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::: Yuan-Hao Chen

Yuan-Hao Chen M.D., Ph.D.

Joint-Appointment Professor
🌟 Director General, Medical Affairs Bureau, MND
🏥 Attending Doctor, Dept. of Neurological Surgery, TSGH 🎓 Professor, Dept. of Surgery, NDMU

🎯 Specialty & Research Interests

Functional Neurosurgery Neuroscience Neuroelectrophysiology Neurodegeneration Disease Neurochemistry

🎓 Education

Aug. 2003 - Sep. 2007
Ph.D. in Medical Sciences
National Defense Medical Center
Aug. 1987 - Aug. 1994
M.D. (Doctor of Medicine)
National Defense Medical Center

📜 Patents

★ Bluetooth wireless transmission system for brain electrochemical signals
TW M548933 U (2017/09~2027/05)
★ Blue-tooth wireless transmission system for cerebral electrophysiological signals
TW M456795U1 (2013/07-2023/03)

💼 Work Experience

Dec. 2025 - Jan. 2026
Deputy Director General
Medical Affairs Bureau, Ministry of National Defense
Dec. 2024 - Nov. 2025
Superintendent
Tri-Service General Hospital
Oct. 2023 - Nov. 2024
President
National Defense Medical Center
Jun. 2023 - Sep. 2023
Superintendent
Tri-Service General Hospital Songshan Branch
Aug. 2020 - Dec. 2022
Director
Dept. of Medical Readiness & Healthcare, Medical Affairs Bureau
Jan. 2019 - Aug. 2020
Executive Dean
National Defense Medical Center
Jan. 2015 - Feb. 2019
Director
Dept. of Neurological Surgery, Tri-Service General Hospital
Jan. 2004 - Jan. 2007
Research Fellow
Electrophysiology Research Section, National Institute on Drug Abuse (NIDA)

📄 Selected Publications (Original Academic Papers)

📊 Academic Impact: 106 Publications | 1,096 Citations | h-index: 20
👇 Scroll down to view recent representative publications
• [2025] Sheng-chin Lin, Wei-Ting Liu, Yuan-Hao Chen, Shih-Hua Lin, Chin Lin (2025, Dec). Artificial intelligence-enabled electrocardiography from scientific research to clinical application. EMBO Molecular Medicine, 1-19.
• [2025] Clark C Chen, Hsu-Tung Lee, Wei-Hsiu Liu... Yuan-Hao Chen... (2025, Nov). CTNI-33. A PIVOTAL PHASE IIB/III STUDY FOR A LOCALIZED GLIOBLASTOMA TREATMENT TARGETING RECEPTOR TYROSINE KINASE DEFINED NETWORK. Neuro-Oncology, 27(S_5).
• [2025] Kai-Chieh Chen, Matthew Kuo, Chun-Ho Lee... Yuan-Hao Chen... (2025, Sep). A Pretraining Approach for Small-sample Training Employing Radiographs (PASTER): a Multimodal Transformer. Journal of Medical Systems, 49(1), 120.
• [2025] Peng-Wei Wang, Da-Tong Ju, Wei-Hsiu Liu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu, Bon-Jour Lin (2025, Jul). Infraorbital nerve as effective intraoperative guidance during the endoscopic transorbital approach to the anterolateral skull base. Neurosurgical Review, 48(1):1-12.
• [2025] Dung-Jang Tsai, Chin Lin, Wei-Ting Liu... Yuan-Hao Chen... (2025, Jun). Artificial intelligence-assisted diagnosis and prognostication in low ejection fraction using electrocardiograms in inpatient department: a pragmatic randomized controlled trial. BMC medicine, 23(1): 342.
• [2025] Ping-Hsuan Hsieh, Chin Lin, Chin-Sheng Lin... Yuan-Hao Chen... (2025, Jun). Economic analysis of an AI-enabled ECG alert system: impact on mortality outcomes from a pragmatic randomized trial. npj Digital Medicine, 8(1):348.
• [2025] Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang (2025, Jan). Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. Iranian Journal of Basic Medical Sciences, 28(9), 1212.
• [2024] Bon-Jour Lin, Da-Tong Ju, Chin Lin, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu (2024, Aug). Optimizing the selection of the endoscopically assisted supracerebellar transtentorial approach to the medial temporo-occipital region. Clinical Anatomy, 38(4), 442-455.
• [2024] Yuan-Hao Chen, Tung-Tai Kuo, Vicki Wang, Pin-Wen Cheng, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. Greig, Lars Olson, Barry J. Hoffer, Kuan-Yin Tseng (2024, Jul). Serotonergic regulation of synaptic DA levels mitigates L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease. Journal of Parkinsons Disease, 14(5), 941-964.
• [2024] Lok-Hi Chow, Pin-Chen Lin, Ying-Jie Chen, Yuan-Hao Chen, Eagle Yi-Kung Huang (2024, May). Yangonin, one of the kavalactones isolated from Piper methysticum G. Forst, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia. Journal of Ethnopharmacology, 333(7):118394.
• [2024] Vicki Wang, KuanYin Tseng, TungTai Kuo... Yuan-Hao Chen* (2024, Apr). Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. Journal of Biomedical Science, 31:38.
• [2024] Bon-Jour Lin, Da-Tong Ju, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Ming-Ying Liu (2024, Jan). Endoscopic transorbital decompression for traumatic superior orbital fissure syndrome. European Archives of Oto-Rhino-Laryngology, 281(5),1-8.
• [2024] Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Hao-Yuan Hung, Pin-Chen Lin, Eagle Yi-Kung Huang (2024, Jan). Intrathecal Injections of Angiotensin IV and Oxytocin Conjugates Induce Antihyperalgesia and Antiallodynia in Both Sexes of Rats. Peptides, 173(1),171150.
• [2023] Eagle Yi-Kung Huang, Hao-Yuan Hung, Yuan-Hao Chen, Jen-Hsin Kao, Ai-Lun Tsai, Lok-Hi Chow (2023, Jul). Effects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats. Nicotine and Tobacco Research, 25(7), 1251-1260.
• [2023] Bon-Jour Lin, Da-Tong Ju... Yuan-Hao Chen... (2023, Mar). Endoscopically assisted presigmoid retrolabyrinthine approach to the lateral mesencephalic sulcus. Neurosurgical Review, 46(1), 73.
• [2023] Kuan-Yin Tseng, Vassilis Stratoulias... Yuan-Hao Chen... (2023, Feb). Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery. Cell Death & Disease, 14(2), 128.
• [2023] Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang... (2023, Feb). PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson’s Disease. International Journal of Molecular Sciences, 24(5), 4687.
• [2022] Kuan-Yin Tseng... Yuan-Hao Chen* (2022, Jul). Tetrabenazine mitigates aberrant release and clearance of dopamine in the nigrostriatal system, and alleviates L-DOPA-induced dyskinesia. Journal of Parkinson's Disease, 12(5):1545-1565.
• [2021] Chi-Tun Tang... Yuan-Hao Chen* (2021, Nov). GRPEL2 knockdown exerts redox regulation in glioblastoma. International Journal of Molecular Sciences, 22(23):12705.
• [2020] Xiao-Jun Feng... Yuan-Hao Chen... (2020, Feb). Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-Induced Parkinsonism in rats. Brain Stimulation, 13(3), 655-663.
• [2019] Yuan-Hao Chen, Vicki Wang... (2019, Dec). Delayed dopamine dysfunction and motor deficits in female Parkinson model mice. International Journal of Molecular Sciences, 20(24), 6251.
• [2016] Yuan-Hao Chen, Eagle Yi-Kung Huang... Barry J. Hoffer (2016, Dec). Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation, 26(7), 1156-1168.
• [2007] Yuan-Hao Chen, Brandon K. Harvey... Carl R. Lupica (2007, Aug). MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector. The FASEB Journal, 22(1), 261-275.
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  • Update Date:2026-05-29