EDUCATION

Jan 2008 National Defense Medical College PhD Degree in Graduate School of
Medical Sciences (Major in Cancer Gene Therapy)
Aug 2002 National Defense Medical College Master Degree in Graduate School of Pharmacology (Clinical Pharmacology)
Aug 1995 Kaohsiung Medical University Bachelor Degree in Pharmacy

SKILLS & EXPERTISE

Oncology Drug Development (Trained in Medigene AG, Munich)
Early Phase Drug Development (Trained in Medigene AG, Munich)
Stem Cells & Cancer Stem Cells
Physiology & Pharmacology
Cancer Gene & Target Therapy
Sales and Marketing Strategies

LANGUAGE SKILLS:

Mandarin
English
Good communicator with team members

Publications

1. Chien-Chih Ou, Shih-Chung Hsu, Yin-Hui Hsieh, Wan-Ling Tzou, Tzu-Chao Chuang, Jah-Yao Liu, and Ming-Ching Kao (2008) Down-regulation of HER2 by RIG1 Involves the PI3K/Akt Pathway in Ovarian Cancer Cells. Carcinogenesis 29: 299-306 (IF=5.406, PhD dissertation)

2. Shih-Chung Hsu, Chien-Chih Ou, Tzu-Chao Chuang, Jhy-Wei Li, Han-Pon Kuo, Jah-Yao Liu, Chin-Shiang Chen, Song-Chow Lin and Ming-Ching Kao. (2008) Growth inhibition of colorectal cancer cells by Ganoderma tsugae extracts via G2/M cell cycle arrest. Journal of Enthopharmacology 120: 394-401

3. Shih-Chung Hsu, Chien-Chih Ou, Tzu-Chao Chuang, Jhy-Wei Li, Yi-Jen Lee, Vinchi Wang , Jah-Yao Liu, Chin-Shiang Chen, Song-Chow Lin, Ming-Ching Kao. (2009) Ganoderma tsugae extract Inhibits Expression of Epidermal Growth Factor Receptor and Angiogenesis in human epidermoid carcinoma Cells: in vitro and in vivo. Cancer Letters 281: 108-116

4. Chuang TC, Hsu SC, Cheng YT, Shao WS, Wu K, Fang GS, Ou CC, Wang V. (2011) Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells. Cancer Letters 311:11-19. (IF: 4.238)

5. Tsai YT, Liu JY, Lee CY, Tsai CS, Chen MH, Ou CC, Chen WH, Loh SH. (2011) Functional characterization of transmembrane intracellular pH regulators and mechanism of alcohol-induced intracellular acidosis in human umbilical cord blood stem cell-like cells. J Cardiovasc Pharmacol. 58:589-601.

6. Ou CC, Chen YW, Hsu SC, Sytwu HK, Loh SH, Li JW, Liu JY. (2012) Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB. Evid Based Complement Alternat Med. 2012:350239 (First author; IF: 4.774, Ranking No. 1)

7. Kuo HP, Hsu SC, Ou CC, Li JW, Tseng HH, Chuang TC, Liu JY, Chen SJ, Su MH, Cheng YC, Chou WY and Kao MC. (2013) Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013: 219472

8. 歐建志, 潘信保, 龍美雲. (2011) Stem Cells (淺談幹細胞). THE JOURNAL OF TAIWAN PHARMACY 27:116-120.

9. 潘信保, 龍美雲, 歐建志. (2012) Cancers & Cancer Stem Cells (癌症與癌症幹細胞). THE JOURNAL OF TAIWAN PHARMACY 28:74-77.

10. Lee YJ, Wu CC, Li JW, Ou CC, Hsu SC, Tseng HH, Kao MC, Liu JY. (2016) A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers. Oncotarget 7: 78499–78515
11. Hsiu-Hsueh Tseng, Wan-Chun Yeh, Yun-Chen Tu, Bi-Fen Yang, Yen-Ting Lai, Yi-Jen Lee, Chien-Chih Ou, Han-Peng Kuo, Ming-Ching Kao, and Jah-Yao Liu. Proteomic profiling of Ganoderma tsugae ethanol extract-induced adipogenesis displaying browning features.. FEBS Letters. 2018 Apr 23. doi: 10.1002/1873-3468.13061. [Epub ahead of print]
SYMPOSIUM PAPERS (abstract and poster)
1. Cheng-I Lin, Chien-Chih Ou, Yi-Jen Chen, Yao-Chang Chen and Shih-Ann Chen (Jul, 2002) Electrophysiology and Arrhythmogenic Activity of Dog Left Inferior Pulmonary Veins, International Journal of Bioelectromagnetism, Montreal, Canada

2. Chien-Chih Ou, Shih-Chung Hsu, Yin-Hui Hsieh, Wan-Ling Tzou, Jah-Yao Liu, and Ming-Ching Kao (Apr, 2007) Down-regulation of HER2 by Interferon-γ-Induced RIG1 Followed by PI3K/Akt/mTOR/VEGF pathway in Ovarian Cancer Cells. American Association of Cancer Research (AACR), 2007 Annual Meeting, LA, USA

3. Chien-Chih Ou, Shih-Chung Hsu, Yin-Hui Hsieh, Wan-Ling Tzou, Jah-Yao Liu, and Ming-Ching Kao (Nov, 2007) Down-regulation of HER2 by RIG1 in Ovarian Cancer Cells. The 1st International Cancer Symposium, Nov 16-17, China Medical University, Taichung

4. Chien-Chih Ou, Yi-Jen Lee, Shih-Wei Tung and Jah-Yao Liu (Nov, 2008) Four-Agents-Decoction Suppresses HER2 Expression in Endometriosis. Annual Meeting of American Congress of Obstetricians and Gynecologists, CA, USA

5. Chien-Chih Ou, Shih-Chung Hsu, Yin-Hui Hsieh, Wan-Ling Tzou, Tzu-Chao Chuang, Jah-Yao Liu and Ming-Ching Kao (Nov, 2008) Downregulation of HER2 by RIG1 Involves the PI3K/Akt Pathway in Ovarian Cancer Cells. The 35th Conference of Military Doctors, Taipei

6. Chien-Chih Ou, Yi-Jen Lee and Jah-Yao Liu (Feb, 2009) Studying on the molecular mechanisms of Four-Agents-Decoction on dysmenorrheal. Annual Meeting of Taiwan Association of Obstetrics and Gynecology, Taichung

7. Chien-Chih Ou, Jah-Yao Liu, Ming-Ching Kao (May, 2009) Molecular Mechanisms of RIG1 Repressing HER2 and Its Downstream Pathway. The 13th Taiwan Joint Cancer Conference, Taipei

8. Chien-Chih Ou, Yuan-Wu Chen, Shih-Chung Hsu, Jah-Yao Liu (Nov, 2009) Downregulation of HER2 by Triptolide
Involves PI3K/Akt Pathway in Ovarian Cancer Cells. The 36th Conference of Military Doctors, Taipei

9. Chien-Chih Ou, Yi-Jen Lee, Shih-Chung Hsu, and Jah-Yao Liu (Nov, 2009) Four-Agents-Decoction Suppresses COX-2 Expression in Endometrial Cells: Possible Role in Relieving Dysmenorrhea. The 36th Conference of Military Doctors, Taipei

10 Han-Peng Kuo, Shih-Chung Hsu, Chien-Chih Ou, Jhy-Wei Li, Hsiu-Hsueh Tseng, Tzu-Chao Chuang, Jah-Yao Liu, Shih-Jung Chen, Muh-Hwan Su, Yung-Chi Cheng, Wei-Yuan Chou, and Ming-Ching Kao (Mar, 2013) Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway. 2013生物醫學年會, Taipei.

BOOKS

Pharmacology and the Nursing Process. (August 2004) Tsang-Hai Book Publishing Company.

AWARDS and HONORS

First Award poster in The 35th Joint Conference of Military Doctors.
Outstanding poster in The 36th Joint Conference of Military Doctors.
First Award poster in The 37th Joint Conference of Military Doctors.
Selected poster in The 13th Taiwan Joint Cancer Conference.
2018 NDMC Outstanding and Honorable Alumni Award

PATENTS

The efficacy study of SBM2 on the disruption of tumor vasculature (USPTO). Inventor: Chien-Chih Ou, Mel Su, Angeline Liu (Issued No: I594982)