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::: I-Chuan Yen

CH
🧪 PHARMACEUTICAL SCIENCES
I-Chuan Yen
I-Chuan Yen 
Associate Professor
Laboratory Profile
Our laboratory primarily focuses on the active components of natural products and Chinese herbal medicines. By integrating natural product chemistry, cellular and molecular biology, and pharmacological techniques, we investigate the underlying mechanisms of herbal medicines and natural products in metabolic diseases, cancer, and inflammation-related disorders. Our core research includes the isolation, identification, and pharmacological evaluation of active components from Antrodia cinnamomea and other natural sources. We utilize cellular and animal models to analyze their regulatory mechanisms in adipogenesis, inflammatory responses, and tumor growth. Relevant studies have demonstrated that natural products exert anti-inflammatory, anti-tumor, and metabolic-regulating effects by modulating multiple signaling pathways, such as mTOR, β-catenin, and the NLRP3 inflammasome. Furthermore, our lab combines medical databases with epidemiological methodologies to conduct integrated analyses of disease risks and the pharmacological effects of natural products. Our ultimate goal is to establish a scientific foundation for natural product drug development and promote the modernization and clinical application of Chinese herbal medicines.
📞 Contact Information
Office Room: Room 9351
Tel: +886-2-8792-3100 ext. 18880
E-mail: yenichuan@mail.ndmutsgh.edu.tw
🎓 Education
B.S., School of Pharmacy, National Defense Medical Center (1996–2000)
M.S., Graduate Institute of Pharmacy, National Defense Medical Center (2003–2005)
Ph.D., Graduate Institute of Medical Sciences, National Defense Medical Center (2011–2017)
💼 Current Positions
Associate Professor, School of Pharmacy, National Defense Medical Center
Committee Member, Pharmacognosy (Including Chinese Materia Medica) Test Bank Group, Ministry of Examination
Committee Member, Project for Promoting Pharmacists' Study of Chinese Medicine and Practicum Capacity (2026), Federation of Taiwan Pharmacists Associations
🏛 Experience
2026/02–present Associate Professor, School of Pharmacy, NDMC
2025/01–2025/12 Committee Member for the Selection of Chinese Medicine Practicum Sites (2025), Federation of Taiwan Pharmacists Associations
2019/05–present Committee Member, Pharmacognosy Test Bank Group, Ministry of Examination
2017/12–2026/02 Assistant Professor, School of Pharmacy, NDMC
2009/06–2017/11 Lecturer, School of Pharmacy, NDMC
2005/08–2009/05 Pharmacist, Tri-Service General Hospital (TSGH)
2002/11–2003/08 Platoon Leader and Medical Supply Officer, Tri-Service Medical Supply Office
2001/08–2002/10 Medical Supply Officer, Matsu Depot, Tri-Service Medical Supply Office
2000/07–2001/07 Medical Supply Officer, Receiving Depot, Tri-Service Medical Supply Office
🔬 Research Fields
Chinese Materia Medica, Pharmacognosy
🧪 Technical Expertise
Isolation and Structural Identification of Chemical Components from Chinese Herbal Medicines and Natural Products
Pharmacology and Disease Mechanism Research of Natural Products (Obesity, NASH, Cancer, Antiviral)
Cellular and Molecular Biology Techniques (Cell Culture, Signal Transduction Analysis)
Gut Microbiota and Metabolic Disease Research
🧾 Publications
(Star-sign*: correspondent；+ indicates co-first author)
  1. Lin KT, Hsieh YC, Chang PK, Lai CW, Lee SY and Yen IC*. 4 Acetyl-antrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation. International Journal of Molecular Medicine. 2026;57(5):126. (IF=5.8)
  2. Pi-Kai Chang, I-Chuan Yen, Wei-Cheng Tsai, Kuen-Tze Lin, and Shih-Yu Lee. Polygonum barbatum extract induces ER stress-mediated UPR and autophagy to suppress colorectal cancer growth. Toxicology Research. 2026;15(1):tfaf188. (IF=2.1)
  3. Lin KT+, Lee SU, Lee YJ, Wu PJ, Chang TC, Chang WL and Yen IC*. Antrodia cinnamomea Extract Attenuates Obesity by Targeting Adipogenic Pathways and Gut Dysbiosis in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences. 2025;26(12):5856. (IF=4.9)
  4. Su WY+, Lo HH, Wen YL, Lu JW, Yen IC, Ho YJ, Kao LT*. Assessing Traditional Chinese Medicines for Anti-Dengue Using a National Health Insurance Research Database and Bioassays. Food Science and Nutrition. 2025;13(3):e70009. (IF=3.8)
  5. Lai ZZ+, Yen IC, Hung HY, Hong CY, Lai CW, Lee YM*. In Vitro Antiviral Activity of Rhodiola crenulata Extract against Zika Virus and Japanese Encephalitis Virus: Viral Binding and Stability. Pharmaceuticals. 2024;17(8):988. (IF=4.8)
  6. Chang PK+, Yen IC, Tsai WC, & Lee SY*. Polygonum barbatum extract reduces colorectal cancer cell proliferation, migration, invasion, and epithelial–mesenchymal transition via YAP and β-catenin pathway regulation. Scientific Reports. 2023;13(1):18368. (IF=3.9)
  7. Tsung TH+, Huang KH, Chien WC, Chen YH, Yen IC, Chung CH, Chen JT, Chen CL*. Uveitis increases the risk of stroke among patients with ankylosing spondylitis: A nationwide population based longitudinal study. Frontiers in Immunology. 2022;959848. (IF=5.9)
  8. Yen IC+, Tu QW, Chang TC, Lin PH, Li YF, Lee SY*. 4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation. Biomedicine & Pharmacotherapy. 2021;138:111504. (IF=7.5)
  9. Lee SY+, Yen IC, Lin JC, Chung MC and Liu WH*. 4-Acetylantrocamol LT3 Inhibits Glioblastoma Cell Growth and Downregulates DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase. American Journal of Chinese Medicine. 2021;49(4):1-17. (IF=5.5)
  10. Wu CH+, Ou CH, Yen IC, Lee SY*. 4-acetylantroquinonol B inhibits osteoclastogenesis by inhibiting the autophagy pathway in a simulated microgravity model. International Journal of Molecular Sciences. 2020;21(18):1-17. (IF=4.9)
  11. Huang LY+, Yen IC, Tsai WC, Lee SY*. Rhodiola crenulata Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells. American Journal of Chinese Medicine. 2020;48(1):91-105. (IF=5.5)
  12. Kao YT+, Li HY, Yen IC, Chang WL, Chang TC*. New phenylethanoid from the flower of Osmanthus fragrans and their bioactivities on human dermal fibroblasts. Phytochemistry Letters. 2020;36:127-133. (IF=1.4)
  13. Chen YL+, Yen IC, Lin KT, Lai FY, Lee SY*. 4-Acetylantrocamol LT3, a New Ubiquinone from Antrodia cinnamomea, Inhibits Hepatocellular Carcinoma HepG2 Cell Growth by Targeting YAP/TAZ, mTOR, and WNT/β-Catenin Signaling. American Journal of Chinese Medicine. 2020;48(5):1243-1261. (IF=5.5)
  14. Yen IC+, Lin JC+, Chen Y, Tu QW and Lee SY*. Antrodia Cinnamomea Attenuates NonAlcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo. American Journal of Chinese Medicine. 2020;48(8):1859-1874. (IF=5.5)
  15. Lin KT+, Lai SW, Hsu SD, Fan CY, Wang HJ, Chang PK, Liu WH, Chen YL, Yen IC, Lee SY*. Shoulder pain and risk of developing hypertension and cardiovascular disease: A nationwide population-based cohort study in Taiwan. Journal of Medical Sciences. 2019;39(3):127-134.
  16. Pi-Kai Chang, I-Chuan Yen, Wei-Cheng Tsai, Tsu-Chung Chang and Shih-Yu Lee. Protective Effects of Rhodiola Crenulata Extract on Hypoxia-Induced Endothelial Damage via Regulation of AMPK and ERK Pathways. International Journal of Molecular Sciences. 2018;19:2286.
  17. I-Chuan Yen, Li-Shian Shi, Min-Chieh Chung, Blerina Ahmetaj-Shala, Tsu-Chung Chang, Shih-Yu Lee*. Antrolone, a new benzoid from Antrodia cinnamomea mycelium, inhibits LPS-induced inflammatory response via balance of the NFκB and Nrf2 pathways in RAW 264.7 macrophage cells. American Journal of Chinese Medicine. 2018;46(06):1297-1313.
  18. Huang, L.-Y.; Yen, I.-C.; Tsai, W.-C.; Ahmetaj-Shala, B.; Chang, T.-C.; Tsai, C.-S.; Lee, S.-Y. Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. American Journal of Chinese Medicine. 2017;45(06):1201-1216.
  19. Yen, I. C.; Lee, S. Y.; Lin, K. T.; Lai, F. Y.; Kuo, M. T.; Chang, W. L. In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea Mycelium. Molecules. 2017;22(5):747.
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  • Update Date:2026-03-24
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