Research Experiences
Aug 2022 – present, Professor National Defense Medical Center, Department of Microbiology and Immunology, Taipei, Taiwan
Apr 2022 – present, Director National Defense Medical Center, Department of Microbiology and Immunology, Taipei, Taiwan
Aug 2019 – Jul 2022, Associate Professor National Defense Medical Center, Department of Microbiology and Immunology, Taipei, Taiwan
Aug 2014 – Jul 2019, Research Fellow; Associate Professor Kaohsiung Veterans General Hospital, Department of Medical Education and Research, Kaohsiung, Taiwan
Mar 2010 – Jul 2014, Associate Research Fellow; Associate Professor Kaohsiung Veterans General Hospital, Department of Medical Research, Kaohsiung, Taiwan
Oct 2006 – Feb 2010, Visiting Fellow/PostDoc Fellow National Institutes of Health, Section on Molecular Genetics of Immunity, NICHD, Bethesda, United States
Aug 2005 – Sep 2006, PostDoc Fellow Academia Sinica, Institute of Biomedical Sciences, Taipei, Taiwan
Skills
Innate Immunity, Toll-Like Receptors, Inflammation, Cytokines
Publications
Hung, CJ., Chen, ZR., Lin, CL. et al. New Phenylpropanoid Derivative and Anti-Inflammatory Constituents from Eupatorium amabile. Chemistry of Natural Compounds 2025, 61 (2), 265-268.
Chin CH, Chen ZR, Chang TH, Liaw CC, Sung PJ, Cheng MJ, Huang CM, Chen JJ. Antioxidant and anti-inflammatory constituents from Myristica elliptica var. simiarum. Chemistry of Natural Compounds 2025, 61 (1), 27-31.
Liao YC, Yeh CC, Chueh YF, Huang MS, Wu JS, Wen YX, Chang YT, Lai YR, Chen JJ, Chang TH*. Effects of the oxoaporphine alkaloid hernandonine on dengue virus. Evidence for its mechanisms of action. Phytomedicine. 2024 Nov;134:155986. doi: 10.1016/j.phymed.2024.155986. Epub 2024 Aug 27. PMID: 39232285.
Lin SL, Lee ST, Huang SE, Chang TH, Geng YJ, Sulistyowati E, Yeh JL. Delivery of Superoxide Dismutase 3 Gene with Baculoviruses Inhibits TNF-α Triggers Vascular Smooth Muscle Cell Proliferation and Inflammation. Curr Gene Ther. 2024 Sep 5. doi: 10.2174/0115665232308789240823052607.
Cheng CY, Huang CM, Lin CL, Chang TH, Sung PJ, Cheng MJ, Chen JJ. A NEW HOMOISOFLAVONOID AND ANTI-INFLAMMATORY CONSTITUENTS FROM Polygonatum alte-lobatum Chemistry of Natural Compounds. 2024 May. 60, 428–431.
Jungbauer-Groznica M, Wiese K, Fischer I, Markus J, Chang TH, Gösler I, Kowalski H, Blaas D, Real-Hohn A. Aichi virus A1 replicates in human intestinal epithelium and bronchial tissue: lung-gut axis? Virus Research. 2024 April 17:199338. doi: 10.1016/j.virusres.2024.199338. Epub ahead of print. PMID: 38373599.
Chin CH, Liaw CC, Chang TH, Shu CW, Sung PJ, Cheng MJ, Wang IC, Chen JJ. Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata. Chemistry of Natural Compounds. 2024 Jan, 60, 50–54.
Cheng CY, Huang CM, Lin CL, Chang TH, Sung PJ, Cheng MJ & Chen JJ. A New Coumarin and Anti-Inflammatory Constituents from Polygonatum chingshuishanianum. Chemistry of Natural Compounds. 2023 Sep. 59, 835–838. https://doi.org/10.1007/s10600-023-04129-x
Chen HM, Huang CM, Huang HY, Chang TH, Liaw CC, Sung PJ, Chu YC, Cheng MJ*, Kuo CW*, Chen JJ*. A New 2H-pyran-2-one derivative and anti-inflammatory constituents from Alpinia pricei var. pricei. Chemistry of Natural Compounds 2023 Jul. 59, 662–665. https://doi.org/10.1007/s10600-023-04081-w.
Wu FS, Huang CM, Chen LC*, Chang TH, Shu CW, Sung PJ, Chu YC, Cheng MJ*, Hsiao JW*, Chen JJ*. New Cinnamic acid derivative and anti-inflammatory constituents from Capparis lanceolaris. Chemistry of Natural Compounds 2023 Jun, 59 (3), 493-496.
Chen HT, Chuang CW, Cheng JC, Yeh YJ, Chang TH, Shi YT, Chao CH. Terpenoids with anti-influenza activity from the leaves of Euphorbia leucocephala. Natural Product Research 2023 Mar; 37 (6):936-943.
Wei KC, Wei WJ, Liao CL, Chang TH*. Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1. Microbiology Spectrum. 2023 Feb 14;11(1):e0358622. doi: 10.1128/spectrum.03586-22.
Tsai WL, Cheng JS, Liu PF, Chang TH, Sun WC, Chen WC, Shu CW. Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells. Aging (Albany NY). 2022 Jul 12;14. doi: 10.18632/aging.204170.
Jan MW, Chiu CY, Chen JJ, Chang TH *, Tsai KJ* Human platelet lysate induces antiviral responses against Parechovirus A3. Viruses. 2022, 14(7), 1499.
Chen HM, Huang CM, Chen LC, Yang CS, Chang TH, Chen CL, Sung PJ, Kuo WL, Cheng MJ, Hsiao JW, Chen JJ. NEW TRITERPENOID AND ANTI-INFLAMMATORY CONSTITUENTS OF Eriobotrya deflexa f. deflexa. Chemistry of Natural Compounds. 2022, 58(3), 1-4.
Wei KC, Lai SF, Huang WL, Yang KC, Lai PC, Wei WJ, Chang TH, Huang YC, Tsai YC, Lin SC, Lin SJ, Lin SC. An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis. Journal of Molecular Medicine (Berl). 2022 Jan;100(1):135-146. doi: 10.1007/s00109-021-02146-3. Epub 2021 Oct 23. PMID: 34689211; PMCID: PMC8724166.
Jan MW, Su HL, Chang TH*, Tsai KJ*. Characterization of Pathogenesis and Inflammatory Responses to Experimental Parechovirus Encephalitis. Front Immunol. 2021 Nov 25;12:753683. doi: 10.3389/fimmu.2021.753683. PMID: 34899705; PMCID: PMC8654935.
Wang IC, Chen LC., Chang TH, Chen CL, Sung PJ, Lin RA, Cheng MJ, Hsiao JW, Chen JJ. New Coumarin and Bioactive Constituents of Chionanthus retusus. Chemistry of Natural Compounds 2021, 57, 835–839. /doi.org/10.1007/s10600-021-03492-x
Chen BC, Huang TS, Huang NY, Chen CS, Chen YS*, Chang TH*. Low Seroprevalence of Aichi Virus Infection in Taiwan. Pathogens 2021, 10 (5), 553. doi.org/10.3390/pathogens10050553
Huang CM, Chang CH, Yang CS, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Cheng CY, Chen JJ. A NEW ACENAPHTHYLENE AND BIOACTIVE CONSTITUENTS OF Salvia arisanensis. Chemistry of Natural Compounds. 2021, 57(6), 991-995. https://doi.org/10.1007/s10600-021-03535-3
Wu FS, Hung CJ, Lin CL, Huang HY, Kuo YH, Chang TH, Chen CL, Sung PJ, Cheng MJ, Kuo CW, Chen JJ. New benzophenone and bioactive constituents of Hypericum nokoense. Chemistry of Natural Compounds 2021, 57 (4), 645-649.
Chiang AJ, Li CJ, Tsui KH, Chang C, Chang YI, Chen LW, Chang TH*, Sheu JJ*. UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR. Biomolecules. 2021, 11(1), 37. doi.org/10.3390/biom11010037.
Kung MH, Jan MW, Chen JJ, Shieh YC, Chang TH*. Detection of Parechovirus A1 with Monoclonal Antibody against Capsid Protein VP0. Microorganisms. 2020 Nov 16;8(11):1794. doi: 10.3390/microorganisms8111794.
Kung MH, Lin YS, Chang TH*. Aichi virus 3C protease modulates LC3- and SQSTM1/p62-involved antiviral response. Theranostics. 2020 Jul 14;10(20):9200-9213. doi: 10.7150/thno.47077.
Chuang FK, Liao CL, Hu MK, Chiu YL, Lee AR, Huang SM, Chiu YL, Tsai PL, Su BC, Chang TH, Lin CC, Shih CC, Yen LC. Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. Int J Mol Sci. 2020 Jun 5;21(11):4050. doi: 10.3390/ijms21114050.
Hsiao JW, Li-Chai Chen LC, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Hung CJ*, Chen JJ*. A New sesquiterpenoid and bioactive constituents of Curcuma zedoaria. Chem Nat Compd 2020, 56:1-5DOI 10.1007/s10600-020-03230-9.
Wu FS, Hung CJ, Lin CL, Chang TH, Chen CL, Sung PJ, Cheng MJ, Huang HT, Che JJ. New Norneolignan and Bioactive Constituents of Clitoria ternatea. Chem Nat Compd 2020. 56:1000-1004. DOI 10.1007/s10600-020-03213-w.
Wei KC, Wei WJ, Liu YS, Yen LC, Chang TH*. Assessment of Prolonged Dengue Virus Infection in Dermal Fibroblasts and Hair-Follicle Dermal Papilla Cells. Viruses (Viruses-Basel). 2020 Feb 28;12(3). pii: E267. doi: 10.3390/v12030267.
Chuang FK, Huang SM, Liao CL, Lee AR, Lien SP, Chiu YL, Chang TH, Tsai PL, Lin RJ, Shih CC, Tsai YJ, Lin GJ, Yen LC. Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. Antimicrob Agents chemother. 2019 Dec 20;64(1). pii: e00941-19.
Hung WT, Cheng MF, Tseng FC, Chen YS, Lee SJ, Chang TH, Lin HH, Hung CH, Wang JL. Bloodstream Infection with Extended-spectrum Beta-lactamase–producing Escherichia coli: the role of virulence genes. Journal of Microbiology, Immunology and Infection. 2019 Dec, 52(6):947-955.
Huang HC, Chen LC, Chang TH, Zhu TF, Chen CL, Cheng MJ, Chen JJ. A New Lignanamide Derivative and Bioactive Constituents of Lycium chinense. Chemistry of Natural Compounds. 2019 Nov 1, 55 (6): 1002-1006.
Fang CW, Chen LC, Huang HC, Chang TH, Chen CL, Cheng MJ and Chen JJ. A NEW ISOCHROMENO[4,3-b]CHROMEN-7(5H)-ONE DERIVATIVE AND BIOACTIVE CONSTITUENTS OF Filipendula kiraishiensis. Chemistry of Natural Compounds. 2019 Sep, 55(5): 821-824.
Chang YT, Kung MH, Hsu TH, Hung WT, Chen YS, Yen LC, Chang TH*. Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells. Viruses. 2019 Aug, 11(8):763 DOI: 10.3390/v11080763.
Lin SL, Yeh JL, Tsai PC, Chang TH, Huang WC, Lee ST, Wassler M, Geng YJ, Sulistyowati E. Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene. Transl Stroke Res. 2019 Aug 15, 10(4):413-427.
Chen BC, Chang JT, Huang TS, Chen JJ, Chen YS, Jan MW, Chang TH*. Parechovirus A Detection by a Comprehensive Approach in a Clinical Laboratory. Viruses (Viruses-Basel). 2018 Dec 12;10(12). pii: E711. doi: 10.3390/v10120711.
Wei CY, Wang SW, Ye JW, Hwang TL, Cheng MJ, Sung PJ, Chang TH, Chen JJ. New Aporphine and Lignan Derivatives from the Root Wood of Hernandia nymphaeifolia with Anti-inflammatory Effect in fMLP/CB-induced Human Neutrophils. Molecules 2018, 23(9), 2286; doi: 10.3390/molecules23092286.
Wei KC, Huang MS and Chang TH* Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells. Frontiers in Cellular and Infection Microbiology 2018 Aug, 8:268, 1-10 ; doi.org/10.3389/fcimb.2018.00268.
Chang JT, Chen YS, Chen BC, Huang TS, Chang TH*. Human Parechovirus Infection in Children in Taiwan: a Retrospective, Single-Hospital Study. Jpn J Infect Dis. 2018 Jul 24;71(4):291-297. doi: 10.7883/yoken.
Cheng LY, Chen CL, Kuo YH, Chang TH, Lin IW, Wang SW, Chung MI, Chen JJ.Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1860-1863. doi:10.1016/j.bmcl. 2018.04.006.
Lin TH, Su HH, Kang HT, Chang TH*. The Interactive Roles of Lipopolysaccharides and dsRNA/Viruses on Respiratory Epithelial Cells and Dendritic Cells in Allergic Respiratory Disorders: The Hygiene Hypothesis (review). Int. J. Mol. Sci. 2017, 18(10), 2219; doi:10.3390/ijms18102219.
Chang JT, Yang CS, Chen BC, Chen YS, Chang TH*. Complete Genome Sequence of the First Human Parechovirus type 3 Isolated in Taiwan. Journal of the Chinese Medical Association. 2017. 80(11):737-739.
Chen JJ, Wang SW, Chen CL, Kuo YH, Cheng MJ, Chang TH, Sung PJ, Kuo WL, Lim YP. A NEW AMIDE AND ANTIOXIDANT CONSTITUENTS OF Piper taiwanense. Chemistry of Natural Compounds 2017, 53 (6), 1117-1121.
Tsai WL, Chang TH*, Sun WC, Chan HH, Wu CC, Hsu PI, Cheng JS and Yu ML. Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase. Oncotarget, 2017. 8(54):91928-91937. //doi.org/10.18632/oncotarget.20248.
Chen CH, Hwang TL, Chen LC, Chang TH, Wei CS, Chen JJ. Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia. Phytochemistry. 2017. 143:186-193. doi: 10.1016/j.phytochem.2017.08.004.
Hsu HC, Tsai SY, Wu SL, Jeang SR, Ho MY, Liou WS, Chiang AJ, Chang TH. Longitudinal perceptions of the side effects of chemotherapy in patients with gynecological cancer. Support Care Cancer. 2017. 25(11):3457-3464. doi:10.1007/s00520-017-3768-7.
Huang NC, Hung WT, Tsai WL, Lai FY, Lin YS, Huang MS, Chen JJ, Lin WY, Weng JR, Chang TH*. Ficus septica plant extracts for treating Dengue virus in vitro. PeerJ. 2017, 5:e3448. doi: 10.7717/peerj.3448.
Tsai WL*, Cheng JS, Shu CW, Lai KH, Chan HH, Wu CC, Wu JM, Hsu PI, Chung RT, Chang TH*. Asunaprevir evokes hepatocytes innate immunity to restrict the replication of hepatitis C and dengue virus. Frontiers in Microbiology, 2017 Apr 20; 8:668 doi.org/10.3389/fmicb.2017.00668.
Lin TH, Cheng CC, Su HH, Huang NC, Chen JJ, Kang HY, Chang TH*. Lipopolysaccharide attenuates induction of pro-allergic cytokines, thymic stromal lymphopoietin and interleukin 33, in respiratory epithelial cells stimulated with polyI:C and Human Parechovirus. Frontiers in Immunology, 2016, 7:440. 1-17.
Chang TH, Yoshimi R, Ozato K. Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6. Journal of Immunology. 2015,195(11):5367-79.
Chen LC, Liao HR, Chen PY, Kuo WL, Chang TH, Sung PJ, Wen ZH, Chen JJ. Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities. Molecules. 2015, 20(10):18551-18564.
Chou CP, Peng NJ, Chang TH, Yang TL, Hu C, Lin HS, Huang JS, Pan HB. Clinical roles of breast 3T MRI, FDG PET/CT, and breast ultrasound for asymptomatic women with an abnormal screening mammogram. Journal of the Chinese Medical Association. 2015, 78(12):719-25.
Chiang AJ, hen DR, Cheng JT, Chang TH*. Detection of human papillomavirus in squamous cell carcinoma arising from dermoid cysts. Taiwan Association of Obstetrics and Gynecology. 2015, 54(5):559-66.
Chen JJ, Yang CK, Kuo YH, Hwang TL, Kuo WL, Lim YP, Sung PJ, Chang TH, Cheng MJ. New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses. International Journal of Molecular Science. 2015, 16:9719-9731.
Peng NJ*, Chou CP, Pan HB, Chang TH*, Hu C, Chiu YL, FU TY, Chang HT. FDG-PET/CT detection of very early breast cancer in women with breast microcalcification lesions found on screening mammography. Journal of Medical Imaging and Radiation Oncology. 2015, 59(4):445-452.
Wang LF, Lin YS, Huang NC, Yu CY, Tsai WL, Chen JJ, Kubota T, Matsuoka M, Chen SR, Yang CS, Lu RW, Lin YL, Chang TH*. Hydroxychloroquine- Inhibited Dengue Virus Is Associated with Host Defense Machinery. Journal of Interferon and Cytokine Research. 2015, 35(3): 143-156. (Featured on the cover)
Chen JJ, Sung PJ, Chen IS, Cheng MJ, Lim YP, Liao HR, Chang TH, Wei DC and Chen JY. Beilschmide, a new amide and cytotoxic constituents from Beilschmiedia erythrophloia. Chemistry of Natural Compounds. 2015, 51(2): 302-305.
Chang JT, Yang CS, Chen YS, Chen BC, Chiang AJ, Chang YH, Tsai WL, Lin YS, David Chao D, Chang TH*. Genome and Infection Characteristics of Human Parechovirus Type 1: the interplay between viral infection and type I interferon antiviral system. PLOS ONE. 2015,10(2):e0116158.
Cho FN#, Chang TH#, Shu CW, Ko MC, Liao SK, Wu KH, Yu MS, Lin SJ, Hong YC, Chen CH, Hung CH, Chang YH. Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptor through trogocytosis. PLOS ONE. 2014, 9(10):e109352. (# equal contribution).
Nakatsu Y, Matsuoka M, Chang TH, Otsuki N, Noda M, Kimura H, Sakai K, Kato H, Takeda M and Toru Kubota. Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production. PLOS ONE. 2014, 9(4):e94999.
Chou CP, Huang NC, Jhuang SJ, Pan HB, Peng NJ, Cheng JT, Chen CF, Chen JJ and Chang TH*. Ubiquitin-conjugating Enzyme UBE2C is Highly Expressed in Breast Microcalcification Lesions. PLOS ONE. 2014, 9(4):e93934.
Chen JJ, Cheng MJ, Liao CH, Sung PJ, Wang TC, Chang TH and Yun-Ping Lim. Gmelinoiridoside, a new iridoid glycoside from Gmelina philippensis. Chemistry of Natural Compounds. 2014, 50(6):1005-08.
Chen YS, Chen BC, Lin YS, Chang JT, Huang TS and Chang TH* Detection of Aichi virus with antibody targeting of conserved viral protein 1 epitope. Applied Microbiology and Biotechnology. 2013, 97(19):8529-8536.
Chang JT, Chen YS, Chen BC, David Chao D, Chang TH* Complete Genome Sequence of the First Aichi Virus Isolated in Taiwan. Genome Announcements. 2013, 1(1). doi:pii: e00107-12.
Chang TH, Xu S, Tailor P, Kanno T, Ozato K. The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation. Journal of Immunology. 2012, 189(7):3548-56.
Chang TH*, Chen SR, Yu CY, Lin YS, Chen YS, Kubota T, Matsuoka M, Lin YL. Dengue virus blocks extracellular signal-regulated kinase and nuclear factor-kB activation to downregulate cytokine production. PLOS ONE. 2012, 7(8):e41635.
Yu CY, Chang TH, Liang JJ, Chiang RL, Lee YL, Liao CL, Lin YL. Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity. PLOS Pathogens. 2012, 8(6):e1002780.
Cho JY, Hwang YL , Chang TH , Lim YP , Sung PJ , Lee TH , Chen JJ. New coumarins and anti-inflammatory constituents from Zanthoxylum avicennae. Food Chemistry. 2012, 135:17-23.
Liang Q, Deng H, Li X, Wu X, Tang Q, Chang TH, Peng H, Rauscher III FJ, Ozato K, Zhu F. Tripartite Motif-Containing Protein 28 is a small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7. Journal of Immunology. 2011, 187:4754-4763.
Ng S-SM, Chang TH, Tailor P, Ozato K, Kino T. Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication in interferon production. FEBS Letter. 2011, 585, 1331.
Yu CY, Chiang RL, Chang TH, Liao CL, Lin YL. The Interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. Journal of Virology. 2010, 84:2424-31.
Ozato K, Yoshimi R, Chang TH, Atsumi T, Wang H, Morse HC 3rd. Comment on “Gene Disruption study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-B-Dependent Cytokine Expression in Fibroblasts”. Journal of Immunology. 2009, 183:7619.
Chang TH, Kubota T, Matsuoka M, Jones S, Bray M, Ozato K. Ebola virus VP35 blocks type I interferon transcription in dendritic cells by interacting with the cellular SUMOylation machinery. PLOS Pathogens. 2009, Jun;5(6):e1000493.
Kubota T, Matsuoka M, Chang TH, Bray M, Jones S, Tashiro M, Kato A, Ozato K. Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. Journal of Virology. 2009 83:6952-6.
Yoshimi R, Chang TH, Atsumi T, Wang H, Morse HC 3rd, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. Journal of Immunology. 2009, 182(12): 7527-38.
Chan YL, Chang TH, Liao CL, Lin YL. The Cellular Antiviral protein Viperin is attenuated by proteasome-mediated protein degradation in Japanese Encephalitis Virus-Infected Cells. Journal of Virology. 2008, 82(21): 10455-64.
Ozato K, Shin DM, Chang TH, Morse HC 3rd. TRIM family proteins and their emerging roles in innate immunity. Nature Immunology Review 2008, 8(11): 849-60.
Kubota T, Matsuoka M, Chang, TH, Tailor P, Sasaki T, Tashiro M, Kato A, Ozato K. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. Journal of Biological Chemistry. 2008, 81(17): 8967-76.
Chang TH, Liao CL, Lin YL. Flavivirus induced interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kB activation. Microbes and Infection. 2006, 8(1): 157-71.
Hung JT, Liao JH, Lin YC, Chang HY, Wu SF., Chang TH, Kung JT, Hsieh SL, McDevitt H, Sytwu HK. Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. Journal of Autoimmunity. 2005, 25(3): 181-92.
(* corresponding author)