Professional Experiences

1. Associate Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center (2022~ )
2. Assistant Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center (2016~2021)
3. Adjunct Lecturer, Graduate Institute of Biology and Anatomy, National Defense Medical Center (2014~2015)
4. Assistant Head Nurse, Surgical Intensive Care Unit of Tri-Service General Hospital (2015.3~2015.6)
5. Nurse, Burn Center of Tri-Service General Hospital (2007.7~2015.2)

Research Interests

1. Wound healing and scar hypertrophy
2. Application of natural polymer in wound dressing and tissue engineering

Awards

1. A pharmaceutical composition to reduce scar formation was awarded the "16th National Innovation Award" (2019.12)

2. First Award of Integrated Curriculum Excellent Teacher (2019.10)

3. First Award of Integrated Curriculum Excellent Teacher (2018.09)

4. Outstanding Achievement Award for National Defense Medical Research and Development Program Results (2017.11)

5. First Award of Integrated Curriculum Excellent Teacher (2017.09)

6. Academic Conference of Military Medicine. Third Award in the Poster Section of Surgical Medicine (2016.11)

7. Preparation and use of skin substitutes was awarded the "9th National Innovation Award" (2012.10)

Academic Achievements

Publications:

1. Chou K.C., Cherng J.H., Ou K.L., & Wang Y.W. (2024). Gold nanoclusters on a silk fibroin scaffold accelerate fibroblast proliferation and improve burn recovery in a mouse burn model. Materials and Design, 244, 113221. (SCI 58/334, MATERIALS SCIENCE, MULTIDISCIPLINARY)本人為通訊作者.
2. Wen, C. C., Huang, S. M., & Wang, Y. W. (2024). Anatomical Anal Stenosis after PPH: Insights from a Retrospective Study and Rat Model. International journal of molecular sciences, 25(6), 3543. (SCI, 74/297, BIOCHEMISTRY & MOLECULAR BIOLOGY)本人為通訊作者.
3. Yi-Wen Wang, Chun-Ting Chen, Kai-Chieh Chou, Shih-Ming Huang, Kuang-Ling Ou (2024, Oct). Low-dose estrogen release from silastic capsule enhanced flap wound healing in an animal model. Int Wound J, 2024;21:e70083. (SCI, IF=2.6；49/212, Surgery). 共同第一作者.
4. Huang, T. Y., Wang, Y. W., Liao, H. X., & Su, W. T. (2024). Sprayable hydroxypropyl chitin/collagen extract of Ampelopsis brevipedunculata hydrogel accelerates wound healing. Journal of wound care, 33(Sup2), S10–S23.(SCI 59/94, DERMATOLOGY) 
5. Tsai C.L., Changchien C.Y., Chen Y., Chang H.H., Tsai W.C., Wang Y.W., Chou K.C., Chiang M.H., Tsai Y.L., Tsai H.C., Wang C.Y., Shen M.S., Cheng L.T., Lin H.Y., Yang T.B., Chian C.F. (2022, Mar) Accelerated Wound Healing and Keratinocyte Proliferation through PI3K/Akt/pS6 and VEGFR2 Signaling by Topical Use of Pleural Fluid. Cells, 11(5):817. (SCIE, 53/195, Cell biology).
6. Chou K.C., Chen C.T., Cherng J.H., Li M.C., Wen C.C., Hu S.I., Wang Y.W. (2021, Oct). Cutaneous regeneration mechanism of β-sheet silk fibroin in a rat burn wound healing model. Polymers, 13(20):3537. (SCI, 16/89, POLYMER SCIENCE). 本人為通訊作者. 
7. Cherng J.H., Chou S.C., Chen C.L., Wang Y.W., Chang S.J., Fan G.Y., Leung F.S., Meng E. (2021, Oct). Bacterial cellulose as a potential bio-scaffold for effective re-epithelialization therapy. Pharmaceutics, 13(10):1592. (SCI, 44/271, PHARMACOLOGY & PHARMACY).
8. Ou K.L., Wen C.C., Lan C.Y., Chen Y.A., Wang C.H., Wang Y.W. (2021, Apr). The optimal application of medium potency topical corticosteroids in preventing laser-induced inflammatory responses—an animal study. Life, 11(4):350. (SCI, 27/93, Biology). 本人為通訊作者. 
9. Chia-Yu Wang, Po-Da Hong, Ding-Han Wang, Juin-Hong Cherng, Shu-Jen Chang, Cheng-Che Liu, Tong-Jing Fang, Yi-Wen Wang (2020, Nov). Polymeric Gelatin Scaffolds Affect Mesenchymal Stem Cell Differentiation and Its Diverse Applications in Tissue Engineering. International Journal of Molecular Sciences, 21(22):8632. (SCI, 74/297, BIOCHEMISTRY & MOLECULAR BIOLOGY). 本人為通訊作者. 
10. Wang Y.W., Liu C.C., Cherng J.H., Lin C.S., Chang S.J., Hong Z.J., Liu C.C., Chiu Y.K., Hsu S.D., Chang H.. Biological effects of chitosan-based dressing on hemostasis mechanism. Polymers, 2019,11(11):1906.
11. Wang C.Y., Sartika D., Wang D.H., Hong P.D., Cherng J.H., Chang S.J., Liu C.C., Wang Y.W.*, Wu S.T.*. Wet-spinning-based Molding Process of Gelatin or Tissue Regeneration. Journal of Visualized Experiments, 2019, 2019(145):e58932.
12. Huang W.S., Wang Y.W., Hung K.C., Hsieh P.S., Fu K.Y., Dai L.G., Liou N.H., Ma K.H., Liu J.C., Dai N.T.. High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content. PeerJ, 2018, 2018(5):e4815.
13. Wang Y.H., Liu C.C., Cherng J.H., Fan G.Y., Wang Y.W., Chang S.J., Hong Z.J., Lin Y.C., Hsu S.D.. Evaluation of Chitosan-based Dressings in a Swine Model of Artery-Injury-Related Shock. Scientific Reports, 2019, 9(1):14608.
14. Dai N.T., Huang W.S., Chang F.W., Wei L.G., Huang T.C., Li J.K., Fu K.Y., Dai L.G., Hsieh P.S., Huang N.C., Wang Y.W., Chang H.I., Parungao R., Wang Y.. Development of a Novel Pre-Vascularized Three-Dimensional Skin Substitute Using Blood Plasma Gel. Cell Transplantation, 2018, 27(10):1535-1547.
15. Meng E., Fan G.Y., Cherng J.H., Chang S.J., Poongodi R., Wang C.H., Wang Y.W., Wang Y.H., Liu C.C.. Severe burn injury in a swine model for clinical dressing assessment. Journal of Visualized Experiments, 2018, 2018(141):e57942.
16. Wang C.C., Wang C.H., Chen H.C., Cherng J.H., Chang S.J., Wang Y.W., Chang A., Yeh J.Z., Huang Y.H., Liu C.C.. Combination of resveratrol-containing collagen with adipose stem cells for craniofacial tissue-engineering applications. International Wound Journal, 2018, 15(4):660-672.
17. Dai N.T., Chang H.I., Wang Y.W., Fu K.Y., Huang T.C., Huang N.C., Li J.K., Hsieh P.S., Dai L.G., Hsu C.K., Maitz P.K.. Restoration of skin pigmentation after deep partial or full-thickness burn injury. Advanced Drug Delivery Reviews, 2018, 123:155-164.
18. Chang Y.L., Huang L.C., Chen Y.C., Wang Y.W., Hueng D.Y., Huang S.M..The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines. International Journal of Biochemistry and Cell Biology, 2017, 92:155-163.
19. Lin C.H., Ho C.W., Chen L.C., Chang C.C., Wang Y.W., Chiou C.P., Chiang S.L.. Effects of a 12-Week exercise training on insulin sensitivity, quality of life, and depression status in patients with type 2 diabetes. Journal of Medical Sciences(Taiwan), 2017,37(6):227-236.
20. Chang Y.L., Liu S.T., Wang Y.W., Lin W.S., Huang S.M.. Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224. Oncotarget, 2018, 9(17):13390-13406.
21. Chang Y.L., Hsu Y.J., Chen Y., Wang Y.W., Huang S.M.. Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines. Oncotarget,2017, 8(60): 101461-101474.
22. Chung M.H., Wang Y.W., Chang Y.L., Huang S.M., Lin W.S.. Risk of cancer in patients with heart failure who use digoxin: A 10-year follow-up study and cell-based verification. Oncotarget, 2017, 8(27):44203-44216.
23. Wang YW, Liou NH, Cherng JH, Chang SJ, Ma KH, Fu E, Liu JC, Dai NT. siRNA-targeting transforming growth factor-β type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. J Invest Dermato. 2014; 134:2016–25. (IF: 7.216, Ranking: 1/62 in Dermatology)

Patents

1. Pharmaceutical composition and method for reducing scar formation

• Taiwan I542352 (2016.07)
• US 20170016005A1 (2017.01)
• Japan 6363737 (2018.07)

Laboratory Descriptions

It is often seen in clinical practice that various problems of wound healing need to be resolved, including wound infection, bleeding after debridement, wound healing difficulties, and scar hyperplasia after healing. Our laboratory is interested in the related issues. The current research focus in our laboratory includes: 1. The effects of regulating the TGF-β signaling pathway of epidermal cells, vascular endothelial cells or fibroblasts on wound healing, angiogenesis and scar hyperplasia; 2. Natural polymer such as silk fibroin Protein (silk fibroin), collagen fibers (gelatin), and chitosan (chitosan), using 3D printing, lyophilization or wet spinning technology to make wound dressings or tissue-engineered skin to the purpose of wound protection, bleeding control, infection prevention and wound healing promotion. Cell experiments and animal experiments are used to explore the treatment effect and the related mechanism. We hoped that these efforts can improve the clinical wound healing related problems.