Professional Experience

• Director, Pharmaceutical Administration Division, Department of Pharmacy Practice, Tri-Service General Hospital
• Head, Pharmaceutical Research Division, Department of Pharmacy Practice, Tri-Service General Hospital
• Chief Pharmacist, Department of Pharmacy Practice, Tri-Service General Hospital
• Committee Member, Medical Quality and Patient Safety Committee, Tri-Service General Hospital
• Hospital Accreditation Liaison, Department of Pharmacy Practice, Tri-Service General Hospital
• Secretary, RCA Task Force, Department of Pharmacy Practice, Tri-Service General Hospital
• Secretary, Adverse Drug Reaction Task Force, Pharmacy and Therapeutics Committee, Tri-Service General Hospital
• Secretary, OSCE (Objective Structured Clinical Examination), Department of Pharmacy Practice, Tri-Service General Hospital
• Supervisor, Inpatient Pharmacy, Tri-Service General Hospital
• Executive Editor, Formosa Journal of Clinical Pharmacy (15th Edition)
• Vice Chair, Young Pharmacists Committee, Taipei Pharmacists Association

Research Interests

• Neuroscience: Neurotoxicity of Recreational Drugs, Parkinson’s Disease
• Radiopharmaceuticals: PET Imaging
• Behavioral Pharmacology

National Science and Technology Council (NSTC) Grants

• Lipopolysaccharide-Induced Parkinson's Disease and Renal Damage: A Cross-System Analysis from Neurological Lesions to Renal Dysfunction (113-2314-B-016-044-MY3)
• Establishment of Screening platform for Neuroprotective Drugs against LPS-indiced Parkinson's Disease Mice by PET Imaging: Multiple Strategies to Regulate L-glutamate Levels of Microglia a (110-2314-B-016-030-MY3)
• Modulation of Microglial Activation for Treatment of Parkinson's Disease: from Basic Research to Population-based Study (108-2320-B-016-002)

Honors and Awards

2024: Annual Outstanding Service Award, Taiwan Society of Health-System Pharmacists

2017–2023: Served as a quality control facilitator at Tri-Service General Hospital, promoting quality improvement initiatives.

•2019: "Intelligent Pneumatic Tube System for Medication Transport" awarded the Smart Healthcare Certification and Symbol of National Quality Award

•2023: "Enhancing Pharmacist Participation in Chemotherapy Rotation Training" received the Bronze Tower Award at the Taiwan Continuous Improvement Awards (Team Category)

2022: Annual Outstanding Service Award, Taiwan Society of Health-System Pharmacists 2021:

•3rd Prize, Outstanding Academic Work Award, Tri-Service General Hospital

•Annual Outstanding Service Award, Taiwan Society of Health-System Pharmacists

2020:

•2nd Prize, Outstanding Academic Work Award, Tri-Service General Hospital

•Honorable Mention, Research Poster Competition, Tri-Service General Hospital

2017:

•Young Outstanding Hospital Pharmacist, Taipei Pharmacists Association

•2nd Prize, Outstanding Academic Work Award, Tri-Service General Hospital

Academic Publications

(1)   Wang, T. A., Li, S. Y., Fann, L. Y., Li, I. H., Liu, T. T., Hung, H. Y., Chang, C. W., Cheng, C. C., Huang, Y. C., Yu, P. Y., and Shih, J. H. (2025) Neuroprotective potential of isofraxidin: Alleviating parkinsonian symptoms, inflammation and microglial activation. Journal of central nervous system disease 17, 11795735241312661.

(2)    Lin, C., Kuo, F. C., Chau, T., Shih, J. H., Lin, C. S., Chen, C. C., Lee, C. C., and Lin, S. H. (2024) Artificial intelligence-enabled electrocardiography contributes to hyperthyroidism detection and outcome prediction. Communications medicine 4, 42.

(3)    Li, I. H., Liu, T. T., Chen, Y. C., Hsiao, S. H., Hung, H. Y., Fann, L. Y., and Shih, J. H. (2023) Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity. Biomed Pharmacother 164, 114880.

(4)    To, S. Y., Kao, L. T., Shih, J. H., Li, I. H., Huang, T. W., Tsai, C. L., Chian, C. F., Ho, C. L., and Chang, P. Y. (2022) Modified-Dose Pembrolizumab and Prognostic Outcomes among Non-Small Cell Lung Cancer Patients: A Chart Review Study. International journal of environmental research and public health 19.

(5)    Zhong, P. X., Li, I. H., Shih, J. H., Yeh, C. B., Chiang, K. W., and Kao, L. T. (2021) Antidepressants and risk of sudden sensorineural hearing loss: a population-based cohort study. International journal of epidemiology 50, 1686-1697.

(6)    Yeh, C. C., Yang, C. P., Ma, K. H., Shih, J. H., Tseng, C. S., and Huang, Y. S. (2021) Endogenous Expression of G-CSF in Rat Dorsal Root Ganglion Neurons after Nerve Injury. Brain sciences 11.

(7)    Tzeng, Y. M., Li, I. H., Kao, H. H., Shih, J. H., Yeh, C. B., Chen, Y. H., and Kao, L. T. (2021) Protective Effects of Anti-depressants against the Subsequent Development of Psoriasis in Patients with Major Depressive Disorder: a Cohort Study. Journal of affective disorders 281, 590-596.

(8)    Wu, F. J., Li, I. H., Chien, W. C., Shih, J. H., Lin, Y. C., Chuang, C. M., Cheng, Y. D., and Kao, L. T. (2020) Androgen deprivation therapy and the risk of iron-deficiency anaemia among patients with prostate cancer: a population-based cohort study. BMJ open 10, e034202.

(9)    Shih, J. H. *, Tsai, Y. F. *, Li, I. H., Chen, M. H., and Huang, Y. S. (2020) Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells. Marine drugs 18. (* Equal contribution)

(10)  Shih, J. H., Li, I. H., Pan, K. T., Wang, C. H., Chen, H. C., Fann, L. Y., Tseng, J. H., and Kao, L. T. (2020) Association between Anemia and Auditory Threshold Shifts in the US Population: National Health and Nutrition Examination Survey. International journal of environmental research and public health 17.

(11)  Shih, J. H., Kao, L. T., Chung, C. H., Liao, G. S., Fann, L. Y., Chien, W. C., and Li, I. H. (2020) Protective Association Between Calcium Channel Blocker Use and Breast Cancer Recurrence in Postsurgical Women: A Population-Based Case-Control Study in Taiwan. Journal of clinical pharmacology 60, 785-792.

(12)  Li, I. H., Shih, J. H., Yeh, T. Y., Lin, H. C., Chen, M. H., and Huang, Y. S. (2020) Lysosomal Dysfunction and Autophagy Blockade Contribute to MDMA-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Chemical research in toxicology 33, 903-914.

(13)  Li, I. H., Pan, K. T., Wang, W. M., Chien, W. C., Shih, J. H., and Kao, L. T. (2020) Digoxin use and following risk of psoriasis: A population-based cohort study in Taiwan. The Journal of dermatology 47, 458-463.

(14)  Kao, L. T., Shih, J. H., Yeh, C. B., Wang, C. H., Chen, H. C., Chien, W. C., and Li, I. H. (2020) Association between major depressive disorder and subsequent tinnitus: A population-based study. Journal of affective disorders 263, 367-372.

(15)  Fann, L. Y., Shih, J. H., Tseng, J. H., Huang, H. S., and Hsiao, S. H. (2020) CC12 Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Lines and Mouse Xenograft Model. Molecules (Basel, Switzerland) 25.

(16)  Fan, H. C., Chang, Y. K., Tsai, J. D., Chiang, K. L., Shih, J. H., Yeh, K. Y., Ma, K. H., and Li, I. H. (2020) The Association Between Parkinson's Disease and Attention-Deficit Hyperactivity Disorder. Cell transplantation 29, 963689720947416.

(17)  Shih, J. H., Chiu, C. H., Ma, K. H., Huang, Y. S., Shiue, C. Y., Yeh, T. Y., Kao, L. T., Lin, Y. Y., and Li, I. H. (2019) Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats. Pharmacological research 142, 283-293.

(18)  Liu, C. T., Kao, L. T., Shih, J. H., Chien, W. C., Chiu, C. H., Ma, K. H., Huang, Y. S., Cheng, C. Y., Shiue, C. Y., and Li, I. H. (2019) The effect of dextromethorphan use in Parkinson's disease: A 6-hydroxydopamine rat model and population-based study. European journal of pharmacology 862, 172639.

(19)  Liu, C. T., Huang, Y. S., Chen, H. C., Ma, K. H., Wang, C. H., Chiu, C. H., Shih, J. H., Kang, H. H., Shiue, C. Y., and Li, I. H. (2019) Evaluation of brain SERT with 4-[(18)F]-ADAM/micro-PET and hearing protective effects of dextromethorphan in hearing loss rat model. Toxicology and applied pharmacology 378, 114604.

(20)  Lin, Y. C., Tsai, C. S., Li, I. H., Tsai, Y. T., Huang, T. Y., Lee, K. F., Lin, C. S. *, Shih, J. H. *, and Kao, L. T. * (2019) Transplant Recipients Using Tacrolimus Had Higher Utilization of Healthcare Services Than Those Receiving Cyclosporine in Taiwan. Front Pharmacol 10, 1074. (* Equal contribution)

(21)  Li, I. H., Wang, W. M., Chien, W. C., Kao, H. H., Shih, J. H., Cheng, Y. D., Pan, K. T., and Kao, L. T. (2019) Benzodiazepine receptor agonists and subsequent risk of psoriasis: A 5-year follow-up cohort study. Journal of the American Academy of Dermatology 81, 1433-1435.

(22)  Li, I. H*., Shih, J. H. *, Tsai, C. S., Chien, W. C., Kao, H. H., Pan, K. T., Cheng, Y. D., and Kao, L. T. (2019) Inverse Association of Fibrates and Liver Cancer: A Population-Based Case-Control Study in Taiwan. Journal of clinical pharmacology 59, 1170-1176. (* Equal contribution)

(23)  Li, I. H., Shih, J. H., Jhao, Y. T., Chen, H. C., Chiu, C. H., Chen, C. F., Huang, Y. S., Shiue, C. Y., and Ma, K. H. (2019) Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[(18)F]-ADAM/Small-Animal Positron Emission Tomography. Molecules (Basel, Switzerland) 24.

(24)  Kao, H. H., Kao, L. T., Li, I. H., Pan, K. T., Shih, J. H., Chou, Y. C., and Wu, S. T. (2019) Androgen Deprivation Therapy Use Increases the Risk of Heart Failure in Patients With Prostate Cancer: A Population-Based Cohort Study. Journal of clinical pharmacology 59, 335-343.

(25)  Chang, J. T., Li, I. H., Shih, J. H., Chien, W. C., Pan, K. T., Wu, S. T., Tsai, C. S., and Kao, L. T. (2019) Health Care Service Utilization After Various Vascular Access Selections. The Journal of surgical research 244, 166-173.

(26)  Wu, H. F., Kao, L. T., Shih, J. H., Kao, H. H., Chou, Y. C., Li, I. H., and Kao, S. (2018) Pioglitazone use and Parkinson's disease: a retrospective cohort study in Taiwan. BMJ open 8, e023302.

(27)  Sun, G. G., Shih, J. H., Chiou, S. H., Hong, C. J., Lu, S. W., and Pao, L. H. (2016) Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. Journal of ethnopharmacology 193, 159-168.

(28)  Shih, J. H., Ma, K. H., Chen, C. F., Cheng, C. Y., Pao, L. H., Weng, S. J., Huang, Y. S., Shiue, C. Y., Yeh, M. K., and Li, I. H. (2016) Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 26, 92-104.