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黃翊恭

國防醫學大學 藥理學研究所

黃 翊 恭 教授、所長 | 國際事務處副處長

Eagle Yi-Kung Huang, Ph.D.
Professor & Director | Deputy Director of International Affairs
Prof. Eagle Yi-Kung Huang
📞 Ext: 18670 ✉️ Email: eyh58@mail.ndmutsgh.edu.tw

👨‍🔬 實驗室研究重點 (Research Focus)

黃教授的研究整合了神經藥理學與新藥開發。本實驗室具備獨特的三大核心技術,致力於從分子設計到功能驗證,開發針對神經系統疾病的新型療法。

🧬 胜肽合成 💊 小分子藥物篩選 ⚡ 電生理技術

🔬 主要研究方向 (Research Directions)

1. 藥物設計與合成

胜肽藥物:設計高穩定性催產素 (Oxytocin) 與內內啡肽 (Endomorphin) 類似物,以克服傳統胜肽藥物易分解的缺點。
小分子藥物:探討檳榔鹼 (Arecoline) 與檳榔次鹼 (Arecaidine) 及其衍生物在神經保護與認知增強上的潛力。

2. 海馬迴突觸可塑性與記憶

利用腦切片電生理技術,探討上述藥物如何調控海馬迴 (Hippocampus) 的長期增益 (LTP) 與長期抑制 (LTD) 現現象,進而解析學習與記憶的神經機制。

3. 成癮與獎賞系統

成癮路徑:研究尼古丁、酒精、檳榔鹼成癮的神經傳導路徑。
治療標靶:探索能夠降低渴求感 (Craving) 與戒斷症狀的新穎治療標靶。

4. 偏頭痛與疼痛機轉

難治型疼痛:探討催產素與新型胜肽藥物如何緩解痛覺過敏 (Hyperalgesia) 與觸發痛 (Allodynia)。
脊髓傳導機轉:利用離體脊髓 (Isolated Spinal Cord) 模型,深入解析慢性疼痛與偏頭痛機轉。

5. 行為神經藥理學

自閉症 (ASD):探討催產素在改善社交缺陷與重複行為中的角色。
性行為:研究中樞神經系統對性行為的生理調控機制。

🎓 學歷 (Education)

生理暨藥理學博士
英國南安普頓大學 (University of Southampton)
畜牧學系學士
國立台灣大學

💼 經歷 (Experience)

訪問學者 - 英國南安普頓大學生化學系
研究員 - 長庚紀念醫院醫學研究中心
助理教授 - 長庚大學臨床醫學研究所
博士後研究 - 國防醫學院藥理學科 / 長庚大學藥理學科
研究助理 - 中央研究院動物研究所內分泌研究室

📚 完整研究論文 (Full Publications)

Przemyslaw Mielczarek, Kinga Hartman, Eagle Yi-Kung Huang, Ewa Gibula-Tarlowska, Pawel Grochecki, Tymoteusz Slowik, Jolanta H Kotlinska, Jerzy Silberring, and Anna Drabik (2025) The Role of LVV-H7 in Alcohol-Induced Reward Mechanisms. Addict Biol. 30(9): e70086.

Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, and Eagle Yi-Kung Huang (2025) Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. Iranian Journal of Basic Medical Sciences 28(9): 1212-1219.

Yuan-Hao Chen, Tung-Tai Kuo, Vicki Wang, Pin-Wen Cheng, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2024) Serotonergic regulation of synaptic dopamine levels mitigates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 14(5): 941-964.

Lok-Hi Chow, Pin-Chen Lin, Ying-Jie Chen, Yuan-Hao Chen, and Eagle Yi-Kung Huang (2024) Yangonin, one of the kavalactones isolated from Piper methysticum G. Frost, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia. Journal of Ethnopharmacology 333: 118394.

Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, and Skye Hsin-Hsien Yeh (2024) Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. J Chin Med Assoc. 87(5): 538-549.

Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-li Choi, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci. 31(1): 38.

Yen-Lun Chen, Yen-Hsun Lai, Eagle Yi-Kung Huang, Hong-Jaan Wang, and Hao-Yuan Hung (2024) Nalbuphine-6-glucuronide is a potent analgesic with superior safety profiles by altering binding affinity and selectivity for mu-/kappa-opioid receptors. Life Science 340: 122441.

Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Hao-Yuan Hung, Pin-Chen Lin, and Eagle Yi-Kung Huang (2024) Intrathecal injections of angiotensin IV and oxytocin conjugates induce antihyperalgesia and antiallodynia in both sexes of rats. Peptides 173: 171150.

Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-li Choi, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2023) PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease. Int J Mol Sci. 24(5): 4687.

Hsu-Kai Huang, Pin-Chen Lin, Tzu-Ting Huang, Hao-Yuan Hung, Tsai-Wang Huang, Eagle Yi-Kung Huang (2023) Nicotine activates HIF-1a and regulates acid extruders through the nicotinic acetylcholine receptor to promote the Warburg effect in non-small cell lung cancer cells. Eur J Pharmacol. 950: 175778.

Eagle Yi-Kung Huang, Hao-Yuan Hung, Yuan-Hao Chen, Jen-Hsin Kao, Ai-Lun Tsai, and Lok-Hi Chow (2023) Effects of dextromethorphan on nicotine-induced reward, behavioral sensitization, withdrawal signs, and drug seeking-related behavior in rats. Nicotine & Tobacco Research 25(7): 1251-1260.

Kwok-On Ng, Lok-Hi Chow, Chun-Chang Yeh, Eagle Yi-Kung Huang, Wei-Cheng Liu, and Ping-Heng Tan (2022) Case report: the management for a gestational hypertensive woman with influenza A virus pneumonia and peripartum cardiomyopathy. BMC Pregnancy Childbirth 22(1): 497.

Kuan-Yin Tseng, Tung-Tai Kuo, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2022) Tetrabenazine mitigates aberrant release and clearance of dopamine in the nigrostriatal system, and alleviates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 12(5): 1545-1565.

Lok-Hi Chow, Hao-Yuan Hung, Wan-Chuan Wu, Yuan-Hao Chen, Weihong Pan, and Eagle Yi-Kung Huang (2022) Estrogen can abolish oxytocin-induced spinal antihyperalgesia. Psychoneuroendocrinology 136: 105603.

Hao-Yuan Hung, Wu-Chien Chien, Chi-Hsiang Chung, Li-Ting Kao, Lok-Hi Chow, Yuan-Hao Chen, Jolanta H. Kotlińska, Jerzy Silberring, and Eagle Yi-Kung Huang (2021) Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study. Drug and Alcohol Dependence 229 (Pt A): 109102.

Hsiao-Ming Chao, Eagle Yi-Kung Huang, and Chieh-Fu Chen (2021) The essentials for the study of vision improving drugs. Journal of Chinese Medicine Research Vol.33: 1-18.

Mielczarek P, Hartman K, Drabik A, Hung HY, Huang EY, Gibula-Tarlowska E, Kotlinska JH, and Silberring J. (2021) Hemorphins-From Discovery to Functions and Pharmacology. Molecules 26(13): 3879.

Wang V, Kuo TT, Huang EY, Ma KH, Chou YC, Fu ZY, Lai LW, Jung J, Choi HI, Choi DS, Li Y, Olson L, Greig NH, Hoffer BJ, and Chen YH (2021) Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease. ACS Pharmacol Transl Sci. 4(2): 858-869.

Hung HY, Chow LH, Kotlinska JH, Drabik A, Silberring J, Chen YH, and Huang EY (2021) LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides 136: 170455.

Loh SH, Chang CY, Huang SF, Chao SC, Lin WK, Huang EY, Tsai CS, and Tsai YT (2020) Functional effects of urotensin-II on intracellular pH regulators in human radial artery smooth muscle cells. Peptides 126: 170236.

Chen YH, Wang V, Huang EY, Chou YC, Kuo TT, Olson L, and Hoffer BJ (2019) Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. Int J Mol Sci. 20(24) pii: E6251.

Chen YH, Hsieh TH, Kuo TT, Kao JH, Ma KH, Huang EY, Chou YC, Olson L, and Hoffer BJ (2019) Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors. J Neurochem. 150(1): 56-73.

Wu WL, Cheng SJ, Lin SH, Chuang YC, Huang EY, and Chen CC (2019) The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Front Cell Neurosci. 13: 86.

Chen YH, Lin BJ, Hsieh TH, Kuo TT, Miller J, Chou YC, Huang EY, and Hoffer BJ (2019) Differences in nicotine encoding dopamine release between the striatum and shell portion of the nucleus accumbens. Cell Transplantation 28(3): 248-261.

Yuan-Hao C, Kuo TT, Huang EY, Hoffer BJ, Kao JH, Chou YC, Chiang YH, and Miller J (2018) Nicotine-induced conditional place preference is affected by head injury: correlation with dopamine release in the nucleus accumbens shell. Int. J. Neuropsychopharmacol. 21(10): 949-961.

Chen YH, Kuo TT, Kao JH, Huang EY, Hsieh TH, Chou YC, and Hoffer BJ (2018) Exercise ameliorates motor deficits and improves dopaminergic functions in the rat hemi-Parkinson's model. Sci Rep. 8(1): 3973.

Chow LH, Chen YH, Lai CF, MD, Lin TY, Chen YJ, Kao JH, and Huang EY (2018) Sex difference of angiotensin IV-, LVV-hemorphin 7-, and oxytocin-induced antiallodynia at the spinal level in mice with neuropathic pain. Anesthesia & Analgesia 126(6): 2093-2101.

Chen YH, Kuo TT, Huang EY, Chou YC, Chiang YH, Hoffer BJ, and Miller J (2018) Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell. Oncotarget 9: 10016-10028.

Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, and Chiang YH (2017) Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience 348: 180-190.

Chen YH, Huang EY, Kuo TT, Miller J, Chiang YH, and Hoffer BJ (2017) Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation 26(7): 1156-1168.

Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, and Eagle Yi-Kung Huang (2016) Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS ONE 11(9): e0162218.

Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, and Lok-Hi Chow (2016) Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. Neuropeptides 59: 63-69.

Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J. Hoffer, Pei-Jie Wu, Hsin-I Ma, Jing-Jr Tsai, Yu-Ching Chou, and Yung-Hsiao Chiang (2016) Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. Brain Res. 1642:581-589.

Eagle Yi-Kung Huang, Yuh-Chiang Shen, and Chieh-Fu Chen (2016) Mitochondria: Target for the develop of anti-inflammatory drugs. Journal of Chinese Medicine 27(1): 2701004.

Lok-Hi Chow, Pao-Luh Tao, Yuan-Hao Chen, Yu-Hui Lin and Eagle Yi-Kung Huang (2015) Angiotensin IV possibly acts through PKMzeta in hippocampus to regulate cognitive memory in rats. Neuropeptides 53: 1-10.

Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao (2015) Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. J. Biomed. Sci. 22(1): 81.

Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Hsin-I Ma, Barry J. Hoffer, Pi-Fen Tsui, Jing-Jr Tsai, Yu-Ching Chou and Yung-Hsiao Chiang (2015) Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. Cell Transplantation 24(10): 2113-2128.

Yi-Ting Tsai, Chung-Yi Lee, Chih-Chin Hsu, Chung-Yi Chang, Ming-Kai Hsueh, Eagle Yi-Kung Huang, Chien-Sung Tsai, and Shih-Hurng Loh (2014) Effects of Urotensin II on intracellular pH regulation in cultured human internal mammary artery smooth muscle cells. Peptides 56: 173-182.

Eagle Yi-Kung Huang, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Tsai Tung-Han, Hsin-l Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Remote effects on the striatal dopamine system after fluid percussion injury. Behavioural Brain Research 267: 156-172.

陳介甫、黃翊恭、吳令怡、廖志飛 (2014) 發炎、發炎體、抗發炎藥 (ISBN 978-986-7825-95-7) 知音出版社

Eagle Yi-Kung Huang, Pi-Fen Tsui, Tung-Tai Kuo, Jing-Jr Tsai, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury. PLOS ONE 9(1): e86354.

Ling-Yi Wu, Chieh-Fu Chen and Eagle Yi-Kung Huang (2013) Obesity related metabolic complications and anti-obesity drugs. Journal of Chinese Medicine 24(2): 261-277.

Yuan-Hao Chen, Tong-Tai Kuo, Ming-Ting Chu, Hsin-I Ma, Yung-Hsiao Chiang and Eagle Yi-Kung Huang (2013) Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in animal seizure model. Neuroimmunomodulation 20(4): 223-232.

Weihong Pan, Xiaojun Wu, Yi He, Hung Hsuchou, Eagle Yi-Kung Huang, Pramod K. Mishra and Abba J. Kastin (2013) Brain interleukin-15 in neuroinflammation and behavior. Neurosci. Biobehav. Rev. 37(2): 184-192.

Lok-Hi Chow, Pao-Luh Tao, Jin-Chung Chen, Ruey-Ming Liao, En-Pei Chang and Eagle Yi-Kung Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides 39(1): 21-28.

Pao-Pao Yang, Eagle Yi-Kung Huang, Yu-Ying Fu, Tsai-Shan Ho and Pao-Luh Tao (2012) Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization. Synapse 66(10): 858-869.

Bor-Chih Cheng, Pao-Luh Tao, Ya-Yun Cheng and Eagle Yi-Kung Huang (2012) LVV-hemorphin 7 and angiotensin IV in correlation with antinociception and anti-thermal hyperalgesia in rats. Peptides 36(1): 9-16.

Weihong Pan, Hung Hsuchou, Bhavaani Jayaram, Reas S. Khan, Eagle Yi-Kung Huang, Xiaojun Wu, Chu Chen and Abba J. Kastin (2012) Leptin action on nonneuronal cells in the CNS: potential clinical applications. Ann N Y Acad Sci. 1264(1): 64-71.

Shih-Lin Chang, Yao-Chang Chen, Yung-Hsin Yeh, Yu-Jun Lai, Hung-I Yeh, Cheng-I Lin, Yung-Kuo Lin, Yenn-Jiang Lin, Tsu-Juey Wu, Yi-Kung Huang, Shih-Ann Chen and Yi-Jen Chen (2011) Heart failure enhances arrhythmogenesis in pulmonary veins. Clin. Exp. Pharmacol. Physiol. 38(10): 666-674.

Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2011) NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study. Drug Alcohol Depend. 118(2-3): 366-374.

Pao-Luh Tao, Jain-Fang Chen and Eagle Yi-Kung Huang (2011) Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. J. Biomed. Sci. 18(1): 64.

Shiou-Lan Chen, Kuei-Ying Hsu, Eagle Yi-Kung Huang, Ru-Band Lu and Pao-Luh Tao (2011) Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug Alcohol Depend. 117(2-3): 164-169.

Chun-Hung Wu, Pao-Luh Tao and Eagle Yi-Kung Huang (2010) Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain. Peptides 31 (7): 1374-1382.

Ling-Yi Wu, Eagle Yi-Kung Huang and Pao-Luh Tao (2010) Co-administration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertility and Sterility 93(5): 1686-1694.

Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang (2009) Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. J. Biomed. Sci. 16: 106.

Wei-Li Wu, Chih-Hung Wang, Eagle Yi-Kung Huang and Chih-Cheng Chen (2009) ASIC3-/- Female Mice with Hearing Deficit Affects Social Development of Pups. PLoS ONE 4(8): e6508.

Chung-Shiun Yang, Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2008) The role of the NR2B subunit of NMDA receptors in morphine rewarding, drug seeking, and behavioral sensitization. Journal of Medical Sciences 28(6): 245-253.

Yu-Jun Lai, Eagle Yi-Kung Huang, Hung-I Yeh, Yen-Lin Chen, Jim Jung-Ching Lin and Cheng-I Lin (2008) On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins. Life Sci. 83: 272-283.

Wei-Li Wang, Sheau-Farn Yeh, Eagle Yi-Kung Huang, Yu-Ling Lu, Chun-Fa Wang, Chi-Ying F. Huang and Wey-Jinq Lin (2007) Mitochondrial anchoring of PKCa by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis 12: 1857-1871.

Wei-Ming Lue, Eagle Yi-Kung Huang, San-Nan Yang, Chih-Shung Wong and Pao-Luh Tao (2007) Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. Synapse 61(6): 420-428.

Eagle Yi-Kung Huang, Hsiang-Jen Hsiao, Wei-Ming Lue and Pao-Luh Tao (2007) U-50,488 decreased the rewarding effect and mesolimbic dopamine neuron activity induced by morphine in rats. Journal of Medical Sciences 27(1): 15-22.

Pao-Pao Yang, Eagle Yi-Kung Huang, Geng-Chang Yeh and Pao-Luh Tao (2006) Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. J. Biomed. Sci. 13(5): 695-702.

Jin-Chung Chen, Wei-Hsin Lee and Eagle Yi-Kung Huang (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(Tic)amide. Peptides 27(5): 1005-1014.

Pao-Luh Tao, Kai-Wen Liang, Wen-Yi Sung, Yung-Tsun Wu and Eagle Yi-Kung Huang (2006) Nalbuphine is effective in decreasing the rewarding effect and drug-seeking behavior induced by morphine in rats. Drug Alcohol Depend. 84: 175-181.

Pao-Luh Tao, Yong-Shang Lai, Lok-Hi Chow and Eagle Yi-Kung Huang (2005) Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord. N-S Arch. Pharmacol. 371:72-80.

Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow and Pao-Luh Tao (2005) Dextromethorphan differentially affects opioid antinociception in rats. Br. J. Pharmacol. 144(3): 400-404.

Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Shen-Kou Tsai and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but not related to descending serotoninergic or adrenergic pathways. J. Biomed. Sci. 11(6): 717-725.

Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Tak-Yu Lee and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine antinociception at the spinal level in rats. Can. J. Anaesth. 51(9): 905-910.

Eagle Yi-Kung Huang, Ching-Ming Chen and Pao-Luh Tao (2004) Supraspinal anti-allodynic and rewarding effects of endomorphins in rats. Peptides 25(4): 577-583.

Eagle Yi-Kung Huang, Te-Chen Liu and Pao-Luh Tao (2003) Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine release at the nucleus accumbens. N-S Arch. Pharmacol. 368: 386-392.

Jin-Chung Chen, Pao-Luh Tao, Jihn-Yih Li, Chung-Hang Wong and Eagle Yi-Kung Huang (2003) Endomorphin-1 and 2 induce naloxone-precipitated withdrawal syndromes in rats. Peptides 24(3): 477-481.

Eagle Yi-Kung Huang, Jihn-Yih Li, Chung-Hang Wong, Peter Pei-Chiung Tan and Jin-Chung Chen (2002) Dansyl-PQRamide, a possible neuropeptide FF receptor antagonist, induces conditioned place preference. Peptides 23(3): 489-496.

Jin-Chung Chen, Kai-Wen Liang, Yi-Kung Huang, Cheng-Sheng Liang and Yao-Chang Chiang (2001) Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine. Life Sci. 68(9): 973-983.

Jihn-Yih Li, Chung-Hang Wong, Eagle Y.-K. Huang, Yen-Chien Lin, Yun-Long Chen, Peter P. C. Tan and Jin-Chung Chen (2001) Modulation of spinal serotonin activity affect the development of morphine tolerance. Anesthesia and Analgesia 92(6): 1563-1568.

Jin-Chung Chen, Kai-Wen Liang and Eagle Yi-Kung Huang (2001) Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. Synapse 39(3): 239-248.

Eagle Yi-Kung Huang, Jihn-Yih Li, Peter Pei-Chiung Tan, Chung-Hang Wong and Jin-Chung Chen (2000) The cardiovascular effects of PFRFamide and PFR(Tic)amide, a possible agonist and antagonist of neuropeptide FF (NPFF). Peptides 21(2): 205-210.

Peter Pei-Chiung Tan, Jin-Chung Chen, Jihn-Yih Li, Kai-Wen Liang, Chung-Hang Wong and Eagle Yi-Kung Huang (1999) Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogs. Peptides 20(10): 1211-1217.

J.-C. Chen, J.-Y. Li, K.-W. Liang and Y.-K. Huang (1999) Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the level of neurotransmitters in the median prefrontal cortex. Brain Res. 816(1): 220-224.

E. Y.-K. Huang, J. Bagust, R. P. Sharma and R. J. Walker (1998) The effect of FMRFamide-like peptides on electrical activity in isolated mammalian spinal cord. Neuroscience Res. 30: 295-301.

S. J. Perry, E. Y.-K. Huang, D. Cronk, J. Bagust, R. Sharma, R. J. Walker, S. Wilson and J. F. Burke (1997) A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Letters 409(3): 426-430.

Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1997) FLFQPQRFamide (NPFF) inhibits the fast wave of the evoked field potential in the rat isolated spinal cord preparation. Br. J. Pharmacol. 120(SS): 233P.

Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1996) Naloxone and desaminoYFLFQPQRamide block potentiation by FLFQPQRFamide (NPFF) of the rat isolated spinal cord monosynaptic reflex (MSR). Br. J. Pharmacol. 117(SS): 314P.

🌍 學術足跡與國際交流 (Global Academic Footprints)

Swipe 👈
Research Visit

赴匈牙利塞格德大學學術訪問

前往匈牙利塞格德大學 (SZTE) 拜會 Karcsúné Kis Gyöngyi 助理教授及其博士生團隊,針對雙邊研究計畫合作與實驗室人員互訪進行具體規劃與研討。

Global Partnership

拜會捷克科學院生理研究所

前往捷克布拉格拜會捷克科學院生理研究所 (CAS) 副所長 Jan Svoboda 博士,針對未來學術研究發展與人員互訪交流計畫進行深度對話與擘劃。

MOU Signing

與捷克科學院簽署合作備忘錄

國防醫學大學藥理學研究所與捷克科學院生理研究所 (FGÚ) 正式簽署合作備忘錄 (MOU),由所長 Ondřej Kuda 博士代表締盟,雙邊國際合作邁向新里程。

Invited Lecture

與波蘭學者進行國際研究合作

與克拉科夫 AGH 科學技術大學 Jerzy Silberring 教授研究室成員於校園內之合照。

Invited Lecture

與波蘭學者進行國際研究合作

與盧布林醫科大學藥理及藥效學系 Jolanta Kotlinska 教授及其秘書聚餐之合照。

Global Partnership

日本產業醫科大學校長上田陽一教授來訪

代表國防藥理所與日本產業醫科大學締結研究合作備忘錄,正式開啟雙邊跨國研究與學者互訪交流。

Global Partnership

捷克科學院學者Jan Svoboda博士來訪

代表國防藥理所與捷克科學院生理所締結合作備忘錄,正式開啟雙邊跨國研究與學者互訪交流。

Conference

參與指標性國際醫學研討會 論文發表

參加波蘭藥理學大會會議,發表最新研究成果,與全球頂尖學者交流。

Global Partnership

與德國DAAD資助的交換學生合影

歡迎來自德國的學生來訪交流。

Public Welfare

志英基金會 醫學講座

致力於社會回饋與醫學科普,受邀擔任基金會主講人,將深奧的藥理知識轉化為大眾健康福音。

🧰實驗工具箱 (Open Bench Tools)

Huang Lab 團隊研發,為日常實驗量身打造的精準數位工具。免費、免安裝,跨平台完美支援手機與電腦,助您大幅提升實驗效率與嚴謹度。

Swipe 👈
🧪
C₁V₁ = C₂V₂
Solution Prep

萬用濃度與配藥計算機

輸入任意三個數值,系統自動精準解出第四個未知數。內建固體粉末配藥模式,支援 Molar 與質量濃度自動換算。

啟動工具 →
⏱️
Screen stays awake
Experiment Timing

實驗專用不休眠計時器

專為實驗室打造的間歇提示計時器。內建強制喚醒技術,確保手機螢幕常亮,並於瀏覽器標籤頁即時顯示倒數。

啟動工具 →
🐭
Birth + Age = Exp. date
Animal Scheduling

實驗動物週齡推算系統

動物排程必備。填入生日、目標週齡或實驗日其中兩項,秒算第三項結果。自動標記週末,嚴謹控管時程。

啟動工具 →
Scan to open Huang Lab Tools
Bench-Ready

手機掃碼・即刻上陣

直接用手機相機掃描上方 QR Code,將全套數位工具帶到實驗桌前,隨時無縫接軌。

工具箱首頁 →
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  • 更新日期:2026-07-13