Research Focus
Integrating Neuropharmacology with Drug Discovery 🧪
Professor Huang's research integrates Neuropharmacology with Drug Discovery. By combining peptide synthesis, small molecule screening, and electrophysiology, his lab aims to develop novel treatments for neurological and psychiatric disorders.
🧬 Peptide Synthesis
💊 Small Molecule Screening
⚡ Electrophysiology
Research Directions
Key Research Areas 🔬
1. Drug Design & Synthesis
Peptides: Designing novel analogs of Oxytocin and Endomorphins to improve stability and efficacy.
Small Molecules: Investigating the therapeutic potential of Arecoline and Arecaidine for neuroprotection.
2. Synaptic Plasticity & Memory
Utilizing brain slice recordings to investigate how novel compounds regulate Long-Term Potentiation (LTP) and Long-Term Depression (LTD) in the hippocampus.
3. Addiction & Reward Systems
Mechanisms: Studying the neural mechanisms of addiction to Nicotine, Alcohol, and Arecoline.
Therapeutic Targets: Exploring novel targets to attenuate craving and withdrawal symptoms.
4. Migraine & Pain Mechanisms
Analgesic Effects: Investigating oxytocin and peptides in attenuating Hyperalgesia and Allodynia.
Spinal Pathways: Using isolated spinal cord preparations to explore pathways underlying chronic pain.
5. Behavioral Neuropharmacology
Autism (ASD): Examining the role of oxytocin in rescuing social deficits and repetitive behaviors.
Sexual Behavior: Exploring the physiological regulation of sexual behavior and the oxytocinergic system.
Academic Background
🎓 Education
Ph.D. in Neuropharmacology
University of Southampton, U.K.
B.Sc. in Animal Science
National Taiwan University
Professional Journey
💼 Experience
Director & Chair - Dept. of Pharmacology, NDMU
Professor - Dept. of Pharmacology, NDMU
Visiting Research Fellow - Univ. of Southampton, U.K.
Research Fellow - Chang Gung Memorial Hospital
Postdoctoral Fellow - NDMC & Chang Gung University
RESEARCH OUTPUTS
📚 Full Publications
Przemyslaw Mielczarek, Kinga Hartman, Eagle Yi-Kung Huang, Ewa Gibula-Tarlowska, Pawel Grochecki, Tymoteusz Slowik, Jolanta H Kotlinska, Jerzy Silberring, and Anna Drabik (2025) The Role of LVV-H7 in Alcohol-Induced Reward Mechanisms. Addict Biol. 30(9): e70086.
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, and Eagle Yi-Kung Huang (2025) Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. Iranian Journal of Basic Medical Sciences 28(9): 1212-1219.
Yuan-Hao Chen, Tung-Tai Kuo, Vicki Wang, Pin-Wen Cheng, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2024) Serotonergic regulation of synaptic dopamine levels mitigates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 14(5): 941-964.
Lok-Hi Chow, Pin-Chen Lin, Ying-Jie Chen, Yuan-Hao Chen, and Eagle Yi-Kung Huang (2024) Yangonin, one of the kavalactones isolated from Piper methysticum G. Frost, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia. Journal of Ethnopharmacology 333: 118394.
Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, and Skye Hsin-Hsien Yeh (2024) Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. J Chin Med Assoc. 87(5): 538-549.
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-li Choi, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci. 31(1): 38.
Yen-Lun Chen, Yen-Hsun Lai, Eagle Yi-Kung Huang, Hong-Jaan Wang, and Hao-Yuan Hung (2024) Nalbuphine-6-glucuronide is a potent analgesic with superior safety profiles by altering binding affinity and selectivity for mu-/kappa-opioid receptors. Life Science 340: 122441.
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Hao-Yuan Hung, Pin-Chen Lin, and Eagle Yi-Kung Huang (2024) Intrathecal injections of angiotensin IV and oxytocin conjugates induce antihyperalgesia and antiallodynia in both sexes of rats. Peptides 173: 171150.
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H Greig, Jin Jung, Ho-li Choi, Lars Olson, Barry J Hoffer, and Kuan-Yin Tseng (2023) PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease. Int J Mol Sci. 24(5): 4687.
Hsu-Kai Huang, Pin-Chen Lin, Tzu-Ting Huang, Hao-Yuan Hung, Tsai-Wang Huang, Eagle Yi-Kung Huang (2023) Nicotine activates HIF-1a and regulates acid extruders through the nicotinic acetylcholine receptor to promote the Warburg effect in non-small cell lung cancer cells. Eur J Pharmacol. 950: 175778.
Eagle Yi-Kung Huang, Hao-Yuan Hung, Yuan-Hao Chen, Jen-Hsin Kao, Ai-Lun Tsai, and Lok-Hi Chow (2023) Effects of dextromethorphan on nicotine-induced reward, behavioral sensitization, withdrawal signs, and drug seeking-related behavior in rats. Nicotine & Tobacco Research 25(7): 1251-1260.
Kwok-On Ng, Lok-Hi Chow, Chun-Chang Yeh, Eagle Yi-Kung Huang, Wei-Cheng Liu, and Ping-Heng Tan (2022) Case report: the management for a gestational hypertensive woman with influenza A virus pneumonia and peripartum cardiomyopathy. BMC Pregnancy Childbirth 22(1): 497.
Kuan-Yin Tseng, Tung-Tai Kuo, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Lars Olson, Barry J Hoffer, and Yuan-Hao Chen (2022) Tetrabenazine mitigates aberrant release and clearance of dopamine in the nigrostriatal system, and alleviates L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease. Journal of Parkinson's Disease 12(5): 1545-1565.
Lok-Hi Chow, Hao-Yuan Hung, Wan-Chuan Wu, Yuan-Hao Chen, Weihong Pan, and Eagle Yi-Kung Huang (2022) Estrogen can abolish oxytocin-induced spinal antihyperalgesia. Psychoneuroendocrinology 136: 105603.
Hao-Yuan Hung, Wu-Chien Chien, Chi-Hsiang Chung, Li-Ting Kao, Lok-Hi Chow, Yuan-Hao Chen, Jolanta H. Kotlińska, Jerzy Silberring, and Eagle Yi-Kung Huang (2021) Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study. Drug and Alcohol Dependence 229 (Pt A): 109102.
Hsiao-Ming Chao, Eagle Yi-Kung Huang, and Chieh-Fu Chen (2021) The essentials for the study of vision improving drugs. Journal of Chinese Medicine Research Vol.33: 1-18.
Mielczarek P, Hartman K, Drabik A, Hung HY, Huang EY, Gibula-Tarlowska E, Kotlinska JH, and Silberring J. (2021) Hemorphins-From Discovery to Functions and Pharmacology. Molecules 26(13): 3879.
Wang V, Kuo TT, Huang EY, Ma KH, Chou YC, Fu ZY, Lai LW, Jung J, Choi HI, Choi DS, Li Y, Olson L, Greig NH, Hoffer BJ, and Chen YH (2021) Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease. ACS Pharmacol Transl Sci. 4(2): 858-869.
Hung HY, Chow LH, Kotlinska JH, Drabik A, Silberring J, Chen YH, and Huang EY (2021) LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides 136: 170455.
Loh SH, Chang CY, Huang SF, Chao SC, Lin WK, Huang EY, Tsai CS, and Tsai YT (2020) Functional effects of urotensin-II on intracellular pH regulators in human radial artery smooth muscle cells. Peptides 126: 170236.
Chen YH, Wang V, Huang EY, Chou YC, Kuo TT, Olson L, and Hoffer BJ (2019) Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. Int J Mol Sci. 20(24) pii: E6251.
Chen YH, Hsieh TH, Kuo TT, Kao JH, Ma KH, Huang EY, Chou YC, Olson L, and Hoffer BJ (2019) Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors. J Neurochem. 150(1): 56-73.
Wu WL, Cheng SJ, Lin SH, Chuang YC, Huang EY, and Chen CC (2019) The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Front Cell Neurosci. 13: 86.
Chen YH, Lin BJ, Hsieh TH, Kuo TT, Miller J, Chou YC, Huang EY, and Hoffer BJ (2019) Differences in nicotine encoding dopamine release between the striatum and shell portion of the nucleus accumbens. Cell Transplantation 28(3): 248-261.
Yuan-Hao C, Kuo TT, Huang EY, Hoffer BJ, Kao JH, Chou YC, Chiang YH, and Miller J (2018) Nicotine-induced conditional place preference is affected by head injury: correlation with dopamine release in the nucleus accumbens shell. Int. J. Neuropsychopharmacol. 21(10): 949-961.
Chen YH, Kuo TT, Kao JH, Huang EY, Hsieh TH, Chou YC, and Hoffer BJ (2018) Exercise ameliorates motor deficits and improves dopaminergic functions in the rat hemi-Parkinson's model. Sci Rep. 8(1): 3973.
Chow LH, Chen YH, Lai CF, MD, Lin TY, Chen YJ, Kao JH, and Huang EY (2018) Sex difference of angiotensin IV-, LVV-hemorphin 7-, and oxytocin-induced antiallodynia at the spinal level in mice with neuropathic pain. Anesthesia & Analgesia 126(6): 2093-2101.
Chen YH, Kuo TT, Huang EY, Chou YC, Chiang YH, Hoffer BJ, and Miller J (2018) Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell. Oncotarget 9: 10016-10028.
Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, and Chiang YH (2017) Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience 348: 180-190.
Chen YH, Huang EY, Kuo TT, Miller J, Chiang YH, and Hoffer BJ (2017) Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation 26(7): 1156-1168.
Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, and Eagle Yi-Kung Huang (2016) Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS ONE 11(9): e0162218.
Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, and Lok-Hi Chow (2016) Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. Neuropeptides 59: 63-69.
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J. Hoffer, Pei-Jie Wu, Hsin-I Ma, Jing-Jr Tsai, Yu-Ching Chou, and Yung-Hsiao Chiang (2016) Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. Brain Res. 1642:581-589.
Eagle Yi-Kung Huang, Yuh-Chiang Shen, and Chieh-Fu Chen (2016) Mitochondria: Target for the develop of anti-inflammatory drugs. Journal of Chinese Medicine 27(1): 2701004.
Lok-Hi Chow, Pao-Luh Tao, Yuan-Hao Chen, Yu-Hui Lin and Eagle Yi-Kung Huang (2015) Angiotensin IV possibly acts through PKMzeta in hippocampus to regulate cognitive memory in rats. Neuropeptides 53: 1-10.
Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao (2015) Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. J. Biomed. Sci. 22(1): 81.
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Hsin-I Ma, Barry J. Hoffer, Pi-Fen Tsui, Jing-Jr Tsai, Yu-Ching Chou and Yung-Hsiao Chiang (2015) Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. Cell Transplantation 24(10): 2113-2128.
Yi-Ting Tsai, Chung-Yi Lee, Chih-Chin Hsu, Chung-Yi Chang, Ming-Kai Hsueh, Eagle Yi-Kung Huang, Chien-Sung Tsai, and Shih-Hurng Loh (2014) Effects of Urotensin II on intracellular pH regulation in cultured human internal mammary artery smooth muscle cells. Peptides 56: 173-182.
Eagle Yi-Kung Huang, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Tsai Tung-Han, Hsin-l Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Remote effects on the striatal dopamine system after fluid percussion injury. Behavioural Brain Research 267: 156-172.
陳介甫、黃翊恭、吳令怡、廖志飛 (2014) 發炎、發炎體、抗發炎藥 (ISBN 978-986-7825-95-7) 知音出版社
Eagle Yi-Kung Huang, Pi-Fen Tsui, Tung-Tai Kuo, Jing-Jr Tsai, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury. PLOS ONE 9(1): e86354.
Ling-Yi Wu, Chieh-Fu Chen and Eagle Yi-Kung Huang (2013) Obesity related metabolic complications and anti-obesity drugs. Journal of Chinese Medicine 24(2): 261-277.
Yuan-Hao Chen, Tong-Tai Kuo, Ming-Ting Chu, Hsin-I Ma, Yung-Hsiao Chiang and Eagle Yi-Kung Huang (2013) Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in animal seizure model. Neuroimmunomodulation 20(4): 223-232.
Weihong Pan, Xiaojun Wu, Yi He, Hung Hsuchou, Eagle Yi-Kung Huang, Pramod K. Mishra and Abba J. Kastin (2013) Brain interleukin-15 in neuroinflammation and behavior. Neurosci. Biobehav. Rev. 37(2): 184-192.
Lok-Hi Chow, Pao-Luh Tao, Jin-Chung Chen, Ruey-Ming Liao, En-Pei Chang and Eagle Yi-Kung Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides 39(1): 21-28.
Pao-Pao Yang, Eagle Yi-Kung Huang, Yu-Ying Fu, Tsai-Shan Ho and Pao-Luh Tao (2012) Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization. Synapse 66(10): 858-869.
Bor-Chih Cheng, Pao-Luh Tao, Ya-Yun Cheng and Eagle Yi-Kung Huang (2012) LVV-hemorphin 7 and angiotensin IV in correlation with antinociception and anti-thermal hyperalgesia in rats. Peptides 36(1): 9-16.
Weihong Pan, Hung Hsuchou, Bhavaani Jayaram, Reas S. Khan, Eagle Yi-Kung Huang, Xiaojun Wu, Chu Chen and Abba J. Kastin (2012) Leptin action on nonneuronal cells in the CNS: potential clinical applications. Ann N Y Acad Sci. 1264(1): 64-71.
Shih-Lin Chang, Yao-Chang Chen, Yung-Hsin Yeh, Yu-Jun Lai, Hung-I Yeh, Cheng-I Lin, Yung-Kuo Lin, Yenn-Jiang Lin, Tsu-Juey Wu, Yi-Kung Huang, Shih-Ann Chen and Yi-Jen Chen (2011) Heart failure enhances arrhythmogenesis in pulmonary veins. Clin. Exp. Pharmacol. Physiol. 38(10): 666-674.
Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2011) NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study. Drug Alcohol Depend. 118(2-3): 366-374.
Pao-Luh Tao, Jain-Fang Chen and Eagle Yi-Kung Huang (2011) Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. J. Biomed. Sci. 18(1): 64.
Shiou-Lan Chen, Kuei-Ying Hsu, Eagle Yi-Kung Huang, Ru-Band Lu and Pao-Luh Tao (2011) Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug Alcohol Depend. 117(2-3): 164-169.
Chun-Hung Wu, Pao-Luh Tao and Eagle Yi-Kung Huang (2010) Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain. Peptides 31 (7): 1374-1382.
Ling-Yi Wu, Eagle Yi-Kung Huang and Pao-Luh Tao (2010) Co-administration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertility and Sterility 93(5): 1686-1694.
Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang (2009) Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. J. Biomed. Sci. 16: 106.
Wei-Li Wu, Chih-Hung Wang, Eagle Yi-Kung Huang and Chih-Cheng Chen (2009) ASIC3-/- Female Mice with Hearing Deficit Affects Social Development of Pups. PLoS ONE 4(8): e6508.
Chung-Shiun Yang, Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2008) The role of the NR2B subunit of NMDA receptors in morphine rewarding, drug seeking, and behavioral sensitization. Journal of Medical Sciences 28(6): 245-253.
Yu-Jun Lai, Eagle Yi-Kung Huang, Hung-I Yeh, Yen-Lin Chen, Jim Jung-Ching Lin and Cheng-I Lin (2008) On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins. Life Sci. 83: 272-283.
Wei-Li Wang, Sheau-Farn Yeh, Eagle Yi-Kung Huang, Yu-Ling Lu, Chun-Fa Wang, Chi-Ying F. Huang and Wey-Jinq Lin (2007) Mitochondrial anchoring of PKCa by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis 12: 1857-1871.
Wei-Ming Lue, Eagle Yi-Kung Huang, San-Nan Yang, Chih-Shung Wong and Pao-Luh Tao (2007) Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. Synapse 61(6): 420-428.
Eagle Yi-Kung Huang, Hsiang-Jen Hsiao, Wei-Ming Lue and Pao-Luh Tao (2007) U-50,488 decreased the rewarding effect and mesolimbic dopamine neuron activity induced by morphine in rats. Journal of Medical Sciences 27(1): 15-22.
Pao-Pao Yang, Eagle Yi-Kung Huang, Geng-Chang Yeh and Pao-Luh Tao (2006) Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. J. Biomed. Sci. 13(5): 695-702.
Jin-Chung Chen, Wei-Hsin Lee and Eagle Yi-Kung Huang (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(Tic)amide. Peptides 27(5): 1005-1014.
Pao-Luh Tao, Kai-Wen Liang, Wen-Yi Sung, Yung-Tsun Wu and Eagle Yi-Kung Huang (2006) Nalbuphine is effective in decreasing the rewarding effect and drug-seeking behavior induced by morphine in rats. Drug Alcohol Depend. 84: 175-181.
Pao-Luh Tao, Yong-Shang Lai, Lok-Hi Chow and Eagle Yi-Kung Huang (2005) Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord. N-S Arch. Pharmacol. 371:72-80.
Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow and Pao-Luh Tao (2005) Dextromethorphan differentially affects opioid antinociception in rats. Br. J. Pharmacol. 144(3): 400-404.
Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Shen-Kou Tsai and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but not related to descending serotoninergic or adrenergic pathways. J. Biomed. Sci. 11(6): 717-725.
Lok-Hi Chow, Eagle Y.-K. Huang, Shung-Tai Ho, Tak-Yu Lee and Pao-Luh Tao (2004) Dextromethorphan potentiates morphine antinociception at the spinal level in rats. Can. J. Anaesth. 51(9): 905-910.
Eagle Yi-Kung Huang, Ching-Ming Chen and Pao-Luh Tao (2004) Supraspinal anti-allodynic and rewarding effects of endomorphins in rats. Peptides 25(4): 577-583.
Eagle Yi-Kung Huang, Te-Chen Liu and Pao-Luh Tao (2003) Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine release at the nucleus accumbens. N-S Arch. Pharmacol. 368: 386-392.
Jin-Chung Chen, Pao-Luh Tao, Jihn-Yih Li, Chung-Hang Wong and Eagle Yi-Kung Huang (2003) Endomorphin-1 and 2 induce naloxone-precipitated withdrawal syndromes in rats. Peptides 24(3): 477-481.
Eagle Yi-Kung Huang, Jihn-Yih Li, Chung-Hang Wong, Peter Pei-Chiung Tan and Jin-Chung Chen (2002) Dansyl-PQRamide, a possible neuropeptide FF receptor antagonist, induces conditioned place preference. Peptides 23(3): 489-496.
Jin-Chung Chen, Kai-Wen Liang, Yi-Kung Huang, Cheng-Sheng Liang and Yao-Chang Chiang (2001) Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine. Life Sci. 68(9): 973-983.
Jihn-Yih Li, Chung-Hang Wong, Eagle Y.-K. Huang, Yen-Chien Lin, Yun-Long Chen, Peter P. C. Tan and Jin-Chung Chen (2001) Modulation of spinal serotonin activity affect the development of morphine tolerance. Anesthesia and Analgesia 92(6): 1563-1568.
Jin-Chung Chen, Kai-Wen Liang and Eagle Yi-Kung Huang (2001) Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. Synapse 39(3): 239-248.
Eagle Yi-Kung Huang, Jihn-Yih Li, Peter Pei-Chiung Tan, Chung-Hang Wong and Jin-Chung Chen (2000) The cardiovascular effects of PFRFamide and PFR(Tic)amide, a possible agonist and antagonist of neuropeptide FF (NPFF). Peptides 21(2): 205-210.
Peter Pei-Chiung Tan, Jin-Chung Chen, Jihn-Yih Li, Kai-Wen Liang, Chung-Hang Wong and Eagle Yi-Kung Huang (1999) Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogs. Peptides 20(10): 1211-1217.
J.-C. Chen, J.-Y. Li, K.-W. Liang and Y.-K. Huang (1999) Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the level of neurotransmitters in the median prefrontal cortex. Brain Res. 816(1): 220-224.
E. Y.-K. Huang, J. Bagust, R. P. Sharma and R. J. Walker (1998) The effect of FMRFamide-like peptides on electrical activity in isolated mammalian spinal cord. Neuroscience Res. 30: 295-301.
S. J. Perry, E. Y.-K. Huang, D. Cronk, J. Bagust, R. Sharma, R. J. Walker, S. Wilson and J. F. Burke (1997) A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Letters 409(3): 426-430.
Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1997) FLFQPQRFamide (NPFF) inhibits the fast wave of the evoked field potential in the rat isolated spinal cord preparation. Br. J. Pharmacol. 120(SS): 233P.
Eagle Yi-Kung Huang, Jeff Bagust, Ram P. Sharma and Robert J. Walker (1996) Naloxone and desaminoYFLFQPQRamide block potentiation by FLFQPQRFamide (NPFF) of the rat isolated spinal cord monosynaptic reflex (MSR). Br. J. Pharmacol. 117(SS): 314P.