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Research Publications

Latest (2024 - 2026)
📄  2026 (Updating) ⬆ TOP
Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A1-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands.

Lin CY, Platt S, Goulding J, Briddon SJ, Kindon ND, Harwood CR, Lai CW, Kellam B, Hill SJ.

J Med Chem. 2026 Feb 12;69(3):2481-2495. | SCI, IF: 6.8
Melatonin-Loaded Sacchachitin Nanofiber Hydrogel as a Novel Non-Steroidal Platform for Atopic Dermatitis Therapy.

Lin CJ, Wen BY, Liang YK, You WC, Ho HO, Sheu MT, Lin HL, Chen LC.

Int J Nanomedicine. 2026 Feb 17;21:574853. | SCI, IF: 6.5
4 Acetyl-antrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation.

Lin KT, Hsieh YC, Chang PK, Lai CW, Lee SY and Yen IC*.

International Journal of Molecular Medicine. 2026;57(5):126. | SCI, IF: 5.8
Agomelatine and the potential inverse risk of metabolic disorders: a nationwide cohort study with an active comparator design in Taiwan.

Wen, Y. L., Huang, Y. C., Liao, C. C., Kao, S., Pan, K. T., Yang, H. W., To, S. Y., Yeh, C. B.*, & Kao, L. T.*

Diabetology & Metabolic Syndrome. 2026. | SCI, IF: 3.9
Physical Therapy Reduced the Risk of Microvascular Complications in the Musculoskeletal Disorders Population With Type 2 Diabetes Mellitus.

Wen, Y. L., Pan, K. T., Liao, C. C., Yang, H. W., To, S. Y., Kao, S.*, & Kao, L. T.*

Archives of Physical Medicine and Rehabilitation. 2025. | SCI, IF: 3.7
Healthcare utilization in cancer patients treated with immune checkpoint inhibitors: a population-based study of all patients and 1-year survivors.

Hsu, C. L., Hsu, L. F., To, S. Y., Lee, C. H., Wen, Y. L., Yang, H. W., Chen, I. W., & Kao, L. T.*

Supportive Care in Cancer, 33(12), 1076. 2025. | SCI, IF: 3.0
Polygonum barbatum extract induces ER stress-mediated UPR and autophagy to suppress colorectal cancer growth.

Pi-Kai Chang, I-Chuan Yen, Wei-Cheng Tsai, Kuen-Tze Lin, and Shih-Yu Lee.

Toxicology Research. 2026;15(1):tfaf188. | SCI, IF: 2.1
📄 2025 (24 Papers) ⬆ TOP
Economic analysis of an AI-enabled ECG alert system: impact on mortality outcomes from a pragmatic randomized trial.

Hsieh, P. H., Lin, C., Lin, C. S., Liu, W. T., Lin, T. K., Tsai, D. J., ... & Tsai, C. S.

npj Digital Medicine, 8(1), 1-7. (2025). | SCI, IF: 15.1
Autoimmune Skin Diseases and Survival Outcomes After Antineoplastic Treatment in Patients with Cancer.

To, S. Y., Lee, C. H., Chen, Y. H., Hsu, L. F., Chen, I. W., Yang, H. W., Wen, Y. L., & Kao, L. T.*

JAMA Dermatology, e251949. (2025). | SCI, IF: 11.0
Psoriasis Risk with Immune Checkpoint Inhibitors.

To, S. Y., Lee, C. H., Chen, Y. H., Hsu, C. L., Yang, H. W., Jiang, Y. S., Wen, Y. L., Chen, I. W., & Kao, L. T.*

JAMA Dermatology, 161(1), 31-38. (2025). | SCI, IF: 11.0
Hormone Therapy and Increased Risk of Psoriasis in Reproductive-age and Postmenopausal Women: A Nationwide Cohort Study and Target Trial Emulation.

Yang, H. W., Chen, Y. H., To, S. Y., Wen, Y. L., Kao, S., Chen, L. H., & Kao, L. T.*

British Journal of Dermatology, ljaf179. (2025). | SCI, IF: 9.6
Sodium-glucose Cotransporter 2 Inhibitors and Inverse Risk of New-onset Atopic Dermatitis in a Cohort with Diabetes: A Nationwide, Active-comparator Study.

Wen, Y. L.#, Hsu, W. T.#, Chen, Y. H., Kao, H. H., Liao, C. C., To, S. Y., Yang, H. W., & Kao, L. T.*

British Journal of Dermatology, 193(1), 74-84. (2025). | SCI, IF: 9.6
Artificial intelligence-assisted diagnosis and prognostication in low ejection fraction using electrocardiograms in inpatient department: a pragmatic randomized controlled trial.

Tsai, D. J., Lin, C., Liu, W. T., Lee, C. C., Chang, C. H., Lin, W. Y., ... Hsieh, P. H. ... & Lin, C. S.

BMC medicine, 23(1), 1-12. (2025). | SCI, IF: 8.3
Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60.

Sung-Ling Tang, Maryam Rachmawati Sumitra, Yu-Cheng Kuo, ... Hong-Jaan Wang, ... Hsu-Shan Huang.

Computers in Biology and Medicine, 2025, 193: 110445. | SCI, IF: 6.3
Machine learning–driven discovery of NSC828779 as a multi-mechanistic NLRP3 inflammasome inhibitor for inflammatory diseases.

SL Tang, MR Sumitra, LC Chen, FC Liu, HL Hsu, YC Kuo, ... HJ Wang, ... HS Huang*.

Comput Biol Med. 2025 May; 197:111110. | SCI, IF: 6.3
Universal Atrial Fibrillation Screening Using Electrocardiographic Artificial Intelligence: A Cost-Effective Approach in Rural Communities.

Liu, W. T., Lin, C. S., Lin, C., Lin, T. K., Lin, W. Y., Lee, C. C., ... & Hsieh, P. H.*

Journal of Medical Systems, 49(1), 145. (2025). | SCI, IF: 5.7
Development of inhalable spray dried nalbuphine hydrochloride powders.

Waiting Tai, HJ Wang, Pancy TH Kwong, Patricia Tang, CC Shih*, HK Chan*.

Int J Pharm. 2025; 682:125952. | SCI, IF: 5.2
Antrodia cinnamomea Extract Attenuates Obesity by Targeting Adipogenic Pathways and Gut Dysbiosis in High-Fat Diet-Fed Mice.

Lin KT+, Lee SU, Lee YJ, Wu PJ, Chang TC, Chang WL and Yen IC*.

Int. J. Mol. Sci. 2025, 26(12), 5856. | SCI, IF: 4.9
Designing Novel Compound Candidates Against SARS-CoV-2 Using Generative Deep Neural Networks and Cheminformatics.

Li, S.-Y.; Hung, C.-M.; Hung, H.-Y.; Lai, C.-W.; Lee, M.-C.

International Journal of Molecular Sciences 26, 12017 (2025). | SCI, IF: 4.9
Selection of an optimal metabolic model for accurately predicting the hepatic clearance of albumin-binding-sensitive drugs.

Ren-Jong Liang, Shu-Hao Hsu, Hsueh-Tien Chen, Wan-Han Chen, Han-Yu Fu, Hsin-Ying Chen, Hong-Jaan Wang, Sung-Ling Tang.

Pharmaceuticals, 2025, 18(7), 991. | SCI, IF: 4.8
Advancing hepatic clearance prediction across in vitro, ex situ, and in vivo systems to facilitate in vitro-to-in vivo extrapolation.

Hsin-Chung Cheng, Hsueh-Tien Chen+, Hsin-Ying Chen, Nai-Hsin Chou, Hong-Jaan Wang, Li-Heng Pao, Sung-Ling Tang.

European Journal of Pharmaceutical Sciences, 2025, 212:107171. | SCI, IF: 4.7
Assessing Traditional Chinese Medicines for Anti-Dengue Using a National Health Insurance Research Database and Bioassays.

Su WY, Lo HH, Wen YL, Lu JW, Yen IC, Ho YJ*, Kao LT*.

Food Sci Nutr. 2025 Feb;13(3):e70009. | SCI, IF: 3.8
Effectiveness of Emotional Freedom Techniques in Alleviating Symptoms Associated with Posttraumatic Stress Disorder: A Systematic Review and Meta-analysis.

Chen, W. T., Chao, T. Y., Huang, W. Z., Hsu, C. W., Tseng, P. T., Tzeng, N. S., ... Hsieh, P. H. ... & Chen, T. Y.

European Archives of Psychiatry and Clinical Neuroscience, 1-11. (2025). | SCI, IF: 3.7
Advancing Pharmacy Students’ Communication Skills through Real-Time Feedback in Innovative Simulations.

Chao, C. Y., Lin, T. K., Hung, N. Y., Hsu, C. L.,* & Kao, L. T.*

American Journal of Pharmaceutical Education, 89(6), 101414. (2025). | SCI, IF: 3.5
Economic impact of patients with medical evacuation in remote islands: a case study in Matsu Islands.

Hsieh, P. H., Shi, B. X., Lai, C. Y., Chen, Y. C., Lin, C., Wu, O., ... & Tsai, S. H.

Frontiers in Public Health, 13, 1542172. (2025). | SCI, IF: 3.4
Cost-Utility Analysis of Eptinezumab for Migraine Prevention in Taiwan.

Chan, C. S., Huang, T. Y., Tseng, W. H., Lin, T.K., Yang, F.C., ... & Hsieh, P. H.*

Health Economics Review. (2025). | SCI, IF: 3.3
Paradigm Shift in the Treatment of Chronic Obstructive Pulmonary Disease Improves Patient Outcomes.

Huang, Y. J., Wang, K. Y., Chien, W. C., Chung, C. H., Kao, L. T., Kao, S., & Chian, C. F.*

International Journal of Chronic Obstructive Pulmonary Disease, 20, 19665-1972. (2025). | SCI, IF: 3.1
Development and Application of a Crosslinked Gelatin Foam Dressing for Wound Recovery.

Meng-Yi Bai, Yu-Ting Liu, Ying-Ting Yeh, Yi-Ling Hong, Yi-Ju Tsai, Yu-Chi Wang, Masahi Kurashina, Mikito Yasuzawa, Sung-Ling Tang.

Natural Sciences, 2025, 5(1-2): e70001. | ESCI, IF: 3.1
Economic evaluation of AI-assisted technologies in healthcare: A systematic review.

Wu, W. T., Chao, Y. W., Lin, T. K., Huang, C. K., & Hsieh, P. H.*

Journal of Food and Drug Analysis, 33(4), 487-500. (2025). | SCI, IF: 3.0
Economic burden of musculoskeletal disorders in Tanzania: results from a community-based survey.

Deidda, M., Grieve, E., Krauth, S., Hsieh, P. H., Yongolo, N., Siebert, S., ... & McIntosh, E.

BMJ open, 15(1), e087425. (2025). | SCI, IF: 2.3
How do musculoskeletal disorders impact on quality of life in Tanzania? Results from a community-based survey.

Grieve, E., Deidda, M., Krauth, S. J., Biswaro, S. M., Halliday, J. E., Hsieh, P. H., ... & McIntosh, E.

BMJ open, 15(12), e092877. (2025). | SCI, IF: 2.3
📄 2024 (23 Papers) ⬆ TOP
Association of Topical Corticosteroid Use during Pregnancy with Stillbirth, Cesarean Delivery, and Neonatal Health Risks in Women with Psoriasis.

Ou, C. H.#, To, S. Y.#, Yang, H. W., Chen Y. H., Hu, Y. C., Chen, L. H., Wen, Y. L., & Kao, L. T.*

Journal of the American Academy of Dermatology, 91(4), 765–768. (2024). | SCI, IF: 11.8
Xin-yi-san Contains Potent Human CYP1A2 Inhibitors and Its Combined Use with Theophylline in Treatment Increases Adverse Risks in Patients.

Kao, L. T., Chen, A. C., Wang, H. J., Wen, Y. L., Lu, C. K., Liaw, C. C., Tsai, K. C., & Ueng, Y. F.*

Phytomedicine, 130, 155760. (2024). | SCI, IF: 8.3
Xin-yi-san contains potent human CYP1A2 inhibitors and its combined use with theophylline in treatment increases adverse risks in patients.

LT Kao, AC Chan, HJ Wang, YL Wen, CK Lu, CC Liaw, KC Tsai, YF Ueng*.

Phytomedicine. 2024 May; 131:155760. | SCI, IF: 7.9
Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells.

Comeo, E.; Goulding, J.; Lin, C.-Y.; Groenen, M.; ... Kellam, B.

J. Med. Chem. 2024, 67 (14), 12099–12117. | SCI, IF: 6.8
Opportunistic screening for asymptomatic left ventricular dysfunction with the use of electrocardiographic artificial intelligence: a cost-effectiveness approach.

Liu, W. T., Hsieh, P. H., Lin, C. S., Fang, W. H., Wang, C. H., Tsai, C. S., ... & Tsai, D. J.

Canadian Journal of Cardiology, 40(7), 1310-1321. (2024). | SCI, IF: 5.3
In Vitro Antiviral Activity of Rhodiola crenulata Extract against Zika Virus and Japanese Encephalitis Virus: Viral Binding and Stability.

Lai ZZ+, Yen IC, Hung HY, Hong CY, Lai CW, Lee YM*.

Pharmaceuticals, 2024 Aug.17(8):988. | SCI, IF: 4.8
In Vitro Antiviral Activity of Rhodiola crenulata Extract against Zika Virus and Japanese Encephalitis Virus: Viral Binding and Stability.

Lai ZZ, Yen IC, Hung HY, Hong CY, Lai CW, Lee YM.

Pharmaceuticals (Basel). 2024 Jul 26;17(8):988. | SCI, IF: 4.8
Suicide-related Risk among Patients Using Branded and Generic Fluoxetine: A Propensity Score-matched, New-user Design in Taiwan.

Zheng, C. W., Huang, Y. C.*, Wen, Y. L., Yang, H. W., To, S. Y., & Kao, L. T.*

BMC psychiatry, 24(1), 844. (2024). | SCI, IF: 3.6
Depressive Disorder and Elevated Risk of Bell’s Palsy: A Nationwide Propensity Score-weighting Study.

Fann, L. Y.,#, Wen, Y. L.#, Huang, Y. C., Cheng, C. C., Huang, Y. C. Fang, C. C., Chen W. T., Yu, P, Y., Pan, H. Y.*, Kao, L. T.*

BMC Psychiatry, 16;24 (1), 284. (2024). | SCI, IF: 3.6
Increased Risk of Sudden Sensorineural Hearing Loss in Patients Receiving Sedative-Hypnotics: A Propensity Score Weighting Cohort Study.

Yang, H. W., Huang, Y. C., Chiang, K. W., Wen, Y. L., To, S. Y., Kao, S., & Kao, L. T.*

Nature and Science of Sleep, 16, 2231–2241. (2024). | SCI, IF: 3.4
Sleep Duration and Kidney Function - Does Weekend Sleep Matter?

Wu, C. C., Yang, P. L., Kao, L. T., Liu, Y. C., Zheng, C. M., Chu, P., Lu, K. C., Chu, C. M., & Chang, Y. T.*

Nature and Science of Sleep, 16, 85–97. (2024). | SCI, IF: 3.4
Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System.

Jenkinson, C. B.; Lin, S.-Y.; Villarreal, M.; Oakley, C. E.; Sherman, D. H.; Lee, C.-K.; Wang, C. C.; and Oakley, B. R.

Journal of Natural Products, 2024, 87: 1704-1713. | SCI, IF: 3.4
Overactive bladder and the subsequent risk of erectile dysfunction: a nationwide population-based cohort study.

Su, Y. C., Hu, Y. C., Liao, C. C., Chen, I. W., Kao, S., Wang, C. C.*, Lee, I. H.*, & Kao, L. T.*

Int Urol Nephrol, 16(1), 163. (2024). | SCI, IF: 3.4
Medication Use Patterns in Pregnant Women with Psoriasis: A Nationwide Study in Taiwan.

Ou, C. H.#, Kao, L. T.#, Yang, H. W., Chiang, Y. L., Wen, Y. L. To, S. Y., & Chen Y. H.*

Clinical and Experimental Dermatology, 49(12), 1619–1626. (2024). | SCI, IF: 2.8
Association between Amiodarone Use and Risk of Cataract: A Population-based Active-Comparator Study.

To, S. Y., Lin, H. T., Liao, C. C., Pan, K. T., Wen, Y. L., Kao, S., & Kao, L. T.*

Postgraduate Medical Journal, 100(1186), 584–591. (2024). | SCI, IF: 2.7
Molecular hydrogen therapy in aneurysmal SAH With RA and newly diagnosed SLE, complicated with acute ischemic infarction.

Chen JY, Lu JW, Feng SW, Ho YJ, Lui SW, Hsieh TY, Liu FC.

In vivo, 2024 Nov, 38 (6) 3131-3137. | SCI, IF: 2.3
Molecular hydrogen therapy in Sjögren's syndrome with pulmonary arterial hypertension and right-sided heart failure.

Lin YT, Lu JW, Ho YJ, Lui SW, Hsieh TY, Liu FC.

In vivo, 2024 Nov, 38 (6) 3117-3124. | SCI, IF: 2.3
Breast Milk Excretion of Dinalbuphine Sebacate Injection Administered After Cesarean Section.

Sung-Ling Tang, Kai-Yi Wang, Wen-Kai Hsiao, Chi-Kang Lin.

Journal of Clinical Pharmacology, 2024, 64(6): 755-761. | SCI, IF: 2.3
Physician Visits for Psoriasis and Reduced Risk of Adverse Pregnancy Outcomes: A Nationwide Study in Taiwan.

Kao, L. T., Yang, H. W., Chang, Y. T., Li, I. H., Chen, L. H., Hu, Y. C., & Chen, Y. H.*

Dermatologica Sinica, 42(2), 110-119. (2024). | SCI, IF: 2.2
Psychological impact of the COVID-19 pandemic on Taiwanese youth: soldiers and college students.

Lu JW, Ho YJ, Tai YM

Discover Psychology, 4: 142. (2024). | ESCI, IF: 1.6
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  • Update Date:2026-08-30
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