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::: Joint Appointments

陳元皓 Joint Appointments

陳元皓 Joint Appointments      
Yuan-Hao Chen, M.D., Ph.D.

Current Positions

Co-appointed Professor, Department of Pharmacology, National Defense Medical University

Professor, Department of Surgery, National Defense Medical University

Deputy Director General, Medical Affairs Bureau Ministry of National Defense

Attending Doctor, Department of Neurological Surgery, Tri-Service General Hospital

Education

PhD in Medical Sciences, National Defense Medical Center (now National Defense Medical University)

MD, National Defense Medical Center (now National Defense Medical University)

Research Areas & Specialties

 * Functional Neurosurgery
 * Neuroscience
 * Neurodegeneration Disease 
 * Neuroelectrophysiology
 * Neurochemistry

Contact Information

Lab: R6311 & R6312

Phone: +886-2-8792-3100 ext. 18673


Research Interests

Professor Yuan-Hao Chen’s laboratory focuses on translational research in neuroscience, neurodegenerative diseases, and functional neurosurgery. By integrating animal models (such as MitoPark mice), neuroelectrophysiology, and molecular biology, the lab investigates the pathogenesis of neurological disorders and develops innovative therapeutic strategies. The main research directions include:
 1. Parkinson's Disease and Neurodegeneration: Investigating the regulatory mechanisms of the dopamine and serotonin systems in Parkinson's disease and L-DOPA-induced dyskinesia (LID). The lab utilizes MitoPark mouse models to study mitochondrial dysfunction and evaluates the neuroprotective potential of emerging therapeutics, such as GLP-1 receptor agonists (e.g., PT320), in delaying dopaminergic neuronal degeneration.
 2. Traumatic Brain Injury (TBI) and Cerebrovascular Diseases: Studying the mechanisms of brain and cervical spine injuries resulting from primary blast waves and ballistics. Furthermore, the lab explores microglia/macrophage activation, the modulation of innate immune responses, and the role of neurotrophic factors like CDNF in promoting neurorepair and functional recovery following intracerebral hemorrhage and stroke.
 3. Artificial Intelligence in Medicine and Clinical Neurosurgery: Applying interdisciplinary AI technologies to enhance clinical diagnosis and prognostication using electrocardiograms and chest radiographs. The research also encompasses targeted therapies for glioblastoma and clinical advancements in endoscopic skull base surgery.

Publications

  1. Chin-Sheng Lin, Wei-Ting Liu, Yuan-Hao Chen, Shih-Hua Lin, Chin Lin (2025, Dec). Artificial intelligence-enabled electrocardiography from scientific research to clinical application. EMBO Molecular Medicine, 1-19. DOI: 10.1038/s44321-025-00351-y. 
  2. Clark C Chen , Hsu-Tung Lee , Wei-Hsiu Liu , Ching-Ann Liu , Hsin-I Ma , Dueng-Yuan Hueng , Yuan-Hao Chen , Wen-Chiuan Tsai , Jen-Wei Liu , Jui-Hao Lee , Chia-Liang Tai , Horng-Jyh Harn , Tzyy-Wen Chiou , Tsung-Lang Chou , Shinn-Zong (John) Lin (2025, Nov). CTNI-33. A PIVOTAL PHASE IIB/III STUDY FOR A LOCALIZED GLIOBLASTOMA TREATMENT TARGETING RECEPTOR TYROSINE KINASE DEFINED NETWORK. Neuro-Oncology, 27(Supplement_5), v133-v133. DOI:10.1093/neuonc/noaf201.0529. 
  3. Kai-Chieh Chen, Matthew Kuo, Chun-Ho Lee, Hao-Chun Liao, Dung-Jang Tsai, Shing-An Lin, Chih-Wei Hsiang, Cheng-Kuang Chang, Kai-Hsiung Ko, Yi-Chih Hsu, Wei-Chou Chang, Guo-Shu Huang, Wen-Hui Fang, Chin-Sheng Lin, Shih-Hua Lin, Yuan-Hao Chen, Yi-Jen Hung, Chien-Sung Tsai, Chin Lin (2025, Sep). A Pretraining Approach for Small-sample Training Employing Radiographs (PASTER): a Multimodal Transformer Trained by Chest Radiography and Free-text Reports. Journal of Medical Systems, 49(1), 120. DOI:0.1007/s10916-025-02263-3. 
  4. Peng-Wei Wang, Da-Tong Ju, Wei-Hsiu Liu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu, Bon-Jour Lin (2025, Jul). Infraorbital nerve as effective intraoperative guidance during the endoscopic transorbital approach to the anterolateral skull base. Neurosurgical Review, 48(1), 1-12. https://doi.org/10.1007/s10143-025-03710-y. 
  5. Dung-Jang Tsai, Chin Lin, Wei-Ting Liu, Chiao-Chin Lee, Chiao-Hsiang Chang, Wen-Yu Lin, Yu-Lan Liu, Da-Wei Chang, Ping-Hsuan Hsieh, Chien-Sung Tsai, Yuan-Hao Chen, Yi-Jen Hung, Chin-Sheng Lin (2025, Jun). Artificial intelligence-assisted diagnosis and prognostication in low ejection fraction using electrocardiograms in inpatient department: a pragmatic randomized controlled trial. BMC medicine, 23(1), 342. https://doi.org/10.1038/s41746-025-01735-7. 
  6. Ping-Hsuan Hsieh, Chin Lin, Chin-Sheng Lin, Wei-Ting Liu, Tsung-Kun Lin, Dung-Jang Tsai, Yi-Jen Hung, Yuan-Hao Chen, Chih-Yuan Lin, Shih-Hua Lin, Chien-Sung Tsai (2025, Jun). Economic analysis of an AI-enabled ECG alert system: impact on mortality outcomes from a pragmatic randomized trial. npj digital medicine, 8(1), 348. https://doi.org/10.1038/s41746-025-01735-7. 
  7. Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang (2025, Jan). Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. Iranian Journal of Basic Medical Sciences, 28(9), 1212. https://dx.doi.org/10.22038/ijbms.2025.86093.18615. 
  8. Bon-Jour Lin, Da-Tong Ju, Chin Lin, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu (2024, Aug). Optimizing the selection of the endoscopically assisted supracerebellar transtentorial approach to the medial temporo‐occipital region: Clinical application of one novel grid coordinate system. Clinical Anatomy, 38(4), 442-455. https://doi.org/10.1002/ca.24208. 
  9. Yuan-Hao Chen, Tung-Tai Kuo, Vicki Wang, Pin-Wen Cheng, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. Greig, Lars Olson, Barry J. Hoffer, Kuan-Yin Tseng (2024, Jul). Serotonergic regulation of synaptic DA levels mitigates L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease. Journal of Parkinsons Disease, 14(5), 941-964. (SCI, 68/272, Neurosciences). NSTC 112-2314-B-016-068-MY3. 本人為第一作者. DOI: 10.3233/JPD-240080. 
  10. Vicki Wang, Kuan Yin Tseng, Tung Tai Kuo, Eagle Yi Kung Huang, Kuo Lun Lan, Zi Rong Chen, Kuo Hsing Ma, Nigel H. Greig, Jin Jung, Ho II Choi, Lars Olson, Barry J. Hoffer, Yuan Hao Chen (2024, Apr). Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. Journal of Biomedical Science, 31, 38. (SCI, 29/190, Medicine, Research and Experimental). MOST 109-2314-B-016-019-MY2. 本人為通訊作者. 
  11. Bon-Jour Lin, Da-Tong Ju, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu (2024, Jan). Endoscopic transorbital decompression for traumatic superior orbital fissure syndrome: from cadaveric study to clinical application. European Archives of Oto-Rhino-Laryngology, 281(5),1-8. DOI: 10.1007/s00405-023-08440-9. 
  12. Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Hao-Yuan Hung, Pin-Chen Lin, Eagle Yi-Kung Huang (2024, Jan). Intrathecal Injections of Angiotensin IV and Oxytocin Conjugates Induce Antihyperalgesia and Antiallodynia in Both Sexes of Rats. Peptides, 173(1),171150. DOI:10.1016/j.peptides.2024.171150. 
  13. Eagle Yi-Kung Huang, Hao-Yuan Hung, Yuan-Hao Chen, Jen-Hsin Kao, Ai-Lun Tsai, Lok-Hi Chow (2023, Jul). Effects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats.. Nicotine and Tobacco Research, 25(7), 1251-1260.. (SCI, 54/562, Medicine - Public Health, Environmental and Occupational Health). DOI: 10.1093/ntr/ntac287. 
  14. Bon-Jour Lin, Da-Tong Ju, Kuan-Yin Tseng, Wei-Hsiu Liu, Chi-Tun Tang, Dueng-Yuan Hueng, Yuan-Hao Chen, Chung-Ching Hsia, Guann-Juh Chen, Hsin-I Ma, Ming-Ying Liu, Tzu-Tsao Chung (2023, Mar). Endoscopically assisted presigmoid retrolabyrinthine approach to the lateral mesencephalic sulcus: a cadaveric study with comparison to the variant supracerebellar infratentorial approaches. Neurosurgical Review, 46(1), 73. (SCI, 140/359, Medicine - Neurology (clinical)). DOI: 10.1007/s10143-023-01979-5. 
  15. Kuan-Yin Tseng, Vassilis Stratoulias, Wei-Fen Hu, Jui-Sheng Wu, Vicki Wang, Yuan-Hao Chen, Anna Seelbach, Henri J. Huttunen, Natalia Kulesskaya, Cheng-Yoong Pang, Jian-Liang Chou, Maria Lindahl, Mart Saarma, Li-Chuan Huang, Mikko Airavaara, Hock-Kean Liew (2023, Feb). Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage.. Cell Death & Disease, 14(2), 128. (SCI, 7/88, Neuroscience - Cellular and Molecular Neuroscience). DOI: 10.1038/s41419-022-05520-2. 
  16. Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Kuan-Yin Tseng (2023, Feb). PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson’s Disease.. International Journal of Molecular Sciences, 24(5), 4687. (SCI, 148/386, Biochemistry, Genetics and Molecular Biology - Molecular Biology). NSTC 111-2314-B-016-051-MY3. DOI: 10.3390/ijms24054687. 
  17. Kun-Ting Hong, Shih-Wei Hsu, Chao-Hsuan Chen, Dueng-Yuan Hueng, Yuan-Hao Chen, Da-Tong Ju, Da-Tian Bau, Chi-Tun Tang (2022, Nov). Endoscope-Assisted Manipulation of Chronic Subdural Hematoma Provide a Novel Solution for Eliminating Septum and Inner Membrane Leading to Reducing Recurrence. in vivo, 36(6): 2774-2779.. (SCI, 100/204, Biochemistry, Genetics and Molecular Biology - General Biochemistry, Genetics and Molecular Biology). DOI: 10.21873/invivo.13014. 
  18. Kuan-Yin Tseng, Tung-Tai Kuo, Vickic Wang, Eagle Yi-Kung Huang, Kuo-Hsinge Ma, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen* (2022, Jul). Tetrabenazine mitigates aberrant release and clearance of dopamine in the nigrostriatal system, and alleviates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease.. Journal of Parkinson's Disease, 2022;12(5):1545-1565. (SCI, 30/88, Cellular and Molecular Neuroscience). NSTC 109-2314-B-016-019-MY2. 本人為通訊作者. DOI: 10.3233/JPD-223195. 
  19. Kuan-Yin Tseng, Jui-Sheng Wu, Yuan-Hao Chen, Mikko Airavaara, Cheng-Yi Cheng, Kuo-Hsing Ma (2022, Jun). Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model. Biomedicines, 10(6): 1466. DOI: 10.3390/biomedicines10061446. 
  20. Chi-Tun Tang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Shih-Ming Huang, Dueng-Yuan Hueng, Chia-Kuang Tsai, Yuan-Hao Chen (2021, Nov). GRPEL2 knockdown exerts redox regulation in glioblastoma. International Journal of Molecular Sciences, 22(23):12705. (SCI). 本人為通訊作者. DOI: 10.3390/ijms222312705. 
  21. Lok-Hi Cho, Wan-Chuan Wu, Chun-Lin Kuo, Hao-Yuan Hung, Yuan-Hao Chen, Weihong Pan, Eagle Yi-Kung Huang (2021, Nov). Estrogen can abolish oxytocin-induced spinal anti-hyperalgesia. Psychoneuroendocrinology, 136, 105603. (SCI). DOI: 10.1016/j.psyneuen.2021.105603. 
  22. Hao-Yuan Hung, Wu-Chien Chien, Chi-Hsiang Chung, Li-Ting Kao, Lok-Hi Chow, Yuan-Hao Chen, Jolanta H. Kotlińska, Jerzy Silberring, Eagle Yi-Kung Huang (2021, Sep). Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study. Drug and Alcohol Dependence, 229, 109102. (SCI). DOI: 10.1016/j.drugalcdep.2021.109102. 
  23. Hsiang-Chih Liao, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Da-Tong Ju, Chi-Tun Tang (2021, May). Thoracic intradural extramedullary lipomas. Journal of Medical Sciences, 41(6), 312. (Scopus). DOI: 10.4103/jmedsci.jmedsci_267_20. 
  24. Tung-Tai Kuo, Vicki Wang, Jui-Sheng Wu, Yuan-Hao Chen, Kuan-Yin Tseng (2021, May). Post-stroke delivery of valproic acid promotes functional recovery and differentially modifies responses of peri-infarct microglia. Frontiers in Molecular Neuroscience, 14, 639145. (SCI). MOST 105-2314-B-016-001-MY3. 本人為通訊作者. DOI: 10.3389/fnmol.2021.639145. 
  25. Reni Ajoy, Yu-Chun Lo, Man-Hau Ho, You-Yin Chen, Yun Wang, Yuan-Hao Chen, Chiu Jing-Yuan, Chun Austin Changou, Yuan-Chin Hsiung, Hui-Min Chen, Tzu-Hao Chang, Cheng-Yang Lee, Yung-Hsiao Chiang, Wen-Chang Chang, Barry Hoffer, Szu-Yi Chou (2021, Apr). CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation. Molecular Psychiatry, 26, 6451–6468. (SCI). DOI: 10.1038/s41380-021-01103-3. 
  26. Vicki Wang, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Yu-Ching Chou, Zhao-Yang Fu, Li-Wen Lai, Jin Jung, Hoi-II Choi, Doo-Sup Choi, Yazhou Li, Lars Olson, Nigel H. Greig, Barry J. Hoffer, and Yuan-Hao Chen (2021, Mar). Sustained release GLP-1 agonist PT320 delays disease progression in a mouse model of Parkinson’s disease. ACS Pharmacology & Translational Science, 4(2), 858-869. MOST 108-2314-B-016-027. 本人為通訊作者. DOI: 10.1021/acsptsci.1c00013. 
  27. Hao-Yuan Hung, Lok-Hi Chow, Jolanta H Kotlinska, Anna Drabik, Jerzy Silberring, Yuan-Hao Chen, Eagle Yi-Kung Huang (2020, Nov). LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides, 136, 170455. (SCI). DOI: 10.1016/j.peptides.2020.170455. 
  28. Tung-Tai Kuo, Rong-Chin Lo, Yuan-Hao Chen, Chung-Ling Tseng (2020, Oct). Implementation of an inexpensive and improved purpose-built high SNR biomedical signal capture, record, and analysis system. Biomedical Engineering: Applications, Basis and Communications, 33(01), 2150004. (EI). DOI: 10.4015/S1016237221500046. 
  29. Bon-Jour Lin, Da-Tong Ju, Yi-Chieh Wu, Hung-Wen Kao, Kuan-Yin Tseng, Tzu-Tsao Chung, Wei-Hsiu Liu, Dueng-Yuan Hueng, Yuan-Hao Chen, Chung-Ching Hsia, Hsin-I Ma, Ming-Ying Liu, Chi-Tun Tang (2020, Sep). Endoscopic transcanal transpetrosal approach to the petroclival region: a cadaveric study with comparison to the Kawase approach. Neurosurgical Review, 44, pages2171–2179. (SCI). DOI: 10.1007/s10143-020-01389-x. 
  30. Chiao-Zhu Li, Chiao-Ching Li, Chi-Tun Tang, Chi-Hsiang Chung, Chien-Yu Ou, Chun-Lin Chen, Nan-Fu Chen, Tzu-Tsao Chung, Dueng-Yuan Hueng, Hsin-I Ma, Ming-Ying Liu, Yuan-Hao Chen, Wu-Chien Chien, Da-Tong Ju (2020, Jul). Association of early vertebroplasty with risk of hip replacement: A nationwide population-based cohort study in Taiwan. Journal of Vascular Surgery, 71(2), 481-489. DOI: 10.1097/MD.0000000000020926. 
  31. Rong-Chin Lo, Tung-Tai Kuo, Ren-Guey Lee, Yuan-Hao Chen, Chuan Chin Lim (2020, Jul). Evoked potential primitives of rat motor cortex signal analysis based on iterated function systems. Biomedical Engineering Applications Basis and Communications, 32(04):2050033. (EI). DOI: 10.4015/S1016237220500337. 
  32. Rong-Chin Lo, Tung-Tai Kuo, Ren-Guey Lee, Yuan-Hao Chen, Chih-Yin Huang (2020, Jul). A technology of renogram dividing based on blood vessels to obtain a more accurate diagnosis. Biomedical Engineering Applications Basis and Communications, 32(05):2050035. (EI). DOI: 10.4015/S1016237220500350. 
  33. Tung-Tai Kuo, Rong-Chin Lo, Ren-Guey Lee, Yuan-Hao Chen, Shang-Hsien Cai (2020, Jul). Activity command encoding of cerebral cortex M1-evoked potentials of the sprague dawley rat using time delay neural networks. Biomedical Engineering Applications Basis and Communications, 32(04):2050034. (EI). DOI: 10.4015/S1016237220500349. 
  34. Bon-Jour Lin, Yi-An Chen, Tzu-Tsao Chung, Wei-Hsiu Liu, Chi-Tun Tang, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu, Hung-Chang Hung, Da-Tong Ju (2020, Apr). Clinical efficacy of minipterional craniotomy with rostral transsylvian-transinsular approach for hypertensive basal ganglion hemorrhage. Journal of Medical Sciences, 40(4), 175. (Scopus). 
  35. Bon-Jour Lin,Da-Tong Ju,Tzu-Hsien Hsu,Yi-An Chen,Tzu-Tsao Chung,Wei-Hsiu Liu,Dueng-Yuan Hueng,Yuan-Hao Chen,Chung-Ching Hsia,Hsin-I Ma,Ming-Ying Liu,Chi-Tun Tang (2020, Apr). Quantitative comparison of endoscopically‐assisted endonasal, sublabial, and transorbital transmaxillary approaches to the anterolateral skull base. Clinical Otolaryngology, 46(1), 123-130. (SCI). DOI: 10.1111/coa.13559. 
  36. Xiao-Jun Feng, Yu-Ting Huang, Ying-Zu Huang, Chi-Wei Kuo, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Yuan-Hao Chen, Kai-Yun Chen, Yung-Hsiao Chiang, Hui-Hua Liu, Jian-Xian Wu, Tsung-Hsun Hsieh (2020, Feb). Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-Induced Parkinsonism in rats. Brain Stimulation, 13(3), 655-663. (SCI). DOI: 10.1016/j.brs.2020.02.002. 
  37. Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh (2019, Dec). Long-term voluntary physical exercise exerts neuroprotective effects and motor disturbance alleviation in a rat model of Parkinson’s disease. Behavioural Neurology, 2019(4):1-10. (SCI). DOI: 10.1155/2019/4829572. 
  38. Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Yu-Ching Chou, Tung-Tai Kuo, Lars Olson, Barry J. Hoffer (2019, Dec). Delayed dopamine dysfunction and motor deficits in female Parkinson model mice. International Journal of Molecular Sciences, 20(24), 6251. (SCI, 145/382, Molecular Biology). MOST 108-2314-B-016-027. 本人為第一作者、通訊作者. DOI: 10.3390/ijms20246251. 
  39. Bon-Jour Lin, Da-Tong Ju, Tzu-Hsien Hsu, Tzu-Tsao Chung, Wei-Hsiu Liu, Dueng-Yuan Hueng, Yuan-Hao Chen, Chung-Ching Hsia, Hsin-I Ma, Ming-Ying Liu, Hung-Chang Hung, Chi-Tun Tang (2019, Jun). Endoscopic transorbital approach to anterolateral skull base through inferior orbital fissure: a cadaveric study. Acta Neurochirurgica, 161(9), 1919-1929. (SCI). DOI: 10.1007/s00701-019-03993-3. 
  40. Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Chih-Yuan Lin, Yuan-Hao Chen, Min-Tser Liao, Wen-I.Liao, Chia-Ching Hsu, Shih-Hung Tsai (2019, Jun). Association between surgical repair of aortic aneurysms and the diagnosis of intracranial aneurysms . Journal of Vascular Surgery, S0741-5214(19)31135-8. . (SCI, 38/212, Surgery). DOI: 10.1016/j.jvs.2019.04.466. 
  41. Bon-Jour Lin, Kun-Ting Hong, Tzu-Tsao Chung, Wei-Hsiu Liu, Dueng-Yuan Hueng, Yuan-Hao Chen, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Hung-Chang Hung, Chi-Tun Tang (2019, Apr). Endoscopic transorbital transtentorial approach to middle incisural space: preclinical cadaveric study. Acta Neurochirurgica, 161(4), 831-839. (SCI). DOI: 10.1007/s00701-019-03831-6. 
  42. Yuan-Hao Chen, Tsung-Hsun Hsieh , Tung-Tai Kuo, Jen-Hsin Kao, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Yu-Ching Chou, Lars Olson, Barry J. Hoffer (2019, Mar). Release parameters during progressive degeneration of dopamine neurons in mouse model reveal earlier impairment of spontaneous than forced behaviors. Journal of Neurochemistry, 150(1), 56-73. (SCI, 67/273, Neurosciences). MOST 105-2314-B-016-001-MY3. 本人為第一作者. DOI: 10.1111/jnc.14702. 
  43. Shao-Wei Feng, Chih-Chuan Hsieh, Yun-Ju Yang, Yuan-Hao Chen, Chi-Tun Tang, Da-Tong Ju (2019, Jan). Hearing preservation after cyberknife stereotactic radiosurgery for vestibular schwannomas. Journal of Medical Sciences, 39(1), 10. (Scopus). DOI: 10.4103/jmedsci.jmedsci_35_17. 
  44. Wen-Shyan Huang, Lin-Gwei Wei, Jhen-Kai Li, Keng-Yen Fu, Tai-Chun Huang, Pai-Shan Hsieh, Nien-Chi Huang, Lien-Guo Dai, Fung-Wei Chang, Shih-Hurng Loh, Yuan-Hao Chen, Bing-Heng Yang, Chia-Yang Shiau, Gwo-Jang Wu, Niann-Tzyy Dai (2019, Jan). Melanocyte differentiation from induced pluripotent stem cells derived from human adipose-derived stem cells. Annals of Plastic Surgery, 82(1S), S119–S125. (SCI). DOI: 10.1097/SAP.0000000000001698. 
  45. Bon-Jour Lin, Kun-Ting Hong, Chin Lin, Tzu-Tsao Chung, Chi-Tun Tang, Dueng-Yuan Hueng, Chung-Ching Hsia, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Yuan-Hao Chen (2018, Nov). Impact of global spine balance and cervical regional alignment on determination of postoperative cervical alignment after laminoplasty. Medicine, 97(45), e13111. (SCI). 本人為通訊作者. DOI: 10.1097/MD.0000000000013111. 
  46. Meng-Chi Lin, Chiao-Zhu Li, Chih-Chuan Hsieh, Kun-Ting Hong, Bon-Jour Lin, Chin Lin, Wen-Chiuan Tsai, Chiao-Hua Lee, Man-Gang Lee, Tzu-Tsao Chung, Chi-Tun Tang, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Yuan-Hao Chen, Dueng-Yuan Hueng (2018, Nov). Preoperative grading of intracranial meningioma by magnetic resonance spectroscopy (1H-MRS). , 13(11), e0207612. (SCI). MOST 106-2314-B-016-012-MY3. DOI: 10.1371/journal.pone.0207612. 
  47. Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J Hoffer, Jen-Hsin Kao, Yu-Ching Chou, Yung-Hsiao Chiang, Jonathan Miller (2018, Oct). Nicotine-induced conditional place preference is affected by head injury: Correlation with dopamine release in the nucleus accumbens shell. International Journal of Neuropsychopharmacology, 21(10), 949-961. (SCI, 73/267, Neurosciences). MOST 105-2314-B-016-001-MY3. 本人為第一作者. DOI: 10.1093/ijnp/pyy055. 
  48. Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng (2018, Jul). Risk of erectile dysfunction after traumatic brain injury: A nationwide population-based cohort study in taiwan. American Journal of Men's Health, 12(4), 913–925. (SCI). DOI: 10.1177/1557988317750970. 
  49. Lok-Hi Chow, Yuan-Hao Chen, Chun-Fu Lai, Tsu-You Lin, Ying-Jie Chen, Jen-Hsin Kao, Eagle Huang (2018, Jun). Sex difference of angiotensin IV–, LVV-Hemorphin 7–, and oxytocin-induced antiallodynia at the spinal level in mice with neuropathic pain. Anesthesia & Analgesia, 126(6), 2093–2101. (SCI). doi: 10.1213/ANE.0000000000002795. 
  50. Yuan-Hao Chen, Bon-Jour Lin, Tsung-Hsun Hsieh, Tung-Tai Kuo, Jonathan Miller, Yu-Ching Chou, Eagle Yi-Kung Huang, Barry J. Hoffer (2018, May). Differences in nicotine encoding dopamine release between the striatum and shell portion of the nucleus accumbens. Cell Transplantation, 28(3), 248-261. (SCI). MOST 105-2341-B-016-001-MY3. 本人為第一作者、通訊作者. DOI: 10.1177/0963689718775382. 
  51. Yuan-Hao Chen, Tung-Tai Kuo, Jen-Hsin Kao, Eagle Yi-Kung Huang, Tsung-Hsun Hsieh, Yu-Ching Chou, Barry J. Hoffer (2018, Mar). Exercise ameliorates motor deficits and improves dopaminergic functions in the rat hemi-Parkinson’s model. Scientific Reports, 2018(3), 3973. (SCI). MOST 105-2314-B-016-001-MY3. 本人為第一作者、通訊作者. DOI:10.1038/s41598-018-22462-y. 
  52. Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J. Hoffer, Yu-Ching Chou, Yung-Hsiao Chiang, Hsin-I Ma, Jonathan P. Miller (2018, Feb). Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam. Oncotarget, 9(14), 11515–11527. (SCI). MOST 105-2314-B-016-001-MY3. 本人為第一作者. DOI: 10.18632/oncotarget.23923. 
  53. Chiao-Zhu Li, Feng-Cheng Liu, Chiao-Ching Li, Meng-Chi Lin, Chih-Chuan Hsieh, Bon-Jour Lin, Nan-Fu Chen, Chun-Lin Chen, Tzu-Tsao Chung, Chi-Tun Tang, Dueng-Yuan Hueng, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Ching Lu, Yuan-Hao Chen (2018, Jan). The efficacy of therapeutic plasma exchange in antiphospholipid antibody-positive patients with spontaneous intracerebral hemorrhage and high d-dimer levels. The Neurologist, 23(1), 7–11. (SCI). 本人為通訊作者. DOI: 10.1097/NRL.0000000000000159. 
  54. Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Yu-Ching Chou, Yung-Hsiao Chiang, Barry J Hoffer, Jonathon Miller (2017, Dec). Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell. Oncotarget, 9(11), 10016–10028. (SCI). MOST 105-2314-B-016-001-MY3. 本人為第一作者. DOI: 10.18632/oncotarget.24245. 
  55. Bon-Jour Lin, Chiao-Zhu Li, Tzu-Tsao Chung, Chi-Tun Tang1, Dueng-Yuan Hueng, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Yuan-Hao Chen (2017, Apr). Minipterional craniotomy with transsylvian-transinsular approach for hypertensive putaminal hemorrhage: A preliminary report. Journal of Medical Sciences, 37(2), 56. (Scopus). 本人為通訊作者. DOI: 10.4103/jmedsci.jmedsci_104_16. 
  56. Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J. Hoffer, Jonathan Miller, Yu-Ching Chou, Yung-Hsiao Chiang (2017, Apr). Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience, 348, 180-190. (SCI). MOST 105-2314-B-016-001-MY3. 本人為第一作者. DOI: 10.1016/j.neuroscience.2017.02.001. 
  57. Chiao-Zhu Li, Chiao-Ching Li, Chih-Chuan Hsieh, Meng-Chi Lin, Dueng-Yuan Hueng, Feng-Chen Liu, Yuan-Hao Chen (2017, Jan). Fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery for a pituitary tumor: A case report. Medicine, 96(1). (SCI). 本人為通訊作者. DOI: 10.1097/MD.0000000000005774. 
  58. Yi-Lin Yu, Yun-Ju Yang, Chin Lin, Chih-Chuan Hsieh, Chiao-Zhu Li, Shao-Wei Feng, Chi-Tun Tang, Tzu-Tsao Chung, Hsin-I Ma, Yuan-Hao Chen, Da-Tong Ju, Dueng-Yuan Hueng (2017, Jan). Analysis of volumetric response of pituitary adenomas receiving adjuvant CyberKnife stereotactic radiosurgery with the application of an exponential fitting model . Medicine, 96(4). (SCI). DOI: 10.1097/MD.0000000000004662. 
  59. Chia-Kuang Tsai, Jiunn-Tay Lee, Yuan-Hao Chen, Chih-Sung Liang, Chun-Chieh Lin, Nai-Wen Chang, Cherry Liu6, Chung-Hsing Chou, Gunng-Shinng Chen, Feng-Cheng Liu, Tzu-Yang Lin, Dueng-Yuan Hueng (2016, Dec). Cell division cycle-associated 7-like gene: A novel biomarker for adverse survival in human high-grade gliomas. Journal of Medical Sciences, 36(6), 224. (Scopus). DOI: 10.4103/1011-4564.196353. 
  60. Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Jonathan Miller, Yung-Hsiao Chiang, Barry J. Hoffer (2016, Dec). Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation, 26(7), 1156-1168. (SCI). MOST 105-2314-B-016-001-MY3. 本人為第一作者、通訊作者. DOI: 10.1177/0963689717714105. 
  61. Bon-Jour Lin, Tzu-Tsao Chung, Meng-Chi Lin, Chin Lin, Dueng-Yuan Hueng, Yuan-Hao Chen, Chung-Ching Hsia, Da-Tong Ju, Hsin-I Ma, Ming-Ying Liu, Chi-Tun Tang (2016, Oct). Quantitative analysis of anatomical relationship between cavernous segment internal carotid artery and pituitary macroadenoma. Medicine, 95(41). (SCI). DOI: 10.1097/MD.0000000000005027. 
  62. Lok-Hi Chow,Yuan-Hao Chen,Wan-Chuan Wu,En-Pei Chang,Eagle Yi-Kung Huang (2016, Sep). Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS One, 11(9), e0162218. (SCI). DOI: 10.1371/journal.pone.0162218. 
  63. Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, Lok-Hi Chow (2016, May). Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. Neuropeptides, 59, 63-69. (SCI). DOI: 10.1016/j.npep.2016.05.005. 
  64. Chi-Yung Yeung, Kun-Ting Hong, Chien-Ping Chiang, Yuan-Hao Chen, Hsin-I Ma, Tung-Hang Tsai (2016, Apr). Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma manifesting as a scalp hematoma after an acute head injury-A case report and literature review. World Neurosurgery, 88, 688.e13-6. (SCI). DOI: 10.1016/j.wneu.2015.11.020. 
  65. Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J Hoffer, Pei-Jie Wu, Hsin-I Ma, Jing-Jr Tsai, Yu-Ching Chou, Yung-Hsiao Chiang (2016, Apr). Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. Brain research, 1642, 581-589. (SCI). 本人為第一作者、通訊作者. DOI: 10.1016/j.brainres.2016.04.013. 
  66. Shao-Wei Feng, Yun-Ju Yang, Chiao-Zhu Li, Meng-Chi Lin, Tzu-Tsao Chung, Yuan-Hao Chen (2016, Feb). Accuracy of spinal screw fixation using intraoperative O arm navigation: Consecutive series of 118 screws. Journal of Medical Sciences, 36(1), 6-13. (Scopus). 本人為通訊作者. DOI: 10.4103/1011-4564.177169. 
  67. Chi-Yung Yeung, Kun-Ting Hong, Chien-Ping Chiang, Yuan-Hao Chen, Hsin-I Ma, Tung-Hang Tsai (2015, Nov). ALK-negative anaplastic large-cell lymphoma presenting as a scalp hematoma after an acute head injury–A case report and literature review. World Neurosurgery, 88, 688-e13. (SCI). DOI: 10.1016/j.wneu.2015.11.020. 
  68. Lok-Hi Chow, Pao-Luh Tao, Yuan-Hao Chen, Yu-Hui Lin, Eagle Yi-Kung Huang (2015, Oct). Angiotensin IV possibly acts through PKMzeta in the hippocampus to regulate cognitive memory in rats. Neuropeptides, 53, 1-10. (SCI). DOI: 10.1016/j.npep.2015.09.004. 
  69. Tzu-Tsao Chung, Cheng-Ta Hsieh, Yuan-Hao Chen, Cheng-Fu Chang (2015, Feb). Effects of Hematoma Reduction by Stereotactic Aspiration for Patients With Spontaneous Intracerebral Hemorrhage. Neurosurgery Quarterly, 25(1), 17-23. DOI: 10.1097/WNQ.0b013e3182a2fd60. 
  70. Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Ku , Hsin-I Ma, Barry J. Hoffer, Pi-Fen Tsui, Jing-Jr Tsai, Yu-Ching Chou , Yung-Hsiao Chiang (2014, Oct). Dopamine Release Impairment in Striatum after Different Levels of Cerebral Cortical Fluid Percussion Injury. Cell Transplantation, 24(10), 2113-28. (SCI). 本人為第一作者. DOI: 10.3727/096368914X683584. 
  71. Chun-Chieh Lin, Tung-Han Tsai, Yueh-Feng Sung, Da-Tong Ju, Yung-Hsiao Chiang, Yuan-Hao Chen (2014, Aug). Frameless Stereotactic Deep Brain Stimulation for Parkinson’s Disease: A Case Report and Technical Note. Journal of Medical Sciences, 34(5), 224-234. (Scopus). 本人為通訊作者. DOI: 10.4103/1011-4564.143652. 
  72. Eagle Yi-Kung Huang, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Tsai Tung-Han, Hsin-I. Ma, Yung-Hsiao Chiang, Yuan-Hao Chen (2014, Jul). Remote Effects on the Striatal Dopamine System after Fluid Percussion Injury. . Behavioural Brain Research, 267, 156-72. (SCI). 本人為通訊作者. DOI: 10.1016/j.bbr.2014.03.033. 
  73. Hung-Che Lin, Wen-Yen Huang, Shyi-Jou Chen, Chun-Jung Juan, Yuan-Hao Chen, Hsin-I Ma, Yu-Ching Chou, Jiunn-Tay Lee, Giia-Sheun Peng, Ya-Ling Chou, Hueng-Chuen Fan (2014, Jul). Whether Spetzler-Martin grading scale is a predictive factor for the prognosis of pediatric patient with intracranial arteriovenous malformations. Journal of Medical Sciences, 34(3): 104-109. 
  74. Tung-Han Tsai, Da-Tong Ju, Yi-Lin Yu, Chi-Tan Tang, Yu-Ching Chou, Yung-Hsiao Chiang, Shinn-Zong Lin, Yuan-Hao Chen (2014, Jul). Frame-Based Stereotactic Deep Brain Stimulation for Parkinson’s Disease: 12-Month Outcomes for Patients in Cross Hair vs. Non-Cross Hair Application Groups. Journal of Medical Sciences, 34(4), 166-174. (Scopus). 本人為通訊作者. DOI: 10.4103/1011-4564.139189. 
  75. Yuan-Hao Chen, Yung-Hsiao Chiang, Hsin-I Ma (2014, Apr). Analysis of Spatial and Temporal Protein Expression in the Cerebral Cortex after Ischemia Reperfusion Injury. . Journal of Clinical Neurology, 10(2), 84-93. (SCI, CLINICAL NEUROLOGY). 本人為第一作者. DOI: 10.3988/jcn.2014.10.2.84. 
  76. Eagle Yi-Kung Huang, Pi-Fen Tsui, Tung-Tai Kuo, Jing-Jr Tsai, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang, Yuan-Hao Chen (2014, Jan). Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury. Plos One , 9(1), e86354. (SCI, 7/56, MULTIDISCIPLINARY SCIENCES). 本人為通訊作者. DOI: 10.1371/journal.pone.0086354. 
  77. Yuan-Hao Chen, Steven D. Chang, Hsin-I Ma, Yu-Ching Chou, Hsing-Lung Chao, Yee-Min Jen, Da-Tong Ju (2013, Dec). Multisession CyberKnife radiosurgery for post-surgical residual and recurrent pituitary adenoma: preliminary result from one center. Journal of Radiosurgery and SBRT, 2(2), 105. 本人為第一作者. 
  78. Cameron H. Good, Huikun Wang, Yuan-Hao Chen, Carlos A. Mejias-Aponte, Alexander F. Hoffman1, and Carl R. Lupica1 (2013, Oct). Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. Journal of Neuroscience, 33(43), 16853-16864. (SCI, 13/110, Neuroscience). DOI: 10.1523/JNEUROSCI.1844-13.2013. 
  79. Yuan-Hao Chen, Tung-Tai Kuo, Ming-Ting Chu, Hsin-I Ma, Yung-Hsiao Chiang, Eagle Yi-Kung Huang (2013, May). Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in an animal seizure model.. Neuroimmunomodulation, 20(4), 223-32. . (SCI). NSTC 98-2314-B-016-016-MY2. 本人為第一作者. DOI: 10.1159/000348440. 
  80. Bon-Jour Lin , Yu-Hao Chen , Tzu-Tsao Chung, Hsin-I Ma , Yuan-Hao Chen (2013, Jan). Pituitary abscess following expanding sphenoid sinus pyocele: Complication of endoscopic endonasal transsphenoidal surgery. Clinical Neurology and Neurosurgery, 115, 1502-1505. (SCI). 本人為通訊作者. DOI: 10.1016/j.clineuro.2012.11.017. 
  81. Cheng-Ta Hsieh, Ming-Ying Liu, Yu-Hao Chen, Cheng-Fu Chang (2011, Oct). Postoperative acute sialadenitis following posterior fossa surgery. Neurosciences (Riyadh), 16(4) : 378-80. (SCI). 
  82. Kai-Yun Chen, Chung-Che Wu, Cheng-Fu Chang, Yuan-Hao Chen, Wen-Ta Chiu, Ya-Hsin Lou, Yen-Hua Chen, Hsiu-Ming Shih, Yung-Hsiao Chiang (2011, Sep). Suppression of Etk/Bmx protects against ischemic brain injury. Cell Transplantation, 21(1), 345-354. (SCI). DOI: 10.3727/096368911X582741. 
  83. Kuan-Yin Tseng, Chung-Ching Hsia, Yuan-Hao Chen, Shin-I Ma, Chi-Tun Tang (2011, May). Use of spinous processes to determine the laterally angulated trajectory for placement of lateral mass screws: An image analysis. Neurology India, 59(3), 362. (SCI). DOI: 10.4103/0028-3886.82729. 
  84. Cheng-Ta Hsieh, Guann-Juh Chen, Hsin-I Ma, Cheng-Fu Chang, Cheng-Ma Cheng, Yih-Huei Su, Da-Tong Ju, Chung-Ching Hsia, Yuan-Hao Chen, Hao-Yiang Wu, Ming-Ying Liu (2011, Mar). The misplacement of external ventricular drain by freehand method in emergent neurosurgery. Acta Neurol Belg, 111, 22-28. 
  85. Wei-Hsiu Liu, Yuan-Hao Chen, Cheng-Ta Hsieh, En-Yuan Lin, Tzu-Tsao Chung, Da-Tong Ju (2008, Apr). Transarterial embolization in the management of life-threatening hemorrhage after maxillofacial trauma: a case report and review of literature. The American Journal of Emergency Medicine, 26(4), 516-e3. DOI: 10.1016/j.ajem.2007.07.036. 
  86. Yuan-Hao Chen, Brandon K. Harvey, Alexander F. Hoffman, Yun Wang, Yung-Hsiao Chiang, Carl R. Lupica (2007, Aug). MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector.. The FASEB Journal, 22(1), 261-275.. (SCI). 本人為第一作者. DOI: 10.1096/fj.07-8797com. 
  87. Yuan-Hao Chen, Shinn-Zong Lin, Yung-Hsiao Chiang, Da-Tong Ju, Ming-Ying Liu, Guann-Juh Chen (2004, Aug). Supraorbital keyhole surgery for optic nerve decompression and dura repair. Journal of neurotrauma, 21(7), 976-981. (SCI). DOI: 10.1089/0897715041526140. 
  88. Yuan-Hao Chen, Yung-Hsiao Chiang, Chung-Ching Hsia, Der-Cherng Chen, Shinn-Zong Lin (2001, Dec). Intracranial double aneurysms associated with thrombosed arteriovenous malformation: a case report. Journal of Medical Sciences, 21(6), 295-300. 本人為第一作者、通訊作者. DOI: 10.6136/JMS.


Patents

  1. Yuan-Hao Chen, Rong-Chin Lo, Tung-Tai Kuo. Bluetooth wireless transmission system for brain electrochemical signals. TW M548933 U, 2017.
  2. Yuan-Hao Chen, Rong-Chin Lo. Blue-tooth wireless transmission system for cerebral electrophysiological signals. TW M456795U1, 2013.

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