Chou and Yung-Hsiao Chiang (2015) Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. Cell Transplantation 24(10): 2113-2128
Yi-Ting Tsai, Chung-Yi Lee, Chih-Chin Hsu, Chung-Yi Chang, Ming-Kai Hsueh, Eagle Yi-Kung Huang, Chien-Sung Tsai, and Shih-Hurng Loh (2014) Effects of Urotensin II on intracellular pH regulation in cultured human internal mammary artery smooth muscle cells. Peptides 56: 173-182
Eagle Yi-Kung Huang, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Tsai Tung-Han, Hsin-I. Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Remote effects on the striatal dopamine system after fluid percussion injury. Behavioural Brain Research 267: 156-172
陳介甫、黃翊恭、吳令怡、廖志飛 (2014) 發炎、發炎體、抗發炎藥 (ISBN 978-986-7825-95-7) 知音出版社
Eagle Yi-Kung Huang, Pi-Fen Tsui, Tung-Tai Kuo, Jing-Jr Tsai, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury. PLoS ONE 9(1): e86354
Ling-Yi Wu, Chieh-Fu Chen and Eagle Yi-Kung Huang (2013) Obesity related metabolic complications and anti-obesity drugs. Journal of Chinese Medicine 24(2): 261-277
Yuan-Hao Chen, Tong-Tai Kuo, Ming-Ting Chu, Hsin-I Ma, Yung-Hsiao Chiang and Eagle Yi-Kung Huang (2013) Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in animal seizure model. Neuroimmunomodulation 20(4): 223-232
Weihong Pan, Xiaojun Wu, Yi He, Hung Hsuchou, Eagle Yi-Kung Huang, Pramod K. Mishra and Abba J. Kastin (2013) Brain interleukin-15 in neuroinflammation and behavior. Neurosci. Biobehav. Rev. 37(2): 184-192
Lok-Hi Chow, Pao-Luh Tao, Jin-Chung Chen, Ruey-Ming Liao, En-Pei Chang and Eagle Yi-Kung Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides 39(1): 21-28
Pao-Pao Yang, Eagle Yi-Kung Huang, Yu-Ying Fu, Tsai-Shan Ho and Pao-Luh Tao (2012) Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization. Synapse 66(10): 858-869
Bor-Chih Cheng, Pao-Luh Tao, Ya-Yun Cheng and Eagle Yi-Kung Huang (2012) LVV-hemorphin 7 and angiotensin IV in correlation with antinociception and anti-thermal hyperalgesia in rats. Peptides 36(1): 9-16
Weihong Pan, Hung Hsuchou, Bhavaani Jayaram, Reas S. Khan, Eagle Yi-Kung Huang, Xiaojun Wu, Chu Chen and Abba J. Kastin (2012) Leptin action on nonneuronal cells in the CNS: potential clinical applications. Ann N Y Acad Sci. 1264(1): 64-71
Shih-Lin Chang, Yao-Chang Chen, Yung-Hsin Yeh, Yu-Jun Lai, Hung-I Yeh, Cheng-I Lin, Yung-Kuo Lin, Yenn-Jiang Lin, Tsu-Juey Wu, Yi-Kung Huang, Shih-Ann Chen and Yi-Jen Chen (2011) Heart failure enhances arrhythmogenesis in pulmonary veins. Clin. Exp. Pharmacol. Physiol. 38(10): 666-674
Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2011) NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study. Drug Alcohol Depend. 118(2-3): 366-374
Pao-Luh Tao, Jain-Fang Chen and Eagle Yi-Kung Huang (2011) Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. J. Biomed. Sci. 18(1): 64
Shiou-Lan Chen, Kuei-Ying Hsu, Eagle Yi-Kung Huang, Ru-Band Lu and Pao-Luh Tao (2011) Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug Alcohol Depend. 117(2-3): 164-169
Chun-Hung Wu, Pao-Luh Tao and Eagle Yi-Kung Huang (2010) Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain. Peptides 31(7): 1374-1382
Ling-Yi Wu, Eagle Yi-Kung Huang and Pao-Luh Tao (2010) Co-administration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertility and Sterility 93(5): 1686-1694
Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang (2009) Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. J. Biomed. Sci. 16: 106
Wei-Li Wu, Chih-Hung Wang, Eagle Yi-Kung Huang and Chih-Cheng Chen (2009) ASIC3-/- Female Mice with Hearing Deficit Affects Social Development of Pups. PLoS ONE 4(8): e6508
Chung-Shiun Yang, Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2008) The role of the NR2B subunit of NMDA receptors in morphine rewarding, drug seeking, and behavioral sensitization. Journal of Medical Sciences 28(6): 245-253
Yu-Jun Lai, Eagle Yi-Kung Huang, Hung-I Yeh, Yen-Lin Chen, Jim Jung-Ching Lin and Cheng-I Lin (2008) On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins. Life Sci. 83: 272-283
Wei-Li Wang, Sheau-Farn Yeh, Eagle Yi-Kung Huang, Yu-Ling Lu, Chun-Fa Wang, Chi-Ying F. Huang and Wey-Jinq Lin (2007) Mitochondrial anchoring of PKCa by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis 12: 1857-1871
Wei-Ming Lue, Eagle Yi-Kung Huang, San-Nan Yang, Chih-Shung Wong and Pao-Luh Tao (2007) Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. Synapse 61(6): 420-428
Eagle Yi-Kung Huang, Hsiang-Jen Hsiao, Wei-Ming Lue and Pao-Luh Tao (2007) U-50,488 decreased the rewarding effect and mesolimbic dopamine neuron activity induced by morphine in rats. Journal of Medical Sciences 27(1): 15-22
Pao-Pao Yang, Eagle Yi-Kung Huang, Geng-Chang Yeh and Pao-Luh Tao (2006) Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. J. Biomed. Sci. 13(5): 695-702
Jin-Chung Chen, Wei-Hsin Lee and Eagle Yi-Kung Huang (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(Tic)amide. Peptides 27(5): 1005-1014
Pao-Luh Tao, Kai-Wen Liang, Wen-Yi Sung, Yung-Tsun Wu and Eagle Yi-Kung Huang (2006) Nalbuphine is effective in decreasing the rewarding effect and drug-seeking behavior induced by morphine in rats. Drug Alcohol Depend. 84: 175-181
Pao-Luh Tao, Yong-Shang Lai, Lok-Hi Chow and Eagle Yi-Kung Huang (2005) Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord. N-S Arch. Pharmacol. 371: 72-80
Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow and Pao-Luh Tao (2005) Dextromethorphan differentially affects opioid antinociception in rats. Br. J. Pharmacol. 144(3): 400-404
Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Shen-Kou Tsai and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but not related to descending serotoninergic or adrenergic pathways. J. Biomed. Sci. 11(6): 717-725
Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Tak-Yu Lee and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine antinociception at the spinal level in rats. Can. J. Anaesth. 51(9): 905-910
Eagle Yi-Kung Huang, Ching-Ming Chen and Pao-Luh Tao (2004) Supraspinal anti-allodynic and rewarding effects of endomorphins in rats. Peptides 25(4): 577-583
Eagle Yi-Kung Huang, Te-Chen Liu and Pao-Luh Tao (2003) Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine release at the nucleus accumbens. N-S Arch. Pharmacol. 368: 386-392
Jin-Chung Chen, Pao-Luh Tao, Jihn-Yih Li, Chung-Hang Wong and Eagle Yi-Kung Huang (2003) Endomorphin-1 and –2 induce naloxone-precipitated withdrawal syndromes in rats. Peptides 24(3): 477-481
Eagle Yi-Kung Huang, Jihn-Yih Li, Chung-Hang Wong, Peter Pei-Chiung Tan and Jin-Chung Chen (2002) Dansyl-PQRamide, a possible neuropeptide FF receptor antagonist, induces conditioned place preference. Peptides 23(3): 489-496
Jin-Chung Chen, Kai-Wen Liang, Yi-Kung Huang, Cheng-Sheng Liang and Yao-Chang Chiang (2001) Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine. Life Sci. 68(9): 973-983
Jihn-Yih Li, Chung-Hang Wong, Eagle Y.-K. Huang, Yen-Chien Lin, Yun-Long Chen, Peter P. C. Tan and Jin-Chung Chen (2001) Modulation of spinal serotonin activity affect the development of morphine tolerance. Anesthesia and Analgesia 92(6): 1563-1568
Jin-Chung Chen, Kai-Wen Liang and Eagle Yi-Kung Huang (2001) Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. Synapse 39(3): 239-248
Eagle Yi-Kung Huang, Jihn-Yih Li, Peter Pei-Chiung Tan, Chung-Hang Wong and Jin-Chung Chen (2000) The cardiovascular effects of PFRFamide and PFR(Tic)amide, a possible agonist and antagonist of neuropeptide FF (NPFF). Peptides 21(2): 205-210
Peter Pei-Chiung Tan, Jin-Chung Chen, Jihn-Yih Li, Kai-Wen Liang, Chung-Hang Wong and Eagle Yi-Kung Huang (1999) Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogs. Peptides 20(10): 1211-1217
J.-C. Chen, J.-Y. Li, K.-W. Liang and Y.-K. Huang (1999) Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the level of neurotransmitters in the median prefrontal cortex. Brain Res. 816(1): 220-224
E. Y.-K. Huang, J. Bagust, R. P. Sharma and R. J. Walker (1998) The effect of FMRFamide-like peptides on electrical activity in isolated mammalian spinal cord. Neuroscience Res. 30: 295-301
S. J. Perry, E. Y.-K. Huang, D. Cronk, J. Bagust, R. Sharma, R. J. Walker, S. Wilson and J. F. Burke (1997) A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Letters 409(3): 426-430
Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1997) FLFQPQRFamide (NPFF) inhibits the fast wave of the evoked field potential in the rat isolated spinal cord preparation. Br. J. Pharmacol. 120(SS): 233P
Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1996) Naloxone and desaminoYFLFQPQRamide block potentiation by FLFQPQRFamide (NPFF) of the rat isolated spinal cord monosynaptic reflex (MSR). Br. J. Pharmacol. 117(SS): 314P
CONFERENCE ABSTRACTS:
Eagle Yi-Kung Huang, Tung-Tai Kuo, and Yuan-Hao Chen (2024) Potential therapeutic effects of angiotensin IV and LVV hemorphin-7 on traumatic brain injury-induced memory and cognition defects. 2024 Military Health System Research Symposium, 26-29 August 2024, Gaylord Palms Resort & Convention Center, Kissimmee, FL, U.S.A.
Eagle Yi-Kung Huang, Ying-Jie Chen, Yuan-Hao Chen, Hiroshi Ueda, and Lok-Hi Chow (2023) Yangonin, one of the kavalactones isolated from Piper methysticum, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia in rats. The 22nd International Congress of International Society for Ethnopharmacology (ISE) & the 10th International Congress of the Society for Ethnopharmacology (SFE) (ISE-SFEC 2023), Imphal, Manipur, India, 24-26 February, 2023. (Best poster award)
Hao-Yuan Hung, Lok-Hi Chow, Jolanta H. Kotlinska, Anna Drabik, Jerzy Silberring, Yuan-Hao Chen, and Eagle Yi-Kung Huang (2020) LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. 2020 MOST Science and Technology International Cooperation Research Symposium, Taipei, Taiwan, 20-21 October, 2020. (Invited speaker)
Eagle Yi-Kung Huang, Yuan-Hao Chen, and Lok-Hi Chow (2019) Sex difference in oxytocin-induced antihyperalgesia and antiallodynia at the spinal cord. The 5th Meeting of the Japanese Branch of International Neuropeptide Society, Tokyo, 26-27 October 2019. (Invited speaker)
Hao-Yuan Hung, Yuan-Hao Chen, and Eagle Yi-Kung Huang (2019) The potential role of LVV-hemorphin 7 in alcohol-induced pain disorders. 20th International Congress of the Polish Pharmacological Society, Lublin, Poland, 5-7 June 2019. (Invited speaker)
Eagle Yi-Kung Huang, Lok-Hi Chow, Yuan-Hao Chen, and Ai-Lun Tsai (2018) Effects of dextromethorphan on nicotine-induced reward, behavioral sensitization, withdrawal signs, and drug seeking-related behavior in rats. The College on Problems of Drug Dependence (CPDD) annual meeting, San Diego, California, U.S.A.
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, and Eagle Yi-Kung Huang (2016) Angiotensin IV acts through c-Met to suppress hippocampal long-term depression (LTD) with a possible connection with memory decay in rats. Zing Conferences, Memory Mechanisms in Health and Disease, Tampa, Florida, U.S.A.
Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, and Lok-Hi Chow (2016) Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. The College on Problems of Drug Dependence (CPDD) annual meeting, Palm Springs, California, U.S.A.
Eagle Yi-Kung Huang (2012) LVV-hemorphin 7, angiotensin IV, and oxytocin in regulation of pain at the spinal cord. Zing Peptide Chemistry Conference, Cancun, Occidental Grand Xcaret Hotel, Mexico
Wan-Chun Wu, Pao-Luh Tao, and Eagle Yi-Kung Huang (2012) Sex difference of oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. 14th World Congress on Pain, Milan, Italy
Eagle Yi-Kung Huang, En-Pei Chang, Ya-Yun Cheng, and Pao-Luh Tao (2011) Potential use of intrathecal oxytocin and related peptides in the treatment of inflammatory hyperalgesia. New Frontiers in Persistent Pain Conference, Paris, France
Eagle Yi-Kung Huang, En-Pei Chang, and Pao-Luh Tao (2010) A possible correlation between the oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Japan
Eagle Yi-Kung Huang and Pao-Luh Tao (2009) A different view in searching for a new drug target: insulin-regulated amino peptidase (IRAP). The 2nd Protein and Peptide Conference & The 2nd World Congress of Industrial Biotechnology 2009, Seoul, Korea
Eagle Yi-Kung Huang, Ya-Yun Cheng, and Pao-Luh Tao (2008) LVV-hemorphin-7 and angiotensin IV in correlation with anti-hyperalgesia in rats. 12th World Congress on Pain, Glasgow, U. K.
Shu-Hsuan Chou, Tsung-Hsun Yang, Eagle Yi-Kung Huang, and Pao-Luh Tao (2007) Mechanisms of dextromethorphan on treatment of morphine rewarding effect. 38th International Narcotics Research Conference, Berlin, Germany
Eagle Yi-Kung Huang, Jun-Hong Wu, and Pao-Luh Tao (2007) Possible mechanisms of neuropeptide FF (NPFF) to modulate the rewarding effect of morphine in rats. 38th International Narcotics Research Conference, Berlin, Germany
Pao-Pao Yang, Sue-Yi Chen, Eagle Yi-Kung Huang, and Pao-Luh Tao (2007) ASIC3 may play an important role in primary afferent depolarization in the spinal cord of rats. 38th International Narcotics Research Conference, Berlin, Germany
Eagle Yi-Kung Huang, Kuei-Ying Hsu, and Pao-Luh Tao (2006) Acid-sensing ion channel 1a (ASIC1a) may play an important role in the expression of morphine addiction. Joint Meeting of the 28th Annual Meeting of the Japanese Society of Biological Psychiatry, the 36th Annual Meeting of the Japanese Society of Neuropsychopharmacology, the 49th Annual Meeting of the Japanese Society of Neurochemistry, Nagoya, Japan
Jain-Fang Chen, Pao-Luh Tao, and Eagle Yi-Kung Huang (2006) Co-administration of dextromethorphan during pregnancy reverses morphine-potentiated psychological dependence and inflammatory hyperalgesia in rat offspring from morphine-addicted dams. 6th European Opioid Conference, Salamanca, Spain
P.-L. Tao, W.-Y. Sung, P.-C. Wu, and E. Y.-K. Huang (2004) Nalbuphine is effective on prevention of morphine addiction. 35th International Narcotics Research Conference, Kyoto, Japan
E. Y.-K. Huang, C.-F. Wu, and P.-L. Tao (2004) Acid-sensing ion channels (ASICs) may play important roles in spinal nociception and hyperalgesia. 35th International Narcotics Research Conference, Kyoto, Japan
P. L. Tao, W. Y. Sung, P. C. Wu, and E. Y.-K. Huang (2003) Dextromethorphan is effective on treatment of morphine addiction. 34th International Narcotics Research Conference, Perpignan, France
E. Y.-K. Huang, Y. H. Lai, and P. L. Tao (2003) The effects of mu-opioids on polysynaptic reflex in the isolated spinal cord preparation of rats. 34th International Narcotics Research Conference, Perpignan, France
E. Y.-K. Huang, J.-C. Chen, and P.-L. Tao (2002) PFR(Tic)amide, a possible antagonist of neuropeptide FF, produces analgesia intrathecally and attenuates amphetamine-induced locomotor sensitization. XIVth World Congress of Pharmacology, San Francisco, CA, U. S. A.
P.-L. Tao, T. C. Liu, and E. Y.-K. Huang (2002) Effect of dextromethorphan on the rewarding and behavioral sensitization induced by morphine. XIVth World Congress of Pharmacology, San Francisco, CA, U. S. A.
P.-L. Tao, C.-M. Chen, and E. Y.-K. Huang (2002) Effects of supraspinal endomorphin-1 and endomorphin–2 on allodynia and rewarding in rats. 33rd International Narcotics Research Conference, Asilomar, Pacific Grove, CA, U. S. A.
E. Y.-K. Huang, H.-J. Hsiao, and P.-L. Tao (2002) The effects of U-50488, a kappa opioid agonist, on morphine rewarding and dependence. 33rd International Narcotics Research Conference, Asilomar, Pacific Grove, CA, U. S. A.
Eagle Yi-Kung Huang, Pao-Luh Tao, Jihn-Yih Li, and Jin-Chung Chen (2001) Endomorphin-1 and –2 induce naloxone-precipitated withdrawal syndromes in rats. 32nd International Narcotics Research Conference, Helsinki, Finland
E. Y.-K. Huang, J.-Y. Li, K.-W. Liang, C.-H. Wong, P. P.-C. Tan, R.-C. Huang, and J.-C. Chen (1999) The cardiovascular effects of PFRFamide and PFR(Tic)amide, a possible agonist and antagonist of neuropeptide FF (NPFF). Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 958
J.-Y. Li, E. Y.-K. Huang, H.-L. Wang, C.-H. Wong, P. P.-C. Tan, and J.-C. Chen (1999) Depletion of spinal serotonin attenuates the rate of morphine tolerance in rats. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 176
J.-C. Chen, Y.-K. Huang, M. Y. Lin, and H. C. Hsieh (1999) The modulatory effect of endomorphin-1 and –2 on the induction and expression of amphetamine sensitization. Soc. Neurosci. Abstr., Vol. 25, Part 2, p. 2082
J.-C. Chen, J.-Y. Li, I.-K. Huang, and K.-W. Liang (1998) The significance of ventral pallidum on behavioral sensitization to amphetamine. Soc. Neurosci. Abstr., Vol. 24, Part 2, p. 1964