Go To Main content
Unit_Image
Back
Font: S M L
:::

::: Hong-Liang Lin

🧪 PHARMACEUTICAL SCIENCE
林宏糧 教授
Hong-Liang Lin
Professor
📞 Contact Information
Lab：R9326｜ Office：R9327
Tel：+886-2-87923100 ext.18890
E-mail：hlglin@mail.ndmutsgh.edu.tw
🎓 Education
1993 ~ 1998 B.S, School of Pharmacy, Taipei Medical College
1998 ~ 2000 M.S., Graduate Institute of Pharmacy, Taipei Medical College
2000 ~ 2008 Ph.D., School of Pharmacy, Taipei Medical University
🏛 Current Positions
2026/02 ~ Present Professor, School of Pharmacy, National Defense Medical University
2019      ~ Present Government Procurement Projects Selection Committee Member, Ministry of Economic Affairs & Taiwan Food and Drug Administration
2019      ~ Present Project Review Committee Member, Ministry of Economic Affairs & Taiwan Food and Drug Administration
2018      ~ Present Government Procurement Projects Selection Committee Member, Indigenous Peoples Commission, Kaohsiung City Government
2018      ~ Present Tribal University Curriculum Review Committee Member, Indigenous Peoples Commission, Kaohsiung City Government
2018      ~ Present Consultant, Indigenous Peoples Commission, Kaohsiung City Government
2025/12 ~ 2027/12 Safety and Protection Committee Member, Cultural Heritage Preservation Office, Pingtung County Government
2025/12 ~ 2028/12 Occupational Safety and Health Committee Member, Chiayi County Health Bureau
2016/09 ~ Present Industrial Pharmacy Committee Member, Pharmaceutical Society of Taiwan
🏛 Experience
2008/08 ~ 2009/06 Postdoctoral Research Fellow, School of Pharmacy, Taipei Medical University
2009/07 ~ 2010/02 Postdoctoral Research Fellow, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes
2010/02 ~ 2010/07 Adjunct Assistant Professor, Department of Biotechnology, Yuanpei University
2010/03 ~ 2010/07 Reviewer / Researcher (Chemistry, Manufacturing and Controls, CMC), Center for Drug Evaluation
2010/08 ~ 2014/07 Assistant Professor, Department of Biotechnology, Yuanpei University
2011/08 ~ 2013/07 Director, Industry–Academia Collaboration Division, Office of Research and Development, Yuanpei University
2012/08 ~ 2013/07 Director, Planning Division, Office of Research and Development, Yuanpei University of Medical Technology
2014/08 ~ 2015/01 Assistant Professor, Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology
2014/08 ~ 2017/07 Director, Industry–Academia Collaboration Center, Office of Research and Development, Yuanpei University of Medical Technology
2015/02 ~ 2017/07 Associate Professor, Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology
2016/08 ~ 2017/07 Consultant, New Taipei Biotechnology and Medical Alliance
2019/02 ~ 2021/01 Assistant Professor, School of Pharmacy, Kaohsiung Medical University
2021/02 ~ 2024/07 Associate Professor, School of Pharmacy, Kaohsiung Medical University
2024/08 ~ 2026/01 Professor, School of Pharmacy, Kaohsiung Medical University
2025/01 ~ 2026/01 Associate Director, Research Center for Indigenous Health Care and Cultural Sustainability, Kaohsiung Medical University
🔬 Research Interest
Pharmaceutics, Industrial Pharmacy, Pharmaceutical Engineering, Drug Delivery Systems and Dosage Form Design, Process Scale-up and Manufacturing Optimization.
🛠️ Technical Expertise
Dosage Form Design and Development, Process Optimization for Biopharmaceutical and Cosmeceutical Manufacturing, Film Coating Technology, Design and Planning of Bioequivalence (BE) Studies, Generic Drug Development, Modified-Release and Controlled-Release Solid Dosage Technologies, Formulation Stability Enhancement.
🧾 Publications
※ Total : 37 (Scroll to view)
  1. Pu-Sheng Wei, Po-Yu Chou, Hao-Yi Hsu, Michael Chen, Yi-Jou Chen, Tung-Han Tsai, Bang-Yu Wen, Ming-Thau Sheu, Kuo-Hsiang Chuang, Hong-Liang Lin*. (2025) Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model. Int J Nanomedicine. 2025, 20, 3083–3111.
  2. Chia-Wei Chu, Wei-Jie Cheng, Bang-Yu Wen, Yu-Kai Liang, Ming-Thau Sheu, Ling-Chun Chen, Hong-Liang Lin*. (2024) Preparation and Rheological Evaluation of Thiol–Maleimide/Thiol–Thiol Double Self-Crosslinking Hyaluronic Acid-Based Hydrogels as Dermal Fillers for Aesthetic Medicine. Gels, 10(12), 776.
  3. Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu, Hong-Liang Lin*. (2023) Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery. Drug Delivery, 2023, 30(1), 2158964.
  4. Chien-Ju Lin, Wen-Ting Cheng, Ling-Chun Chen, Tzu-Ling Chen, Ming-Thau Sheu, Hong-Liang Lin*. (2023) Oral metronomic therapy of pancreatic cancer with gemcitabine and paclitaxel co-loaded in lecithin-based Self-Nanoemulsifying preconcentrate (LBSNEP). International Journal of Pharmaceutics, 2023, 645(15).
  5. Chien-Ju Lin†, Hong-Liang Lin,†, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu , Ling-Chun Chen* and Wei-Jie Cheng*. (2023) Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich lasma for Diabetic Wound Treatment. Journal of Functional Biomaterials, 14(8), 423.
  6. Yu-Kai Liang, Wen-Ting Cheng, Ling-Chun Chen, Ming-Thau Sheu, Hong-Liang Lin*. (2023) Development of Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) of Ciprofloxacin Hydrochloride with Hydrophobically Modified Hydroxypropyl Methylcellulose: Formulation, Physicochemical Characterization, and In vivo Pharmacokinetics. Pharmaceutics, 15(5), 1428.
  7. Yu-Hsuan Liu, Ling-Chun Chen, Wen-Ting Cheng, Pu-Sheng Wei, Chien-Ming Hsieh, Ming-Thau Sheu, Shyr-Yi Lin, Hsiu-O Ho* and Hong-Liang Lin*. (2023) Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer. Pharmaceutics. 2023 Jan 31;15(2):473.
  8. Chia-Wei Chu, Zhu Liduzi Jiesisibieke, Yu-Pei Yang, Pao-Chu Wu, Hong-Liang Lin, Tao-Hsin Tung. (2022) Association of COVID-19 vaccination with herpes zoster: a systematic review and meta-analysis. Expert Rev Vaccines. 21(5):601-608.
  9. Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu and Hong-Liang Lin. (2021) Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery. Drug Deliv.
  10. Chen Ling-Chun, Cheng Wei-Jie, Lin Shyr-Yi, Hung Ming-Tse, Sheu Ming-Thau, Lin Hong-Liang, Hsieh Chien-Ming. (2021) CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas. Drug Deliv. 28(1):2205-2217.
  11. Chen Ling-Chun, Lin Shyr-Yi, Sheu Ming-Thau, Su Ching-Hua, Lin Hong-Liang, Hsieh Chien-Ming. (2021) Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing. Carbohydr Polym. 268:118239.
  12. Wu Meng-Huang, Wang Weu, Chao Fang-Ching, Hsieh Chien-Ming, Chen Ling-Chun, Lin Hong-Liang, Ho Hsiu-O, Huang Tsung-Jen, Sheu Ming-Thau. (2021) One-pot fabrication of sacchachitin for production of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) utilized as scaffolds to enhance bone regeneration. Carbohydr Polym. 254: 117270.
  13. Lin Hong-Liang, Cheng WT, Chen LC, Ho HO, Lin SY, Hsieh CM. (2021) Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability. Int J Nanomedicine. 16:651-665. [SCI] (IF2020=6.400；R/C=56/352，PHARMACOLOGY & PHARMACY)
  14. Lin Hong-Liang, Wu Ting-Huan, Ho Hsiu-O, Chao Fang-Ching, Wu Meng-Huang, Liu Der-Zen, Chen Ling-Chun, Sheu Ming-Thau*.(2020) TEMPO-Oxidized Sacchachitin Nanofibers (TOSCNFs) Combined with Platelet-Rich Plasma (PRP) for Management of Dry Eye Syndrome. Int. J. Nanomed. 13: 7079-7094. [SCI] (IF2020=6.400；R/C=56/352，PHARMACOLOGY & PHARMACY)
  15. Lin Hong-Liang, Chen Ling-Chun, Cheng Wen-Ting, Cheng Wei-Jie, Ho Hsiu-O, Sheu Ming-Thau*.(2020) Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib. Pharmaceutics. 12(2): 137-151. [SCI] (IF2020=6.321；R/C=31/352，PHARMACOLOGY & PHARMACY)
  16. Chao Fang-Ching, Wu Meng-Huang, Chen Ling-Chun, Lin Hong-Liang, Liu Der-Zen, Ho Hsiu-O*, Sheu Ming-Thau *.(2020) Preparation and Characterization of Chemically TEMPO-oxidized and Mechanically Disintegrated Sacchachitin Nanofibers (SCNF) for Enhanced Diabetic Wound Healing. Carbohydr. Polym. 2020(15):1721-1730. [SCI] (IF2020=9.381；R/C=1/58，CHEMISTRY, ORGANIC)
  17. Cheng Wei-Jie, Chen Ling-Chun, Ho Hsiu-O, Lin Hong-Liang, Sheu Ming-Thau *. (2018) Stearyl Polyethylenimine (stPEI) Complexed with Plasmids as the Core of Human Serum Albumin (Plasmid/stPEI/HSA) Nanoparticles Non-Covalently Bound to CRISPR/Cas9 Plasmids or siRNA for Disrupting or Silencing PD-L1 Expression for Immunotherapy. Int. J. Nanomed. 13: 7079-7094. [SCI] (IF2020=6.400；R/C=56/352，PHARMACOLOGY & PHARMACY)
  18. Lin Hong-Liang, Huang Yu-Ting, Lin Shan-Yang Lin*. (2016) Spectroscopic and thermal approaches to investigate the formation mechanism of piroxicam–saccharin co-crystal induced by liquid-assisted grinding or thermal stress. J. Therm. Anal. Calorim. 123:2345-2356. [SCI] (IF2020=4.626；R/C=18/71，THERMODYNAMICS)
  19. Lin Shan-Yang, Lin Hong-Liang, Chi Ying-Ting, Hung Ru-Ying, Huang Yu-Ting, Hsieh Wei-Hsien Hsieh, Kao Chi-Yu. (2016) Influence of Soluplus on Solid-State Properties and Physical Stability of Indomethacin-Saccharin Co-crystal Formation Prepared by Air-Drying Process. J. Pharm. Innov. 11:109-119. [SCI] (IF2020=2.750；R/C=231/352，PHARMACOLOGY & PHARMACY)
  20. Lin Shan-Yang*, Lin Hong-Liang, Chi Ying-Ting, Hung Ru-Ying, Huang Yu-Ting, Kao Chi-Yu, Hsieh Wei-Hsien. (2016) Povacoat affecting solid-state polymorphic changes of indomethacin after co-evaporation from different types of solvents via conventional and microwave drying techniques. Asian Journal of Pharmaceutical Sciences. 11(3): 376-384.[SCI] (IF2020=6.598；R/C=34/352，PHARMACOLOGY & PHARMACY)
  21. Lin Shan-Yang*, Lin Hong-Liang, Hung Ru-Ying, Huang Yu-Ting and Kao Chi-Yu. (2015) Effect of Povacoat or Soluplus on Solid-State Characterization of Indomethacin-Nicotinamide Co-Crystal Formation. Pharm. Anal. Acta. 6:8
  22. Lin Shan-Yang*, Lin Hong-Liang, Chi Ying-Ting, Huang Yu-Ting, Kao Chi-Yu, Hsieh Wei-Hsien. (2015) Thermoanalytical and Fourier transform infrared spectral curve-fitting techniques used to investigate the amorphous indomethacin formation and its physical stability in Indomethacin-Soluplus® solid dispersions. Int. J. Pharmaceut. 496: 457-465. →Int. J. Pharm.[SCI] (IF2020=5.875；R/C=18/352，PHARMACOLOGY & PHARMACY)
  23. Lin Hong-Liang, Chi Ying-Ting, Huang Yu-Ting, Kao Chi-Yu and Lin Shan-Yang*.(2015) DSC-FTIR Combined Approaches Used to Simultaneously Prepare/Determine the Amorphous Solid Dispersions of Indomethacin/Soluplus in Real-time. EC Pharmaceutical Science 2.1: 183-193.
  24. Kao Chi-Yu, Huang Huai-Han, Huang Yu-Ting, Lin Hong-Liang, Lin Shan-Yang*. (2015) Thermoanalytical and spectroscopic studies on amorphization and phase transition of amorphous indomethacin prepared by two melt-cooling processes. Sci. Letter. J. , 4: 148
  25. Lin Hong-Liang*, Zhang Gang-Chun, Lin Shan-Yang**. (2015) Real-time co-crystal screening and formation between indomethacin and saccharin via DSC analytical technique or DSC–FTIR microspectroscopy. J. Therm. Anal. Calorim. 120: 679-687. [SCI] (IF2020=4.626；R/C=18/71，THERMODYNAMICS)
  26. Lin Hong-Liang*, Zhang Gang-Chun, Huang Yu-Ting, Lin Shan-Yang**. (2014) An Investigation of Indomethacin–Nicotinamide Cocrystal Formation Induced by Thermal Stress in the Solid or Liquid State. J. Pharm. Sci. 103: 2386-2395. [SCI] (IF2020=3.534；R/C=51/216，CHEMISTRY, MULTIDISCIPLINARY)
  27. Lin Hong-Liang*, Wu Tieh-Kang, Lin Shan-Yang**. (2014) Screening and characterization of cocrystal formation of metaxalone with short-chain dicarboxylic acids induced by solvent-assistedgrinding approach. Thermochim. Acta 575: 313-321. [SCI] (IF2020=3.115；R/C=26/71，THERMODYNAMICS)
  28. Lee Lin-Wen, Hung Sheng-Feng, Lin Hong-Liang, Ho Hsiu-O, Sheu Ming-Thau*. (2013) Development of Timely Controlled-Release Systems for Chronotherapy of Propranolol with Minimization of the pH Effect in the Simulated Gastrointestinal Medium. J. Food Drug Anal. 21: 115-125. [SCI] (IF2020=6.079；R/C=29/352，PHARMACOLOGY & PHARMACY)
  29. Lin Hong-Liang, Hsu Po-Chun, Lin Shan-Yang*. (2013) Theophylline-citric acid co-crystals easily induced by DSC-FTIR microspectroscopy or different storage conditions. Asian Journal of Pharmaceutical Sciences. 8: 19-27. [SCI] (IF2020=6.598；R/C=34/352，PHARMACOLOGY & PHARMACY)
  30. Lin Hong-Liang, Zhang Gang-Chun, Hsu Po-Chun, Lin Shan-Yang*. (2013) A portable fiber-optic Raman analyzer for fast real-time screening and identifying cocrystal formation of drug-coformer via grinding process. Microchem. J. 110: 15-20. [SCI] (IF2020=4.821；R/C=12/93，CHEMISTRY, ANALYTICAL)
  31. Hsu Po-Chun, Lin Hong-Liang, Wang Shun-Li**, Lin Shan-Yang*. (2012) Solid-state thermal behavior and stability studies of theophylline-citric acid cocrystals prepared by neat cogrinding or thermal treatment. J. Solid State Chem. 192: 238-245. [SCI] (IF2020=3.498；R/C=13/43，CHEMISTRY, INORGANIC & NUCLEAR)
  32. Zhang Gang-Chun, Lin Hong-Liang*, Lin Shan-Yang**. (2012) Thermal analysis and FTIR spectral curve-fitting investigation of formation mechanism and stability of indomethacin-saccharin cocrystals via solid-state grinding process. J. Pharmaceut. Biomed. Anal. 66: 162-169. [SCI] (IF2020=3.935；R/C=16/93，CHEMISTRY, ANALYTICAL)
  33. Lin Hong-liang, Lin Shan-Yang*, Lin Chih-Cheng, Hsu Cheng-Hung, Wu Tieh-Kang, Huang Yu-Ting. (2012) Mechanical grinding effect on thermodynamics and inclusion efficiency of loratadine–cyclodextrin inclusion complex formation. Carbohydr. Polym. 87: 512-517. [SCI] (IF2020=9.381；R/C=1/58，CHEMISTRY, ORGANIC)
  34. Wu Tieh-Kang, Lin Shan-Yang*, Lin Hong-liang, Huang Yu-Ting. (2011) Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time. Bioorg. Med. Chem. Lett. 21: 3148-3151. [SCI] (IF2020=2.823；R/C=14/58，CHEMISTRY, ORGANIC)
  35. Lin Shan-Yang*, Cheng Wen-Ting, Wei Yen-Shan, Lin Hong-liang. (2011) DSC-FTIR microspectroscopy used to investigate the heat-induced intramolecular cyclic anhydride formation between Eudragit E and PVA copolymer. Polym. J. 43: 577–580. [SCI] (IF2020=3.080；R/C=42/90，POLYMER SCIENCE)
  36. Lin Hong-Liang, Lin Shyr-Yi, Lin Ying-Ku, Ho Hsiu-O, Lo Yo-Wen, Sheu Ming-Thau*. (2008) Release characteristics and in vitro–in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling. Eur. J. Pharm. Biopharm. 70: 289–301. [SCI] (IF2020=5.571；R/C=19/352，PHARMACOLOGY & PHARMACY)
  37. Lin Hong-Liang, Ho Hsiu-O, Chen Chi-Chia, Yeh Ta-Shuong, Sheu Ming-Thau*. (2008) Process and formulation characterizations of the thermal adhesion granulation (TAG) process for improving granular properties. Int. J. Pharmaceut. 357: 206–212. [SCI] (IF2020=5.875；R/C=18/352，PHARMACOLOGY & PHARMACY)
💡 Patents
※ Total : 9 (Scroll to view)
  1. 中華民國專利證書 發明第 I 434930號
  2. 新穎性軟膠囊膠皮技術開發與安定性改善應用研究(NSC 101-2622-B-264-001-CC3)/ 計畫主持人[110,000]
  3. 控時釋放膜衣包覆技術/計畫主持人[100,000]
  4. 改善藥物溶解度固體分散技術/計畫主持人[200,000]
  5. 具難溶性藥品組合藥物制放技術平台產品(MOST 104–2622-B-264-001-CC2)/計畫主持人[215,000]
  6. Doxazosin XL 4mg Tablets產品處方與製程技術/計畫主持人[1,000,000]
  7. 微膠囊化技術開發高劑量紅藜錠劑產品/計畫主持人[120,000]
  8. 海洋深層水微粉化技術/計畫主持人[80,000]
  9. 控釋型肥料技術/計畫主持人[60,000]
📑 Research Projects
※ Total : 14 (Scroll vertically to browse)
  1. Technical Development and Evaluation of Modified-Release Solid Dosage Forms (099-GOVE6023-01), Metal Industries Research & Development Centre, Dec 2010 – May 2011. [Principal Investigator]
  2. Undergraduate Student Research Project: Preparation of Acetaminophen–Ibuprofen Cocrystals via a Novel Hot-Melt Method and Improvement of Tabletability (Project No. 109-2813-C-037-001-E, Jul 1, 2020 – Feb 28, 2021)
NSTC Projects
※ Scroll horizontally to view the full table
Year Discipline Code Project Title Funding Category Role Approved Budget (NTD)
114 Traditional Chinese Medicine Therapeutic Effects and Mechanisms of Altersolanol A and PLGA-PEG-PLGA Copolymer Nanoparticles Against Malignant Glioblastoma Using Cell/Animal Models and Network Pharmacology Research Project (General) Co-PI 3,000,000
113 Biomedical Materials Formulation Design and Pharmacokinetic Study of an Aripiprazole Injectable with Dual Release (Immediate and Long-Acting) Profiles Research Project (General) PI 1,166,000
112 Biomedical Materials A Non-Contractile Thermosensitive PLGA In Situ Hydrogel for Subcutaneous Sustained Delivery of a Bispecific Anti-PSMA/Anti-CD3 Antibody Research Project (General) PI 1,189,000
111 Biomedical Materials Synergistic Therapy for Pancreatic Cancer Using an Oral Self-Emulsifying Microemulsion Co-Loaded with CPT-11 and Rapamycin Research Project (General) PI 1,078,000
110 Industry-Academia Technology Alliance Medical Imaging Industry Technology Platform (2/3) Research Project (Industry-Academia Technology Alliance) Co-PI 1,600,000
109 Traditional Chinese Medicine Investigation of Taiwan Incense Cedar Leaf Extract and Anticancer Components for Malignant Glioma: Progression, Cancer Stemness, Combined Radio/Chemotherapy, and Nano-Formulation Mechanisms Research Project (New Faculty) Co-PI 1,050,000
109 Industry-Academia Technology Alliance Medical Imaging Industry Technology Platform (1/3) Research Project (Industry-Academia Technology Alliance) Co-PI 2,300,000
109 Pharmacy A Nanoemulsifying Gastric-Retentive Oral Drug Delivery System to Enhance Irinotecan Bioavailability and Therapeutic Efficacy via Dual Inhibition of P-glycoprotein and CYP3A4 Research Project (General) PI 1,100,000
108 Pharmacy Development of High-Efficiency Propolis-Flavonoid Toothpaste and Mouthwash Products Industry-Academia Collaborative Research (Applied) PI 800,000
104 Pharmacy Product Development of a Controlled-Release Technology Platform for Poorly Soluble Combination Drugs Industry-Academia Collaborative Research (Development) PI 1,130,000
101 Pharmacy Development of Novel Softgel Shell Technology and Applications for Stability Improvement Industry-Academia Collaborative Research (Applied) PI 900,000
100 Food Engineering Functional Activity Exploration and Product Development from By-Products Generated During Rye Beer Production Industry-Academia Collaborative Research (Applied) Co-PI 600,000
🧾 Conference Papers
※ Total : 17 (Scroll to view)
  1. 林志城、王元辰、莊路德、林宏糧、楊智強，「紅酒生產中減廢回收的多酚其保健機能與產品開發」，台灣食品科技學會第41次年會，嘉義：嘉義大學，民國100年12月2日－民國100年12月2日。
  2. Shan-Yang Lin, Wen-Ting Cheng, Hong-Liang Lin(林宏糧), Yu-Ting Huang, “Thermodynamics and Phase Transition of Metoclopramide HCl Monohydrate in the Dehydration and Recrystallization Processes,”15th International Congress on Thermal Analysis and Calorimetry (ICTAC15), Osaka, Osaka, Japan, 2012, 8, 20－2012, 8, 24.
  3. Wen-Ting Cheng, Hong-Liang Lin(林宏糧), Yu-Ting Huang, Shan-Yang Lin*, “Thermodynamics and Phase Transition of Metoclopramide HCL Monohydrate in the Dehydration and Recrystallization Processes,”15th International Congress on Thermal Analysis and Calorimetry, 大阪, 大阪, 日本, 2012, 8, 20－2012, 8, 24.
  4. Hong-Liang Lin(林宏糧), Po-Chun Hsu, Gang-Chun Zhang, Yu-Ting Huang, Shan-Yang Lin, “Grinding process-induced Cocrystal Formation Between Theophylline and Citric Acid,”2012年台灣藥學會, 中國醫藥大學, Taichung, Taiwan, 2012, 11, 25－2012, 11, 25.
  5. Hong-liang Lin(林宏糧),Ying-Ji Lin, Keng-long Chang, Jheng-kai Huang.「Development of Theophylline Sustained Release Dosage Forms」，2013中華民國生醫材料及藥物制放年會暨國科會成果發表，Kaohsiung：Taiwan，民國102年5月4日－民國102年5月5日。
  6. Hong-liang Lin(林宏糧), Gang-Chun Zhang, Yu-Ting Huang, Shan-Yang Lin, “Studies on Indomethacin-Saccharin Cocrystal Formation and Its Stability in Soft Gelatin Capsule ,”7th International Symposium on Acid-Base Catalysis, Japan, Tokyo, Japan, 2013, 5, 12－2013, 5, 15.
  7. Hong-Liang Lin(林宏糧), Po-Chun Hsu, Yu-Ting Huang, Shan-Yang Lin*, “Simultaneous DSC-FTIR Microspectroscopy Quickly Screen and Detect the Co-crystal Formation of Theophylline and Citric Acid,”Seventh International Conference on Advanced Vibrational Spectroscopy (ICAVS-7), 神戶, 神戶, 日本, 2013, 8, 25－2013, 8, 30.
  8. 林翰亞, 劉明憲, 林盈吉, 黃鉦凱, 林宏糧, “Formulation Design and Pharmacokinetic Study of Cyclobenzaprine HCl Extended Release Tablets in Healthy Volunteers,”2014年中華民國生醫材料及藥物制放研討會暨海峽兩岸生醫材料及藥物制放研討會 , 清華大學, 新竹, 台灣, 2014, 5, 2－2014, 5, 2.
  9. 黃鉦凱、劉明憲、林翰亞、林盈吉、黃懷翰、林宏糧，「海洋深層水礦質微粉化技術及錠劑產品開發」，2014年醫護與健康科技研討會，宜蘭：宜蘭，民國103年5月30日－民國103年5月30日。[佳作]
  10. Hong-Liang Lin(林宏糧).Formulation and Development of Dutasteride/Tamsulosin Pellets Dosage Form for Benign Prostatic Hyperplasia. 4th International Conference on“Medical, Medicine and Health Sciences”, 28-29 May , 2016 Osaka, Japan.
  11. Jia-Chi Fan, Guan-Wei Chen, Jiahorng Liaw, Shan-Yang Lin, Hong-Liang Lin(林宏糧), Wei-Hsien Hsieh. Sustained release formulation for citronella oil. 2016年台灣藥學會, 台北醫學大學, 2016/12/17, Taipei, Taiwan.
  12. Jia-Yin Liang, Hong-Liang Lin(林宏糧).Evaluation of the properties of Ibuprofen granules prepared by thermal adhesion granulation method. 2020中華民國生醫材料及藥物制放學會年會, 2020/08/18, Taipei, Taiwan.
  13. Fei-Shan Lin, Hong-Liang Lin(林宏糧).以Fenofibrate製備與開發自微乳化藥物傳遞系統研究. 2020中華民國生醫材料及藥物制放學會年會, 2020/08/18, Taipei, Taiwan.
  14. Chin-Hsuan Hung, Yu-Kai Liang and Hong-Liang Lin. Development of high-dose extended-release pellets of quetiapine with Eudragit RL and RS. 2021中華民國生醫材料及藥物制放學會年會 暨 2021科技部生科司工程醫學學門成果發表會。
  15. Yu-Ren Wang, Yu-Kai Liang and Hong-Liang Lin. Development of gastroretentive drug delivery system(GRDDS) of dipyridamole. 2022 中華民國生醫材料及藥物制放學會年會暨 科技部生科司工程醫學學門成果發表會。
  16. Yu-Kai Liang and Hong-Liang Lin*.Enhancement of therapeutic Effects on Pancreatic Cancer via Synergistic Triple-combination with Orally Administered Irinotecan, Rapamycin and Silymarin-loaded Self-microemulsifying Drug Delivery System. The 14th Cell and Gene Therapy Symposium and Antibody Engineering and Innovative Immunotherapy Technology Forum. 22-23 Sep, 2023, Shanghai, China.
  17. Yu-Kai Liang, Yu-Ren Wang, Hao-Yi Hsu and Hong-Liang Lin*. Non-covalent Decoration of Trispecific T-cell Engagers on PEGylated Micellar Nanocarriers for Prolonged Cancer Immunotherapy. The 29th Annual Meeting of Japanese Association of Cancer Immunology. 24-26 July, 2025, Nagoya, Japan.
📚 Books and Book Chapters
  1. Shan-Yang Lin, Shan-Yang Lin, Hong-Liang Lin(林宏糧), Chih-Cheng Lin, Cheng-Hung Hsu, Tieh-kang Wu, Yu-Ting Huang. Thermodynamic Study of Grinding-Induced Loratadine Inclusion Complex Formation Using Thermal Analysis and Curve-Fitted FTIR Determination, Thermodynamics – Physical Chemistry of Aqueous Systems, 978-953-307-3187, Juan Carlos Moreno-Pirajan, Intech, 2011, pp. 317-326.
  2. Lee T.H., Lin S.Y., Lin H.L.(林宏糧), Huang Y.T., Wu T.K., Lin C.C., Trehalose and mannitol improved thermal stability of salmon calcitonin in both aqueous solution and lyophilized solid form. Internat Proc. 4th Eur Conf Chem Life Sci. , 978-88-7587-631-9, Medimond, Bologna, Italy, 2011, pp.63-69.
🤝 Industry–Academia Collaborative Research Funding
※ Total : 10 (Scroll to view)
  1. 鹽酸胺苯環庚烯緩釋錠劑處方開發研究計畫/計畫主持人[350,000]
  2. 治療轉移性結腸直腸癌 Oxaliplatin 50mg/10ml I.V.注射劑產品處方開發計畫/計畫主持人[300,000]
  3. PTS處方開發計畫/計畫主持人[500,000]
  4. IBUPROFEN高劑載處方研究開發計畫與推廣計畫/計畫主持人[600,000]
  5. Beatamethasone Dipropionate/ Clotrimazole/ Gentamicin Sulfate軟膏安定性改善計畫/計畫主持人[100,000]
  6. Chloramphenicol/ Dexamethasone 眼藥水安定性改善計畫/計畫主持人[100,000]
  7. 益生菌活菌顆粒劑產品開發計畫/計畫主持人[400,000]
  8. Sitagliptin處方設計與製程開發計畫/計畫主持人[800,000]
  9. 冬蟲夏草指標性成分分析與安定性評估/計劃編號：S107018/計畫主持人[525,000]，108/01/04～109/02/29。
  10. 固定複方藥物西格列汀與二甲二胍延長釋放產品開發KN-108KN003(108/10/01~109/09/30) (中山高醫產學合作計畫300,000)/計畫主持人。
🏭 Industry-Sponsored R&D Achievements
 Regulatory Approvals : 18  ｜ Technology Transfers: 10 ｜ Pilot Study: 1 
※ Total : 29 (Scroll to view)
Drug Development
Drugs Dosage Dose Status
Immediate-Release Dosage Form
Acetylcysteine Effervescent Tablet 600mg 🔵 
Cilostazol Immediate Release/ Tablet 50mg 🟢 
Fenofibrate Immediate Release/Tablet 160mg 🟢 
Fenofibrate Immediate Release/Capsule 200mg 🟢 
Simvastatin Immediate Release/Tablet 40mg 🟢 
Fexofenadine Immediate Release/Tablet 60mg 🟢 
Gliclazide Immediate Release/Tablet 80mg 🟢               
Pioglitazone Immediate Release/Tablet 30mg 🟢
Losartan Immediate Release/Tablet 100mg 🟢 
Orlistat Immediate Release/Capsule 120mg 🟢
Quetiapine Immediate Release/Tablet 200mg 🟢 
Risperidone Immediate Release/Tablet 2mg 🟢 
Modified-Release Dosage Forms
Cetirizine / pseudoephedrine Extended Release/Tablet 5/120mg 🔵 
Gliclazide Modified Release/Tablet 30mg 🟢 
Diltiazem Prolonged Release/Tablet 180mg 🟠 
Dipyridamole Retard Release/Capsule 200mg 🔵 
Doxazosin Extended Release/Tablet 4mg 🟢 
Nifedipine Sustained Release/Capsule 30mg 🔵 
Propranolol Extended Release/Capsule 80mg 🔵 
Ambroxol Sustained Release/Capsule 75 mg 🔵
Ambroxol Sustained Release/Tablet 75 mg 🟢 
Omeprazole Film-coated Tablet 20mg 🟢 
Omeprazole Capsule 40mg 🔵 
Pantoprazole Gastro-resistant/ Tablet 40mg 🟢
Tamsulosin Sustained Release/D. Tablet 0.2mg 🟢 
Tamsulosin Sustained Release/Capsule 0.2mg 🟢
Theophylline Sustained Release/Capsule 400mg 🔵 
Tramadol Sustained Release/Tablet 100mg 🟢
Formulation Stability Enhancement for Pharmaceutical and Cosmetic Products
Drugs Dosage Dose Note
Acetylcysteine Effervescent Tablet 600mg
Dexamethasone, Hydroquinone, Tretinoin Cream 藥妝
Glucosamine Sulfate Capsule 250 mg
Hydroquinone Cream 40 mg 藥妝
Nifedipine Soft capsule 10 mg
Tranexamic acid, Salicylic acid Keep water white cream 藥妝
Scale-Up and Manufacturing Optimization
Drugs Dosage Dose
Acetylcysteine Effervescent Tablet 600mg
Ambroxol HCl Sustained Release/Tablet 75 mg
Fenofibrate Immediate Release/Tablet 160mg
Fenofibrate Immediate Release/Capsule 200mg
Gliclazide Modified Release/Tablet 30 mg
Orlistat Immediate Release/Capsule 60/120mg
Simethicone Immediate Release/Tablet 40 mg
  • Views:516
  • Update Date:2026-03-10
  • Contact Us