Education

Ph.D., Graduate Institute of Medical Sciences, Taipei Medical University

Professional Experiences

1.Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica
2.Assistant Professor, Division of Cardiovascular Surgery, Tri-Service General Hospital
3.Short-term Visiting Scholar, Cardiovascular Program, Boston Children's Hospital, Harvard University, USA
4.Internship in Radiological Medicine and Imaging, Singapore General Hospital
5.Member, American Physiological Society (APS)

Research Interests

•Gender differences in angiogenesis and vascular remodeling
•Endocrine physiology
•Sex hormone-related cancers (e.g., prostate cancer)

Recent Publications

1.Huo YN, Yang HY, Ke HY, Lin CY, Tsai CS. (2024, Nov). Androgen receptor activation inhibits endothelial cell migration in vitro and angiogenesis in vivo . Eur J Cell Biol, 103(4):151456.

2.Liu CH, Wen ZH, Huo YN, Lin CY, Yang HY, Tsai CS. (2024, Aug). Piscidin-1 regulates lipopolysaccharide-induced intracellular calcium, sodium dysregulation, and oxidative stress in atrial cardiomyocytes.. Eur J Pharmacol., 5;976:176695.

3.Lu MK, Huo YN, Tai BY, Lin CY, Yang HY, Tsai CS. (2024, Jul). Ziprasidone triggers inflammasome signaling via PI3K-Akt-mTOR pathway to promote atrial fibrillation.. Biomed Pharmacother, 75:116649.

4.H. C. Wang, Y. N. Huo and W. S. Lee (2023, Nov). Activation of progesterone receptor is essential for folic acid-regulated cancer cell proliferation and migration . JOURNAL OF NUTRITIONAL BIOCHEMISTRY.

5.H. Y. Yang, J. Y. Chen, Y. N. Huo, P. L. Yu, P. Z. Lin, S. C. Hsu, et al. (2022, May). The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts . LIFE SCIENCES.

6.H. C. Wang, Y. N. Huo and W. S. Lee (2020, Nov). Folic acid prevents the progesterone-promoted proliferation and migration in breast cancer cell lines . EUROPEAN JOURNAL OF NUTRITION.

7.X. S. Cheng, Y. N. Huo, Y. Y. Fan, C. X. Xiao, X. M. Ouyang, L. Y. Liang, et al. (2020, Aug). Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice . Cellular and Molecular Medicine.

8.Y. N. Huo, S. D. Yeh and W. S. Lee (2019, Nov). Androgen receptor activation reduces the endothelial cell proliferation through activating the cSrc/AKT/p38/ERK/NFκB-mediated pathway. J Steroid Biochem Mol Biol.

9.P. C. Ting, W. R. Lee, Y. N. Huo, S. P. Hsu and W. S. Lee (2019, Jan). Folic acid inhibits colorectal cancer cell migration. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.

10.H. C. Wen, Y. N. Huo, C. M. Chou and W. S. Lee (2018, Nov). PMA inhibits endothelial cell migration through activating the PKC-delta/Syk/NF-kappaB-mediated up-regulation of Thy-1 . Scientific Reports.

11.Y. N. Huo, W. Chen and X. X. Zheng (2015, Nov). ROS, MAPK/ERK and PKC play distinct roles in EGF-stimulated human corneal cell proliferation and migration. Cell Mol Biol.

12. T. S. Lee, J. J. Lin, Y. N. Huo and W. S. Lee (2015, Jul). Progesterone Inhibits Endothelial Cell Migration Through Suppression of the Rho Activity Mediated by cSrc Activation . J Cell Biochem.

13.Sung-Po Hsu 1, Ho-Ching Yang, Chun-Ting Kuo, Heng-Ching Wen, Li-Ching Chen, Yen-Nien Huo, Wen-Sen Lee (2015, Jan). Progesterone receptor-NFkappaB complex formation is required for progesterone-induced NFkappaB nuclear translocation and binding onto the p53 promoter . Endocrinology.

14.H. C. Wen, C. Kao, R. C. Hsu, Y. N. Huo, P. C. Ting, L. C. Chen (2013, Apr). Thy-1-induced migration inhibition in vascular endothelial cells through reducing the RhoA activity. PLoS One.