實驗室的研究方向主要在探討肥胖、代謝症候群和第二型糖尿病病理機轉和治療策略。經過多年來的努力，不僅建置目前獨步國內評估肥胖、代謝性症候群和糖尿病的小鼠代謝核心實驗室（Mouse Metabolic Core），建立關鍵核心技術，包括評估活體胰島素敏感性的 euglycemic hyperinsulinemic clamp technique with tracer dilution method，和活體胰臟胰島素分泌功能的 hyperglycemic clamp technique 黃金標準方法（Gold standard）。

實驗室亦同時發展使用多種發炎相關基因全身和條件式基因剔除及基因轉殖鼠模式，配合多項分子生物學以及基因體和蛋白體學的實驗技術和分析方法，以進一步探討其細胞間和細胞內作用機轉。迄今發表的相關研究成果提供進一步的證據，有助於釐清肥胖發展的能量調控機轉及糖尿病之胰島素抗性與其相關症候群的交互關係以及其形成的可能病因，並提供相關疾病治療上的重要參考。

此外，為擴展生理學在轉譯醫學的應用，實驗室亦朝與臨床新陳代謝科和產學研合作上發展，期望建立國內基礎及臨床有關代謝症候群的藥物和診斷試劑完整開發平台。

1. Pei-Chi Chan, Chun-Han Jhuang, Hsin-Yi Chang, Po Shiuan Hsieh* (2026, Mar). Brown Adipocyte-Derived Serum Amyloid A 3 Alters Diet-Induced Thermogenesis and Impacts Weight Gain. Journal of Nutrional Biochemistry, 151, 2026, 110263. (SCI, Q1, 18/112, Nutrition & Dietetics). NSTC 111-2320-B-016-016-MY3. 本人為通訊作者.
2. Pei-Chi Chan, Pei-Ru Lin, Yu-Feng Tian, Po-Shiuan Hsieh* (2026). Cold-Induced Serum Amyloid A3 Amplifies cAMP–PKA Signaling to Drive Adaptive Thermogenesis in Brown Adipocytes. iScience. (Accepted). (SCI, Q1, 19/134, Multidisciplinary Sciences). NSTC 111-2320-B-016-003-MY3. 本人為通訊作者.
3. Tai C-S, Chung H-Y, Lin T-H, Chang C-K, Perng C-L, Po-Shiuan Hsieh*, Shang H-S, Jian M-J. (2025, Oct). Rapid Nanopore Sequencing of Positive Blood Cultures Using Automated Benzyl-Alcohol Extraction Improves Time-Critical Sepsis Management. Antibiotics, 14(10):1001. (SCI, 17/137, Q1, Infectious Diseases). 本人為通訊作者.
4. Jiung-Pang Huang, Kuan-Hsing Chen, Po-Shiuan Hsieh, Chao-Yu Kuo, Chao Lan Yu & Li-Man Hung (2025, Sep). Genetic deficiency of CCL5 exhibits the phenotypes of HFpEF and aggravates apoptotic cardiomyopathy in HFD-induced diabetic mice. Journal of Molecular Medicine. (SCI, Q1, Medicine, Research & Experimental).
5. Tai C, Jian M, Lin T, Chung H, Chang C, Perng C, Po-Shiuan Hsieh*, Shang H. (2025, Jul). Analytical performance evaluation of a multiplex real-time RT-PCR kit for simultaneous detection of SARS-CoV-2, influenza A/B, and RSV. Peer Journal, 13:e19693. (SCI, 47/135, Q2, Multidisciplinary Sciences). 本人為通訊作者.
6. Chuang-Yen Huang, I-Shan Han, Po-Shiuan Hsieh, Min-Chien Tsai, Hung-Che Chien (2025, Jan). Dichloroacetate, a pyruvate dehydrogenase activator, alleviates high-fat-induced impairment of myogenic differentiation in skeletal muscles. Basic & Clinical Pharmacology & Toxicology. (SCI, 167/329, Pharmacology & Pharmacy).
7. Chuang-Yen Huang, I-Shan Han, Po-Shiuan Hsieh, Min-Chien Tsai, Hung-Che Chien (2024, Nov). Dichloroacetate, a pyruvate dehydrogenase activator, alleviates high-fat-induced impairment of myogenic differentiation in skeletal muscles. Basic & Clinical Pharmacology & Toxicology, 2024; 1–12. doi:10.1111/bcpt.14102. (SCI, 167/329, Pharmacology & Pharmacy).
8. Tai, C.-S.; Jian, M.-J.; Lin, T.-H.; Chung, H.-Y.; Chang, C.-K.; Perng, C.-L.; Hsieh, P.-S.; Shang, H.-S. (2024, Oct). Diagnostic Accuracy of the LabTurbo QuadAIO Common Flu Assay for Detecting Influenza A Virus, Influenza B Virus, RSV, and SARS-CoV-2. Diagnostics, 2024, 14, 2200. (SCI, 59/329, Medicine, general & internal). 本人為通訊作者.
9. Jung-Mou Yang, I-Shan Han, Tsung-Hua Chen, Po-Shiuan Hsieh, Min-Chien Tsai, Hung-Che Chien (2024, Sep). Pharmacological activation of pyruvate dehydrogenase by dichloroacetate protects against obesity-induced muscle atrophy in vitro and in vivo. European Journal of Pharmacology, 979, 176854. (SCI, 75/254, Pharmacology & Pharmacy).
10. Sy-Jou Chen, Hung-Che Chien, Shih-Hung Tsai, Yu-Sin Jheng, Yi Chen, Po-Shiuan Hsieh, Pi-Fen Tsui, Shu Chien, Min-Chien Tsai (2024, Jul). Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ-Associated Smooth Muscle Cell Phenotypic Switching. Journal of Pineal Research, 76:e12988. https://doi.org/10.1111/jpi.12988. (SCI, 13/186, Endocrine & Metabolism).
11. Chien-Wei Chen, Luen-Kui Chen, Yi-Ting Chung, Shui-Yu Liu, Shuoh-Wen Chen, Yuan-I Chang, Po-Shiuan Hsieh, Chi-Chang Juan (2023, Dec). Cysteinecysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle. Inflammation, 46(6), 2089–2101. (SCI, 63/200, Medicine - Immunology and Allergy).
12. Chih‐Feng Lien, Chin‐Sheng Lin, Song‐Kun Shyue, Po-Shiuan Hsieh, Sy‐Jou Chen, Yi‐Tan Lin, Shu Chien, Min‐Chien Tsai (2023, Mar). Peroxisome proliferator‐activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching. British Journal of Pharmacology, 1–17. https://doi.org/10.1111/bph.16074. (SCI, 14/303, Q1, Pharmocology & Pharmacy). MOST 109-2314-B-016-042-MY3.
13. Nian-Sheng Tzeng, Yu-Yin Yang, Chen-Cheng Lin, Po-Shiuan Hsieh, Yia-Ping Liu (2023, Jan). Effects of Early Risperidone Treatment on Metabolic Parameters in Socially Isolated Rats—Implication of Antipsychotic Intervention across Developmental Stages of Schizophrenia. Journal of Integrative Neuroscience, 22(1), 22. (SCI, 81/110, Neuroscience, general Neuroscience).
14. Chan, Pei-Chi, Chieh-Hua Lu, Hung-Che Chien, Yu-Feng Tian, and Po-Shiuan Hsieh. (2022, Nov). Adipose Tissue-Derived CCL5 Enhances Local ProInflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences, 23(22):14226. (SCI, 69/297, Q1, Biochemistry & Molecular Biology). NSTC 111-2320-B-016-003-MY3. 本人為通訊作者.
15. Liao, Tzu-Chieh, Jiung-Pang Huang, Yu-Ting Tsai, Wei-Ching Shih, Chi-Chang Juan, Po-Shiuan Hsieh, Li-Man Hung, Chao-Lan Yu (2022, Oct). Granulocytic MDSC with Deficient CCR5 Alleviates Lipogenesis and Inflammation in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences, 23(21):13048. (SCI, 69/297, Q1, Biochemistry & Molecular Biology).
16. Yeh, Chia-Tsui, Chia-Ying Lee, Yi-Jung Ho, Sin-An Chen, Liang-Yu Chen, Ping-Cheng Liu, Yuan-Fan Chin, An-Yu Chen, Po-Shiuan Hsieh, Yi-Jen Hung, Cheng-Cheung Chen, Yu-Chie Wang, and Guan-Chiun Lee (2022, Sep). Immunoglobulin Y Specific for SARS-CoV-2 Spike Protein Subunits Effectively Neutralizes SARS-CoV-2 Infectivity and Ameliorates Disease Manifestations In Vivo. Biomedicines, 10(11):2774. https://doi.org/10.3390/biomedicines10112774. (SCI, 121/297, Biochemistry & Molecular Biology).
17. Chan, Pei-Chi, and Po-Shiuan Hsieh. (2022, Aug). The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases. International Journal of Molecular Sciences, 23(16):9448. (SCI, 69/297, Q1, Biochemistry & Molecular Biology). MOST 110-2320-B-016-003. 本人為通訊作者.
18. Li-Jen Tsai, Chi-Hsiang Chung, Chien-Jung Lin, Sheng-Chiang Su, Feng-Chih Kuo, Jhih-Syuan Liu, Kuan-Chan Chen, Li-Ju Ho, Chih-Chun Kuo, Chun-Yung Chang, Ming-Hsun Lin, Nain-Feng Chu, Chien-Hsing Lee, Chang-Hsun Hsieh, Yi-Jen Hung, Po-Shiuan Hsieh, Fu-Huang Lin, Chieh-Hua Lu, Wu-Chien Chien (2022, Jun). Traditional Chinese medicine attenuates hospitalization and mortality risks in diabetic patients with carcinoma in situ in Taiwan. Integrative Medicine Research, 11(2):100831. (SCI, 7/30, Q1, Integrative & Complementary Medicine).
19. Po-Chang Shih, Yi-Wen Mao, Yi-Wen Mao, Yi-Wen Mao, Jhe-Wei Hu, Han-Yi Hsieh, Tsai-Miao Shih, Lu-Ping Lu, Wei-Hua Chang, Chan-Hui Huang, ChiaHung Lin, Chih-Hung Lin, Peng Tan, Ya-Ching Yang, Ming-Hong Chien, ChenChe Su, Cheng-Hsin Yeh, Pei-Yun Chuang, Tien-Lan Hsieh, Ching-Cheng Wang, Po-Shiuan Hsieh, Teh-Ying Chou, and Guochuan Emil Tsai* (2022, May). Development of Ultrapure and Potent Tannic Acids as a Pan-coronal Antiviral Therapeutic. ACS Pharmacology and Translational Sciences, 2022, 5(6), 400–412. (SCI, 101/357, Pharmacology & Pharmacy).
20. Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh (2022, Jan). Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity. Clinical Science, 136(1):121–137. (SCI, 31/140, Medicine, Research & Experimental). MOST 107-2320-B-016-MY3. 本人為通訊作者.
21. Pei-Chi Chan, Po-Shiuan Hsieh (2021, Dec). The chemokine systems at the crossroads of inflammation and energy metabolism in the development of obesity. International Journal of Molecular Science, 22(24):13528. (SCI, 67/295, Biochemistry & Molecular Biology). MOST 107-2320-B-016-MY3. 本人為通訊作者. https://doi.org/10.3390/ijms222413528.
22. Pei-Chi Chan, Min-Tser Liao, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh (2021, Jan). Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models. European Journal of Pharmacology, 891, 173703. (SCI, 96/271 Pharmacology & Pharmacy). MOST 107-2320-B-016-010-MY3. 本人為通訊作者.

1. Jesmine Khan, Po-Shiuan Hsieh. Cellular Metabolism and Related Disorders (1) (ISBN: 978-1-83880-181-6). London, United Kingdom: IntechOpen. Jul, 2020.

1. Pei-Chi Chan, Po-Shiuan Hsieh (2020, Sep). Importance of tissue CCL5/CCR5 signaling on monocytic-MDSCs-derived macrophage polarization and inflammation in epididymal fat of high fat diet-induced obese mice. 56th EASD Annual Meeting of the European Association for the Study of Diabetes, Virtual meeting. MOST 109-2320-B-016-016. 本人為通訊作者. Diabetologia 2020, 63 (Suppl 1):S83-S84.
2. Pei-Chi Chan, Po-Shiuan Hsieh (2019, Mar). Importance of RANTES/CCR5 signaling in lipid oxidation and adaptive thermogenesis in mice. The 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) 2019 Congress.