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Ya-Jen Chang Professor (joint appointment)

Ya-Jen Chang Professor (joint appointment)      
Ya-Jen Chang, Ph.D.

Current Position

Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan

Education

Ph.D., Pharmacology, National Taiwan University, Taiwan 

Experience

Faculty Academic Appointments

●Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan

●Instructor in Pediatrics, Harvard Medical School, USA

●Research Associate in Immunology, Boston Children’s Hospital, Harvard Medical School, USA

Specialty

Allergy and asthma
Innate immunity and mucosal immunology
Immunopharmacology 

Contact

02-27899050 (Lab) (IBMS Room No: N527)
02-27898594 (Fax)
Email: yajchang@ibms.sinica.edu.tw
Lab website:   www.ibms.sinica.edu.tw/ya-jen-chang/

Pulications

  1. Luo CH, Shao JS, Lai AC, Huang WC, Wu KC, Chen WY, Chen CC, Lukacs NW, (Chang YJ*) A pulmonary innate lymphoid cell-driven serotonergic neuroimmune axis orchestrates airway hyperreactivity and cough hypersensitivity. Immunity 59, 1-18 (2026-09) [JCR] [WOS]
  2. Huang TC, Shao JS, Lai AC, Wu KC, Lin DF, (Chang YJ*) Lung dysbiosis disrupts an FFAR2-mediated innate immune circuit against Klebsiella pneumoniae. Theranostics 16(10), 5348-5369 (2026-03) [JCR] [WOS]
  3. Hu DW*, Huang CH, He YH, Wei YL, Hu SW, Cheng FJ, Huynh TK, Chen BR, Wang BW, Kuan LC, Lee DY, Yeh MH, (Chang YJ), Liu LC, Hung MC, Huang WC* SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early-Onset of Breast Cancer.. Advanced Science e10811, 1-19 (2025-09) [JCR] [WOS]
  4. Shao JS, Lai AC, Huang WC, Wu KC, Chi PY, Chang YM, (Chang YJ*) Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s.. Journal of Clinical Investigation 135(16), e187372 (2025-07) [JCR] [WOS]
  5. Wang YC, Wu PH, Ting WC, Wang YF, Yang MH, Su TH, Su JY, Sun HI, Huang WM, Tsai PL, Wernig G, Ho PC, Wang L, Wu CT, Chang YL, Chen TC, Meng TC, Chang YM, Lai SL, Li CW, Ko TM, Yang KC, (Chang YJ), Chern Y, Kuo MC, Huang YT, Tzeng YS, Tang JL, Chen SY* Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells.. Nature Communications 16, 5600 (2025-06) [JCR] [WOS]
  6. Thio CL, Shao JS, Luo CH, (Chang YJ*) Decoding Innate Lymphoid Cells and Innate-like Lymphocytes in Asthma: Pathways to Mechanisms and Therapies. Journal of Biomedical Science 32, 48 (2025-05) [JCR] [WOS]
  7. Lai AC, Gonzalez-Cuesta M, Ho CH, Chi PY, Wu KC, Rocha G, Munoz-García JC, Angulo J, García Fernandez JM, (Chang YJ*), Ortiz Mellet C* α-GalCer sp2-iminoglycolipid analogs as CD1d-dependent iNKT modulators: Evaluation of their immunotherapeutic potential in murine models of asthma and autoimmune hepatitis. European Journal of Medicinal Chemistry 282, 117060 (2025-01) [JCR] [WOS]
  8. Lin YC, (Chang YJ), Gau SS, Lo CM, Yang RB* SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation.. Cardiovascular Research cvae, 132 (2024-06) [JCR] [WOS]
  9. Luo CH, Lai AC, Tsai CC, Chen WY, Chang YS, Chung EJ, (Chang YJ*) Staphylococcus aureus exacerbates dermal IL-33-ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin. JCI Insight 9(6), e166821 (2024-02) [JCR] [WOS]
  10. Thio CL, (Chang YJ*) Modulation of pulmonary group 2 innate lymphoid cell function in asthma: From inflammatory mediators to environmental and metabolic factors Experimental and Molecular Medicine 10.1038, 1-13 (2023-09) [JCR] [WOS]
  11. Tsai CH, Lai AC, Lin YC, Chi PY, Chen YC, Yang YH, Chen CH, Shen SY, Hwang TL, Su MW, Hsu IL, Maitland-van der Zee AH, McGeachie MJ, Tantisira KG, (Chang YJ*), Lee YL* Neutrophil extracellular trap production and CCL4L2 expression influence corticosteroid response in asthma Science Translational Medicine 15, eadf3843 (2023-06) [JCR] [WOS]
  12. Luo CH, Lai AC*, (Chang YJ*) Butyrate inhibits Staphylococcus aureus aggravated dermal IL-33 expression and skin inflammation through histone deacetylase inhibition. Frontiers in Immunology 14, 1114699 (2023-05) [JCR] [WOS]
  13. González-Cuesta M, Lai AC, Chi PY, Hsu IL, Liu NT, Wu KC, García Fernández M, (Chang YJ*), Ortiz Mellet C* Serine-/Cysteine-Based sp2‑Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma Journal of Medicinal Chemistry (2023-03) [JCR] [WOS]
  14. Thio CL, Lai AC, Wang JC, Chi PY, Chang YL, Ting YT, Chen SY, (Chang YJ*) Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter–induced airway inflammation JCI Insight 7(23), e164157 (2022-12) [JCR] [WOS]
  15. Thio CL, Lai AC, Ting YT, Chi PY, (Chang YJ*) The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function Cell Reports 40, 111437 (2022-09) [JCR] [WOS]
  16. Chung EJ, Luo CH, Thio CL, (Chang YJ*) Immunomodulatory Role of Staphylococcus aureus in Atopic Dermatitis Pathogens 11, 422-432 (2022-03) [JCR] [WOS]
  17. Li LC, Chen WY, Chen JB, Lee WC, Chang CC, Tzeng HT, Huang CC, (Chang YJ), Yang JL The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia Biomedicines 9, 1252 (2021-09) [JCR] [WOS]
  18. He YH, Yeh MH, Chen HF, Wang TS, Wong RH, Wei YL, Huynh TK, Hu DW, Cheng FJ, Chen JY, Hu SW, Huang CC, Chen Y, Yu J, Cheng WC, Shen PC, Liu LC, Huang CH, (Chang YJ), Huang WC. ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions. Molecular Therapy-Nucleic Acids 25, 536-553 (2021-08) [JCR] [WOS]
  19. Chen WY*, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, (Chang YJ*) Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics 11(6), 2594-2611 (2021-01) [JCR] [WOS]
  20. Hsu TS, Lin YL, Wang YA, Mo ST, Chi PY, Lai AC, Pan HY, (Chang YJ), Lai MZ. HIF-2α is indispensable for regulatory T cell function Nature Communications 11, 5005, 1-16 (2020-10) [JCR] [WOS]
  21. Tsai CH, Wu AC, Chiang BL, Yang YH, Hung SP, Su MW, (Chang YJ), Lee YL CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children Thorax 75(9), 725-734 (2020-09) [JCR] [WOS]
  22. Lai YT, Chao HW, Lai AC, Lin SH, (Chang YJ)*, Huang YS* CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis Journal of Biomedical Science 27:52, 1-17 (2020-04) [JCR] [WOS]
  23. Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, (Chang YJ*) Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy 75 (4), 818-830 (2020-04) [JCR] [WOS]
  24. Lai AC, Chi PY, Thio CL , Han YC, Kao HN, Hsieh HW, Gervay-Hague J*, (Chang YJ*) α-Lactosylceramide protects against iNKT-mediated murine airway hyperreactivity and liver injury through competitive inhibition of CD1d binding. Frontiers in Chemistry 7(811), 1-12 (2019-11) [JCR] [WOS]
  25. Thio CL, Lai AC, Chi PY, Webster G, (Chang YJ*) Toll-like receptor 9–dependent interferon production prevents group 2 innate lymphoid cell–driven airway hyperreactivity Journal of Allergy and Clinical Immunology 144(3), 682-697 (2019-09) [JCR] [WOS]
  26. Chuang YT, Leung K, (Chang YJ), DeKruyff RH, Savage PB, Cruse R, Benoit C, Elewaut D, Baumgarth N, Umetsu DT A natural killer T cell subset that protects against airway hyperreactivity. Journal of Allergy and Clinical Immunology 143 (2), 565-576 (2019-02) [JCR] [WOS]
  27. Thio CL, Chi PY, Lai AC, (Chang YJ*) Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. Journal of Allergy and Clinical Immunology 142(6), 1867-1883 (2018-12) [JCR] [WOS]
  28. Chen WY*, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, (Chang YJ*) IL-33/ST2 axis mediates the hyperplasia of intrarenal urothelium in obstructive renal injury. Experimental and Molecular Medicine 50(4), 1-11 (2018-04) [JCR] [WOS]
  29. Hsieh WC, Hsu TS, (Chang YJ), Lai MZ IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells Nature Communications 9(1), 1-15 (2018-01) [JCR] [WOS]
  30. Chen LY, Yang-Yen HF, Tsai CC, Thio CL, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, (Chang YJ), Chen YT, Yen JJ Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. Journal of Investigative Dermatology 137(4), 894-904 (2017-04) [JCR] [WOS]
  31. Lai YT, Su CK, Jiang ST, (Chang YJ), Lai AC, Huang YS Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction Journal of Neuroscience 36(50), 12661-12676 (2016-12) [JCR] [WOS]
  32. Chen WY, (Chang YJ), Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL. Upregulation of Interleukin-33 in obstructive renal injury. Biochemical and Biophysical Research Communications 473(4), 1026-1032 (2016-05) [JCR] [WOS]
  33. (Chang YJ*), Hsuan YC, Lai AC, Han YC, Hou DR* Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4\'-epi-C-Glycoside of KRN7000. Organic Letters 18(4), 808-811 (2016-02) [JCR] [WOS]
  34. Ho KC, Chiang YJ, Lai AC, Liao NS, (Chang YJ), Yang-Yen HF, Yen JJ CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death & Disease 5, e1518, 1-11 (2014-11) [JCR] [WOS]
  35. Yu S, Kim HY, (Chang YJ), DeKruyff RH, Umetsu DT Innate lymphoid cells and asthma. Journal of Allergy and Clinical Immunology 133(4), 943-950 (2014-04) [JCR] [WOS]
  36. Lin J, (Chang YJ), Yang WB, Yu AL, Wong CH The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes. PLoS One 9(4), e94040, 1-12 (2014-04) [JCR] [WOS]
  37. Huang JR, Tsai YC, (Chang YJ), Wu JC, Hung JT, Lin KH, Wong CH, Yu AL alpha-Galactosylceramide but not phenyl-glycolipids induced NKT cell anergy and IL-33-mediated myeloid-derived suppressor cell accumulation via upregulation of egr2/3. Journal of Immunology 192(4), 1972-1981 (2014-02) [JCR] [WOS]
  38. Kim HY, Lee HJ, (Chang YJ), Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nature Medicine 20(1), 54-61 (2014-01) [JCR] [WOS]
  39. (Chang YJ*), DeKruyff RH, Umetsu DT* The role of type 2 innate lymphoid cells in asthma. Journal of Leukocyte Biology 94(5), 933-940 (2013-11) [JCR] [WOS]
  40. Albacker LA*, Chaudhary V*, (Chang YJ*), Kim HY*, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nature Medicine 19(10), 1297-1304 (2013-10) [JCR] [WOS]
  41. Kim HY*, (Chang YJ*), Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. Journal of Allergy and Clinical Immunology 132(2), 414-425 (2013-08) [JCR] [WOS]
  42. (Chang YJ), DeKruyff RH, Umetsu DT Immune Homeostasis of the Lung: The Role of Regulatory NKT Cells in Asthma Immune Homeostasis of the Lung: The Role of Regulatory NKT Cells in Asthma 107-124 (2012-06-06) [JCR] [WOS]
  43. Kim HY*, (Chang YJ*), Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.129(1):216-27 Journal of Allergy and Clinical Immunology 129(1), 216-227 (2012-01) [JCR] [WOS] 

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  • Update Date:2026-10-16
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