Education

Ph.D. University of London (Pharmacology)

Professional Experiences

Executive Committee Member, Graduate Institute of Life Sciences, National Defense Medical University (2014-present)
Chair, Systemic Biology Section, Graduate Institute of Life Sciences, National Defense Medical Center (2008-2012)
Chairman, Department and Institute of Pharmacology, National Defense Medical Center (2005-2011)
Visiting Professor, Department of Physiology, Medical College of Georgia, U.S.A. (2005-2006)
Visiting Professor, Department of Pharmacology and Pharmacy, University of Bath, U.K. (2002-2003)
Committeeman of Education Evaluation Committee, National Defense Medical Center (2001-2005)
Associate Editor of Journal of Medical Science, National Defense Medical Center (2001-2005; 2019-present)
General Secretary of The Pharmacological Society in Taiwan (2000-2004)
Professor, Department of Pharmacology, National Defense Medical Center (2000-present)
Visiting Associate Professor, Department of Physiology, University of Michigan, U.S.A. (1999-2000)
Associate Professor, Department of Pharmacology, National Defense Medical Center (1995-2000)
Post-doctor, The William Harvey Research Institute, St. Bartholomew's Hospital Medical College, University of London, U.K. (1995)
Senior Instructor, Department of Pharmacology, National Defense Medical Center (1990-1992)
Research Fellow, Department of Physiology, University of Michigan, U.S.A. (1989-1990)
Instructor, Department of Pharmacology, National Defense Medical Center (1987-1989)

Honors and Awards

World’s Top 2% Scientists in Scientific impact of academic career (1960~2021) (1960~2022) (1960~2023) (1960~2024)
Top Ten Distinguished Young Men in 2002 in Taiwan (elected by Taiwanese Young Businessmen Society) (2002)
Award for Excellent Military Medical Fellows/Teachers (Ministry of National Defense, Taiwan/R.O.C.) (1998, 2000, 2001, 2002)
Award for Excellent Scientific Article (elected by The Pharmacological Society in Taiwan, Taiwan/R.O.C.) (1997)
Award for Excellent Scientific Article (elected by Chinese Physiological Society, Taiwan/R.O.C.) (1991)
Award of Merit to Chin-Chen Wu for Research Achievement (Univ. of Michigan, U.S.A.) (1990)

Research Interests

Dr. Wu has been working on the cardiovascular diseases field since 1986. After he earned his Ph.D. degree, his research is more focusing on the pathogenesis and possible therapy of sepsis/septic shock. His ongoing researches are to investigate the effect of perivascular adipose tissue in the regulation of vascular tone and to examine old drugs new use in the sepsis animals. Recently, he extends his sepsis/septic shock research to Chinese Medicine. He wishes to have breakthrough findings both in pathogenesis and therapy from the view of Chinese Medicine.

Recent Publications

1. Hung, H.Y., C.C. Shih, M.H. Liao, S.J. Chen, H.C. Huang, C.C. Wu*: NKCC1 inhibition as a breakthrough in combating coagulopathy and boosting survival in LPS-induced DIC rat model. Eur. J. Pharmacol. 1008:178348, 2025.

2. Ke, H.Y., M.H. Chen, C.M. Tsao, H.P. Hii, C.W. Kuo, S.M. Ka, C.C. Wu, C.C. Shih: Therapeutic potential of butyrate against heat stress-induced intestinal damage, systemic inflammation, and multiple organ dysfunction: Insights from in vitro and in vivo experiments. Eur. J. Pharmacol. 999:177710, 2025.

3. Ke H.Y., J.H. Chen, S.Y. Kao, C.M. Tsao, C.W. Kuo, C.C. Wu, C.C. Shih: Heat stress–induced platelet dysfunction is associated with loss of fibrinogen and is improved by fibrinogen supplementation. Thrombosis Research 241:109091, 2024.

4. Kao S.Y., C.M. Tsao, H.Y. Ke, M.F. Chou, C.C. Wu, C.C. Shih: Loss of plasma fibrinogen contributes to platelet hyporeactivity in rats with septic shock. Thrombosis Research 241:109072, 2024.

5. Sung S.Y., Y.W. Lin, C.C. Wu, C.Y. Lin, P.S. Hsu, S. Periasamy, B. Nagarajan, D.J. Hsieh, Y.T. Tsai, C.S. Tsai and F.Y. Lin: Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats. Biomaterials Science 11(7):2566-2580, 2023.

6. Shih, C.C., S.J. Chen, W.K. Chang, H.J. Tsai, H.C. Huang, C.C. Wu, C.M. Tsao: Stimulation of angiotensin II type 2 receptor attenuates organ injury and mortality in septic rats after peritonitis. J. Chin. Med. Assoc. 86(7):688-695, 2023.

7. Shih, C.C., W.C. Liao, H.Y. Ke, C.W. Kuo, C.M. Tsao, W.C. Tsai, Y.L. Chiu, H.C. Huang, C.C. Wu*: Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke. Biomedicine and Pharmacotherapy 161:114565, 2023.

8. Hii , H.P., W.Z. Lo, Y.H. Fu, M.H. Chen, C.C. Shih, C.M. Tsao, S.M. Ka, Y.L. Chiu, C.C. Wu, C.C. Shih: Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol. Life Sciences, 310:121039, 2022.

9. Tsai, H.J., C.F. Chian, C.C. Shih, S.J. Chen, W.J. Liaw, H.C. Huang, C.M. Tsao, C.C. Wu*: Olmesartan ameliorates organ injury and mortality in rats with peritonitis-induced sepsis. J. Surg.Res. 279:526-532, 2022.

10. Tsai, H.J., C.C. Shih, K.Y. Chang, M.H. Liao, W.J. Liaw, C.C. Wu, C.M. Tsao: Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Sci. Report 11:610, 2021.